Persephone Borrow

Summary

Affiliation: Edward Jenner Institute for Vaccine Research
Country: UK

Publications

  1. pmc Inhibition of the type I interferon antiviral response during arenavirus infection
    Persephone Borrow
    Nuffield Department of Clinical Medicine, The Jenner Institute, University of Oxford, Compton, Newbury, Berkshire RG20 7NN, UK E mail
    Viruses 2:2443-80. 2010
  2. ncbi request reprint Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFN
    Maria Montoya
    Viral Immunology Group, Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    J Immunol 174:1851-61. 2005
  3. doi request reprint Kinetics of expansion of epitope-specific T cell responses during primary HIV-1 infection
    Emma L Turnbull
    Viral Immunology Group, Jenner Institute, University of Oxford, Compton, United Kingdom
    J Immunol 182:7131-45. 2009
  4. ncbi request reprint Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions
    Delyth M Reid
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, RG20 7NN, UK
    J Leukoc Biol 76:86-94. 2004
  5. ncbi request reprint Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice
    Elma Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
    Int Immunol 16:1323-32. 2004
  6. ncbi request reprint Virus infection-associated bone marrow B cell depletion and impairment of humoral immunity to heterologous infection mediated by TNF-alpha/LTalpha
    Persephone Borrow
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, UK
    Eur J Immunol 35:524-32. 2005
  7. ncbi request reprint Type I interferons produced by dendritic cells promote their phenotypic and functional activation
    Maria Montoya
    Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    Blood 99:3263-71. 2002
  8. ncbi request reprint Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon
    Agnes Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England
    Nat Immunol 4:1009-15. 2003
  9. ncbi request reprint A role for the transcription factor RelB in IFN-alpha production and in IFN-alpha-stimulated cross-priming
    Agne Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
    Eur J Immunol 36:2085-93. 2006
  10. pmc Integrating in silico and in vitro analysis of peptide binding affinity to HLA-Cw*0102: a bioinformatic approach to the prediction of new epitopes
    Valerie A Walshe
    The Jenner Institute, University of Oxford, Compton, Berkshire, United Kingdom
    PLoS ONE 4:e8095. 2009

Collaborators

  • Darren R Flower
  • Emma L Turnbull
  • Lisa Hyland
  • Agnes Le Bon
  • Andrew J McMichael
  • Brandon F Keele
  • Simon Y C Wong
  • Rachel E Owen
  • Philip J Norris
  • Philip R Taylor
  • Arend Mulder
  • Paul Klenerman
  • Gordon D Brown
  • Fabrizio Mattei
  • Maria Montoya
  • Andrea R Stacey
  • Matthew J Edwards
  • Delyth M Reid
  • Holger B Kramer
  • Li Qin
  • Valerie A Walshe
  • Elizabeth Taylor
  • Pierre Pellegrino
  • Ian Williams
  • Mailee Wong
  • Ute Christiane Meier
  • Elma Z Tchilian
  • Nicola A Jones
  • Benedikt M Kessler
  • Michael K P Liu
  • Kerry J Lavender
  • Katalin Di Gleria
  • Alison Simmons
  • Barton F Haynes
  • Nancy Gasper-Smith
  • Dongfeng Li
  • Frans H J Claas
  • Elizabeth A Haygreen
  • Douglas Grove
  • Steven G Self
  • Allan DeCamp
  • Mila Lebedeva
  • John Heitman
  • Jo Turner
  • Isabel K Macdonald
  • Irini A Doytchinova
  • Channa K Hattotuwagama
  • Nikolai Naoumov
  • Andrew Worth
  • Olena Buchatska
  • Christian Willberg
  • Miranda Ashton
  • Kwok Tang
  • Phillipa Newton
  • Quentin D Bickle
  • Sam Hou
  • Martin A Nowak
  • Ritu Dawes
  • Michael S Saag
  • Xiping Wei
  • George M Shaw
  • David Tough
  • Siamon Gordon
  • Peter C L Beverley
  • Beatrice H Hahn
  • Franziska Michor
  • David F Tough
  • Giovanna Schiavoni
  • Ion Gresser
  • Filippo Belardelli

