Brett P Lyons

Summary

Affiliation: Fisheries and Aquaculture Science
Country: UK

Publications

  1. ncbi request reprint Phototoxicity of pyrene and benzo[a]pyrene to embryo-larval stages of the Pacific oyster Crassostrea gigas
    B P Lyons
    Ceentre for Environment, Fisheries and Aquaculture Science, Lowestoft, UK
    Mar Environ Res 54:627-31. 2002
  2. ncbi request reprint The detection of biomarkers of genotoxin exposure in the European flounder (Platichthys flesus) collected from the River Tyne Estuary
    B P Lyons
    Centre for Environment Fisheries and Aquaculture Sciences CEFAS, Lowestoft Laboratory, Suffolk, UK
    Mutat Res 446:111-9. 1999
  3. ncbi request reprint 32P-postlabelling analysis of DNA adducts and EROD induction as biomarkers of genotoxin exposure in dab (Limanda limanda) from British coastal waters
    B P Lyons
    Centre for Environment, Fisheries and Aquaculture Science, Pakefield Road, Lowestoft, Suffolk NR33 0HT, UK
    Mar Environ Res 50:575-9. 2000
  4. ncbi request reprint A biological effects monitoring survey of Cardigan Bay using flatfish histopathology, cellular biomarkers and sediment bioassays: findings of the Prince Madog Prize 2003
    Brett P Lyons
    The Centre for Environment, Fisheries and Aquaculture Sciences, Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, UK
    Mar Environ Res 62:S342-6. 2006
  5. ncbi request reprint DNA adduct analysis and histopathological biomarkers in European flounder (Platichthys flesus) sampled from UK estuaries
    B P Lyons
    Lowestoft Laboratory, The Centre for Environment, Fisheries and Aquaculture Science, Pakefield Road, Lowestoft, Suffolk NR33 0HT, UK
    Mutat Res 552:177-86. 2004
  6. ncbi request reprint The viviparous blenny (Zoarces viviparus) as a bioindicator of contaminant exposure: application of biomarkers of apoptosis and DNA damage
    Brett P Lyons
    CEFAS Lowestoft Laboratory, Pakefield Road, Lowestoft, Suffolk NR33 0HT, UK
    Mar Environ Res 58:757-61. 2004
  7. doi request reprint Gene expression analyses of hepatocellular adenoma and hepatocellular carcinoma from the marine flatfish Limanda limanda
    Hamish J Small
    Centre for Environment, Fisheries and Aquaculture Science Cefas, Barrack Road, Weymouth, Dorset DT4 8UB, UK
    Dis Aquat Organ 88:127-41. 2010
  8. ncbi request reprint Comparison of biomarker and pathological responses in flounder (Platichthys flesus L.) induced by ingested polycyclic aromatic hydrocarbon (PAH) contamination
    W J Reynolds
    The Centre for Environment, Fisheries and Aquaculture Sciences, Remembrance Avenue, Burnham on Crouch, Essex CM0 8HA, UK
    Chemosphere 52:1135-45. 2003
  9. ncbi request reprint Histopathological biomarkers in estuarine fish species for the assessment of biological effects of contaminants
    G D Stentiford
    CEFAS Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, UK
    Mar Environ Res 55:137-59. 2003
  10. doi request reprint Using biological effects tools to define Good Environmental Status under the European Union Marine Strategy Framework Directive
    B P Lyons
    Centre for Environment, Fisheries and Aquaculture Science, Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, United Kingdom
    Mar Pollut Bull 60:1647-51. 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Phototoxicity of pyrene and benzo[a]pyrene to embryo-larval stages of the Pacific oyster Crassostrea gigas
    B P Lyons
    Ceentre for Environment, Fisheries and Aquaculture Science, Lowestoft, UK
    Mar Environ Res 54:627-31. 2002
    ..3 +/- 0.1 microW/cm2 and UVA = 456.2 +/- 55 microW/cm2). A linear relationship was also demonstrated for benzo[a]pyrene phototoxicity with decreasing UV light intensity...
