Brian M Frier

Summary

Country: UK

Publications

  1. ncbi request reprint Serum thyrotropin is a better predictor of future thyroid dysfunction than thyroid autoantibody status in biochemically euthyroid patients with diabetes: implications for screening
    Roderick E Warren
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Thyroid 14:853-7. 2004
  2. ncbi request reprint How hypoglycaemia can affect the life of a person with diabetes
    Brian M Frier
    Department of Diabetes, Royal Infirmary, Edinburgh
    Diabetes Metab Res Rev 24:87-92. 2008
  3. doi request reprint Hypoglycaemia: an overview
    Alex J Graveling
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, United Kingdom
    Prim Care Diabetes 3:131-9. 2009
  4. doi request reprint Cognitive functioning in type 1 diabetes: the Diabetes Control and Complications Trial (DCCT) revisited
    B M Frier
    Department of Diabetes, Royal Infirmary, Edinburgh, Scotland, EH16 4SA, UK
    Diabetologia 54:233-6. 2011
  5. ncbi request reprint Morbidity of hypoglycemia in type 1 diabetes
    Brian M Frier
    Department of Diabetes, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, Scotland, UK
    Diabetes Res Clin Pract 65:S47-52. 2004
  6. ncbi request reprint Epidemiology, short and long-term consequences of hypoglycaemia
    B M Frier
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Diabetes Nutr Metab 15:378-84; discussion 384-5. 2002
  7. pmc Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Jie Ding
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Diabetes 59:2883-9. 2010
  8. ncbi request reprint Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes
    Andrew J Sommerfield
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh EH16 4ES, Scotland, U K
    Diabetes Care 27:2335-40. 2004
  9. pmc Effects of acute insulin-induced hypoglycemia on spatial abilities in adults with type 1 diabetes
    Rohana J Wright
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, U K
    Diabetes Care 32:1503-6. 2009
  10. pmc Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Diabetes Care 33:714-20. 2010

Collaborators

Detail Information

Publications73

  1. ncbi request reprint Serum thyrotropin is a better predictor of future thyroid dysfunction than thyroid autoantibody status in biochemically euthyroid patients with diabetes: implications for screening
    Roderick E Warren
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Thyroid 14:853-7. 2004
    ..To ascertain the predictive values of thyroid autoantibodies and thyrotropin (TSH) levels for subsequent thyroid dysfunction in patients with diabetes...
  2. ncbi request reprint How hypoglycaemia can affect the life of a person with diabetes
    Brian M Frier
    Department of Diabetes, Royal Infirmary, Edinburgh
    Diabetes Metab Res Rev 24:87-92. 2008
    ....
  3. doi request reprint Hypoglycaemia: an overview
    Alex J Graveling
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, United Kingdom
    Prim Care Diabetes 3:131-9. 2009
    ..Hypoglycaemia can disrupt many everyday activities such as driving, work performance and recreational pursuits. Measures to reduce the risk of hypoglycaemia are labour-intensive and require substantial resources...
  4. doi request reprint Cognitive functioning in type 1 diabetes: the Diabetes Control and Complications Trial (DCCT) revisited
    B M Frier
    Department of Diabetes, Royal Infirmary, Edinburgh, Scotland, EH16 4SA, UK
    Diabetologia 54:233-6. 2011
    ..Although the degree of cognitive impairment was mild and limited to a few domains, these decrements may influence the performance of everyday activities, such as driving...
  5. ncbi request reprint Morbidity of hypoglycemia in type 1 diabetes
    Brian M Frier
    Department of Diabetes, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, Scotland, UK
    Diabetes Res Clin Pract 65:S47-52. 2004
    ..Appreciation of the potential morbidities of hypoglycemia should encourage physicians to utilize therapeutic regimens that decrease the risk of severe hypoglycemia...
  6. ncbi request reprint Epidemiology, short and long-term consequences of hypoglycaemia
    B M Frier
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Diabetes Nutr Metab 15:378-84; discussion 384-5. 2002
  7. pmc Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Jie Ding
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Diabetes 59:2883-9. 2010
    ..A considerable homology exists between the retinal and cerebral microcirculations; a hypothesized association between diabetic retinopathy (DR) and cognitive decline was examined in older people with type 2 diabetes...
