Alex Doney

Summary

Country: UK

Publications

  1. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
  2. pmc Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight
    Alex Doney
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, United Kingdom
    BMC Genet 3:21. 2002
  3. pmc Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus
    Alex S F Doney
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, United Kingdom
    BMC Genet 4:11. 2003
  4. ncbi Association of common variation in glutathione S-transferase genes with premature development of cardiovascular disease in patients with systemic sclerosis
    Colin N A Palmer
    Ninewells Hospital and Medical School, Dundee, Scotland, UK
    Arthritis Rheum 48:854-5. 2003
  5. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
  6. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
  7. ncbi Glutathione S-transferase M1 and P1 genotype, passive smoking, and peak expiratory flow in asthma
    Colin N A Palmer
    Population Pharmacogenetics Group, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Pediatrics 118:710-6. 2006
  8. ncbi Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study
    Alex S F Doney
    Institute for Cardiovascular Research, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, Scotland
    Arterioscler Thromb Vasc Biol 24:2403-7. 2004
  9. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
  10. ncbi Increased cardiovascular morbidity and mortality in type 2 diabetes is associated with the glutathione S transferase theta-null genotype: a Go-DARTS study
    Alex S F Doney
    Institute for Cardiovascular Research, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, Scotland
    Circulation 111:2927-34. 2005

Detail Information

Publications12

  1. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  2. pmc Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight
    Alex Doney
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, United Kingdom
    BMC Genet 3:21. 2002
    ..Both rare alleles are in linkage disequilibrium and the independent associations of these two polymorphisms have not been addressed...
  3. pmc Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus
    Alex S F Doney
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, United Kingdom
    BMC Genet 4:11. 2003
    ..We have investigated its role in age of diagnosis, body weight and glycaemic control in 1,950 individuals with type 2 diabetes in Tayside, Scotland, and compared the ARE2 allele frequencies with 1,014 local schoolchildren...
  4. ncbi Association of common variation in glutathione S-transferase genes with premature development of cardiovascular disease in patients with systemic sclerosis
    Colin N A Palmer
    Ninewells Hospital and Medical School, Dundee, Scotland, UK
    Arthritis Rheum 48:854-5. 2003
  5. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  6. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
    ..67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass...
  7. ncbi Glutathione S-transferase M1 and P1 genotype, passive smoking, and peak expiratory flow in asthma
    Colin N A Palmer
    Population Pharmacogenetics Group, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Pediatrics 118:710-6. 2006
    ..Our purpose with this work was to assess the contribution of glutathione S-transferase gene variants to asthma susceptibility and pulmonary function in relation to tobacco smoke exposure in the home...
  8. ncbi Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study
    Alex S F Doney
    Institute for Cardiovascular Research, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, Scotland
    Arterioscler Thromb Vasc Biol 24:2403-7. 2004
    ..We therefore investigated the association of these 2 variants with cardiovascular events in people with type 2 diabetes...
  9. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  10. ncbi Increased cardiovascular morbidity and mortality in type 2 diabetes is associated with the glutathione S transferase theta-null genotype: a Go-DARTS study
    Alex S F Doney
    Institute for Cardiovascular Research, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, Scotland
    Circulation 111:2927-34. 2005
    ..We prospectively determined smoking-related cardiovascular morbidity by GST genotype in a large cohort of individuals with type 2 diabetes using a population-based diabetes research database (DARTS)...
  11. ncbi Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study
    Ewan R Pearson
    Division of Medicine and Therapeutics, University of Dundee, Dundee, UK
    Diabetes 56:2178-82. 2007
    ..We hypothesized that variation in TCF7L2 would influence response to sulfonylureas but not metformin. We studied the effect of TCF7L2 rs12255372 and rs7903146 genotypes on glycemic response...
  12. doi Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study
    Louise A Donnelly
    Division of Community Health Sciences, Mackenzie Building, Kirsty Semple Way, Dundee, Scotland, UK
    Pharmacogenet Genomics 18:279-87. 2008
    ..We sought to evaluate the association of the APOE genotype with the low-density lipoprotein cholesterol (LDLc)-lowering response to statins, in a large population-based cohort of patients with diabetes...