Genomes and Genes
Affiliation: Edward Jenner Institute for Vaccine Research
- Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte responseNicola A Jones
Viral Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England, UK
J Exp Med 200:1243-56. 2004....
- Inhibition of the type I interferon antiviral response during arenavirus infectionPersephone Borrow
Nuffield Department of Clinical Medicine, The Jenner Institute, University of Oxford, Compton, Newbury, Berkshire RG20 7NN, UK E mail
Viruses 2:2443-80. 2010....
- Kinetics of expansion of epitope-specific T cell responses during primary HIV-1 infectionEmma L Turnbull
Viral Immunology Group, Jenner Institute, University of Oxford, Compton, United Kingdom
J Immunol 182:7131-45. 2009....
- A role for the transcription factor RelB in IFN-alpha production and in IFN-alpha-stimulated cross-primingAgne Le Bon
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
Eur J Immunol 36:2085-93. 2006..In summary, these results show that the RelB/NF-kappaB pathway is required for optimal IFN-alpha production after LCMV infection and suggest a crucial role for RelB in IFN-alpha-stimulated cross-priming of CD8(+) T cell responses...
- Escape is a more common mechanism than avidity reduction for evasion of CD8+ T cell responses in primary human immunodeficiency virus type 1 infectionEmma L Turnbull
Nuffield Department of Clinical Medicine, University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
Retrovirology 8:41. 2011..This study addressed the relative extent to which HIV-specific T cell responses are impacted by viral mutational escape versus reduction in response avidity during the first year of infection...
- Integrating in silico and in vitro analysis of peptide binding affinity to HLA-Cw*0102: a bioinformatic approach to the prediction of new epitopesValerie A Walshe
The Jenner Institute, University of Oxford, Compton, Berkshire, United Kingdom
PLoS ONE 4:e8095. 2009..Here, we describe the development and deployment of a reliable peptide-binding prediction method for a previously poorly-characterized human MHC class I allele, HLA-Cw*0102...
- Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infectionHolger B Kramer
Henry Wellcome Building for Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom
PLoS Pathog 6:e1000893. 2010..Insights gained into the mechanism of action of acute-phase reactants and other innate molecules against HIV and how they are induced could be exploited for the future development of more efficient prophylactic vaccine strategies...
- Reciprocal immunomodulation in a schistosome and hepatotropic virus coinfection modelMatthew J Edwards
Viral Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
J Immunol 175:6275-85. 2005....
- HIV-1 epitope-specific CD8+ T cell responses strongly associated with delayed disease progression cross-recognize epitope variants efficientlyEmma L Turnbull
The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, United Kingdom
J Immunol 176:6130-46. 2006..A better understanding of the features of T cell responses associated with long-term control of viral replication should facilitate rational vaccine design...
- Development of the antibody response in acute HIV-1 infectionMarlen M I Aasa-Chapman
Department of Immunology, University College London and the Edward Jenner Institute for Vaccine Research, Compton, UK
AIDS 18:371-81. 2004..Cytotoxic T lymphocytes have been shown to reduce viraemia during acute HIV-1 infection; however the role of neutralizing antibodies in this process is unclear. One confounding factor may be artefacts introduced by viral culture...
- Multiple mechanisms contribute to impairment of type 1 interferon production during chronic lymphocytic choriomeningitis virus infection of miceLian Ni Lee
The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, United Kingdom
J Immunol 182:7178-89. 2009..Understanding the mechanisms involved may assist in development of strategies for control of virus persistence and superinfection...
- Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFNMaria Montoya
Viral Immunology Group, Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
J Immunol 174:1851-61. 2005....
- Analysis of peptide-protein binding using amino acid descriptors: prediction and experimental verification for human histocompatibility complex HLA-A0201Pingping Guan
Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
J Med Chem 48:7418-25. 2005..6 and 0.7 and r2 between 0.6 and 0.9). Further to the QSAR analysis, 15 peptides were synthesized and tested using a T2 stabilization assay. All peptides bound to HLA-A0201 well, and four peptides were identified as high-affinity binders...
- Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infectionsAndrea R Stacey
The Jenner Institute, University of Oxford, Compton, Berkshire RG20 7NN, United Kingdom
J Virol 83:3719-33. 2009..The intense early cytokine storm in acute HIV-1 infection may have immunopathological consequences, promoting immune activation, viral replication, and CD4(+) T-cell loss...
- CD45 is required for type I IFN production by dendritic cellsMaria Montoya
The Edward Jenner Institute for Vaccine Research, Compton, UK
Eur J Immunol 36:2150-8. 2006..These data indicate that lack of CD45 expression in DC has a profound effect on their function. This is largely restored by CD45RABC or CD45RO transgenes...
