Persephone Borrow

Summary

Affiliation: Edward Jenner Institute for Vaccine Research
Country: UK

Publications

  1. pmc Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte response
    Nicola A Jones
    Viral Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England, UK
    J Exp Med 200:1243-56. 2004
  2. pmc Inhibition of the type I interferon antiviral response during arenavirus infection
    Persephone Borrow
    Nuffield Department of Clinical Medicine, The Jenner Institute, University of Oxford, Compton, Newbury, Berkshire RG20 7NN, UK E mail
    Viruses 2:2443-80. 2010
  3. doi Kinetics of expansion of epitope-specific T cell responses during primary HIV-1 infection
    Emma L Turnbull
    Viral Immunology Group, Jenner Institute, University of Oxford, Compton, United Kingdom
    J Immunol 182:7131-45. 2009
  4. ncbi A role for the transcription factor RelB in IFN-alpha production and in IFN-alpha-stimulated cross-priming
    Agne Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
    Eur J Immunol 36:2085-93. 2006
  5. pmc Escape is a more common mechanism than avidity reduction for evasion of CD8+ T cell responses in primary human immunodeficiency virus type 1 infection
    Emma L Turnbull
    Nuffield Department of Clinical Medicine, University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    Retrovirology 8:41. 2011
  6. pmc Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection
    Holger B Kramer
    Henry Wellcome Building for Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom
    PLoS Pathog 6:e1000893. 2010
  7. pmc Integrating in silico and in vitro analysis of peptide binding affinity to HLA-Cw*0102: a bioinformatic approach to the prediction of new epitopes
    Valerie A Walshe
    The Jenner Institute, University of Oxford, Compton, Berkshire, United Kingdom
    PLoS ONE 4:e8095. 2009
  8. ncbi Reciprocal immunomodulation in a schistosome and hepatotropic virus coinfection model
    Matthew J Edwards
    Viral Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    J Immunol 175:6275-85. 2005
  9. ncbi HIV-1 epitope-specific CD8+ T cell responses strongly associated with delayed disease progression cross-recognize epitope variants efficiently
    Emma L Turnbull
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, United Kingdom
    J Immunol 176:6130-46. 2006
  10. ncbi Development of the antibody response in acute HIV-1 infection
    Marlen M I Aasa-Chapman
    Department of Immunology, University College London and the Edward Jenner Institute for Vaccine Research, Compton, UK
    AIDS 18:371-81. 2004

