Nick Curzen

Summary

Affiliation: Derriford Hospital
Country: UK

Publications

  1. doi request reprint Transcatheter aortic valve implantation: the state of play
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton University Hospital, UK
    Future Cardiol 6:243-54. 2010
  2. doi request reprint Is there evidence for prognostic benefit following PCI in stable patients? COURAGE and its implications: an interventionalist's view
    N P Curzen
    Wessex Cardiothoracic Unit, Southampton University Hospitals NHS Trust, Southampton SO16 6YD, UK
    Heart 96:103-5. 2010
  3. pmc Percutaneous coronary intervention in unprotected left main stem disease: the state of play
    N Curzen
    Wessex Cardiothoracic Unit, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK
    Heart 91:iii39-41. 2005
  4. pmc Consent in cardiology: there may be trouble ahead?
    Nick Curzen
    Wessex Cardiac Unit, Southampton University Hospital, Southampton SO16 6YD, UK
    Heart 91:977-80. 2005
  5. doi request reprint Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Heart 97:1661-7. 2011
  6. ncbi request reprint Viewpoint: thrombolysis or angioplasty in the real world: a UK perspective
    Nick Curzen
    Wessex Cardiac Unit, Southampton University, Hospital, UK
    Circulation 113:f89-91. 2006
  7. ncbi request reprint Extensive coronary thrombus causing full thickness myocardial infarction
    Nicholas Curzen
    Wessex Cardiac Unit, Southampton University Hospital, Southampton, UK
    Acute Card Care 9:253. 2007
  8. pmc Point-of-care platelet function assays demonstrate reduced responsiveness to clopidogrel, but not aspirin, in patients with Drug-Eluting Stent Thrombosis whilst on dual antiplatelet therapy
    Alex R Hobson
    Wessex Cardiac Unit, Southampton University Hospital, Southampton, UK
    Thromb J 6:1. 2008
  9. doi request reprint Personalised antiplatelet therapy in stent thrombosis: observations from the Clopidogrel Resistance in Stent Thrombosis (CREST) registry
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
    Heart 98:706-11. 2012
  10. doi request reprint Coronary revascularisation in chronic kidney disease. Part II: acute coronary syndromes
    Mike Seddon
    Wessex Cardiac Unit, Southampton University Hospitals NHS Trust, Tremona Road, Southampton SO16 6YD, UK
    J Ren Care 36:118-26. 2010

