Robert G Edwards

Summary

Affiliation: Dry Drayton
Country: UK

Publications

  1. ncbi request reprint Fundamentals of human embryonic growth in vitro and the selection of high-quality embryos for transfer
    Irene Boiso
    Reproductive Medicine Service, Department of Obstetrics and Gynaecology, Institut Universitari Dexeus, Paseo Bonanova 89 91, Barcelona, 08017, Spain
    Reprod Biomed Online 5:328-50. 2002
  2. ncbi request reprint Ethics and moral philosophy in the initiation of IVF, preimplantation diagnosis and stem cells
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 10:1-8. 2005
  3. ncbi request reprint Will stem cells in cord blood, amniotic fluid, bone marrow and peripheral blood soon be unnecessary in transplantation?
    Robert G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB23 8DB, UK
    Reprod Biomed Online 14:396-401. 2007
  4. ncbi request reprint Human implantation: the last barrier in assisted reproduction technologies?
    Robert G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 14:5-22. 2007
  5. ncbi request reprint Stem cells today: A. Origin and potential of embryo stem cells
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 8:275-306. 2004
  6. ncbi request reprint Stem cells today: B1. Bone marrow stem cells
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 9:541-83. 2004
  7. ncbi request reprint Genetics of polarity in mammalian embryos
    Robert G Edwards
    Editorial Office, Reproductive BioMedicine Online, Park Lane, Dry Drayton, Cambridge B3 8DB, UK
    Reprod Biomed Online 11:104-14. 2005
  8. ncbi request reprint Changing genetic world of IVF, stem cells and PGD. A. Early methods in research
    R G Edwards
    Reprod Biomed Online 11:750-60. 2005
  9. ncbi request reprint Changing genetic world of IVF, stem cells and PGD. B. Polarities and gene expression in differentiating embryo cells and stem cells
    R G Edwards
    Reprod Biomed Online 11:761-76. 2005
  10. ncbi request reprint Changing genetic world of IVF, stem cells and PGD. C. Embryogenesis and the differentiation of the haemopoietic system
    R G Edwards
    Reprod Biomed Online 11:777-85. 2005