Collaborators

Detail Information

Publications30

  1. pmc Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte response
    Nicola A Jones
    Viral Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England, UK
    J Exp Med 200:1243-56. 2004
    ....
  2. pmc Inhibition of the type I interferon antiviral response during arenavirus infection
    Persephone Borrow
    Nuffield Department of Clinical Medicine, The Jenner Institute, University of Oxford, Compton, Newbury, Berkshire RG20 7NN, UK E mail
    Viruses 2:2443-80. 2010
    ....
  3. doi Kinetics of expansion of epitope-specific T cell responses during primary HIV-1 infection
    Emma L Turnbull
    Viral Immunology Group, Jenner Institute, University of Oxford, Compton, United Kingdom
    J Immunol 182:7131-45. 2009
    ....
  4. ncbi A role for the transcription factor RelB in IFN-alpha production and in IFN-alpha-stimulated cross-priming
    Agne Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
    Eur J Immunol 36:2085-93. 2006
    ..In summary, these results show that the RelB/NF-kappaB pathway is required for optimal IFN-alpha production after LCMV infection and suggest a crucial role for RelB in IFN-alpha-stimulated cross-priming of CD8(+) T cell responses...
  5. pmc Escape is a more common mechanism than avidity reduction for evasion of CD8+ T cell responses in primary human immunodeficiency virus type 1 infection
    Emma L Turnbull
    Nuffield Department of Clinical Medicine, University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    Retrovirology 8:41. 2011
    ..This study addressed the relative extent to which HIV-specific T cell responses are impacted by viral mutational escape versus reduction in response avidity during the first year of infection...
  6. pmc Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection
    Holger B Kramer
    Henry Wellcome Building for Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom
    PLoS Pathog 6:e1000893. 2010
    ..Insights gained into the mechanism of action of acute-phase reactants and other innate molecules against HIV and how they are induced could be exploited for the future development of more efficient prophylactic vaccine strategies...
  7. pmc Integrating in silico and in vitro analysis of peptide binding affinity to HLA-Cw*0102: a bioinformatic approach to the prediction of new epitopes
    Valerie A Walshe
    The Jenner Institute, University of Oxford, Compton, Berkshire, United Kingdom
    PLoS ONE 4:e8095. 2009
    ..Here, we describe the development and deployment of a reliable peptide-binding prediction method for a previously poorly-characterized human MHC class I allele, HLA-Cw*0102...
  8. ncbi Reciprocal immunomodulation in a schistosome and hepatotropic virus coinfection model
    Matthew J Edwards
    Viral Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    J Immunol 175:6275-85. 2005
    ....
  9. ncbi HIV-1 epitope-specific CD8+ T cell responses strongly associated with delayed disease progression cross-recognize epitope variants efficiently
    Emma L Turnbull
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, United Kingdom
    J Immunol 176:6130-46. 2006
    ..A better understanding of the features of T cell responses associated with long-term control of viral replication should facilitate rational vaccine design...
  10. ncbi Development of the antibody response in acute HIV-1 infection
    Marlen M I Aasa-Chapman
    Department of Immunology, University College London and the Edward Jenner Institute for Vaccine Research, Compton, UK
    AIDS 18:371-81. 2004
    ..Cytotoxic T lymphocytes have been shown to reduce viraemia during acute HIV-1 infection; however the role of neutralizing antibodies in this process is unclear. One confounding factor may be artefacts introduced by viral culture...
  11. doi Multiple mechanisms contribute to impairment of type 1 interferon production during chronic lymphocytic choriomeningitis virus infection of mice
    Lian Ni Lee
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, United Kingdom
    J Immunol 182:7178-89. 2009
    ..Understanding the mechanisms involved may assist in development of strategies for control of virus persistence and superinfection...
  12. ncbi Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFN
    Maria Montoya
    Viral Immunology Group, Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    J Immunol 174:1851-61. 2005
    ....
  13. pmc Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections
    Andrea R Stacey
    The Jenner Institute, University of Oxford, Compton, Berkshire RG20 7NN, United Kingdom
    J Virol 83:3719-33. 2009
    ..The intense early cytokine storm in acute HIV-1 infection may have immunopathological consequences, promoting immune activation, viral replication, and CD4(+) T-cell loss...
  14. ncbi Analysis of peptide-protein binding using amino acid descriptors: prediction and experimental verification for human histocompatibility complex HLA-A0201
    Pingping Guan
    Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
    J Med Chem 48:7418-25. 2005
    ..6 and 0.7 and r2 between 0.6 and 0.9). Further to the QSAR analysis, 15 peptides were synthesized and tested using a T2 stabilization assay. All peptides bound to HLA-A0201 well, and four peptides were identified as high-affinity binders...
  15. ncbi CD45 is required for type I IFN production by dendritic cells
    Maria Montoya
    The Edward Jenner Institute for Vaccine Research, Compton, UK
    Eur J Immunol 36:2150-8. 2006
    ..These data indicate that lack of CD45 expression in DC has a profound effect on their function. This is largely restored by CD45RABC or CD45RO transgenes...
  16. pmc The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
    Nilu Goonetilleke
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, England, UK
