Christopher J. A. Duncan
Affiliation: University of Oxford
Location: Oxford, UK
- Eosinophils from patients with asthma express higher levels of the pan-leucocyte receptor CD45 and the isoform CD45ROM G Blaylock
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen Medical School, Aberdeen, UK
Clin Exp Allergy 33:936-41. 2003..Comparisons were made between expression of CD45, CD45RA, CD45RB and CD45RO by eosinophils from asthmatic patients and non-asthmatic atopic and non-atopic, non-asthmatic control subjects...
- Clinical assessment of a recombinant simian adenovirus ChAd63: a potent new vaccine vectorGeraldine A O'Hara
Centre for Clinical Vaccinology and Tropical Medicine and the Jenner Institute Laboratories, University of Oxford, UK
J Infect Dis 205:772-81. 2012..Use of potently immunogenic human adenoviruses as vaccine vectors could overcome this problem, but these are limited by preexisting immunity to human adenoviruses...
- Viral determinants of HIV-1 macrophage tropismChristopher J A Duncan
Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK
Viruses 3:2255-79. 2011....
- A decade of vaccinating allergic travellers: a clinical auditAndrew D McCallum
Regional Infectious Diseases Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
Travel Med Infect Dis 9:231-7. 2011..Unduly conservative guidelines risk withholding vaccines providing protection against dangerous pathogens but which can be safely administered...
- Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectorsSusanne H Sheehy
Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Churchill Hospital, Oxford, UK
Mol Ther 19:2269-76. 2011..Further studies are required to assess whether this strategy can achieve protective efficacy against blood-stage malaria infection...
- Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909Christopher J A Duncan
Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom
PLoS ONE 6:e22271. 2011..Here we report the first study to examine the relationship between in vivo Plasmodium falciparum growth rates and in vitro GIA in humans experimentally infected with blood-stage malaria...
- Infectious disease telephone consultations: Numerous, varied and an important educational resourceC J A Duncan
J Infect 54:515-6. 2007
- Control of eosinophil toxicity in the lungG M Walsh
Allergic and Asthmatic Inflammation Group, School of Medicine, University of Aberdeen, Scotland, UK
Curr Drug Targets Inflamm Allergy 4:481-6. 2005..This review will discuss both the potential and shortcomings of these diverse approaches to limit eosinophil toxicity in the asthmatic lung...
- Reduced eosinophil apoptosis in induced sputum correlates with asthma severityC J A Duncan
Allergic and Asthmatic Inflammation Research Group, Dept of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen Medical School, Aberdeen, UK
Eur Respir J 22:484-90. 2003....
- Distinguishing malaria and influenza: early clinical features in controlled human experimental infection studiesPatrick J Lillie
Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
Travel Med Infect Dis 10:192-6. 2012..These data support incorporating travel history into pandemic algorithms...
- Risk factors for failure of outpatient parenteral antibiotic therapy (OPAT) in infective endocarditisChristopher J A Duncan
Glasgow OPAT Service, Brownlee Centre for Infectious Diseases, Tropical Medicine and Counselling, Gartnavel General Hospital, 1053 Great Western Rd, Glasgow G12 0YN, UK
J Antimicrob Chemother 68:1650-4. 2013..To identify risk factors for failure of outpatient antibiotic therapy (OPAT) in infective endocarditis (IE)...
- Incidental diagnosis in healthy clinical trial subjectsChristopher J A Duncan
Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Drive, OX3 7LJ, United Kingdom
Clin Transl Sci 5:348-50. 2012..02 χ(2) for trend) but not females (p= 0.82). These data will assist those planning and conducting phase I/II vaccine trials in healthy volunteers, and importantly should strengthen the informed consent of future trial participants...
- Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy?Christopher J A Duncan
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
Hum Vaccin Immunother 8:706-14. 2012..More work is needed to establish the utility of GIA for blood-stage vaccine development...
- Outpatient parenteral antimicrobial therapy with ceftriaxone, a reviewChristopher J A Duncan
Brownlee Centre for Infection, Tropical Medicine and Counselling, Gartnaval Hospital, Glasgow, G12 0YN, UK
Int J Clin Pharm 34:410-7. 2012..Considering the expansion of OPAT programmes both in the UK and worldwide, revisiting the role of ceftriaxone in OPAT in the context of changing antimicrobial prescribing practices is timely...
- Controlled human blood stage malaria infection: current status and potential applicationsChristopher J A Duncan
Sir William Dunn School of Pathology, University of Oxford, United Kingdom
Am J Trop Med Hyg 86:561-5. 2012..We summarize clinical, parasitologic, and immunologic data from all BSP challenges to date, explore differences between the BSP and sporozoite models, and propose future applications for BSP challenge...