Affiliation: Edward Jenner Institute for Vaccine Research
Tchilian E, Dawes R, Hyland L, Montoya M, Le Bon A, Borrow P, et al. Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice. Int Immunol. 2004;16:1323-32 pubmed
..These effects are more prominent in CD8 than CD4 cells. The transgenic mice share several properties with humans expressing variant CD45 alleles and provide a model to understand immune function in variant individuals. ..