Deborah Layton

Summary

Affiliation: Drug Safety Research Unit
Country: UK

Publications

  1. doi request reprint Examining the tolerability of the non-sedating antihistamine desloratadine: a prescription-event monitoring study in England
    Deborah Layton
    Drug Safety Research Unit, Southampton, UK
    Drug Saf 32:169-79. 2009
  2. ncbi request reprint Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England
    D Layton
    Department of Pharmacology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Eur J Clin Pharmacol 57:167-76. 2001
  3. ncbi request reprint Comparison of incidence rates of cerebrovascular accidents and transient ischaemic attacks in observational cohort studies of patients prescribed risperidone, quetiapine or olanzapine in general practice in England including patients with dementia
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK
    J Psychopharmacol 19:473-82. 2005
  4. ncbi request reprint Safety profile of raloxifene as used in general practice in England: results of a prescription-event monitoring study
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK
    Osteoporos Int 16:490-500. 2005
  5. ncbi request reprint Safety profile of celecoxib as used in general practice in England: results of a prescription-event monitoring study
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, SO31 1AA, UK
    Eur J Clin Pharmacol 60:489-501. 2004
  6. ncbi request reprint Comparison of the incidence rates of thromboembolic events reported for patients prescribed celecoxib and meloxicam in general practice in England using Prescription-Event Monitoring (PEM) data
    Deborah Layton
    Drug Safety Research Unit, University of Southampton, Southampton, UK
    Rheumatology (Oxford) 42:1354-64. 2003
  7. ncbi request reprint Comparison of the incidence rates of thromboembolic events reported for patients prescribed rofecoxib and meloxicam in general practice in England using prescription-event monitoring (PEM) data
    D Layton
    Drug Safety Research Unit, University of Southampton, Southampton, UK
    Rheumatology (Oxford) 42:1342-53. 2003
  8. ncbi request reprint Comparison of the incidence rates of selected gastrointestinal events reported for patients prescribed celecoxib and meloxicam in general practice in England using prescription-event monitoring (PEM) data
    D Layton
    Drug Safety Research Unit, University of Southampton, Southampton, UK
    Rheumatology (Oxford) 42:1332-41. 2003
  9. ncbi request reprint Comparison of the incidence rates of selected gastrointestinal events reported for patients prescribed rofecoxib and meloxicam in general practice in England using prescription-event monitoring data
    D Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK
    Rheumatology (Oxford) 42:622-31. 2003
  10. ncbi request reprint Evaluation of risk profiles for gastrointestinal and cardiovascular adverse effects in nonselective NSAID and COX-2 inhibitor users: a cohort study using pharmacy dispensing data in The Netherlands
    Deborah Layton
    Drug Safety Research Unit, Blundell Lane, Southampton, Hampshire, England
    Drug Saf 31:143-58. 2008

