Salvador J. Diaz-Cano

Summary

Affiliation: Kings College Hospital NHS Foundation Trust
Location: London, UK
URL: http://www.interpathology.org/interpathology.org/
Summary:
Kings College Hospital, Dept Histopathology - Consultant Physician Pathologist. Kings Health Partners, Reader in Cellular and Molecular Pathology Appointed: 2004. The general activity and profile of the Dept Histopathology at KCH can be visited at KingsPath website.

Gerson Lehrman Groups Council of Healthcare Advisors, Council Member Appointed: 2004 to present

University of Malaga, Medicine, Anatomic Pathology, Histology and Anatomic Pathology, Visiting Professor Appointed: 2001 to present

Publications

  1. ncbi Kinetic topographical heterogeneity in follicular thyroid neoplasms and growth patterns
    S J Diaz-Cano
    Histopathology 51:416-8. 2007
  2. ncbi Cytoarchitectural and kinetic features in the histological evaluation of follicular thyroid neoplasms
    S Arif
    Department of Pathology, Barts and The London Hospital, London, UK
    Histopathology 50:750-63. 2007
  3. ncbi Histologic criteria for adrenocortical proliferative lesions: value of mitotic figure variability
    Alfredo Blanes
    Department of Pathology, University Hospital, Malaga, Spain
    Am J Clin Pathol 127:398-408. 2007
  4. ncbi Complementary analysis of microsatellite tumor profile and mismatch repair defects in colorectal carcinomas
    Alfredo Blanes
    Department of Pathology, University of Malaga School of Medicine, Spain
    World J Gastroenterol 12:5932-40. 2006
  5. ncbi Molecular mechanisms in melanoma
    Salvador J Diaz-Cano
    N Engl J Med 355:1395; author reply 1396. 2006
  6. ncbi Axillary sinuses and cervical swellings
    S Flann
    Department of Dermatology, King s College Hospital, London, UK
    Clin Exp Dermatol 31:487-8. 2006
  7. ncbi Topographic molecular profile of pheochromocytomas: role of somatic down-regulation of mismatch repair
    Alfredo Blanes
    Department of Pathology, University of Malaga School of Medicine, Malaga E29010, Spain
    J Clin Endocrinol Metab 91:1150-8. 2006
  8. ncbi Trichogerminoma: further evidence to support a specific follicular neoplasm
    L Pozo
    Histopathology 46:108-10. 2005
  9. ncbi Microsatellite instability in colon cancer
    Juan J Jimenez
    N Engl J Med 349:1774-6; author reply 1774-6. 2003
  10. ncbi Reduced expression of the growth hormone and type 1 insulin-like growth factor receptors in human somatotroph tumours and an analysis of possible mutations of the growth hormone receptor
    Blerina Kola
    Departments of Endocrinology and Histopatholgy, St Bartholomew s Hospital and National Institute of Neurology and Neurosurgery, London, UK
    Clin Endocrinol (Oxf) 59:328-38. 2003