  8. ncbi request reprint Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes
    Andrew J Sommerfield
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh EH16 4ES, Scotland, U K
    Diabetes Care 27:2335-40. 2004
    ..To examine the effects of acute hyperglycemia on cognitive function and mood in people with type 2 diabetes...
  9. pmc Effects of acute insulin-induced hypoglycemia on spatial abilities in adults with type 1 diabetes
    Rohana J Wright
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, U K
    Diabetes Care 32:1503-6. 2009
    ..The deterioration in spatial abilities observed during modest experimental hypoglycemia provides novel information on the cerebral hazards of hypoglycemia that has potential relevance to everyday activities...
  10. pmc Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Diabetes Care 33:714-20. 2010
    ..We aimed to determine whether fasting cortisol levels are associated with cognitive ability and estimated lifetime cognitive change in an elderly population with type 2 diabetes...
  11. pmc Effects of acute insulin-induced hypoglycemia on indices of inflammation: putative mechanism for aggravating vascular disease in diabetes
    Rohana J Wright
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
    Diabetes Care 33:1591-7. 2010
    ..To examine the effects of acute insulin-induced hypoglycemia on inflammation, endothelial dysfunction, and platelet activation in adults with and without type 1 diabetes...
  12. ncbi request reprint Moderate hypoglycaemia after learning does not affect memory consolidation and brain activation during recognition in non-diabetic adults
    Roderick E Warren
    Department of Diabetes, Royal Infirmary of Edinburgh, UK
    Diabetes Metab Res Rev 24:247-52. 2008
    ..This study examined whether moderate hypoglycaemia occurring after learning would disrupt the consolidation process, and used functional magnetic resonance imaging (fMRI) to identify accompanying changes in brain activation...
  13. ncbi request reprint An evaluation of methods of assessing impaired awareness of hypoglycemia in type 1 diabetes
    Jacqueline Geddes
    Diabetes Department, Royal Infirmary of Edinburgh, Edinburgh, UK
    Diabetes Care 30:1868-70. 2007
  14. ncbi request reprint Acute hypoglycemia impairs nonverbal intelligence: importance of avoiding ceiling effects in cognitive function testing
    Roderick E Warren
    Department of Diabetes, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, Scotland, U K
    Diabetes Care 27:1447-8. 2004
  15. ncbi request reprint Cognitive ability and brain structure in type 1 diabetes: relation to microangiopathy and preceding severe hypoglycemia
    Stewart C Ferguson
    Department of Diabetes, The Royal Infirmary of Edinburgh, Edinburgh, U K
    Diabetes 52:149-56. 2003
    ..Chronic hyperglycemia (inferred by the presence of background diabetic retinopathy) may affect brain structure and function...
  16. doi request reprint Prevalence of impaired awareness of hypoglycaemia and frequency of hypoglycaemia in insulin-treated type 2 diabetes
    Josefine E Schopman
    Department of Diabetes, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, Scotland, UK
    Diabetes Res Clin Pract 87:64-8. 2010
    ..The present study sought to ascertain the prevalence of impaired awareness of hypoglycaemia (IAH) in people with insulin-treated Type 2 diabetes (T2DM) and its effect on risk of hypoglycaemia...
  17. ncbi request reprint Absence of sexual dimorphism in the symptomatic responses to hypoglycemia in adults with and without type 1 diabetes
    Jacqueline Geddes
    Department of Diabetes, The Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, UK
    Diabetes Care 29:1667-9. 2006
  18. doi request reprint Metabolic parameters associated with arterial stiffness in older adults with Type 2 diabetes: the Edinburgh Type 2 diabetes study
    Wei Leng Teoh
    Metabolic Unit, Western General Hospital, Edinburgh, UK
    J Hypertens 31:1010-7. 2013
    ..The aim of this study was to determine whether there was a link between PWV and clinical variables associated with central obesity, in men and women with Type 2 diabetes...