  2. ncbi request reprint The detection of biomarkers of genotoxin exposure in the European flounder (Platichthys flesus) collected from the River Tyne Estuary
    B P Lyons
    Centre for Environment Fisheries and Aquaculture Sciences CEFAS, Lowestoft Laboratory, Suffolk, UK
    Mutat Res 446:111-9. 1999
    ..The in vivo dosing of flounder with benzo[a]pyrene (BaP) to produced DNA adducts in similar chromatographic positions to the diagonal radioactive zones in the Tyne caught flounder are also described...
  3. ncbi request reprint 32P-postlabelling analysis of DNA adducts and EROD induction as biomarkers of genotoxin exposure in dab (Limanda limanda) from British coastal waters
    B P Lyons
    Centre for Environment, Fisheries and Aquaculture Science, Pakefield Road, Lowestoft, Suffolk NR33 0HT, UK
    Mar Environ Res 50:575-9. 2000
    ..No correlation could be found in this study between EROD activity and the level of DNA adducts...
  4. ncbi request reprint A biological effects monitoring survey of Cardigan Bay using flatfish histopathology, cellular biomarkers and sediment bioassays: findings of the Prince Madog Prize 2003
    Brett P Lyons
    The Centre for Environment, Fisheries and Aquaculture Sciences, Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, UK
    Mar Environ Res 62:S342-6. 2006
    ..The alignment of biological effects measures via such integrated cruise programs are discussed. This work was partly funded under the auspices of the 2003 Prince Madog Prize...
  5. ncbi request reprint DNA adduct analysis and histopathological biomarkers in European flounder (Platichthys flesus) sampled from UK estuaries
    B P Lyons
    Lowestoft Laboratory, The Centre for Environment, Fisheries and Aquaculture Science, Pakefield Road, Lowestoft, Suffolk NR33 0HT, UK
    Mutat Res 552:177-86. 2004
    ....
  6. ncbi request reprint The viviparous blenny (Zoarces viviparus) as a bioindicator of contaminant exposure: application of biomarkers of apoptosis and DNA damage
    Brett P Lyons
    CEFAS Lowestoft Laboratory, Pakefield Road, Lowestoft, Suffolk NR33 0HT, UK
    Mar Environ Res 58:757-61. 2004
    ..Further studies on the use of germ cell apoptotic rate at different estuarine sites are required if it is to be used as a reproductive biomarker of contaminant exposure in male fish...
  7. doi request reprint Gene expression analyses of hepatocellular adenoma and hepatocellular carcinoma from the marine flatfish Limanda limanda
    Hamish J Small
    Centre for Environment, Fisheries and Aquaculture Science Cefas, Barrack Road, Weymouth, Dorset DT4 8UB, UK
    Dis Aquat Organ 88:127-41. 2010
    ..To the best of our knowledge, this is the first report of the association of vitellogenin expression with tumors of wild fish...
  8. ncbi request reprint Comparison of biomarker and pathological responses in flounder (Platichthys flesus L.) induced by ingested polycyclic aromatic hydrocarbon (PAH) contamination
    W J Reynolds
    The Centre for Environment, Fisheries and Aquaculture Sciences, Remembrance Avenue, Burnham on Crouch, Essex CM0 8HA, UK
    Chemosphere 52:1135-45. 2003
    ..No significant histopathological changes were observed. The results are discussed with respect to the implications for the use of these methods in environmental monitoring studies...
  9. ncbi request reprint Histopathological biomarkers in estuarine fish species for the assessment of biological effects of contaminants
    G D Stentiford
    CEFAS Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, UK
    Mar Environ Res 55:137-59. 2003
    ..As such, it provides a powerful integrative tool for the assessment of biological effects of contaminants in these environments...
  10. doi request reprint Using biological effects tools to define Good Environmental Status under the European Union Marine Strategy Framework Directive
    B P Lyons
    Centre for Environment, Fisheries and Aquaculture Science, Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, United Kingdom
    Mar Pollut Bull 60:1647-51. 2010
    ....