- The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infectionNilu Goonetilleke
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, England, UK
J Exp Med 206:1253-72. 2009..These included clusters of mutations in envelope that were targeted by NAbs, a few isolated sites that reverted to the consensus sequence, and bystander mutations in linkage with T cell-driven escape...
- Emergence of a distinct HIV-specific IL-10-producing CD8+ T-cell subset with immunomodulatory functions during chronic HIV-1 infectionGenevieve Clutton
Oxford NIHR Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Eur J Immunol 43:2875-85. 2013..Production of IL-10 by HIV-specific CD8(+) T cells may represent an adaptive regulatory response to monocyte activation during chronic infection. ..
- Relative resistance of HIV-1 founder viruses to control by interferon-alphaAngharad E Fenton-May
Nuffield Department of Medicine, University of Oxford, NDM Research Building, Old Road Campus, Headington, Oxford OX3 7FZ, UK
Retrovirology 10:146. 2013..To address this hypothesis, the relative resistance of virus isolates derived from HIV-1-infected individuals during acute and chronic infection to control by type 1 IFNs was analysed...
- Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactionsDelyth M Reid
The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, RG20 7NN, UK
J Leukoc Biol 76:86-94. 2004..Tissue localization thus revealed potential roles of Dectin-1 in leukocyte interactions during innate immune responses and T cell development...
- Altered CD45 isoform expression affects lymphocyte function in CD45 Tg miceElma Z Tchilian
The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
Int Immunol 16:1323-32. 2004..These effects are more prominent in CD8 than CD4 cells. The transgenic mice share several properties with humans expressing variant CD45 alleles and provide a model to understand immune function in variant individuals...
- The immune response during acute HIV-1 infection: clues for vaccine developmentAndrew J McMichael
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
Nat Rev Immunol 10:11-23. 2010..In this Review, we discuss recent studies on the kinetics and quality of early immune responses to HIV-1 and their implications for developing a successful preventive HIV-1 vaccine...
- Association of strong virus-specific CD4 T cell responses with efficient natural control of primary HIV-1 infectionSimone E Gloster
Edward Jenner Institute for Vaccine Research, Compton, UK
AIDS 18:749-55. 2004..To investigate whether there are differences in the virus-specific CD4 T cell response during primary HIV-1 infection in patients who naturally (without antiretroviral intervention) control viral replication with differing efficiencies...
- Type I interferons produced by dendritic cells promote their phenotypic and functional activationMaria Montoya
Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
Blood 99:3263-71. 2002..These results show that DCs both secrete and respond to type I IFN, identifying type I interferons as autocrine DC activators...
- Cross-priming of CD8+ T cells stimulated by virus-induced type I interferonAgnes Le Bon
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England
Nat Immunol 4:1009-15. 2003..These data identify expression of IFN-alpha/beta as a mechanism for the induction of cross-priming during virus infections...
- Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infectionsUte Christiane Meier
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berks RG20 7NN, United Kingdom
J Virol 79:12365-74. 2005..We hypothesize that the reduced levels of IL-15 present in the serum during HIV and HCV infections might impact NK cell homeostasis, contributing to the common alterations of the NK pool observed in these unrelated infections...
- Innate immunity against HIV: a priority target for HIV prevention researchPersephone Borrow
Nuffield Department of Clinical Medicine, University of Oxford, The Jenner Institute, Compton, Newbury, Berkshire, UK
Retrovirology 7:84. 2010..Priority areas are identified where there are opportunities to accelerate the translation of recent gains in understanding of innate immunity into the design of improved or novel vaccine and microbicide strategies against HIV infection...
- Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsetsEriko Yamada
The Edward Jenner Institute for Vaccine Research, Compton, Newbury RG20 7NN, UK
J Gen Virol 86:2507-12. 2005..However, those PBMC subsets reported to be infected by HCV in vivo (monocytes, DCs and B cells) also exhibited residual, CD81-independent binding, indicating roles for SR-BI/other receptor(s) in mediating haematopoietic cell infection...
- Innate immunity in acute HIV-1 infectionPersephone Borrow
Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
Curr Opin HIV AIDS 6:353-63. 2011..The importance of interactions between HIV-1 and innate responses in determining events throughout AHI is increasingly recognized, and is reviewed here...
- Virus infection-associated bone marrow B cell depletion and impairment of humoral immunity to heterologous infection mediated by TNF-alpha/LTalphaPersephone Borrow
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, UK
Eur J Immunol 35:524-32. 2005....
- Towards the chemometric dissection of peptide--HLA-A*0201 binding affinity: comparison of local and global QSAR modelsIrini A Doytchinova
Edward Jenner Institute for Vaccine Research, RG20 7NN, Compton, Berkshire, UK
J Comput Aided Mol Des 19:203-12. 2005..The results suggest that, in their interactions with the MHC molecule, the peptide acts as a complicated ensemble of multiple amino acids mutually potentiating each other...