Detail Information

Publications34

  1. doi request reprint Examining the tolerability of the non-sedating antihistamine desloratadine: a prescription-event monitoring study in England
    Deborah Layton
    Drug Safety Research Unit, Southampton, UK
    Drug Saf 32:169-79. 2009
    ..Desloratadine is a non-sedating, long-acting histamine H(1) receptor antagonist indicated for the symptomatic relief of allergic rhinitis (AR) and chronic idiopathic urticaria in patients aged>12 years...
  2. ncbi request reprint Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England
    D Layton
    Department of Pharmacology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Eur J Clin Pharmacol 57:167-76. 2001
    ..To investigate whether an association between the use of selective serotonin reuptake inhibitor (SSRI) antidepressants and abnormal bleeding is demonstrated in a large population study...
  3. ncbi request reprint Comparison of incidence rates of cerebrovascular accidents and transient ischaemic attacks in observational cohort studies of patients prescribed risperidone, quetiapine or olanzapine in general practice in England including patients with dementia
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK
    J Psychopharmacol 19:473-82. 2005
    ..However, dementia appears to be an important risk factor. These results should be considered alongside other pharmacoepidemiological studies on this topic...
  4. ncbi request reprint Safety profile of raloxifene as used in general practice in England: results of a prescription-event monitoring study
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK
    Osteoporos Int 16:490-500. 2005
    ..There were also a small number of reports of events associated with venous thromboembolism and visual disorders that require further investigation...
  5. ncbi request reprint Safety profile of celecoxib as used in general practice in England: results of a prescription-event monitoring study
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, SO31 1AA, UK
    Eur J Clin Pharmacol 60:489-501. 2004
    ..A post-marketing surveillance study using the technique of Prescription Event Monitoring was undertaken to monitor the safety of celecoxib, a cyclo-oxygenase (COX)-2 inhibitor, as prescribed in primary care in England...
  6. ncbi request reprint Comparison of the incidence rates of thromboembolic events reported for patients prescribed celecoxib and meloxicam in general practice in England using Prescription-Event Monitoring (PEM) data
    Deborah Layton
    Drug Safety Research Unit, University of Southampton, Southampton, UK
    Rheumatology (Oxford) 42:1354-64. 2003
    ..The Drug Safety Research Unit monitored the post marketing safety of these drugs in England using the non-interventional observational cohort technique of Prescription-Event Monitoring (PEM)...
  7. ncbi request reprint Comparison of the incidence rates of thromboembolic events reported for patients prescribed rofecoxib and meloxicam in general practice in England using prescription-event monitoring (PEM) data
    D Layton
    Drug Safety Research Unit, University of Southampton, Southampton, UK
    Rheumatology (Oxford) 42:1342-53. 2003
    ..The Drug Safety Research Unit (DSRU) monitored the post-marketing safety of these drugs in England using the non-interventional observational cohort technique of prescription-event monitoring (PEM)...
  8. ncbi request reprint Comparison of the incidence rates of selected gastrointestinal events reported for patients prescribed celecoxib and meloxicam in general practice in England using prescription-event monitoring (PEM) data
    D Layton
    Drug Safety Research Unit, University of Southampton, Southampton, UK
    Rheumatology (Oxford) 42:1332-41. 2003
    ....
  9. ncbi request reprint Comparison of the incidence rates of selected gastrointestinal events reported for patients prescribed rofecoxib and meloxicam in general practice in England using prescription-event monitoring data
    D Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK
    Rheumatology (Oxford) 42:622-31. 2003
    ....
  10. ncbi request reprint Evaluation of risk profiles for gastrointestinal and cardiovascular adverse effects in nonselective NSAID and COX-2 inhibitor users: a cohort study using pharmacy dispensing data in The Netherlands
    Deborah Layton
    Drug Safety Research Unit, Blundell Lane, Southampton, Hampshire, England
    Drug Saf 31:143-58. 2008
    ..The channelling paradox may exist for cyclo-oxygenase (COX)-2 selective inhibitors ('coxibs') instead of traditional nonselective NSAIDs in relation to both gastrointestinal (GI) and cardiovascular (CV) safety...
  11. pmc Safety profile of rofecoxib as used in general practice in England: results of a prescription-event monitoring study
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Southampton, UK