Collaborators

Detail Information

Publications62

  1. ncbi Kinetic topographical heterogeneity in follicular thyroid neoplasms and growth patterns
    S J Diaz-Cano
    Histopathology 51:416-8. 2007
  2. ncbi Cytoarchitectural and kinetic features in the histological evaluation of follicular thyroid neoplasms
    S Arif
    Department of Pathology, Barts and The London Hospital, London, UK
    Histopathology 50:750-63. 2007
    ..The diagnosis of follicular thyroid carcinomas is mainly based on capsular and vascular invasion. The aim of this study was to determine the diagnostic relevance of nuclear features, inflammation and stromal changes...
  3. ncbi Histologic criteria for adrenocortical proliferative lesions: value of mitotic figure variability
    Alfredo Blanes
    Department of Pathology, University Hospital, Malaga, Spain
    Am J Clin Pathol 127:398-408. 2007
    ..SDDS is the most useful system for distinguishing tumors from ACNH (myxoid stroma and anisokaryosis)...
  4. ncbi Complementary analysis of microsatellite tumor profile and mismatch repair defects in colorectal carcinomas
    Alfredo Blanes
    Department of Pathology, University of Malaga School of Medicine, Spain
    World J Gastroenterol 12:5932-40. 2006
    ..MSI is an excellent functional and prognostically useful marker, whereas MMR immunohistochemistry can guide gene sequencing...
  5. ncbi Molecular mechanisms in melanoma
    Salvador J Diaz-Cano
    N Engl J Med 355:1395; author reply 1396. 2006
  6. ncbi Axillary sinuses and cervical swellings
    S Flann
    Department of Dermatology, King s College Hospital, London, UK
    Clin Exp Dermatol 31:487-8. 2006
  7. ncbi Topographic molecular profile of pheochromocytomas: role of somatic down-regulation of mismatch repair
    Alfredo Blanes
    Department of Pathology, University of Malaga School of Medicine, Malaga E29010, Spain
    J Clin Endocrinol Metab 91:1150-8. 2006
    ..Despite extensive molecular investigation of adrenal pheochromocytomas, no information is available on their molecular and mismatch repair (MMR) profiles by topographic compartments...
  8. ncbi Trichogerminoma: further evidence to support a specific follicular neoplasm
    L Pozo
    Histopathology 46:108-10. 2005
  9. ncbi Microsatellite instability in colon cancer
    Juan J Jimenez
    N Engl J Med 349:1774-6; author reply 1774-6. 2003
  10. ncbi Reduced expression of the growth hormone and type 1 insulin-like growth factor receptors in human somatotroph tumours and an analysis of possible mutations of the growth hormone receptor
    Blerina Kola
    Departments of Endocrinology and Histopatholgy, St Bartholomew s Hospital and National Institute of Neurology and Neurosurgery, London, UK
    Clin Endocrinol (Oxf) 59:328-38. 2003
    ..We hypothesized that the physiological IGF-I/GH negative feedback loop may be reset in somatotroph adenomas, specifically in terms of the level of expression of these receptors or mutations of the GH receptor (GH-R) in such tumours...
  11. ncbi Malignant melanoma in an 8-year-old Caribbean girl: diagnostic criteria and utility of sentinel lymph node biopsy
    A J Durrani
    Department of Plastic Surgery, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK
    Br J Dermatol 148:569-72. 2003
    ..These criteria include the distinction from MM mimics, especially Spitz tumours, and an appropriate use of staging techniques such as SLN biopsy to influence management...
  12. ncbi Difference between familial and sporadic medullary thyroid carcinomas
    Lisa Mears
    Am J Surg Pathol 27:266-7. 2003
  13. ncbi The correlation of regression with the grade of dysplasia (atypia) in melanocytic naevi
    L Pozo
    Histopathology 52:387-9. 2008
  14. ncbi Trichilemmal carcinoma with neuroendocrine differentiation
    L Pozo
    Department of Dermatology, Homerton University Hospital, London, UK
    Clin Exp Dermatol 33:128-31. 2008
    ....
  15. doi General morphological and biological features of neoplasms: integration of molecular findings
    S J Diaz-Cano
    Department of Histopathology, King s College Hospital and King s College London School of Medicine, London, UK
    Histopathology 53:1-19. 2008
    ..Sensible application of molecular markers in tumour pathology always needs solid morphological support...
  16. doi Classification of parathyroid cancer
    Klaus Martin Schulte
    Department of Endocrine Surgery, King s College Hospital, King s Health Partners, London, UK
    Ann Surg Oncol 19:2620-8. 2012
    ....
  17. pmc Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design
    Salvador J Diaz-Cano
    Department Histopathology, King s College Hospital and King s Health Partners, Denmark Hill, London SE5 9RS, UK E Mail Tel 44 20 3299 3041
    Int J Mol Sci 13:1951-2011. 2012
    ..This knowledge would constitute a solid scientific background for future therapeutic planning...
  18. doi Lingual necrosis secondary to mucormycosis
    R Dua
    Department of Oral and Maxillofacial Surgery, King s College Hospital, United Kingdom
    Br J Oral Maxillofac Surg 50:e96-8. 2012
    ..Mucormycosis is a rare fungal infection with a high mortality that affects immunocompromised patients. This is an unusual case of necrosis of the tongue in a patient with pulmonary mucormycosis, diabetes mellitus, and aplastic anaemia...
  19. doi Inflammatory diseases of the parathyroid gland
    Nadia Talat
    Department of Endocrine Surgery, King s College Hospital NHS Foundation Trust and King s Health Partners, London, UK
    Histopathology 59:897-908. 2011
    ..Inflammatory disorders of the parathyroid gland are very rare as compared with those of other endocrine organs. The aim of this study was to provide the first systematic review of this condition...
  20. doi Heterogeneous topographic profiles of kinetic and cell cycle regulator microsatellites in atypical (dysplastic) melanocytic nevi