  19. ncbi request reprint Moderate hypoglycemia impairs multiple memory functions in healthy adults
    Andrew J Sommerfield
    Department of Diabetes, Royal Infirmary of Edinburgh, Scotland
    Neuropsychology 17:125-32. 2003
    ..These findings are informative concerning the metabolic basis of adequate memory function and are of practical importance to people with insulin-treated diabetes, in whom hypoglycemia is common...
  20. ncbi request reprint Delayed recovery of cognitive function following hypoglycemia in adults with type 1 diabetes: effect of impaired awareness of hypoglycemia
    Nicola N Zammitt
    Department of Diabetes, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, Scotland, UK
    Diabetes 57:732-6. 2008
    ..Recovery times of cognitive functions were examined after exposure to hypoglycemia in people with diabetes with and without impaired hypoglycemia awareness...
  21. pmc Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Riccardo E Marioni
    Centre for Population Health Sciences, University of Edinburgh, Scotland, UK
    Diabetes 59:710-3. 2010
    ....
  22. ncbi request reprint Effects of acute hypoglycemia on motivation and cognitive interference in people with type 1 diabetes
    Vincent McAulay
    Department of Diabetes, Royal Infirmary, Edinburgh, Scotland, UK
    J Clin Psychopharmacol 26:143-51. 2006
    ..To examine the effect of acute hypoglycemia on motivation and cognitive interference in adult humans with type 1 diabetes...
  23. doi request reprint Modeling the effects of hypoglycemia on a two-choice task in adult humans
    Jacqueline Geddes
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Neuropsychology 24:652-60. 2010
    ....
  24. ncbi request reprint The symptoms of hyperglycaemia in people with insulin-treated diabetes: classification using principal components analysis
    Roderick E Warren
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
    Diabetes Metab Res Rev 19:408-14. 2003
    ....
  25. doi request reprint The role of metabolic derangements and glucocorticoid excess in the aetiology of cognitive impairment in type 2 diabetes. Implications for future therapeutic strategies
    Mark W J Strachan
    Metabolic Unit, Western General Hospital, Edinburgh, UK
    Diabetes Obes Metab 11:407-14. 2009
    ..Large-scale epidemiological and intervention studies are now underway, which should enhance our understanding and management of cognitive impairment in type 2 diabetes...
  26. ncbi request reprint Vessel wall stiffness in type 1 diabetes and the central hemodynamic effects of acute hypoglycemia
    Andrew J Sommerfield
    Department of Diabetes, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, Scotland, UK
    Am J Physiol Endocrinol Metab 293:E1274-9. 2007
    ..To examine the effects of intravenous insulin and acute hypoglycemia on arterial wall stiffness and central hemodynamic responses in adults with and without type 1 diabetes...
  27. ncbi request reprint Hypoglycaemia and cognitive function
    Roderick E Warren
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
    Diabetes Obes Metab 7:493-503. 2005
    ..Children may be more prone to acute metabolic insults, and there is evidence of developmental disadvantage associated with hypoglycaemic episodes...
  28. ncbi request reprint Frequency, severity, and morbidity of hypoglycemia occurring in the workplace in people with insulin-treated diabetes
    Alastair M Leckie
    Institute of Occupational Medicine, Edinburgh, Scotland, U K
    Diabetes Care 28:1333-8. 2005
    ..Hypoglycemia was examined in regularly employed people with insulin-treated diabetes to ascertain the frequency and consequences of this problem in the workplace...
  29. doi request reprint Modeling the consistency of hypoglycemic symptoms: high variability in diabetes
    Nicola N Zammitt
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom
    Diabetes Technol Ther 13:571-8. 2011
    ..The aim of the present study was to examine symptoms of hypoglycemia, to develop a method to quantify individual differences in the consistency of symptom reporting, and to investigate which factors affect these differences...
  30. doi request reprint Medically minimising the impact of hypoglycaemia in type 2 diabetes: a review
    Radzi M Noh
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, UK
    Expert Opin Pharmacother 12:2161-75. 2011
    ..Large trials that have examined strict glycaemic control and cardiovascular outcomes in T2DM have highlighted the potential harm of exposure to hypoglycaemia in people with coronary heart disease...