    Br J Clin Pharmacol 55:166-74. 2003
    ..A postmarketing Prescription-Event Monitoring study was undertaken to monitor the safety of rofecoxib, a cyclo-oxygenase (COX)-2 selective inhibitor prescribed in primary care in England...
  12. ncbi request reprint Pharmacovigilance of over-the-counter products based in community pharmacy: methodological issues from pilot work conducted in Hampshire and Grampian, UK
    D Layton
    Drug Safety Research Unit, Bursledon Hall, Southampton SO31 1AA, UK
    Pharmacoepidemiol Drug Saf 11:503-13. 2002
    ..The aim of this initial pilot work, using an observational cohort design, was to determine the feasibility of conducting a pharmacovigilance study of a non-prescription medicine, based in community pharmacies...
  13. doi request reprint Prescriber adoption of newly approved selective COX-2 inhibitors
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK
    Pharmacoepidemiol Drug Saf 17:1168-74. 2008
    ..This study examines if COX-2 inhibitors (coxibs) were prescribed by subsets of practitioners and describes GP adoption patterns of coxibs and existing NSAIDs over time...
  14. ncbi request reprint A comparison of reported gastrointestinal and thromboembolic events between rofecoxib and celecoxib using observational data
    Rachna Kasliwal
    Drug Safety Research Unit, Southampton, UK
    Drug Saf 28:803-16. 2005
    ....
  15. ncbi request reprint Serious skin reactions and selective COX-2 inhibitors: a case series from prescription-event monitoring in England
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Southampton, UK
    Drug Saf 29:687-96. 2006
    ..Our objectives were to identify and describe cases of serious skin reactions reported during postmarketing studies of COX-2 selective inhibitors...
  16. ncbi request reprint Do some inhibitors of COX-2 increase the risk of thromboembolic events?: Linking pharmacology with pharmacoepidemiology
    David W J Clark
    New Zealand Pharmacovigilance Centre, Department of Preventive and Social Medicine, School of Medicine and Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Drug Saf 27:427-56. 2004
    ..This is particularly important in the elderly, in patients with cardiovascular/renal disease and in patients with other risk factors that might predispose them to adverse events...
  17. ncbi request reprint Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England
    Deborah Layton
    Drug Safety Research Unit, Southampton, Hants, UK
    Drug Saf 29:897-909. 2006
    ....
  18. ncbi request reprint Identification and evaluation of a possible signal of exacerbation of colitis during rofecoxib treatment, using Prescription-Event Monitoring data
    D Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK
    J Clin Pharm Ther 29:171-81. 2004
    ..The introduction of a new computer system in January 2000 enabled the development of an automated signal generation system to compliment the process of identification of possible safety signals in drug data collected using PEM...
  19. doi request reprint Drug utilization of Intrinsa (testosterone patch) in England: interim analysis of a prescription-event monitoring study to support risk management
    Vicki Osborne
    Drug Safety Research Unit, Bursledon Hall, Southampton, UK
    Drug Saf 33:213-21. 2010
    ....
  20. doi request reprint Incidence of venous thromboembolism in users of strontium ranelate: an analysis of data from a prescription-event monitoring study in England
    Vicki Osborne
    Drug Safety Research Unit, Bursledon Hall, Southampton, UK
    Drug Saf 33:579-91. 2010
    ..Strontium ranelate is indicated for the treatment of postmenopausal osteoporosis. An association between strontium ranelate and venous thromboembolism (VTE) was identified in an analysis of phase III clinical trials...
  21. doi request reprint Safety profile of oxcarbazepine: results from a prescription-event monitoring study
    Yvonne Buggy
    Drug Safety Research Unit, Southampton, United Kingdom
    Epilepsia 51:818-29. 2010
    ..To monitor safety of oxcarbazepine, prescribed in primary care in England, using prescription-event monitoring (PEM)...
  22. doi request reprint Neuropsychiatric events with varenicline: a modified prescription-event monitoring study in general practice in England
    Yvonne Buggy
    Drug Safety Research Unit, Bursledon Hall, Southampton, SO31 1AA, UK
    Drug Saf 36:521-31. 2013
    ..In response to this regulatory warning, the Drug Safety Research Unit conducted a modified prescription-event monitoring (M-PEM) study to monitor the safety of varenicline...
  23. doi request reprint Modified prescription-event monitoring studies: a tool for pharmacovigilance and risk management
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK
    Drug Saf 34:e1-9. 2011