  11. ncbi request reprint The toxicological impacts of oil and chemically dispersed oil: UV mediated phototoxicity and implications for environmental effects, statutory testing and response strategies
    M F Kirby
    CEFAS Burnham Laboratory, Remembrance Avenue, Burnham on Crouch, Essex CM0 8HA, UK
    Mar Pollut Bull 54:472-5. 2007
  12. ncbi request reprint Liver tumors in wild flatfish: a histopathological, proteomic, and metabolomic study
    G D Stentiford
    CEFAS Weymouth Laboratory, Weymouth, Dorset, United Kingdom
    OMICS 9:281-99. 2005
    ..In this study, we present pilot data, which illustrates that proteomics and metabolomics can be used to discriminate fish liver tumors and suggest future directions for work of this type...
  13. doi request reprint Evaluating legacy contaminants and emerging chemicals in marine environments using adverse outcome pathways and biological effects-directed analysis
    Thomas H Hutchinson
    Centre for Environment, Fisheries and Aquaculture Science, Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, United Kingdom Electronic address
    Mar Pollut Bull 74:517-25. 2013
    ....
  14. doi request reprint Cryopreservation and storage of mussel (Mytilus spp.) haemocytes for latent analysis by the Comet assay
    Anthony Kwok
    Centre for Environment, Fisheries and Aquaculture Science, CEFAS Weymouth Laboratory, Weymouth, United Kingdom
    Mutat Res 750:86-91. 2013
    ....
  15. ncbi request reprint Isolation of the retinoblastoma cDNA from the marine flatfish dab (Limanda limanda) and evidence of mutational alterations in liver tumors
    Frances A Du Corbier
    Centre for Environment, Fisheries and Aquaculture Science Cefas, The Nothe, Weymouth, Dorset DT4 8UB, UK
    Environ Sci Technol 39:9785-90. 2005
    ..The ecotoxicological relevance of the Rb mutations in feral fish liver tumors, in terms of future genome instability and possible development of a genotoxicity biomarker, is discussed...
  16. ncbi request reprint Exposure of sticklebacks (Gasterosteus aculeatus) to cadmium sulfide nanoparticles: biological effects and the importance of experimental design
    Matthew B Sanders
    CEFAS Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset, UK
    Mar Environ Res 66:161-3. 2008
    ..The results are discussed emphasising the fundamental importance of experimental design and the need to understand the behaviour of nanoparticles in the aqueous phase...
  17. pmc The nuclear receptor gene family in the Pacific oyster, Crassostrea gigas, contains a novel subfamily group
    Susanne Vogeler
    Centre for Environment, Fisheries and Aquaculture Science, CEFAS Weymouth Laboratory, Barrack Road, Weymouth DT4 8UB, UK
    BMC Genomics 15:369. 2014
    ..However, the understanding of nuclear receptor presence, function and xenobiotic disruption in the phylum Mollusca is limited...
  18. ncbi request reprint Plasma proteome analysis reveals the geographical origin and liver tumor status of Dab (Limanda limanda) from UK marine waters
    Douglas G Ward
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Environ Sci Technol 40:4031-6. 2006
    ..Furthermore, accurate selection of sample groups is critical for avoiding effects of confounding factors such as age, gender, and geographic origin of samples...
  19. ncbi request reprint Isolation of differentially expressed genes from contaminant exposed European flounder by suppressive, subtractive hybridisation
    Derek L Sheader
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mar Environ Res 58:553-7. 2004
    ..These clones will form part of a flounder cDNA array for validation and future applications, with full identification being pursued for those expressed sequence tags for which differential expression can be confirmed by array technology...
  20. ncbi request reprint Oxidative stress response of European flounder (Platichthys flesus) to cadmium determined by a custom cDNA microarray
    Derek L Sheader
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mar Environ Res 62:33-44. 2006
    ....