Steven S Gill

Summary

Affiliation: Derriford Hospital
Country: UK

Publications

  1. ncbi request reprint Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
    Steven S Gill
    Frenchay Hospital, Institute of Neurosciences, Bristol, UK
    Nat Med 9:589-95. 2003
  2. ncbi request reprint Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study
    Nikunj K Patel
    Frenchay Hospital, Institute of Neurosciences, Bristol, United Kingdom
    Ann Neurol 57:298-302. 2005
  3. ncbi request reprint Clinical outcomes from bilateral versus unilateral stimulation of the pedunculopontine nucleus with and without concomitant caudal zona incerta region stimulation in Parkinson's disease
    Sadaquate Khan
    Department of Neurosurgery, Institute of Neurosciences, Frenchay Hospital, Bristol
    Br J Neurosurg 26:722-5. 2012
  4. doi request reprint Outcomes from stimulation of the caudal zona incerta and pedunculopontine nucleus in patients with Parkinson's disease
    Sadaquate Khan
    Department of Neurosurgery, Institute of Neurosciences, Frenchay Hospital, Bristol, UK
    Br J Neurosurg 25:273-80. 2011
  5. pmc Benefits of putaminal GDNF infusion in Parkinson disease are maintained after GDNF cessation
    Nikunj K Patel
    From the Institute of Clinical Neurosciences N K P, S J, S S G, Frenchay Hospital, Bristol and Imperial College London N P, G R H, D J B, Division of Brain Sciences, Hammersmith Hospital, London, UK
    Neurology 81:1176-8. 2013
  6. doi request reprint A magnetic resonance imaging-directed method for transventricular targeting of midline structures for deep brain stimulation using implantable guide tubes
    Sadaquate Khan
    Institute of Neurosciences, Frenchay Hospital, Bristol, United Kingdom
    Neurosurgery 66:234-7; discussion 237. 2010
  7. ncbi request reprint Unilateral subthalamotomy in the treatment of Parkinson's disease
    Nikunj K Patel
    Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK
    Brain 126:1136-45. 2003
  8. ncbi request reprint Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism
    Puneet Plaha
    Institute of Neurosciences, Department of Neurosurgery, Frenchay Hospital Bristol, UK
    Brain 129:1732-47. 2006
  9. ncbi request reprint Magnetic resonance imaging-directed method for functional neurosurgery using implantable guide tubes
    Nikunj K Patel
    Institute of Neurosciences, Frenchay Hospital, Bristol, England
    Neurosurgery 61:358-65; discussion 365-6. 2007
  10. doi request reprint Comparison of atlas- and magnetic-resonance-imaging-based stereotactic targeting of the subthalamic nucleus in the surgical treatment of Parkinson's disease
    Nikunj K Patel
    Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK
    Stereotact Funct Neurosurg 86:153-61. 2008

Collaborators

  • Nikunj K Patel
  • David J Brooks
  • Alan L Whone
  • Ingram Wright
  • P Brown
  • Seth Love
  • Nicola Pavese
  • Sadaquate Khan
  • Neil U Barua
  • Puneet Plaha
  • Shazia Javed
  • Marcella J Wyatt
  • Alison S Bienemann
  • Paul White
  • Lucy Mooney
  • Alexandros G Androulidakis
  • Crispin C Wigfield
  • Alethea B Tabor
  • Shirley Hesketh
  • Helen C Hailes
  • J Scott Miners
  • Katharina Welser
  • Emma Castrique
  • Nicholas Park
  • Michael Carter
  • Philip Jardine
  • Peta Sharples
  • Christopher W Pleydell-Pearce
  • Vladimir Litvak
  • Y Ben-Shlomo
  • James T Robertson
  • Newton H Metcalf
  • Richard J Nelson

