R A North

Summary

Affiliation: Geneva Biomedical Research Institute
Country: UK

Publications

  1. ncbi request reprint Families of ion channels with two hydrophobic segments
    R A North
    Glaxo Institute for Molecular Biology, 14 Chemin des Aulx, Plan les Quates, 1228 Geneva, Switzerland
    Curr Opin Cell Biol 8:474-83. 1996
  2. ncbi request reprint Nucleotide receptors
    R A North
    Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, 14 Chemin des Aulx, Plan les Ouates, 1228 Geneva, Switzerland
    Curr Opin Neurobiol 7:346-57. 1997
  3. ncbi request reprint Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels
    G Collo
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    J Neurosci 16:2495-507. 1996
  4. ncbi request reprint The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
    A Surprenant
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Science 272:735-8. 1996
  5. pmc An antagonist-insensitive P2X receptor expressed in epithelia and brain
    G Buell
    Glaxo Institute for Molecular Biology, Plan les Ouates, 1228 Geneva, Switzerland
    EMBO J 15:55-62. 1996
  6. ncbi request reprint Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons
    C Lewis
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Nature 377:432-5. 1995
  7. ncbi request reprint Contribution of individual subunits to the multimeric P2X(2) receptor: estimates based on methanethiosulfonate block at T336C
    R Stoop
    Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, Geneva, Switzerland
    Mol Pharmacol 56:973-81. 1999
  8. ncbi request reprint The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA
    F Rassendren
    Geneva Biomedical Research Institute, GlaxoWellcome Research and Development, Plan les Ouates, 1228 Geneva, Switzerland
    J Biol Chem 272:5482-6. 1997
  9. ncbi request reprint Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor
    C Virginio
    Geneva Biomedical Research Institute, Glaxo Wellcome, Switzerland
    Neuropharmacology 36:1285-94. 1997
  10. ncbi request reprint Functional selectivity of orphanin FQ for its receptor coexpressed with potassium channel subunits in Xenopus laevis oocytes
    H Matthes
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Mol Pharmacol 50:447-50. 1996