  31. doi request reprint Vascular disease and diabetes: is hypoglycaemia an aggravating factor?
    Rohana J Wright
    Department of Diabetes, Royal Infirmary of Edinburgh, UK
    Diabetes Metab Res Rev 24:353-63. 2008
    ..The concept that acute hypoglycaemia could aggravate vascular complications associated with diabetes is discussed in relation to evolving comprehension of the pathogenesis of atherosclerosis and blood vessel disease...
  32. ncbi request reprint Insulin analogues and other developments in insulin therapy for diabetes
    Vincent McAulay
    Department of Diabetes, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, Scotland, UK
    Expert Opin Pharmacother 4:1141-56. 2003
    ..All insulin preparations are associated with the common side effect of hypoglycaemia, and encourage weight gain...
  33. ncbi request reprint Nocturnal hypoglycemia: clinical manifestations and therapeutic strategies toward prevention
    Kate V Allen
    Department of Diabetes, Royal Infirmary, Edinburgh, Scotland, United Kingdom
    Endocr Pract 9:530-43. 2003
    ..To review the features of nocturnal hypoglycemia and various preventive strategies...
  34. ncbi request reprint Short-term, delayed, and working memory are impaired during hypoglycemia in individuals with type 1 diabetes
    Andrew J Sommerfield
    Department of Diabetes, Royal Infirmary of Edinburgh, Scotland, UK
    Diabetes Care 26:390-6. 2003
    ..To examine the effects of acute insulin-induced hypoglycemia on short-term, delayed, and working memory in individuals with type 1 diabetes...
  35. ncbi request reprint The relationship between type 2 diabetes and cognitive dysfunction: longitudinal studies and their methodological limitations
    Kate V Allen
    Department of Diabetes, Royal Infirmary of Edinburgh, Scotland, UK
    Eur J Pharmacol 490:169-75. 2004
    ..These studies provide compelling evidence to support the view that people with type 2 diabetes are at increased risk of developing cognitive impairment in comparison with the general population...
  36. ncbi request reprint Food cravings during acute hypoglycaemia in adults with Type 1 diabetes
    Mark W J Strachan
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, Scotland, EH16 4SA, United Kingdom
    Physiol Behav 80:675-82. 2004
    ..No controlled studies have examined the effects of hypoglycaemia on food cravings. Thus, the aim of this study was to examine change in cravings for eight specified food types during euglycaemia and insulin-induced hypoglycaemia...
  37. ncbi request reprint Hypoglycemia in type 2 diabetes: pathophysiology, frequency, and effects of different treatment modalities
    Nicola N Zammitt
    Department of Diabetes, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, Scotland, U K
    Diabetes Care 28:2948-61. 2005
  38. ncbi request reprint Frequency of severe hypoglycemia requiring emergency treatment in type 1 and type 2 diabetes: a population-based study of health service resource use
    Graham P Leese
    Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
    Diabetes Care 26:1176-80. 2003
    ..To determine the incidence, predisposing factors, and costs of emergency treatment of severe hypoglycemia in people with type 1 and type 2 diabetes...
  39. doi request reprint The relationship between type 2 diabetes and dementia
    Mark W J Strachan
    Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh EH42XU, UK
    Br Med Bull 88:131-46. 2008
    ..The prevalence of type 2 diabetes and dementia are set to rise inexorably over the next 30-40 years. There are now substantial data to suggest that type 2 diabetes is associated with an increased risk of dementia...
  40. doi request reprint Drug-induced hypoglycaemia in type 2 diabetes
    Berit Inkster
    Royal Infirmary of Edinburgh, Department of Diabetes, 51 Little France Crescent, Edinburgh, EH16 4SA, UK
    Expert Opin Drug Saf 11:597-614. 2012
    ..Hypoglycaemia is a side effect caused by some therapies for type 2 diabetes, which can cause physical, social and psychological harm. Hypoglycaemia also prevents attainment of treatment goals and satisfactory glycaemic control...