    J Exp Med 206:1253-72. 2009
    ..These included clusters of mutations in envelope that were targeted by NAbs, a few isolated sites that reverted to the consensus sequence, and bystander mutations in linkage with T cell-driven escape...
  17. doi Emergence of a distinct HIV-specific IL-10-producing CD8+ T-cell subset with immunomodulatory functions during chronic HIV-1 infection
    Genevieve Clutton
    Oxford NIHR Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK
    Eur J Immunol 43:2875-85. 2013
    ..Production of IL-10 by HIV-specific CD8(+) T cells may represent an adaptive regulatory response to monocyte activation during chronic infection. ..
  18. ncbi Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice
    Elma Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
    Int Immunol 16:1323-32. 2004
    ..These effects are more prominent in CD8 than CD4 cells. The transgenic mice share several properties with humans expressing variant CD45 alleles and provide a model to understand immune function in variant individuals...
  19. ncbi Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions
    Delyth M Reid
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, RG20 7NN, UK
    J Leukoc Biol 76:86-94. 2004
    ..Tissue localization thus revealed potential roles of Dectin-1 in leukocyte interactions during innate immune responses and T cell development...
  20. pmc Relative resistance of HIV-1 founder viruses to control by interferon-alpha
    Angharad E Fenton-May
    Nuffield Department of Medicine, University of Oxford, NDM Research Building, Old Road Campus, Headington, Oxford OX3 7FZ, UK
    Retrovirology 10:146. 2013
    ..To address this hypothesis, the relative resistance of virus isolates derived from HIV-1-infected individuals during acute and chronic infection to control by type 1 IFNs was analysed...
  21. ncbi Association of strong virus-specific CD4 T cell responses with efficient natural control of primary HIV-1 infection
    Simone E Gloster
    Edward Jenner Institute for Vaccine Research, Compton, UK
    AIDS 18:749-55. 2004
    ..To investigate whether there are differences in the virus-specific CD4 T cell response during primary HIV-1 infection in patients who naturally (without antiretroviral intervention) control viral replication with differing efficiencies...
  22. pmc The immune response during acute HIV-1 infection: clues for vaccine development
    Andrew J McMichael
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Nat Rev Immunol 10:11-23. 2010
    ..In this Review, we discuss recent studies on the kinetics and quality of early immune responses to HIV-1 and their implications for developing a successful preventive HIV-1 vaccine...
  23. ncbi Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon
    Agnes Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England
    Nat Immunol 4:1009-15. 2003
    ..These data identify expression of IFN-alpha/beta as a mechanism for the induction of cross-priming during virus infections...
  24. ncbi Type I interferons produced by dendritic cells promote their phenotypic and functional activation
    Maria Montoya
    Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    Blood 99:3263-71. 2002
    ..These results show that DCs both secrete and respond to type I IFN, identifying type I interferons as autocrine DC activators...
  25. ncbi Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets
    Eriko Yamada
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury RG20 7NN, UK
    J Gen Virol 86:2507-12. 2005
    ..However, those PBMC subsets reported to be infected by HCV in vivo (monocytes, DCs and B cells) also exhibited residual, CD81-independent binding, indicating roles for SR-BI/other receptor(s) in mediating haematopoietic cell infection...
  26. pmc Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infections
    Ute Christiane Meier
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berks RG20 7NN, United Kingdom
    J Virol 79:12365-74. 2005
    ..We hypothesize that the reduced levels of IL-15 present in the serum during HIV and HCV infections might impact NK cell homeostasis, contributing to the common alterations of the NK pool observed in these unrelated infections...
  27. pmc Innate immunity against HIV: a priority target for HIV prevention research
    Persephone Borrow
    Nuffield Department of Clinical Medicine, University of Oxford, The Jenner Institute, Compton, Newbury, Berkshire, UK
    Retrovirology 7:84. 2010
    ..Priority areas are identified where there are opportunities to accelerate the translation of recent gains in understanding of innate immunity into the design of improved or novel vaccine and microbicide strategies against HIV infection...
  28. ncbi Towards the chemometric dissection of peptide--HLA-A*0201 binding affinity: comparison of local and global QSAR models
    Irini A Doytchinova
    Edward Jenner Institute for Vaccine Research, RG20 7NN, Compton, Berkshire, UK
    J Comput Aided Mol Des 19:203-12. 2005
    ..The results suggest that, in their interactions with the MHC molecule, the peptide acts as a complicated ensemble of multiple amino acids mutually potentiating each other...
  29. ncbi Virus infection-associated bone marrow B cell depletion and impairment of humoral immunity to heterologous infection mediated by TNF-alpha/LTalpha
    Persephone Borrow
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, UK
    Eur J Immunol 35:524-32. 2005
    ....
  30. pmc Innate immunity in acute HIV-1 infection
    Persephone Borrow
    Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Curr Opin HIV AIDS 6:353-63. 2011
    ..The importance of interactions between HIV-1 and innate responses in determining events throughout AHI is increasingly recognized, and is reviewed here...