Graeme P Currie

Summary

Country: UK

Publications

  1. ncbi request reprint Effects of tiotropium and other long acting bronchodilators in chronic obstructive pulmonary disease
    Graeme P Currie
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Foresterhill, Scotland, UK
    Pulm Pharmacol Ther 19:112-9. 2006
  2. pmc Pharmacological management--inhaled treatment
    Graeme P Currie
    Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
    BMJ 332:1439-41. 2006
  3. pmc ABC of chronic obstructive pulmonary disease. Acute exacerbations
    Graeme P Currie
    Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
    BMJ 333:87-9. 2006
  4. ncbi request reprint Long-acting beta2-agonists in asthma: not so SMART?
    Graeme P Currie
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Drug Saf 29:647-56. 2006
  5. ncbi request reprint Effects of asthma treatment: the present and future
    Graeme P Currie
    Specialist Registrar, Aberdeen Royal Infirmary, Department of Respiratory Medicine, Foresterhill, Aberdeen AB25 2ZN, UK
    Expert Rev Clin Immunol 2:547-60. 2006
  6. ncbi request reprint Long-acting bronchodilator or leukotriene modifier as add-on therapy to inhaled corticosteroids in persistent asthma?
    Graeme P Currie
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, AB25 2ZN Scotland, UK
    Chest 128:2954-62. 2005
  7. pmc A chronic pneumothorax and fitness to fly
    Graeme P Currie
    Department of Respiratory Medicine, Chest Clinic C, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, Scotland, UK
    Thorax 62:187-9. 2007
  8. doi request reprint Endobronchial ultrasound-transbronchial needle aspiration and its practical application
    G P Currie
    Chest Clinic C, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK
    QJM 104:653-62. 2011
  9. pmc Pneumothorax: an update
    Graeme P Currie
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Postgrad Med J 83:461-5. 2007
  10. pmc Recent developments in asthma management
    Graeme P Currie
    Chest Clinic C, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN
    BMJ 330:585-9. 2005