Detail Information

Publications20

  1. ncbi request reprint Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
    Steven S Gill
    Frenchay Hospital, Institute of Neurosciences, Bristol, UK
    Nat Med 9:589-95. 2003
    ..This study warrants careful examination of GDNF as a treatment for Parkinson disease...
  2. ncbi request reprint Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study
    Nikunj K Patel
    Frenchay Hospital, Institute of Neurosciences, Bristol, United Kingdom
    Ann Neurol 57:298-302. 2005
    ....
  3. ncbi request reprint Clinical outcomes from bilateral versus unilateral stimulation of the pedunculopontine nucleus with and without concomitant caudal zona incerta region stimulation in Parkinson's disease
    Sadaquate Khan
    Department of Neurosurgery, Institute of Neurosciences, Frenchay Hospital, Bristol
    Br J Neurosurg 26:722-5. 2012
    ..If unilateral Pedunculopontine nucleus stimulation is as efficacious as bilateral stimulation this would lead to less surgical risk...
  4. doi request reprint Outcomes from stimulation of the caudal zona incerta and pedunculopontine nucleus in patients with Parkinson's disease
    Sadaquate Khan
    Department of Neurosurgery, Institute of Neurosciences, Frenchay Hospital, Bristol, UK
    Br J Neurosurg 25:273-80. 2011
    ..We performed bilateral deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) in combination with the caudal zona incerta (cZi) in order to determine their efficacy in alleviating these symptoms...
  5. pmc Benefits of putaminal GDNF infusion in Parkinson disease are maintained after GDNF cessation
    Nikunj K Patel
    From the Institute of Clinical Neurosciences N K P, S J, S S G, Frenchay Hospital, Bristol and Imperial College London N P, G R H, D J B, Division of Brain Sciences, Hammersmith Hospital, London, UK
    Neurology 81:1176-8. 2013
    ..1-3) We now provide clinical and PET evidence of persistent efficacy lasting for at least 3 years following cessation of GDNF infusion in a patient with PD. This is a single-case observational study, providing Class IV evidence. ..
  6. doi request reprint A magnetic resonance imaging-directed method for transventricular targeting of midline structures for deep brain stimulation using implantable guide tubes
    Sadaquate Khan
    Institute of Neurosciences, Frenchay Hospital, Bristol, United Kingdom
    Neurosurgery 66:234-7; discussion 237. 2010
    ..We describe a novel method for accurate and safe transventricular targeting...
  7. ncbi request reprint Unilateral subthalamotomy in the treatment of Parkinson's disease
    Nikunj K Patel
    Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK
    Brain 126:1136-45. 2003
    ..Com bined lesioning of the dorsolateral STN and H2/ZI is particularly effective...
  8. ncbi request reprint Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism
    Puneet Plaha
    Institute of Neurosciences, Department of Neurosurgery, Frenchay Hospital Bristol, UK
    Brain 129:1732-47. 2006
    ..We discuss the implications of this finding and the potential role played by the ZI in Parkinson's disease...
  9. ncbi request reprint Magnetic resonance imaging-directed method for functional neurosurgery using implantable guide tubes
    Nikunj K Patel
    Institute of Neurosciences, Frenchay Hospital, Bristol, England
    Neurosurgery 61:358-65; discussion 365-6. 2007
    ..We present a magnetic resonance imaging-directed stereotactic system using implantable guide tubes for targeting deep brain nuclei in functional neurosurgery...
  10. doi request reprint Comparison of atlas- and magnetic-resonance-imaging-based stereotactic targeting of the subthalamic nucleus in the surgical treatment of Parkinson's disease
    Nikunj K Patel
    Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK
    Stereotact Funct Neurosurg 86:153-61. 2008
    ....
  11. ncbi request reprint Convection-enhanced delivery of neprilysin: a novel amyloid-β-degrading therapeutic strategy
    Neil U Barua
    Functional Neurosurgery Research Group, University of Bristol, Bristol, UK
    J Alzheimers Dis 32:43-56. 2012
    ..CED of NEP has therapeutic potential as a dynamically controllable Aβ(40)-degrading therapeutic strategy for AD. Further studies are required to determine the longer term effects on Aβ (including Aβ(42)) and on cognitive function...
  12. ncbi request reprint MRI-directed subthalamic nucleus surgery for Parkinson's disease
    Nikunj K Patel
    Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK
    Stereotact Funct Neurosurg 78:132-45. 2002
    ....
  13. ncbi request reprint High frequency stimulation of the mamillothalamic tract for the treatment of resistant seizures associated with hypothalamic hamartoma
    Sadaquate Khan
    Institute of Neurosciences, Frenchay Hospital, Bristol, United Kingdom
    Epilepsia 50:1608-11. 2009
    ..An improvement in mood was reported by the patient's primary carers and demonstrated on quality of life questionnaires...
  14. ncbi request reprint Stimulation of the subthalamic region for essential tremor
    Puneet Plaha
    Department of Neurosurgery, Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, United Kingdom
    J Neurosurg 101:48-54. 2004
    ..The goal of this study was to determine the safety and efficacy of bilateral subthalamic region stimulation in the treatment of essential tremor (ET)...
  15. ncbi request reprint Convection-enhanced drug delivery to the brain: therapeutic potential and neuropathological considerations
    Neil U Barua
    Department of Neurosurgery, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, UK
    Brain Pathol 24:117-27. 2014
    ..In this review, we consider the factors most likely to influence the success or failure of CED, and review its application to the treatment of high-grade glioma, Parkinson's disease (PD) and Alzheimer's disease (AD). ..
  16. ncbi request reprint Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease
    Puneet Plaha
    Institute of Neurosciences, Frenchay Hospital, Bristol, UK
    Neuroreport 16:1883-7. 2005
    ..If these findings are replicated in a larger number of patients, pedunculopontine nucleus stimulation may provide the means to alleviate these disabling and otherwise treatment-resistant symptoms of advanced Parkinson's disease...
  17. pmc Intrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model
    Neil U Barua
    Department of Neurosurgery, Frenchay Hospital, Bristol, BS16 1LE, UK
    Fluids Barriers CNS 9:2. 2012
    ..abstract:..
  18. ncbi request reprint The new Frenchay artificial cervical joint: results from a two-year pilot study
    Crispin C Wigfield
    Department of Neurosurgery, The Academic Centre, Frenchay Hospital, Bristol, United Kingdom
    Spine (Phila Pa 1976) 27:2446-52. 2002
    ..A clinical prospective observational cohort study of 15 patients undergoing cervical intervertebral disc replacement...
  19. ncbi request reprint Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain
    Seth Love
    Nat Med 11:703-4. 2005
  20. doi request reprint Local field potential recordings from the pedunculopontine nucleus in a Parkinsonian patient
    Alexandros G Androulidakis
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
    Neuroreport 19:59-62. 2008
    ....