    ..M-PEM studies therefore have an important contribution to make to pharmacovigilance and the risk management of medicines by providing valuable information on the use of new medications under real-life situations...
  24. ncbi request reprint Results of a postal survey of the reasons for non-response by doctors in a Prescription Event Monitoring study of drug safety
    Cheryl Key
    Drug Safety Research Unit, Burseldon Hall, Southampton SO31 1AA, UK
    Pharmacoepidemiol Drug Saf 11:143-8. 2002
    ..The manufacturer was conducting a concurrent postmarketing surveillance study. The aim of this cross-sectional study, was to identify reasons for non-response by general practitioners in England...
  25. ncbi request reprint Profiles of hepatic and dysrhythmic cardiovascular events following use of fluoroquinolone antibacterials: experience from large cohorts from the Drug Safety Research Unit Prescription-Event Monitoring database
    D W Clark
    Drug Safety Research Unit, Bursledon Hall, Southampton, UK
    Drug Saf 24:1143-54. 2001
    ..This requires further investigation by other types of epidemiological study...
  26. doi request reprint Examining the utilization and tolerability of the non-sedating antihistamine levocetirizine in England using prescription-event monitoring data
    Deborah Layton
    Drug Safety Research Unit, Southampton, UK
    Drug Saf 34:1177-89. 2011
    ..Levocetirizine was launched onto the UK market in September 2001. It is indicated for symptomatic treatment of allergic rhinitis (AR), including persistent AR and chronic idiopathic urticaria...
  27. pmc Deep vein thrombosis and pulmonary embolism reported in the Prescription Event Monitoring Study of Yasmin
    Hilary M Pearce
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK
    Br J Clin Pharmacol 60:98-102. 2005
    ..To evaluate cases of deep vein thrombosis (DVT) and pulmonary embolism (PE) reported in a prescription event monitoring study of Yasmin, an oral contraceptive...
  28. ncbi request reprint Causal association in pharmacovigilance and pharmacoepidemiology: thoughts on the application of the Austin Bradford-Hill criteria
    Saad A W Shakir
    Drug Safety Research Unit, Bursledon Hall, Southampton, United Kingdom
    Drug Saf 25:467-71. 2002
    ..Further work is required to develop strategies to handle these limitations...
  29. ncbi request reprint Prolongation of the QT interval and cardiac arrhythmias associated with cisapride: limitations of the pharmacoepidemiological studies conducted and proposals for the future
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton SO31 1AA, UK
    Pharmacoepidemiol Drug Saf 12:31-40. 2003
    ..Such proactive surveillance could avoid unnecessary delays for other drugs where QT prolongation and serious cardiac arrhythmias may be an issue...
  30. ncbi request reprint Prescription-event monitoring and reporting of adverse drug reactions
    E Heeley
    Drug Safety Research Unit, Bursledon Hall, SO31 1AA, Southampton, UK
    Lancet 358:1872-3. 2001
    ..Our results should not be extrapolated to calculate incidence rates of adverse drug reactions in the community from spontaneous reports...
  31. ncbi request reprint Safety profile of tolterodine as used in general practice in England: results of prescription-event monitoring
    D Layton
    Drug Safety Research Unit, Southampton, England
    Drug Saf 24:703-13. 2001
    ..CONCLUSIONS: Tolterodine is well tolerated in general practice at the recommended daily dose. Hallucinations, tachycardia and palpitations are infrequently associated with the drug...
  32. ncbi request reprint Safety of nateglinide as used in general practice in England: results of a prescription-event monitoring study
    B Twaites
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, Hampshire SO31 1AA, UK
    Acta Diabetol 44:233-9. 2007
    ..Two pregnancies (< 0.1%) and 73 deaths (1.6%) were reported. Nateglinide appeared to be generally well tolerated when used in combination with metformin for the treatment of Type 2 diabetes...
  33. pmc Influenza H1N1 (swine flu) vaccination: a safety surveillance feasibility study using self-reporting of serious adverse events and pregnancy outcomes
    Isla S Mackenzie
    Medicines Monitoring Unit, Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Br J Clin Pharmacol 73:801-11. 2012
    ....
  34. doi request reprint New postgraduate qualifications in pharmacovigilance from the Drug Safety Research Unit in the UK
    Elizabeth Lynn
    Drug Safety Research Unit, Bursledon Hall, Southampton, UK
    Drug Saf 34:89-91. 2011
    ..Flexibility is ensured by the availability of a wide choice of units, the use of online facilities for learning and assessment, and the possibility that previous relevant training or experience may be counted towards the awards...