A Achari

Summary

Affiliation: Geneva Biomedical Research Institute
Country: UK

Publications

  1. ncbi Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase
    A Achari
    Glaxo Wellcome Research and Development, Beckenham, Kent, UK
    Nat Struct Biol 4:490-7. 1997
  2. ncbi 2.0 A X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue
    D K Stammers
    Glaxo Wellcome R and D, Medicines Research Centre, Stevenage, UK
    FEBS Lett 456:49-53. 1999
  3. ncbi Glucose-6-phosphate isomerase
    A Achari
    Philos Trans R Soc Lond B Biol Sci 293:145-57. 1981

Collaborators

  • D K Stammers
  • J N Champness
  • P K Bryant
  • J Rosemond
  • D O Somers
  • D L Scott

Detail Information

Publications3

  1. ncbi Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase
    A Achari
    Glaxo Wellcome Research and Development, Beckenham, Kent, UK
    Nat Struct Biol 4:490-7. 1997
    ..The 7,8-dihydropterin pyrophosphate (DHPPP) substrate binds in a deep cleft in the barrel, whilst sulfanilamide binds closer to the surface. The DHPPP ligand site is highly conserved amongst prokaryotic and eukaryotic DHPSs...
  2. ncbi 2.0 A X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue
    D K Stammers
    Glaxo Wellcome R and D, Medicines Research Centre, Stevenage, UK
    FEBS Lett 456:49-53. 1999
    ....
  3. ncbi Glucose-6-phosphate isomerase
    A Achari
    Philos Trans R Soc Lond B Biol Sci 293:145-57. 1981
    ..It seems possible that glucose-6-phosphate isomerase, triose phosphate isomerase and pyruvate kinase all contain a histidine and a glutamate residue at the active site...