Detail Information

Publications46

  1. ncbi request reprint Fundamentals of human embryonic growth in vitro and the selection of high-quality embryos for transfer
    Irene Boiso
    Reproductive Medicine Service, Department of Obstetrics and Gynaecology, Institut Universitari Dexeus, Paseo Bonanova 89 91, Barcelona, 08017, Spain
    Reprod Biomed Online 5:328-50. 2002
    ..New outlooks in this field are summarized...
  2. ncbi request reprint Ethics and moral philosophy in the initiation of IVF, preimplantation diagnosis and stem cells
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 10:1-8. 2005
    ..The progress of these studies is related to ethical issues emerging during these years. The current status of these studies is outlined, together with a brief moral philosophy as practised by the original investigators...
  3. ncbi request reprint Will stem cells in cord blood, amniotic fluid, bone marrow and peripheral blood soon be unnecessary in transplantation?
    Robert G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB23 8DB, UK
    Reprod Biomed Online 14:396-401. 2007
    ..The advantages and disadvantages of these various classes are described in relation to potential methods involving gene conversion to change somatic cells to ES cells...
  4. ncbi request reprint Human implantation: the last barrier in assisted reproduction technologies?
    Robert G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 14:5-22. 2007
    ..New aspects of knowledge include the use of human oocyte maturation in vitro as an approach to simpler forms of IVF, and new concepts in developmental genetics...
  5. ncbi request reprint Stem cells today: A. Origin and potential of embryo stem cells
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 8:275-306. 2004
    ..ES cells offer wide therapeutic potentials for humans, although extensive clinical trials are still awaited...
  6. ncbi request reprint Stem cells today: B1. Bone marrow stem cells
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 9:541-83. 2004
    ....
  7. ncbi request reprint Genetics of polarity in mammalian embryos
    Robert G Edwards
    Editorial Office, Reproductive BioMedicine Online, Park Lane, Dry Drayton, Cambridge B3 8DB, UK
    Reprod Biomed Online 11:104-14. 2005
    ..Some implications of these findings are considered...
  8. ncbi request reprint Changing genetic world of IVF, stem cells and PGD. A. Early methods in research
    R G Edwards
    Reprod Biomed Online 11:750-60. 2005
    ..Later, the genetic controls of ES cell differentiation were assessed, together with factors switching them along specific differentiation pathways. Marker genes identified ES cells differentiating into various tissues...
  9. ncbi request reprint Changing genetic world of IVF, stem cells and PGD. B. Polarities and gene expression in differentiating embryo cells and stem cells
    R G Edwards
    Reprod Biomed Online 11:761-76. 2005
    ..Developmental genetics gained immense analytical power as cDNA libraries, microarrays, transcriptomes RNAi and other methods clarified the roles of hundreds of genes in pre- and early post-implantation embryos and stem cells...
  10. ncbi request reprint Changing genetic world of IVF, stem cells and PGD. C. Embryogenesis and the differentiation of the haemopoietic system
    R G Edwards
    Reprod Biomed Online 11:777-85. 2005
    ..They may be the source of pluripotent haemopoietic cells formed in blastocyst injection chimaeras, a characteristic typical of ES cells. Their role as the founder cell of haemopoietic and mesenchymal tissues is discussed...
  11. ncbi request reprint Genetics, epigenetics and gene silencing in differentiating mammalian embryos
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 13:732-53. 2006
    ..Unique features of gene expression or gene modification are described for each developmental stage...
  12. ncbi request reprint Human implantation: the last barrier in assisted reproduction technologies?
    Robert G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 13:887-904. 2006
    ..New aspects of knowledge include the use of human oocyte maturation in vitro as an approach to simpler forms of IVF, and new concepts in developmental genetics...
  13. ncbi request reprint The significance of parthenogenetic virgin mothers in bonnethead sharks and mice
    R G Edwards
    Reproductive Medicine Online, Duck End Farm, Park Lane, Dry Drayton, Cambridge CB23 8DB, UK
    Reprod Biomed Online 15:12-5. 2007
    ..Modifying epigenesis had thus opened pathways to full-term parthenogenetic development. The birth of these parthenogenotes fulfils the attempts of earlier scientists to invoke parthenogenesis in experimental animals...
  14. ncbi request reprint IVF, IVM, natural cycle IVF, minimal stimulation IVF - time for a rethink
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB23 8DB, UK
    Reprod Biomed Online 15:106-19. 2007
    ..These three approaches are now practised in increasing numbers of IVF clinics, and may well replace routine IVF. The events leading to current interest in these methods will be discussed briefly in this review...
  15. ncbi request reprint A burgeoning science of embryological genetics demands a modern ethics
    R G Edwards
    Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 15:34-40. 2007
    ..The future may have even more bizarre possibilities such as producing medicines in cow's milk or trees and delaying death for many years...
  16. ncbi request reprint From embryonic stem cells to blastema and MRL mice
    R G Edwards
    Reproductive BioMedicine Online, Park Lane, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 16:425-61. 2008
    ..These matters are discussed at the end of this review where various investigations clarify the benefits and drawbacks of these varied approaches to tissue repair...
  17. ncbi request reprint United Nations and human cloning: a slender and fortunate defence for biomedical research
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 7:700-2. 2003
    ..Current liberalism in studies on assisted conception, clearly threatened by powerful adversaries, will have to be fortified to maintain the current impetus into newer forms of clinical care...
  18. ncbi request reprint Tribute to Georgeanna and Howard Jones
    Robert G Edwards
    Editor, Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK E mail
    Reprod Biomed Online 6:352-60. 2003
    ..A brief conclusion describes some of the friendships initiated in Johns Hopkins and still intact today...
  19. ncbi request reprint Human reproductive cloning a step nearer
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 6:399-400. 2003
  20. ncbi request reprint Are major defects in children conceived in vitro due to innate problems in patients or to induced genetic damage?
    Robert G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 7:131-8. 2003
