Nick Curzen

Summary

Affiliation: Derriford Hospital
Country: UK

Publications

  1. ncbi Transcatheter aortic valve implantation: the state of play
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton University Hospital, UK
    Future Cardiol 6:243-54. 2010
  2. ncbi Viewpoint: thrombolysis or angioplasty in the real world: a UK perspective
    Nick Curzen
    Wessex Cardiac Unit, Southampton University, Hospital, UK
    Circulation 113:f89-91. 2006
  3. ncbi Extensive coronary thrombus causing full thickness myocardial infarction
    Nicholas Curzen
    Wessex Cardiac Unit, Southampton University Hospital, Southampton, UK
    Acute Card Care 9:253. 2007
  4. ncbi Is there evidence for prognostic benefit following PCI in stable patients? COURAGE and its implications: an interventionalist's view
    N P Curzen
    Wessex Cardiothoracic Unit, Southampton University Hospitals NHS Trust, Southampton SO16 6YD, UK
    Heart 96:103-5. 2010
  5. ncbi Point-of-care platelet function assays demonstrate reduced responsiveness to clopidogrel, but not aspirin, in patients with Drug-Eluting Stent Thrombosis whilst on dual antiplatelet therapy
    Alex R Hobson
    Wessex Cardiac Unit, Southampton University Hospital, Southampton, UK
    Thromb J 6:1. 2008
  6. ncbi Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Heart 97:1661-7. 2011
  7. ncbi Consent in cardiology: there may be trouble ahead?
    Nick Curzen
    Wessex Cardiac Unit, Southampton University Hospital, Southampton SO16 6YD, UK
    Heart 91:977-80. 2005
  8. ncbi Percutaneous coronary intervention in unprotected left main stem disease: the state of play
    N Curzen
    Wessex Cardiothoracic Unit, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK
    Heart 91:iii39-41. 2005
  9. ncbi Personalised antiplatelet therapy in stent thrombosis: observations from the Clopidogrel Resistance in Stent Thrombosis (CREST) registry
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
    Heart 98:706-11. 2012
  10. ncbi Coronary revascularisation in chronic kidney disease. Part II: acute coronary syndromes
    Mike Seddon
    Wessex Cardiac Unit, Southampton University Hospitals NHS Trust, Tremona Road, Southampton SO16 6YD, UK
    J Ren Care 36:118-26. 2010

