Christopher J. A. Duncan

Summary

Affiliation: University of Oxford
Location: Oxford, UK

Publications

  1. ncbi Eosinophils from patients with asthma express higher levels of the pan-leucocyte receptor CD45 and the isoform CD45RO
    M G Blaylock
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen Medical School, Aberdeen, UK
    Clin Exp Allergy 33:936-41. 2003
  2. pmc Clinical assessment of a recombinant simian adenovirus ChAd63: a potent new vaccine vector
    Geraldine A O'Hara
    Centre for Clinical Vaccinology and Tropical Medicine and the Jenner Institute Laboratories, University of Oxford, UK
    J Infect Dis 205:772-81. 2012
  3. pmc Viral determinants of HIV-1 macrophage tropism
    Christopher J A Duncan
    Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK
    Viruses 3:2255-79. 2011
  4. doi A decade of vaccinating allergic travellers: a clinical audit
    Andrew D McCallum
    Regional Infectious Diseases Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    Travel Med Infect Dis 9:231-7. 2011
  5. pmc Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors
    Susanne H Sheehy
    Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Churchill Hospital, Oxford, UK
    Mol Ther 19:2269-76. 2011
  6. pmc Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909
    Christopher J A Duncan
    Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e22271. 2011
  7. ncbi Infectious disease telephone consultations: Numerous, varied and an important educational resource
    C J A Duncan
    J Infect 54:515-6. 2007
  8. ncbi Control of eosinophil toxicity in the lung
    G M Walsh
    Allergic and Asthmatic Inflammation Group, School of Medicine, University of Aberdeen, Scotland, UK
    Curr Drug Targets Inflamm Allergy 4:481-6. 2005
  9. ncbi Reduced eosinophil apoptosis in induced sputum correlates with asthma severity
    C J A Duncan
    Allergic and Asthmatic Inflammation Research Group, Dept of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen Medical School, Aberdeen, UK
    Eur Respir J 22:484-90. 2003
  10. pmc Risk factors for failure of outpatient parenteral antibiotic therapy (OPAT) in infective endocarditis
    Christopher J A Duncan
    Glasgow OPAT Service, Brownlee Centre for Infectious Diseases, Tropical Medicine and Counselling, Gartnavel General Hospital, 1053 Great Western Rd, Glasgow G12 0YN, UK
    J Antimicrob Chemother 68:1650-4. 2013

Collaborators

Detail Information

Publications17

  1. ncbi Eosinophils from patients with asthma express higher levels of the pan-leucocyte receptor CD45 and the isoform CD45RO
    M G Blaylock
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen Medical School, Aberdeen, UK
    Clin Exp Allergy 33:936-41. 2003
    ..Comparisons were made between expression of CD45, CD45RA, CD45RB and CD45RO by eosinophils from asthmatic patients and non-asthmatic atopic and non-atopic, non-asthmatic control subjects...
  2. pmc Clinical assessment of a recombinant simian adenovirus ChAd63: a potent new vaccine vector
    Geraldine A O'Hara
    Centre for Clinical Vaccinology and Tropical Medicine and the Jenner Institute Laboratories, University of Oxford, UK
    J Infect Dis 205:772-81. 2012
    ..Use of potently immunogenic human adenoviruses as vaccine vectors could overcome this problem, but these are limited by preexisting immunity to human adenoviruses...
  3. pmc Viral determinants of HIV-1 macrophage tropism
    Christopher J A Duncan
    Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK
    Viruses 3:2255-79. 2011
    ....
  4. doi A decade of vaccinating allergic travellers: a clinical audit
    Andrew D McCallum
    Regional Infectious Diseases Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    Travel Med Infect Dis 9:231-7. 2011
    ..Unduly conservative guidelines risk withholding vaccines providing protection against dangerous pathogens but which can be safely administered...
  5. pmc Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors
    Susanne H Sheehy
    Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Churchill Hospital, Oxford, UK
    Mol Ther 19:2269-76. 2011
    ..Further studies are required to assess whether this strategy can achieve protective efficacy against blood-stage malaria infection...
  6. pmc Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909
    Christopher J A Duncan
    Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e22271. 2011
    ..Here we report the first study to examine the relationship between in vivo Plasmodium falciparum growth rates and in vitro GIA in humans experimentally infected with blood-stage malaria...
  7. ncbi Infectious disease telephone consultations: Numerous, varied and an important educational resource
    C J A Duncan
    J Infect 54:515-6. 2007
  8. ncbi Control of eosinophil toxicity in the lung
    G M Walsh
    Allergic and Asthmatic Inflammation Group, School of Medicine, University of Aberdeen, Scotland, UK
    Curr Drug Targets Inflamm Allergy 4:481-6. 2005
    ..This review will discuss both the potential and shortcomings of these diverse approaches to limit eosinophil toxicity in the asthmatic lung...
  9. ncbi Reduced eosinophil apoptosis in induced sputum correlates with asthma severity
    C J A Duncan
    Allergic and Asthmatic Inflammation Research Group, Dept of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen Medical School, Aberdeen, UK
    Eur Respir J 22:484-90. 2003
    ....
  10. pmc Risk factors for failure of outpatient parenteral antibiotic therapy (OPAT) in infective endocarditis
    Christopher J A Duncan
    Glasgow OPAT Service, Brownlee Centre for Infectious Diseases, Tropical Medicine and Counselling, Gartnavel General Hospital, 1053 Great Western Rd, Glasgow G12 0YN, UK
    J Antimicrob Chemother 68:1650-4. 2013
    ..To identify risk factors for failure of outpatient antibiotic therapy (OPAT) in infective endocarditis (IE)...
  11. pmc Incidental diagnosis in healthy clinical trial subjects
    Christopher J A Duncan
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Drive, OX3 7LJ, United Kingdom
    Clin Transl Sci 5:348-50. 2012
    ..02 χ(2) for trend) but not females (p= 0.82). These data will assist those planning and conducting phase I/II vaccine trials in healthy volunteers, and importantly should strengthen the informed consent of future trial participants...
  12. pmc Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy?
    Christopher J A Duncan
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Hum Vaccin Immunother 8:706-14. 2012
    ..More work is needed to establish the utility of GIA for blood-stage vaccine development...
  13. doi Outpatient parenteral antimicrobial therapy with ceftriaxone, a review
    Christopher J A Duncan
    Brownlee Centre for Infection, Tropical Medicine and Counselling, Gartnaval Hospital, Glasgow, G12 0YN, UK
    Int J Clin Pharm 34:410-7. 2012
    ..Considering the expansion of OPAT programmes both in the UK and worldwide, revisiting the role of ceftriaxone in OPAT in the context of changing antimicrobial prescribing practices is timely...
  14. pmc Controlled human blood stage malaria infection: current status and potential applications
    Christopher J A Duncan
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    Am J Trop Med Hyg 86:561-5. 2012
    ..We summarize clinical, parasitologic, and immunologic data from all BSP challenges to date, explore differences between the BSP and sporozoite models, and propose future applications for BSP challenge...