    ..Various genetic and developmental factors in infertile couples influencing the origin of such birth outcomes are assessed, and the significance of imprinting and its embryological roles are discussed...
  21. ncbi request reprint Aspects of the molecular regulation of early mammalian development
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 6:97-113. 2003
    ..A general summary briefly describes some other aspects of regulation, especially chromosomal anomalies in human embryos...
  22. ncbi request reprint Towards single births after assisted reproduction treatment
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 7:506-8. 2003
    ..This massive failure of most embryos to implant poses numerous questions on the evolution of this situation in humans...
  23. ncbi request reprint Defining IVF terminology
    Robert Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 14:553-4. 2007
    ..Rapid recent advances in in-vitro fertilization (IVF) and in-vitro maturation (IVM) of human oocytes are leading to vast changes in the practice of IVF. This article attempts to define the various approaches to these new methods...
  24. ncbi request reprint Initial differentiation of blastomeres in 4-cell human embryos and its significance for early embryogenesis and implantation
    Robert G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 11:206-18. 2005
    ..Special attention is paid to well-characterized trophectoderm, the trophectoderm stem cell, and possible new forms of clinical application...
  25. ncbi request reprint An astonishing journey into reproductive genetics since the 1950's
    Robert G Edwards
    Reproductive BioMedicine Online, Cambridge, UK
    Reprod Nutr Dev 45:299-306. 2005
    ..Nevertheless it is a pleasure to recall how we shared so much in common. I still admire him as an inspiration to many colleagues and students, and a father figure in French agricultural research...
  26. ncbi request reprint Personal pathways to embryonic stem cells
    R G Edwards
    Editor, Reproductive BioMedicine Online Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 4:263-78. 2002
    ..No signs of inflammation or cancer were noted. First studies on human embryo stem cells began, but were ended by an ethical decision preventing supplies of human blastocysts for research...
  27. ncbi request reprint Cloning and embryo stem cells meet further but limited approvals
    R G Edwards
    Reproductive BioMedicine Online, Cambridge, UK
    Reprod Biomed Online 10:141. 2005
  28. ncbi request reprint Reproductive rhythms, longevity and cancer
    R G Edwards
    Reproductive BioMedicine Online, Cambridge, UK
    Reprod Biomed Online 4:93-6. 2002
  29. ncbi request reprint Chorionic gonadotrophin, genes and embryonic signals regulating the implantation window
    R G Edwards
    Chief Editor, Reproductive BioMedicine Online, Cambridge, UK
    Reprod Biomed Online 14:538-40. 2007
  30. ncbi request reprint Are minimal stimulation IVF and IVM set to replace routine IVF?
    R G Edwards
    Reproductive BioMedicine Online, Cambridge, UK
    Reprod Biomed Online 14:267-70. 2007
  31. ncbi request reprint Molecular genetics analyses in basic and clinical embryology
    R G Edwards
    Chief Editor, Reproductive BioMedicine Online, Cambridge, UK
    Reprod Biomed Online 5:220-1. 2002
  32. ncbi request reprint Transcriptomes and the analysis of mouse embryo, stem cells and tissue stem cells
    R G Edwards
    Reproductive BioMedicine Online, Cambridge, UK
    Reprod Biomed Online 8:358-9. 2004
  33. ncbi request reprint Ethics of preimplantation diagnosis: recordings from the Fourth International Symposium on Preimplantation Genetics
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge BB3 8DB, UK
    Reprod Biomed Online 6:170-80. 2003
    ....
  34. ncbi request reprint Two immensely complex and difficult ethical cases of IVF
    R G Edwards
    Chief Editor, Reproductive BioMedicine Online, Cambridge, UK
    Reprod Biomed Online 5:219-20. 2002
  35. ncbi request reprint Human chimaeras and understanding early development
    R G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 5:103. 2002
  36. ncbi request reprint New outlooks on IVF spermatozoa
    R G Edwards
    Chief Editor, Reproductive BioMedicine Online, Cambridge, UK
    Reprod Biomed Online 5:89. 2002
  37. ncbi request reprint New outlooks on gene activation and X inactivation in mouse embryos
    R G Edwards
    Reproductive BioMedicine Online, Cambridge, UK
    Reprod Biomed Online 8:248-50. 2004
  38. ncbi request reprint Frozen embryos discarded in court decision
    Fiona G A Bennett
    Reproductive BioMedicine Online, Cambridge, UK
    Reprod Biomed Online 7:593-4. 2003
  39. ncbi request reprint Cell differentiation in the preimplantation human embryo
    Christoph Hansis
    Program for In Vitro Fertilization, Reproductive Surgery and Infertility, New York University School of Medicine, 660 First Ave, 5th Floor, New York, NY 10016, USA
    Reprod Biomed Online 6:215-20. 2003
    ..Problems in jointly identifying maternal proteins and embryonic and maternal transcripts for specific proteins within one cell, and the nature of early cell allocation in mouse and human embryo, are discussed...
  40. ncbi request reprint On a fallacious invocation of the Barker hypothesis of anomalies in newborn rats due to mothers' food restriction in preimplantation phases
    Eurof Walters
    Babraham Institute and Churchill College, Cambridge, UK
    Reprod Biomed Online 7:580-2. 2003
    ..The findings reported in this study should be withdrawn, and a rigorous statistical evaluation should be carried out to provide a proper assessment of the data...
  41. ncbi request reprint The early days of IVF
    Bart C Fauser
    Hum Reprod Update 11:437-8. 2005
  42. ncbi request reprint Introduction: human embryo implantation failure and recurrent miscarriage: basic science and clinical practice
    Luciano G Nardo
    Department of Reproductive Medicine, St Mary s Hospital, Manchester M13 0JH, UK
    Reprod Biomed Online 13:11-2. 2006
  43. ncbi request reprint The Lasker Foundation and recognition of scientific excellence
    Robert G Edwards
    Cambridge University, England
    JAMA 294:1422-3. 2005
  44. ncbi request reprint Averting abnormal inheritance: potential of gene therapy and preimplantation diagnosis
    Adrian J Thrasher
    Consultant in Paediatric Immunology, Molecular Immunology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Reprod Biomed Online 8:99-106. 2004
    ..This paper discusses the finer details of these options, their safety and the ethical issues they have raised...
  45. ncbi request reprint Public objections to designer babies and cloning in USA: not quite what was expected
    Joe Leigh Simpson
    Reprod Biomed Online 6:147-8. 2003