Affiliation: Frimley Park Hospital
- Mucosal addressin cell adhesion molecule (MAdCAM-1) expression is upregulated in the cirrhotic liver and immunolocalises to the peribiliary plexus and lymphoid aggregatesAftab Ala
Faculty of Health and Medical Sciences, University of Surrey, Surrey, GU2 7TE, UK
Dig Dis Sci 58:2528-41. 2013..Enhanced cell expression of MAdCAM-1 is critical in tissue recruitment of lymphocytes in response to stimuli expressing the α4β7 integrin. MAdCAM-1 is well characterized in gut mucosa with emerging evidence of hepatic expression...
- Wilson's diseaseAftab Ala
UCL Institute of Hepatology, Hampstead Campus, Division of Medicine, Royal Free and University College Medical School, University College London, London, UK
Lancet 369:397-408. 2007..Liver transplantation corrects the underlying pathophysiology and can be lifesaving. The discovery of the Wilson's disease gene has opened up a new molecular diagnostic approach, and could form the basis of future gene therapy...
- Wilson disease: pathophysiology, diagnosis, treatment, and screeningAftab Ala
Division of Liver Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Clin Liver Dis 8:787-805, viii. 2004..Future cell-based and genetic therapies may provide a cure for this disorder...
- Histopathology and clinical correlates of end-stage hepatitis B cirrhosis: a possible mechanism to explain the response to antiviral therapySamuel H Sigal
Center for Liver Disease and Transplantation, New York Weill Cornell Medical Center, 525 East 68th Street, Box 308, New York, NY 10021, USA
Liver Transpl 11:82-8. 2005..In conclusion, high-grade inflammation is common in end-stage HBV cirrhosis, but it is not readily detected by biochemical and virologic parameters. High-grade inflammation is associated with a greater degree of hepatic decompensation...
- Wilson disease in septuagenarian siblings: Raising the bar for diagnosisAftab Ala
Division of Liver Diseases, Recanati Miller Transplant Institute, The Mount Sinai Medical Center, New York, NY, USA
Hepatology 41:668-70. 2005..Environmental and extragenic factors are pivotal determinants of disease phenotype. We suggest that WD must be considered at all ages in patients with hepatic disease, neurological disease, or psychiatric symptoms...