Collaborators

Detail Information

Publications29

  1. doi request reprint Transcatheter aortic valve implantation: the state of play
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton University Hospital, UK
    Future Cardiol 6:243-54. 2010
    ..We will also look at the potential future role of TAVI and the challenges involved in setting up a TAVI service...
  2. doi request reprint Is there evidence for prognostic benefit following PCI in stable patients? COURAGE and its implications: an interventionalist's view
    N P Curzen
    Wessex Cardiothoracic Unit, Southampton University Hospitals NHS Trust, Southampton SO16 6YD, UK
    Heart 96:103-5. 2010
    ..Such a strategy applied to COURAGE (and perhaps also to SYNTAX) might provide a very different comparative outcome...
  3. pmc Percutaneous coronary intervention in unprotected left main stem disease: the state of play
    N Curzen
    Wessex Cardiothoracic Unit, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK
    Heart 91:iii39-41. 2005
  4. pmc Consent in cardiology: there may be trouble ahead?
    Nick Curzen
    Wessex Cardiac Unit, Southampton University Hospital, Southampton SO16 6YD, UK
    Heart 91:977-80. 2005
  5. doi request reprint Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Heart 97:1661-7. 2011
    ..Previous studies have observed a clustering of adverse events following clopidogrel cessation 1 year after DES, the aetiology of which is poorly understood...
  6. ncbi request reprint Viewpoint: thrombolysis or angioplasty in the real world: a UK perspective
    Nick Curzen
    Wessex Cardiac Unit, Southampton University, Hospital, UK
    Circulation 113:f89-91. 2006
  7. ncbi request reprint Extensive coronary thrombus causing full thickness myocardial infarction
    Nicholas Curzen
    Wessex Cardiac Unit, Southampton University Hospital, Southampton, UK
    Acute Card Care 9:253. 2007
    ..No further intervention was therefore indicated. At one-year follow-up, the patient remains free of angina with NYHA Class 1 symptoms of heart failure...
  8. pmc Point-of-care platelet function assays demonstrate reduced responsiveness to clopidogrel, but not aspirin, in patients with Drug-Eluting Stent Thrombosis whilst on dual antiplatelet therapy
    Alex R Hobson
    Wessex Cardiac Unit, Southampton University Hospital, Southampton, UK
    Thromb J 6:1. 2008
    ..Whilst the aetiology of stent thrombosis (ST) is multifactorial there is increasing evidence from laboratory-based assays that hyporesponsiveness to antiplatelet therapy is a factor in some cases...
  9. doi request reprint Personalised antiplatelet therapy in stent thrombosis: observations from the Clopidogrel Resistance in Stent Thrombosis (CREST) registry
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
    Heart 98:706-11. 2012
    ..The prevalence of APT hyporesponsiveness in a 'real world' registry of ST patients and the feasibility of personalising APT are reported...
  10. doi request reprint Coronary revascularisation in chronic kidney disease. Part II: acute coronary syndromes
    Mike Seddon
    Wessex Cardiac Unit, Southampton University Hospitals NHS Trust, Tremona Road, Southampton SO16 6YD, UK
    J Ren Care 36:118-26. 2010
    ..This review summarises the current evidence regarding the treatment of patients with CKD presenting with acute coronary syndromes, in particular with respect to coronary revascularisation strategies...
  11. pmc Monitoring the effectiveness of antiplatelet therapy: opportunities and limitations
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton University Hospital School, UK
    Br J Clin Pharmacol 72:683-96. 2011
    ..With the advent of newer, more potent antiplatelet agents and their associated increased bleeding risks, it will become imperative in the future to select the most appropriate, safe and effective drug...
  12. ncbi request reprint Malignancy: an unrecognized risk factor for coronary stent thrombosis?
    Alex R Hobson
    Wessex Cardiac Unit, Southampton University Hospitals NHS Trust, Southampton S016 6YD, United Kingdom
    J Invasive Cardiol 20:E120-3. 2008
    ....
  13. doi request reprint "Short" thrombelastography as a test of platelet reactivity in response to antiplatelet therapy: validation and reproducibility
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton University Hospital, UK
    Platelets 22:210-6. 2011
    ..Short Thrombelastography (s-TEG) is a validated test that allows rapid measurement of clotting responses to antiplatelet therapy...
  14. doi request reprint A randomized crossover study comparing the antiplatelet effect of plavix versus generic clopidogrel
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
    J Cardiovasc Pharmacol 60:495-501. 2012
    ..However, there is insufficient evidence to show that their pharmacodynamic effect is equivalent to Plavix...
  15. doi request reprint Gender and responses to aspirin and clopidogrel: insights using short thrombelastography
    Alex R Hobson
    Wessex Cardiothoracic Unit, Southampton University Hospital, UK
    Cardiovasc Ther 27:246-52. 2009
    ..Differences in clotting tendency and response to antiplatelet therapy may contribute to the excess risk observed in young women but are not observed in older female patients...
  16. doi request reprint Clopidogrel withdrawal: is there a "rebound" phenomenon?
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, Southampton University Hospital, UK
    Thromb Haemost 105:211-20. 2011
    ....
  17. doi request reprint Coronary revascularisation in chronic kidney disease. Part 1: stable coronary artery disease
    Mike Seddon
    Wessex Cardiac Unit, Southampton University Hospitals NHS Trust, Tremona Road, Southampton, SO16 6YD, UK
    J Ren Care 36:106-17. 2010