  41. ncbi request reprint Hypoglycaemia and driving in people with insulin-treated diabetes: adherence to recommendations for avoidance
    A J Graveling
    Department of Diabetes, Royal Infirmary of Edinburgh, Scotland, UK
    Diabet Med 21:1014-9. 2004
    ..It is not known how many insulin-treated drivers are familiar with, or adhere to, recommended safe practice...
  42. ncbi request reprint Symptoms of hypoglycaemia in people with diabetes
    V McAulay
    Department of Diabetes, Royal Infirmary, Edinburgh, UK
    Diabet Med 18:690-705. 2001
    ..In addition, the routine assessment of hypoglycaemia symptoms in the diabetic clinic is emphasized as an important part of the regular review of people with diabetes who are treated with insulin...
  43. ncbi request reprint Apolipoprotein-e influences aspects of intellectual ability in type 1 diabetes
    Stewart C Ferguson
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, Scotland, U K
    Diabetes 52:145-8. 2003
    ..The APOE epsilon4 genotype is associated with specific cognitive disadvantage in young women with type 1 diabetes. APOE epsilon4 is unlikely to mediate susceptibility to hypoglycemia-induced cognitive disadvantage...
  44. ncbi request reprint Managing hypoglycaemia
    Brian M Frier
    Department of Diabetes, Royal Infirmary, Edinburgh
    Practitioner 249:564, 566, 568 passim. 2005
  45. ncbi request reprint Severe hypoglycaemia in patients with type 1 diabetes and impaired awareness of hypoglycaemia: a comparative study of insulin lispro and regular human insulin
    S C Ferguson
    Department of Diabetes, Royal Infirmary of Edinburgh, 1 Lauriston Place, Edinburgh EH3 9YW, Scotland, UK
    Diabetes Metab Res Rev 17:285-91. 2001
    ..Insulin lispro may have a beneficial role in the management of patients with diabetes at risk of severe hypoglycaemia, although a larger study is required to confirm these findings...
  46. doi request reprint Risks of marathon running and hypoglycaemia in Type 1 diabetes
    A J Graveling
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
    Diabet Med 27:585-8. 2010
    ..However, metabolic events occurring in the 48 h before the exercise can influence the risk and responses to exercise-induced hypoglycaemia...
  47. ncbi request reprint Hypoglycaemia in insulin-treated Type 2 diabetes: frequency, symptoms and impaired awareness
    J N Henderson
    Department of Diabetes, Royal Infirmary, Edinburgh, UK
    Diabet Med 20:1016-21. 2003
    ..A retrospective survey was made of 215 people with insulin-treated Type 2 diabetes to quantify the frequency and nature of hypoglycaemia experienced...
  48. ncbi request reprint Symptomatic and counterregulatory hormonal responses to acute hypoglycaemia induced by insulin aspart and soluble human insulin in Type 1 diabetes
    B M Frier
    Department of Diabetes, The Royal Infirmary of Edinburgh, Edinburgh, UK
    Diabetes Metab Res Rev 16:262-8. 2000
    ..Secondary objectives were to compare the counterregulatory, symptomatic and physiological responses to hypoglycaemia...
  49. ncbi request reprint Plasma endothelin response to acute hypoglycaemia in adults with Type 1 diabetes
    R J Wright
    Department of Diabetes, Royal Infirmary of Edinburgh, UK
    Diabet Med 24:1039-42. 2007
    ..To determine whether acute insulin-induced hypoglycaemia provokes a detectable alteration in peripheral plasma endothelin (ET) concentrations in humans with Type 1 diabetes...
  50. doi request reprint Effects of acute insulin-induced hypoglycaemia on psychomotor function: people with type 1 diabetes are less affected than non-diabetic adults
    J Geddes
    Department of Diabetes, The Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK
    Diabetologia 51:1814-21. 2008
    ..We examined the effects of acute insulin-induced hypoglycaemia on psychomotor function in non-diabetic volunteers and in adults with type 1 diabetes...