    Ehab A Husain
    Department of Histopathology, Barts and The London Hospitals, London, UK
    Mod Pathol 24:471-86. 2011
    ..Melanocytic nevi and low-grade atypical melanocytic nevi show low incidence of microsatellite abnormalities, and kinetic features that make progression unlikely...
  21. doi The clinical spectrum of multiple endocrine neoplasia type 2a caused by the rare intracellular RET mutation S891A
    Klaus Martin Schulte
    Department of Endocrine Surgery, King s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom
    J Clin Endocrinol Metab 95:E92-7. 2010
    ..A strong genotype-phenotype correlation results in major implications for the clinical approach. More information on less common mutations is needed to advance specific guidance...
  22. doi Congenital segmental emphysema: an evolving lesion
    S Paramalingam
    King s College Hospital, Paediatric Surgery, London, United Kingdom
    Eur J Pediatr Surg 20:78-81. 2010
    ..It is characterised by antenatal detection and post-natal evolution from an initially solid segmental appearance to a hyperlucent and hyperinflated segment...
  23. doi Coexistent intraurothelial carcinoma and muscle-invasive urothelial carcinoma of the bladder: clonality and somatic down-regulation of DNA mismatch repair
    Alfredo Blanes
    Department of Pathology, University Hospital of Malaga, 29071 Malaga, Spain
    Hum Pathol 40:988-97. 2009
    ..Low-grade dysplasia is however unlikely connected with this molecular progression...
  24. doi Dermoscopy of trichostasis spinulosa
    Lucia Pozo
    Homerton University Hospital, London, England
    Arch Dermatol 144:1088. 2008
  25. doi Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast
    Patricia E Ellis
    Department of Obstetrics and Gynaecology, Royal Free and University College Medical School Hampstead Campus, University College London, London, UK
    Mod Pathol 21:1192-9. 2008
    ..Abnormal plakoglobin expression may be involved in the formation of some cases of Paget's of the vulva and the breast...
  26. pmc Clonal origin and expansions in neoplasms: biologic and technical aspects must be considered together
    Lucia Pozo-Garcia
    Am J Pathol 162:353-4; author reply 354-5. 2003
  27. pmc Clonality as expression of distinctive cell kinetics patterns in nodular hyperplasias and adenomas of the adrenal cortex
    S J Diaz-Cano
    Department of Pathology, Tufts University New England Medical Center, Boston, Massachusetts, USA
    Am J Pathol 156:311-9. 2000
    ..57). We concluded that only simultaneous down-regulated apoptosis and high proliferation result in selective kinetic advantage, dominant clone expansion, and unbalanced methylation patterns of androgen receptor alleles in ACNHs and ACAs...
  28. ncbi Kinetic profiles by topographic compartments in muscle-invasive transitional cell carcinomas of the bladder: role of TP53 and NF1 genes
    Alfredo Blanes
    Department of Pathology, University Hospital, Malaga, Spain
    Am J Clin Pathol 118:93-100. 2002
    ....
  29. ncbi Polyarteritis nodosa developing after discoid lupus erythematosus
    E Letellier
    Department of Clinical Immunology, St Bartholomews and the Royal London School of Medicine and Dentistry, UK
    Clin Exp Rheumatol 19:738-9. 2001
    ..We describe a patient with discoid lupus erythematosus whose pattern of disease evolved into a systemic vasculitis polyarteritis nodosa...
  30. ncbi Contribution of the microvessel network to the clonal and kinetic profiles of adrenal cortical proliferative lesions
    S J Diaz-Cano
    Department of Pathology, Tufts University-New England Medical Center, Boston, MA, USA
    Hum Pathol 32:1232-9. 2001
    ..In conclusion, the kinetic advantage of monoclonal adrenal cortical lesions (increased proliferation, decreased apoptosis) is maintained by parallel increases in microvessel area and density...
  31. ncbi Germline RET 634 mutation positive MEN 2A-related C-cell hyperplasias have genetic features consistent with intraepithelial neoplasia
    S J Diaz-Cano
    Department of Pathology, Tufts University New England Medical Center, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 86:3948-57. 2001
    ....
  32. ncbi Molecular and kinetic features of transitional cell carcinomas of the bladder: biological and clinical implications
    S I Baithun
    Department of Pathology, St Bartholomew's, Royal London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Virchows Arch 438:289-97. 2001
    ....
  33. ncbi PCR techniques for clonality assays
    S J Diaz-Cano
    Department of Pathology, Tufts University New England Medical Center, Boston, Massachusetts, USA
    Diagn Mol Pathol 10:24-33. 2001
    ....
  34. ncbi Critical analysis of histologic criteria for grading atypical (dysplastic) melanocytic nevi
    L Pozo
    Department of Dermatology, St Bartholomew's and The London Hospitals, London, England
    Am J Clin Pathol 115:194-204. 2001
    ..Histologic criteria can reliably distinguish AMN-severe but fail to differentiate AMN-mild from AMN-moderate. AMN from atypical-mole syndrome cannot be diagnosed using pathologic criteria alone...
  35. ncbi E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice
    R Smits
    Medical Genetics Center, Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 119:1045-53. 2000
    ..In addition, loss or haploinsufficiency of E-cadherin may affect tumorigenesis by altering its cell-adhesive and associated functions...
  36. ncbi Clonal patterns in phaeochromocytomas and MEN-2A adrenal medullary hyperplasias: histological and kinetic correlates
    S J Diaz-Cano
    Department of Pathology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    J Pathol 192:221-8. 2000
    ..A subgroup of PCCs characterized by balanced methylation of androgen receptor alleles, high cellular turnover, and stromal proliferation also shows locally invasive features...