Collaborators

Detail Information

Publications24

  1. ncbi Transcatheter aortic valve implantation: the state of play
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton University Hospital, UK
    Future Cardiol 6:243-54. 2010
    ..We will also look at the potential future role of TAVI and the challenges involved in setting up a TAVI service...
  2. ncbi Viewpoint: thrombolysis or angioplasty in the real world: a UK perspective
    Nick Curzen
    Wessex Cardiac Unit, Southampton University, Hospital, UK
    Circulation 113:f89-91. 2006
  3. ncbi Extensive coronary thrombus causing full thickness myocardial infarction
    Nicholas Curzen
    Wessex Cardiac Unit, Southampton University Hospital, Southampton, UK
    Acute Card Care 9:253. 2007
    ..No further intervention was therefore indicated. At one-year follow-up, the patient remains free of angina with NYHA Class 1 symptoms of heart failure...
  4. ncbi Is there evidence for prognostic benefit following PCI in stable patients? COURAGE and its implications: an interventionalist's view
    N P Curzen
    Wessex Cardiothoracic Unit, Southampton University Hospitals NHS Trust, Southampton SO16 6YD, UK
    Heart 96:103-5. 2010
    ..Such a strategy applied to COURAGE (and perhaps also to SYNTAX) might provide a very different comparative outcome...
  5. ncbi Point-of-care platelet function assays demonstrate reduced responsiveness to clopidogrel, but not aspirin, in patients with Drug-Eluting Stent Thrombosis whilst on dual antiplatelet therapy
    Alex R Hobson
    Wessex Cardiac Unit, Southampton University Hospital, Southampton, UK
    Thromb J 6:1. 2008
    ..Whilst the aetiology of stent thrombosis (ST) is multifactorial there is increasing evidence from laboratory-based assays that hyporesponsiveness to antiplatelet therapy is a factor in some cases...
  6. ncbi Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Heart 97:1661-7. 2011
    ..Previous studies have observed a clustering of adverse events following clopidogrel cessation 1 year after DES, the aetiology of which is poorly understood...
  7. ncbi Consent in cardiology: there may be trouble ahead?
    Nick Curzen
    Wessex Cardiac Unit, Southampton University Hospital, Southampton SO16 6YD, UK
    Heart 91:977-80. 2005
  8. ncbi Percutaneous coronary intervention in unprotected left main stem disease: the state of play
    N Curzen
    Wessex Cardiothoracic Unit, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK
    Heart 91:iii39-41. 2005
  9. ncbi Personalised antiplatelet therapy in stent thrombosis: observations from the Clopidogrel Resistance in Stent Thrombosis (CREST) registry
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
    Heart 98:706-11. 2012
    ..The prevalence of APT hyporesponsiveness in a 'real world' registry of ST patients and the feasibility of personalising APT are reported...
  10. ncbi Coronary revascularisation in chronic kidney disease. Part II: acute coronary syndromes
    Mike Seddon
    Wessex Cardiac Unit, Southampton University Hospitals NHS Trust, Tremona Road, Southampton SO16 6YD, UK
    J Ren Care 36:118-26. 2010
    ..This review summarises the current evidence regarding the treatment of patients with CKD presenting with acute coronary syndromes, in particular with respect to coronary revascularisation strategies...
  11. ncbi Monitoring the effectiveness of antiplatelet therapy: opportunities and limitations
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton University Hospital School, UK
    Br J Clin Pharmacol 72:683-96. 2011
    ..With the advent of newer, more potent antiplatelet agents and their associated increased bleeding risks, it will become imperative in the future to select the most appropriate, safe and effective drug...
  12. ncbi Malignancy: an unrecognized risk factor for coronary stent thrombosis?
    Alex R Hobson
    Wessex Cardiac Unit, Southampton University Hospitals NHS Trust, Southampton S016 6YD, United Kingdom
    J Invasive Cardiol 20:E120-3. 2008
    ....
  13. ncbi "Short" thrombelastography as a test of platelet reactivity in response to antiplatelet therapy: validation and reproducibility
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton University Hospital, UK
    Platelets 22:210-6. 2011
    ..Short Thrombelastography (s-TEG) is a validated test that allows rapid measurement of clotting responses to antiplatelet therapy...
  14. ncbi Gender and responses to aspirin and clopidogrel: insights using short thrombelastography
    Alex R Hobson
    Wessex Cardiothoracic Unit, Southampton University Hospital, UK
    Cardiovasc Ther 27:246-52. 2009
    ..Differences in clotting tendency and response to antiplatelet therapy may contribute to the excess risk observed in young women but are not observed in older female patients...
  15. ncbi Clopidogrel withdrawal: is there a "rebound" phenomenon?
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton University Hospital, UK
    Thromb Haemost 105:211-20. 2011
    ....
  16. ncbi Coronary revascularisation in chronic kidney disease. Part 1: stable coronary artery disease
    Mike Seddon
    Wessex Cardiac Unit, Southampton University Hospitals NHS Trust, Tremona Road, Southampton, SO16 6YD, UK
    J Ren Care 36:106-17. 2010
    ..This review summarises the current evidence regarding the treatment of coronary artery disease in patients with CKD, with the focus on coronary revascularisation by percutaneous coronary intervention or coronary artery bypass grafting...
  17. ncbi A novel fifteen minute test for assessment of individual time-dependent clotting responses to aspirin and clopidogrel using modified thrombelastography
    Alex R Hobson
    Wessex Cardiothoracic Unit, Southampton University Hospital, Southampton, UK
    Platelets 18:497-505. 2007
    ....
  18. ncbi A randomized crossover study comparing the antiplatelet effect of plavix versus generic clopidogrel
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom University of Southampton Faculty of Medicine, Southampton, United Kingdom
    J Cardiovasc Pharmacol 60:495-501. 2012
    ..However, there is insufficient evidence to show that their pharmacodynamic effect is equivalent to Plavix...
  19. ncbi Takotsubo cardiomyopathy: a diagnostic challenge
    Mehmood Zeb
    Wessex Cardiothoracic Unit, Southampton University Hospitals NHS Trust, Southampton, SO16 6YD, UK
    Postgrad Med J 87:51-9. 2011
    ..This article examines the takotsubo cardiomyopathy literature and discusses the pathophysiology, clinical features, management, and prognosis of this condition in the context of an illustrated case...
  20. ncbi Tumour necrosis factor antagonists and the risk of cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review
    Sarah L Westlake
    Department of Rheumatology, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Rheumatology (Oxford) 50:518-31. 2011
    ..However, the extent to which these agents also reduce cardiovascular disease (CVD) is uncertain. The purpose of this study was to explore the effect of anti-TNF agents on CVD in RA using a systematic literature review...
  21. ncbi Reducing transfer times for coronary angiography in patients with acute coronary syndromes: one solution to a national problem
    N G Bellenger
    Wessex Cardiac Unit, Southampton University Hospitals NHS Trust, Southampton SO16 6YD, UK
    Postgrad Med J 82:411-3. 2006
    ..The current average waiting time of up to 21 days contravenes evidence based early intervention, creates geographical inequity of access, wastes bed days, and is unsatisfactory for patients...
  22. ncbi Detection of evolving right ventricular infarct during right coronary artery stent insertion using PRIME ECG body surface mapping with colour map reconstruction
    Simon D Carley
    Department of Emergency Medicine, Manchester Royal Infirmary, Manchester, UK
    Resuscitation 61:361-4. 2004
    ..CONCLUSION: Isolated RVI may be missed on 12 lead ECG criteria. Body surface mapping (BSM) allows unequivocal diagnosis of isolated RVI by colour map reconstruction that is able to localise the ischaemic change...
  23. ncbi Seeing transient regional myocardial ischaemia through new eyes
    Robert Hatrick
    Wessex Cardiac Unit, Southampton University Hospitals Trust, Southampton, UK
    Int J Cardiovasc Intervent 7:155-8. 2005
  24. ncbi Hospital stay in patients with non-ST-elevation acute coronary syndromes
    Nick G Bellenger
    Lancet 363:1399-400. 2004