  51. ncbi request reprint Attentional functioning is impaired during acute hypoglycaemia in people with Type 1 diabetes
    V McAulay
    Department of Diabetes, Royal Infirmary, Edinburgh and Department of Psychology, University of Edinburgh, Edinburgh, UK
    Diabet Med 23:26-31. 2006
    ..To examine the effects of acute insulin-induced hypoglycaemia on different aspects of attention and on general non-verbal reasoning in people with Type 1 diabetes...
  52. pmc Pubertal stage and hypoglycaemia counterregulation in type 1 diabetes
    L A Ross
    Section of Child Life and Health, Department of Reproductive and Developmental Sciences, University of Edinburgh, Scotland, UK
    Arch Dis Child 90:190-4. 2005
    ..To compare physiological and autonomic responses to acute hypoglycaemia in diabetic children in pre-, mid-, and post-pubertal stages of development...
  53. pmc Prevalence of and risk factors for hepatic steatosis and nonalcoholic Fatty liver disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Rachel M Williamson
    Metabolic Unit, Western General Hospital, Edinburgh, UK
    Diabetes Care 34:1139-44. 2011
    ..We aimed to determine the prevalence and clinical correlates of these conditions in a large cohort of people with type 2 diabetes...
  54. ncbi request reprint Evaluation of an on-call diabetes service in a large teaching hospital
    P Perros
    Department of Diabetes, Royal Infirmary, Edinburgh, Scotland, UK
    Diabet Med 17:386-9. 2000
    ..To assess prospectively the activity and effectiveness of a diabetes specialist on-call service...
  55. ncbi request reprint Evaluation of serum markers of neuronal damage following severe hypoglycaemia in adults with insulin-treated diabetes mellitus
    M W Strachan
    Department of Diabetes, Royal Infirmary of Edinburgh, UK
    Diabetes Metab Res Rev 15:5-12. 1999
    ..Neurone-specific enolase (NSE) and protein S-100 (S-100) may be used as markers of acute neuronal damage in humans with neurological disorders...
  56. ncbi request reprint Serum angiotensin-converting enzyme and frequency of severe hypoglycaemia in Type 1 diabetes: does a relationship exist?
    N N Zammitt
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
    Diabet Med 24:1449-54. 2007
    ..To ascertain whether this reported association could be replicated in a different country, it was re-examined in 300 individuals with Type 1 diabetes...
  57. doi request reprint Prevalence of impaired awareness of hypoglycaemia in adults with Type 1 diabetes
    J Geddes
    Department of Diabetes, Royal Infirmary of Edinburgh, UK
    Diabet Med 25:501-4. 2008
    ....
  58. ncbi request reprint Young adults with Type 1 diabetes in tertiary education: do students receive adequate specialist care?
    J Geddes
    Department of Diabetes, The Royal Infirmary, Edinburgh, UK
    Diabet Med 23:1155-7. 2006
    ..To examine the clinical characteristics of, and diabetes management provided for, young people with Type 1 diabetes in tertiary education...
  59. ncbi request reprint The effects of acute hypoglycaemia on memory acquisition and recall and prospective memory in type 1 diabetes
    R E Warren
    Department of Diabetes, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, UK
    Diabetologia 50:178-85. 2007
    ..This study assessed whether moderate hypoglycaemia disrupts learning and recall in isolation, and utilised a novel test of prospective memory which may better reflect the role of memory in daily life than conventional tests...
  60. ncbi request reprint Optimal time of administration of insulin lispro. Importance of meal composition
    M W Strachan
    Department of Diabetes, Royal Infirmary of Edinburgh, Scotland, U K
    Diabetes Care 21:26-31. 1998
    ..To compare the glucodynamics of pre- and postprandial administration of insulin lispro using test meals of differing composition...
  61. ncbi request reprint Effects of acute hypoglycaemia on auditory information processing in adults with Type I diabetes
    M W J Strachan
    Department of Diabetes, Royal Infirmary of Edinburgh, Scotland, United Kingdom
    Diabetologia 46:97-105. 2003
    ..Acute hypoglycaemia in humans causes general impairment of cognitive function, but information about its effects on more specific cognitive processes is limited...