    ..This review summarises the current evidence regarding the treatment of coronary artery disease in patients with CKD, with the focus on coronary revascularisation by percutaneous coronary intervention or coronary artery bypass grafting...
  18. ncbi request reprint Does the VerifyNow P2Y12 assay overestimate "therapeutic response" to clopidogrel? Insights using short thrombelastography
    Vikram Khanna
    Prof N Curzen, Wessex Cardiothoracic Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, United Kingdom, Tel 44 2380794972, Fax 44 2380795174
    Thromb Haemost 111:1150-9. 2014
    ..This could have implications for the ability of VN-P2Y12 to stratify patients as "responders" or "non-responders" to clopidogrel. ..
  19. doi request reprint Detection of transient regional myocardial ischemia using body surface Delta map in patients referred for myocardial perfusion imaging--a pilot study
    Mehmood Zeb
    Wessex Cardiac Unit, Southampton University Hospital, Southampton, UK Faculty of Medicine, University of Southampton, Southampton, UK Electronic address
    J Electrocardiol 46:627-34. 2013
    ..The BSM Delta map is an intuitive color display of digitally subtracted ST-segment shift derived from two 80-electrode BSM recordings at baseline and at peak stress, and has shown promise as a tool for detection of TRMI...
  20. doi request reprint "Aspirin resistance" in ischemic stroke: insights using short thrombelastography
    Nalyaka Sambu
    Wessex Cardiothoracic Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK Faculty of Medicine, University of Southampton, Southampton, UK
    J Stroke Cerebrovasc Dis 22:1412-9. 2013
    ..We investigated whether pharmacological responses to aspirin can be reliably determined from a functional test of AA-induced whole-blood clotting...
  21. ncbi request reprint A novel fifteen minute test for assessment of individual time-dependent clotting responses to aspirin and clopidogrel using modified thrombelastography
    Alex R Hobson
    Wessex Cardiothoracic Unit, Southampton University Hospital, Southampton, UK
    Platelets 18:497-505. 2007
    ....
  22. doi request reprint Should ischemia be the main target in selecting a percutaneous coronary intervention strategy?
    Kristel Longman
    Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
    Expert Rev Cardiovasc Ther 11:1051-9. 2013
    ..We discuss the recent evidence and propose an ischemia-driven approach for selecting a percutaneous coronary intervention strategy...
  23. ncbi request reprint Does routine pressure wire assessment influence management strategy at coronary angiography for diagnosis of chest pain?: the RIPCORD study
    Nick Curzen
    From University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom N C, O R, Z N, P G, A C, S C Faculty of Medicine, University of Southampton, Southampton, United Kingdom N C, B D D Freeman Hospital, Newcastle upon Tyne, and Newcastle University, Tyne and Wear, United Kingdom A Z Golden Jubilee Hospital, Glasgow, United Kingdom K O Belfast City Hospital, Belfast, United Kingdom C H John Radcliffe Hospital, Oxford, United Kingdom A B Leeds General Infirmary, Leeds, United Kingdom S W Queen Alexandra Hospital, Portsmouth, United Kingdom A H Royal Derby Hospital, Derby, United Kingdom K C Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom D H S and Musgrove Park Hospital, Taunton, United Kingdom D M
    Circ Cardiovasc Interv 7:248-55. 2014
    ..The impact of routine FFR at the time of diagnostic CA on patient management has not been determined...
  24. doi request reprint Takotsubo cardiomyopathy: a diagnostic challenge
    Mehmood Zeb
    Wessex Cardiothoracic Unit, Southampton University Hospitals NHS Trust, Southampton, SO16 6YD, UK
    Postgrad Med J 87:51-9. 2011
    ..This article examines the takotsubo cardiomyopathy literature and discusses the pathophysiology, clinical features, management, and prognosis of this condition in the context of an illustrated case...
  25. doi request reprint Tumour necrosis factor antagonists and the risk of cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review
    Sarah L Westlake
    Department of Rheumatology, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Rheumatology (Oxford) 50:518-31. 2011
    ..However, the extent to which these agents also reduce cardiovascular disease (CVD) is uncertain. The purpose of this study was to explore the effect of anti-TNF agents on CVD in RA using a systematic literature review...
  26. pmc Reducing transfer times for coronary angiography in patients with acute coronary syndromes: one solution to a national problem
    N G Bellenger
    Wessex Cardiac Unit, Southampton University Hospitals NHS Trust, Southampton SO16 6YD, UK
    Postgrad Med J 82:411-3. 2006
    ..The current average waiting time of up to 21 days contravenes evidence based early intervention, creates geographical inequity of access, wastes bed days, and is unsatisfactory for patients...
  27. ncbi request reprint Detection of evolving right ventricular infarct during right coronary artery stent insertion using PRIME ECG body surface mapping with colour map reconstruction
    Simon D Carley
    Department of Emergency Medicine, Manchester Royal Infirmary, Manchester, UK
    Resuscitation 61:361-4. 2004
    ..Using computer-derived colour reconstruction of the ECG data, the changes of isolated right ventricular infarction is obvious, in contrast to the transient and equivocal changes seen on the 12 lead ECG...
  28. ncbi request reprint Seeing transient regional myocardial ischaemia through new eyes
    Robert Hatrick
    Wessex Cardiac Unit, Southampton University Hospitals Trust, Southampton, UK
    Int J Cardiovasc Intervent 7:155-8. 2005
  29. ncbi request reprint Hospital stay in patients with non-ST-elevation acute coronary syndromes
    Nick G Bellenger
    Lancet 363:1399-400. 2004