Detail Information

Publications15

  1. pmc Inhibition of the type I interferon antiviral response during arenavirus infection
    Persephone Borrow
    Nuffield Department of Clinical Medicine, The Jenner Institute, University of Oxford, Compton, Newbury, Berkshire RG20 7NN, UK E mail
    Viruses 2:2443-80. 2010
    ....
  2. ncbi request reprint Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFN
    Maria Montoya
    Viral Immunology Group, Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    J Immunol 174:1851-61. 2005
    ....
  3. doi request reprint Kinetics of expansion of epitope-specific T cell responses during primary HIV-1 infection
    Emma L Turnbull
    Viral Immunology Group, Jenner Institute, University of Oxford, Compton, United Kingdom
    J Immunol 182:7131-45. 2009
    ....
  4. ncbi request reprint Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions
    Delyth M Reid
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, RG20 7NN, UK
    J Leukoc Biol 76:86-94. 2004
    ..Tissue localization thus revealed potential roles of Dectin-1 in leukocyte interactions during innate immune responses and T cell development...
  5. ncbi request reprint Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice
    Elma Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
    Int Immunol 16:1323-32. 2004
    ..These effects are more prominent in CD8 than CD4 cells. The transgenic mice share several properties with humans expressing variant CD45 alleles and provide a model to understand immune function in variant individuals...
  6. ncbi request reprint Virus infection-associated bone marrow B cell depletion and impairment of humoral immunity to heterologous infection mediated by TNF-alpha/LTalpha
    Persephone Borrow
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, UK
    Eur J Immunol 35:524-32. 2005
    ....
  7. ncbi request reprint Type I interferons produced by dendritic cells promote their phenotypic and functional activation
    Maria Montoya
    Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    Blood 99:3263-71. 2002
    ..These results show that DCs both secrete and respond to type I IFN, identifying type I interferons as autocrine DC activators...
  8. ncbi request reprint Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon
    Agnes Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England
    Nat Immunol 4:1009-15. 2003
    ..These data identify expression of IFN-alpha/beta as a mechanism for the induction of cross-priming during virus infections...
  9. ncbi request reprint A role for the transcription factor RelB in IFN-alpha production and in IFN-alpha-stimulated cross-priming
    Agne Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
    Eur J Immunol 36:2085-93. 2006
    ..In summary, these results show that the RelB/NF-kappaB pathway is required for optimal IFN-alpha production after LCMV infection and suggest a crucial role for RelB in IFN-alpha-stimulated cross-priming of CD8(+) T cell responses...
  10. pmc Integrating in silico and in vitro analysis of peptide binding affinity to HLA-Cw*0102: a bioinformatic approach to the prediction of new epitopes
    Valerie A Walshe
    The Jenner Institute, University of Oxford, Compton, Berkshire, United Kingdom
    PLoS ONE 4:e8095. 2009
    ..Here, we describe the development and deployment of a reliable peptide-binding prediction method for a previously poorly-characterized human MHC class I allele, HLA-Cw*0102...
  11. pmc Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte response
    Nicola A Jones
    Viral Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England, UK
    J Exp Med 200:1243-56. 2004
    ....
  12. ncbi request reprint Reciprocal immunomodulation in a schistosome and hepatotropic virus coinfection model
    Matthew J Edwards
    Viral Immunology Group, The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    J Immunol 175:6275-85. 2005
    ....
  13. pmc Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections
    Andrea R Stacey
    The Jenner Institute, University of Oxford, Compton, Berkshire RG20 7NN, United Kingdom
    J Virol 83:3719-33. 2009
    ..The intense early cytokine storm in acute HIV-1 infection may have immunopathological consequences, promoting immune activation, viral replication, and CD4(+) T-cell loss...
  14. pmc Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection
    Holger B Kramer
    Henry Wellcome Building for Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom
    PLoS Pathog 6:e1000893. 2010
    ..Insights gained into the mechanism of action of acute-phase reactants and other innate molecules against HIV and how they are induced could be exploited for the future development of more efficient prophylactic vaccine strategies...
  15. pmc Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infections
    Ute Christiane Meier
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berks RG20 7NN, United Kingdom
    J Virol 79:12365-74. 2005
    ..We hypothesize that the reduced levels of IL-15 present in the serum during HIV and HCV infections might impact NK cell homeostasis, contributing to the common alterations of the NK pool observed in these unrelated infections...