Affiliation: Edward Jenner Institute for Vaccine Research
- Inhibition of the type I interferon antiviral response during arenavirus infectionPersephone Borrow
Nuffield Department of Clinical Medicine, The Jenner Institute, University of Oxford, Compton, Newbury, Berkshire RG20 7NN, UK E mail
Viruses 2:2443-80. 2010....
- Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFNMaria Montoya
Viral Immunology Group, Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
J Immunol 174:1851-61. 2005....
- Kinetics of expansion of epitope-specific T cell responses during primary HIV-1 infectionEmma L Turnbull
Viral Immunology Group, Jenner Institute, University of Oxford, Compton, United Kingdom
J Immunol 182:7131-45. 2009....
- Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactionsDelyth M Reid
The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, RG20 7NN, UK
J Leukoc Biol 76:86-94. 2004..Tissue localization thus revealed potential roles of Dectin-1 in leukocyte interactions during innate immune responses and T cell development...
- Altered CD45 isoform expression affects lymphocyte function in CD45 Tg miceElma Z Tchilian
The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
Int Immunol 16:1323-32. 2004..These effects are more prominent in CD8 than CD4 cells. The transgenic mice share several properties with humans expressing variant CD45 alleles and provide a model to understand immune function in variant individuals...
- Virus infection-associated bone marrow B cell depletion and impairment of humoral immunity to heterologous infection mediated by TNF-alpha/LTalphaPersephone Borrow
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, UK
Eur J Immunol 35:524-32. 2005....
- Type I interferons produced by dendritic cells promote their phenotypic and functional activationMaria Montoya
Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
Blood 99:3263-71. 2002..These results show that DCs both secrete and respond to type I IFN, identifying type I interferons as autocrine DC activators...
- Cross-priming of CD8+ T cells stimulated by virus-induced type I interferonAgnes Le Bon
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England
Nat Immunol 4:1009-15. 2003..These data identify expression of IFN-alpha/beta as a mechanism for the induction of cross-priming during virus infections...
- A role for the transcription factor RelB in IFN-alpha production and in IFN-alpha-stimulated cross-primingAgne Le Bon
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
Eur J Immunol 36:2085-93. 2006..In summary, these results show that the RelB/NF-kappaB pathway is required for optimal IFN-alpha production after LCMV infection and suggest a crucial role for RelB in IFN-alpha-stimulated cross-priming of CD8(+) T cell responses...
- Integrating in silico and in vitro analysis of peptide binding affinity to HLA-Cw*0102: a bioinformatic approach to the prediction of new epitopesValerie A Walshe
The Jenner Institute, University of Oxford, Compton, Berkshire, United Kingdom
PLoS ONE 4:e8095. 2009..Here, we describe the development and deployment of a reliable peptide-binding prediction method for a previously poorly-characterized human MHC class I allele, HLA-Cw*0102...
- Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte responseNicola A Jones
Viral Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England, UK
J Exp Med 200:1243-56. 2004....
- Reciprocal immunomodulation in a schistosome and hepatotropic virus coinfection modelMatthew J Edwards
Viral Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
J Immunol 175:6275-85. 2005....
- Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infectionsAndrea R Stacey
The Jenner Institute, University of Oxford, Compton, Berkshire RG20 7NN, United Kingdom
J Virol 83:3719-33. 2009..The intense early cytokine storm in acute HIV-1 infection may have immunopathological consequences, promoting immune activation, viral replication, and CD4(+) T-cell loss...
- Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infectionHolger B Kramer
Henry Wellcome Building for Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom
PLoS Pathog 6:e1000893. 2010..Insights gained into the mechanism of action of acute-phase reactants and other innate molecules against HIV and how they are induced could be exploited for the future development of more efficient prophylactic vaccine strategies...
- Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infectionsUte Christiane Meier
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berks RG20 7NN, United Kingdom
J Virol 79:12365-74. 2005..We hypothesize that the reduced levels of IL-15 present in the serum during HIV and HCV infections might impact NK cell homeostasis, contributing to the common alterations of the NK pool observed in these unrelated infections...