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Families of ion channels with two hydrophobic segments
    R A North
    Glaxo Institute for Molecular Biology, 14 Chemin des Aulx, Plan les Quates, 1228 Geneva, Switzerland
    Curr Opin Cell Biol 8:474-83. 1996
    ..The mechanosensitive channel of bacteria has emerged as the simplest form of a channel protein subunit with two hydrophobic domains...
  2. ncbi request reprint Nucleotide receptors
    R A North
    Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, 14 Chemin des Aulx, Plan les Ouates, 1228 Geneva, Switzerland
    Curr Opin Neurobiol 7:346-57. 1997
    ..Recent studies suggest that it is important to use purified nucleotides in such classifications. Several P2Y receptors have a very widespread tissue distribution...
  3. ncbi request reprint Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels
    G Collo
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    J Neurosci 16:2495-507. 1996
    ..The functional properties and tissue distribution of these six P2X receptors indicate new roles for ATP-gated ion channels...
  4. ncbi request reprint The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
    A Surprenant
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Science 272:735-8. 1996
    ..Thus, the P2X7 (or P2Z) receptor is a bifunctional molecule that could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells...
  5. pmc An antagonist-insensitive P2X receptor expressed in epithelia and brain
    G Buell
    Glaxo Institute for Molecular Biology, Plan les Ouates, 1228 Geneva, Switzerland
    EMBO J 15:55-62. 1996
    ..They also introduce a new phenotype for ATP responses at P2X receptors--insensitivity to currently known antagonists...
  6. ncbi request reprint Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons
    C Lewis
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Nature 377:432-5. 1995
    ..Although in some tissues responses to ATP can be accounted for by homomeric channels, our results indicate that ATP-gated channels of sensory neurons may form by a specific heteropolymerization of P2X receptor subunits...
  7. ncbi request reprint Contribution of individual subunits to the multimeric P2X(2) receptor: estimates based on methanethiosulfonate block at T336C
    R Stoop
    Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, Geneva, Switzerland
    Mol Pharmacol 56:973-81. 1999
    ..The present results show that a "per-subunit" channel block causes the blocking effects of MTSET and they suggest that not four but maximally three subunits actively participate in the channel formation...
  8. ncbi request reprint The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA
    F Rassendren
    Geneva Biomedical Research Institute, GlaxoWellcome Research and Development, Plan les Ouates, 1228 Geneva, Switzerland
    J Biol Chem 272:5482-6. 1997
    ..Expression of chimeric molecules indicated that some of the differences between the rat and human receptor could be reversed by exchanging the intracellular C-terminal domain of the proteins...
  9. ncbi request reprint Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor
    C Virginio
    Geneva Biomedical Research Institute, Glaxo Wellcome, Switzerland
    Neuropharmacology 36:1285-94. 1997
    ..Thus, calmidazolium can block activation of the ionic channel but this does not prevent the formation of the large permeabilizing pore...
  10. ncbi request reprint Functional selectivity of orphanin FQ for its receptor coexpressed with potassium channel subunits in Xenopus laevis oocytes
    H Matthes
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Mol Pharmacol 50:447-50. 1996
    ..3 nM) but not to orphanin FQ. Thus, both kappa and orphanin FQ receptors readily couple to potassium channels, but the highly selective activation by dynorphin and orphanin FQ is consistent with distinct functional pathways in vivo...
  11. pmc Calcium permeability and block at homomeric and heteromeric P2X2 and P2X3 receptors, and P2X receptors in rat nodose neurones
    C Virginio
    Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, 14 Chemin des Aulx, 1228 Plan les Ouates, Geneva, Switzerland
    J Physiol 510:27-35. 1998
    ..The correspondence in properties between P2X2/3 receptors and nodose ganglion neurones further supports the conclusion that the native alpha,beta-methylene ATP-sensitive receptor is a P2X2/3 heteromultimer...
  12. ncbi request reprint The S. cerevisiae outwardly-rectifying potassium channel (DUK1) identifies a new family of channels with duplicated pore domains
    J D Reid
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Receptors Channels 4:51-62. 1996
    ..Additional sequences with the duplicate pore motif were found in C. elegans, suggesting that these proteins represent a novel structural family of potassium channel proteins...
  13. pmc Effects of barium, lanthanum and gadolinium on endogenous chloride and potassium currents in Xenopus oocytes
    T Tokimasa
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    J Physiol 496:677-86. 1996
    ..5. It is proposed that lanthanum, gadolinium and barium can usefully separate these endogenous membrane currents in Xenopus oocytes...
  14. ncbi request reprint A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP
    S Valera
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Nature 371:516-9. 1994
    ..The P2x receptor thus defines a new family of ligand-gated ion channels...
  15. pmc Proteomic and functional evidence for a P2X7 receptor signalling complex
    M Kim
    Institute of Molecular Physiology, University of Sheffield, Alfred Denny Building, Western Bank, Sheffield S10 2TN, UK
    EMBO J 20:6347-58. 2001
    ..Others, such as RPTPbeta, might exert feedback control of the channel itself through its dephosphorylation...
  16. ncbi request reprint Differential assembly of rat purinergic P2X7 receptor in immune cells of the brain and periphery
    M Kim
    Institute of Molecular Physiology, University of Sheffield, Alfred Denny Building, Western Bank, Sheffield S10 2TN, United Kingdom
    J Biol Chem 276:23262-7. 2001
    ....
  17. ncbi request reprint Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptor
    L H Jiang
    Institute of Molecular Physiology, University of Sheffield, Alfred Denny Building, Western Bank, Sheffield S10 2TN, United Kingdom
    J Biol Chem 276:14902-8. 2001
    ..The results suggest that Val(48) at the outer end of the first hydrophobic segment takes part in the gating movement of channel opening...
  18. ncbi request reprint Rapid secretion of interleukin-1beta by microvesicle shedding
    A Mackenzie
    Institute of Molecular Physiology, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Immunity 15:825-35. 2001
    ..We conclude that microvesicle shedding is a major secretory pathway for rapid IL-1beta release from activated monocytes and may represent a more general mechanism for secretion of similar leaderless secretory proteins...
  19. ncbi request reprint Pharmacology and function of nicotinic acetylcholine and P2X receptors in the enteric nervous system
    J J Galligan
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI, USA
    Neurogastroenterol Motil 16:64-70. 2004
    ..P2X receptors mediating fast synaptic excitation are predominately P2X2 homomeric receptors...
  20. ncbi request reprint International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits
    B S Khakh
    Division of Biology 156 29, California Institute of Technology, Pasadena, California, USA
    Pharmacol Rev 53:107-18. 2001
    ..The current nomenclature is based largely on recombinant receptor studies and detailed knowledge of endogenous P2X receptors in native tissues is limited because of lack of good selective agonists and antagonists for each receptor type...
  21. ncbi request reprint Cloning, functional expression, and developmental regulation of a neuropeptide Y receptor from Drosophila melanogaster
    X J Li
    Vollum Institute, Portland, Oregon
    J Biol Chem 267:9-12. 1992
    ..The molecular characterization of this receptor should lead to a better understanding of the functional role of this important family of hormone receptors in adult organisms and during development...
  22. ncbi request reprint Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family
    M P Kavanaugh
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201 3098
    J Biol Chem 269:15445-50. 1994
    ..These results demonstrate that domains of these transporters can function in chimeric combinations to control viral receptor and transport functions...
  23. pmc Cloning, heterologous expression and developmental regulation of a Drosophila receptor for tachykinin-like peptides
    X J Li
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    EMBO J 10:3221-9. 1991
    ..These observations demonstrate that the tachykinin family of peptide transmitters and their receptors represent an evolutionarily ancient form of cellular communication within the nervous system.(ABSTRACT TRUNCATED AT 250 WORDS)..
  24. ncbi request reprint Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channel
    Y C Cai
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    DNA Cell Biol 11:163-72. 1992
    ....
  25. ncbi request reprint Cloning and expression of a rat somatostatin receptor enriched in brain
    X J Li
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 267:21307-12. 1992
    ..This pattern contrasts with the exclusive peripheral expression of a recently cloned human SRIF receptor. The cDNA probe of rat receptor detects mRNA from mouse brain but not from human cerebral cortex and cerebellum...
  26. pmc P2X1 and P2X4 receptor currents in mouse macrophages
    J A Sim
    Faculty of Life Sciences, University of Manchester, Manchester, Lancashire, UK
    Br J Pharmacol 152:1283-90. 2007
    ..Activation of P2X receptors on macrophages is an important stimulus for cytokine release. This study seeks evidence for functional expression of P2X receptors in macrophages that had been only minimally activated...