  62. ncbi request reprint The role of cortisol in the peripheral granulocyte response to insulin-induced hypoglycaemia in man
    B M Fisher
    Department of Diabetes, Western Infirmary, Glasgow, Scotland
    Horm Metab Res 21:253-7. 1989
    ..02). This suggests that the rise in peripheral granulocytes following insulin-induced hypoglycaemia in man is mediated by cortisol released from the adrenal gland, following activation of the hypothalamic-pituitary-adrenal axis...
  63. ncbi request reprint Cognitive function and information processing in type 2 diabetes
    R Cosway
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    Diabet Med 18:803-10. 2001
    ..However, other diabetes-related factors, such as macrovascular disease, hypertension and depression, may contribute more to previously observed cognitive decrements in Type 2 diabetes...
  64. ncbi request reprint Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies
    M W Strachan
    Department of Diabetes, Royal Infirmary of Edinburgh, U K
    Diabetes Care 20:438-45. 1997
    ..The etiology of any cognitive decrement in type II diabetes is likely to result from an interaction between metabolic abnormalities intrinsic to diabetes, diabetes-specific complications, and other diabetes-related disorders...
  65. ncbi request reprint Increased CD40 ligand and platelet-monocyte aggregates in patients with type 1 diabetes mellitus
    S A Harding
    Cardiovascular Research Unit, Royal Infirmary of Edinburgh, Edinburgh EH16 4SB, Scotland, UK
    Atherosclerosis 176:321-5. 2004
    ..We investigated whether CD40 ligand (L) expression and platelet-monocyte aggregation are increased in patients with type 1 diabetes...
  66. ncbi request reprint Prevalence of pernicious anaemia in patients with Type 1 diabetes mellitus and autoimmune thyroid disease
    P Perros
    Department of Diabetes, Royal Infirmary, Edinburgh, Scotland, UK
    Diabet Med 17:749-51. 2000
    ..To determine the prevalence of pernicious anaemia in patients with Type 1 diabetes mellitus and autoimmune thyroid disease...
  67. ncbi request reprint Acute hypoglycemia impairs the functioning of the central but not peripheral nervous system
    M W Strachan
    Department of Diabetes, Royal Infirmary of Edinburgh, Scotland, Edinburgh, UK
    Physiol Behav 72:83-92. 2001
    ....
  68. ncbi request reprint Child and parental mental ability and glycaemic control in children with Type 1 diabetes
    L A Ross
    Department of Child Life and Health, University of Edinburgh, Edinburgh, UK
    Diabet Med 18:364-9. 2001
    ..Many psycho-social factors can affect the glycaemic control of children with Type 1 diabetes, but the influence of the intelligence of the child and their parents has not been reported...
  69. ncbi request reprint Acute hypoglycemia in humans causes attentional dysfunction while nonverbal intelligence is preserved
    V McAulay
    Department of Diabetes, Royal Infirmary, Edinburgh, Scotland, UK
    Diabetes Care 24:1745-50. 2001
    ..On the basis of these results, it can be surmised that many complex attention tasks relevant to everyday life are impaired during moderate hypoglycemia...
  70. ncbi request reprint Influence of an early-onset age of type 1 diabetes on cerebral structure and cognitive function
    Stewart C Ferguson
    Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, Scotland, U K
    Diabetes Care 28:1431-7. 2005
    ..We hypothesized that if differences in neuroradiological structure and cognitive ability coexisted in those who had EOD, then an organic component to their etiology was likely...
  71. ncbi request reprint Thyroid autoimmunity at onset of type 1 diabetes as a predictor of thyroid dysfunction: response to Gonzalez et al
    Roderick E Warren
    Diabetes Care 30:e120; author reply e121. 2007
  72. pmc Diabetes, cognitive impairment, and dementia
    Mark W J Strachan
    BMJ 336:6. 2008
  73. ncbi request reprint [Does recurrent exposure to severe hypoglycaemia affect cognitive function?]
    Brian M Frier
    Pol Arch Med Wewn 117:341-2. 2007