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Effects of tiotropium and other long acting bronchodilators in chronic obstructive pulmonary disease
    Graeme P Currie
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Foresterhill, Scotland, UK
    Pulm Pharmacol Ther 19:112-9. 2006
    ..This evidence based review article discusses the use of long acting bronchodilators in COPD with a particular emphasis on the putative benefits of tiotropium...
  2. pmc Pharmacological management--inhaled treatment
    Graeme P Currie
    Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
    BMJ 332:1439-41. 2006
  3. pmc ABC of chronic obstructive pulmonary disease. Acute exacerbations
    Graeme P Currie
    Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
    BMJ 333:87-9. 2006
  4. ncbi request reprint Long-acting beta2-agonists in asthma: not so SMART?
    Graeme P Currie
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Drug Saf 29:647-56. 2006
    ..This evidence-based review discusses the data from SMART and highlights potentially important drawbacks with regular use of LABAs in persistent asthma...
  5. ncbi request reprint Effects of asthma treatment: the present and future
    Graeme P Currie
    Specialist Registrar, Aberdeen Royal Infirmary, Department of Respiratory Medicine, Foresterhill, Aberdeen AB25 2ZN, UK
    Expert Rev Clin Immunol 2:547-60. 2006
    ..In this review, existing and potential future pharmacological strategies involved in the management of asthma will be highlighted...
  6. ncbi request reprint Long-acting bronchodilator or leukotriene modifier as add-on therapy to inhaled corticosteroids in persistent asthma?
    Graeme P Currie
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, AB25 2ZN Scotland, UK
    Chest 128:2954-62. 2005
    ..We also highlight the results of all published studies that have performed direct comparisons of both LABAs and LTRAs as add-on therapy to inhaled corticosteroids...
  7. pmc A chronic pneumothorax and fitness to fly
    Graeme P Currie
    Department of Respiratory Medicine, Chest Clinic C, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, Scotland, UK
    Thorax 62:187-9. 2007
    ..We outline their histories and subsequent evaluation which consisted of clinical assessment, computed tomographic imaging, a hypoxic challenge test and exposure to a hypoxic hypobaric environment in a decompression chamber...
  8. doi request reprint Endobronchial ultrasound-transbronchial needle aspiration and its practical application
    G P Currie
    Chest Clinic C, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK
    QJM 104:653-62. 2011
    ..We describe the clinical use, indications for and limitations of EBUS-TBNA along with several illustrated clinical examples...
  9. pmc Pneumothorax: an update
    Graeme P Currie
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Postgrad Med J 83:461-5. 2007
    ..This evidence based review highlights current practices involved in the management of patients with a pneumothorax...
  10. pmc Recent developments in asthma management
    Graeme P Currie
    Chest Clinic C, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN
    BMJ 330:585-9. 2005
  11. ncbi request reprint The expanding role of leukotriene receptor antagonists in chronic asthma
    Graeme P Currie
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland
    Ann Allergy Asthma Immunol 97:731-41, quiz 741-2, 793. 2006
    ..To provide a comprehensive review of studies that evaluate the effects of leukotriene receptor antagonists in adult chronic asthma...
  12. pmc Phosphodiesterase 4 inhibitors in chronic obstructive pulmonary disease: a new approach to oral treatment
    Graeme P Currie
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland, UK
    Br J Clin Pharmacol 65:803-10. 2008
    ..They are also generally well tolerated. Further studies are required to determine fully their long-term beneficial and adverse effect profiles and ultimately where they might comfortably sit in management algorithms...
  13. ncbi request reprint Indacaterol Novartis/skyePharma
    Graeme P Currie
    Aberdeen Royal Infirmary, Foresterhill Road, Aberdeen, AB25 2ZN, UK
    Curr Opin Investig Drugs 7:457-63. 2006
    ..In January 2006, Novartis expected phase III clinical trials to start in early 2006, with submission planned for 2007...
  14. ncbi request reprint Reactivation of tuberculosis after apparently adequate chemoprophylaxis
    Graeme P Currie
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, Scotland, UK
    J Infect 51:e305-8. 2005
    ..Thorax 2000;55:887-901]. We report a case involving a close contact where current guidelines were followed, but failed to prevent subsequent development of active disease from the same strain of M. tuberculosis...
  15. pmc Effects of hydrofluoroalkane formulations of ciclesonide 400 microg once daily vs fluticasone 250 microg twice daily on methacholine hyper-responsiveness in mild-to-moderate persistent asthma
    Daniel K C Lee
    Asthma and Allergy Research Group, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee DDI 9SY, Scotland, UK
    Br J Clin Pharmacol 58:26-33. 2004
    ....
  16. ncbi request reprint Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma
    Daniel K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    J Allergy Clin Immunol 111:337-41. 2003
    ..Modern H(1)-antihistamines differ in their in vitro binding affinity, but their comparative in vivo bioactivity in asthmatic airways is unknown...
  17. ncbi request reprint Effects of fluticasone plus salmeterol versus twice the dose of fluticasone in asthmatic patients
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY Dundee, Scotland, UK
    Eur J Clin Pharmacol 59:11-5. 2003
    ..Since it is unclear how this translates into effects on surrogate inflammatory markers, we evaluated the anti-inflammatory activity of fluticasone plus salmeterol in combination versus twice the dose of fluticasone alone...
  18. pmc A proof of concept study to evaluate putative benefits of montelukast in moderate persistent asthmatics
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Br J Clin Pharmacol 55:609-15. 2003
    ..The latter was done to dissociate the effects of montelukast from ICS...
  19. pmc The arginine-16 beta2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterol
    Daniel K C Lee
    Asthma and Allergy Research Group, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Br J Clin Pharmacol 57:68-75. 2004
    ..The relationship between beta2-adrenoceptor polymorphisms and bronchoprotective response with long-acting beta2-adrenoceptor agonists is unknown...
  20. ncbi request reprint Does bronchial hyperresponsiveness in asthma matter?
    Graeme P Currie
    Chest Clinic C, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland, UK
    J Asthma 41:247-58. 2004
    ....
  21. ncbi request reprint Effects of dual therapy with corticosteroids plus long acting beta2-agonists in asthma
    Graeme P Currie
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, AB25 2ZN Scotland, UK
    Respir Med 99:683-94. 2005
    ..This evidenced-based review article discusses the effects of such combination inhalers upon a variety of outcome parameters and their effects upon asthmatics across a range of severities...
  22. pmc ABC of chronic obstructive pulmonary disease. Pharmacological management--oral treatment
    Graeme P Currie
    Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
    BMJ 332:1497-9. 2006
  23. ncbi request reprint Effects of montelukast on surrogate inflammatory markers in corticosteroid-treated patients with asthma
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Am J Respir Crit Care Med 167:1232-8. 2003
    ..Further studies are required to evaluate whether these effects of montelukast translate into clinical benefits...
  24. pmc Oxygen and inhalers
    Graeme P Currie
    Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
    BMJ 333:34-6. 2006
  25. pmc ABC of chronic obstructive pulmonary disease. Diagnosis
    Graeme P Currie
    Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
    BMJ 332:1261-3. 2006
  26. ncbi request reprint Assessment of bronchial responsiveness following exposure to inhaled occupational and environmental agents
    Graeme P Currie
    Chest Clinic C, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland
    Toxicol Rev 23:75-81. 2004
    ..Bronchial hyperresponsiveness in reactive airways dysfunction syndrome can persist for many years after initial exposure and serial changes can be used to assess recovery and subsequent disability over time...
  27. doi request reprint Closed pleural biopsy to diagnose mesothelioma: dead or alive?
    Kris M McLaughlin
    Department of Respiratory Medicine, Aberdeen Royal Infirmary, Aberdeen, UK
    Lung Cancer 65:388-9. 2009
    ..It should therefore still be considered as a first line investigation in suspected mesothelioma especially in centres where CT-guided or thoracoscopic pleural biopsy are not immediately available...
  28. pmc Immediate and early discharge for patients with exacerbations of chronic obstructive pulmonary disease: is there a role in "real life"?
    Mahendran Chetty
    Respiratory Unit, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, Scotland, UK
    Int J Chron Obstruct Pulmon Dis 1:401-7. 2006
    ..We highlight the current literature which has evaluated the role of hospital at home and assisted discharge schemes and discuss our own "real life" service operating in a large teaching hospital in Scotland...
  29. ncbi request reprint Variation in lung cancer survival rates between countries: do differences in data reporting contribute?
    Claire A Butler
    Department of Respiratory Medicine, United Hospitals NHS Trust, Bush Road, Antrim BT41 2QB, Northern Ireland, UK
    Respir Med 100:1642-6. 2006
    ..Differences in patients, disease, investigation and treatment are thought to account for some survival shortfalls but it is not known whether differences in collection or processing of data also contribute...
  30. pmc Smoking cessation
    Prasima Srivastava
    Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
    BMJ 332:1324-6. 2006
  31. pmc ABC of chronic obstructive pulmonary disease.Non-pharmacological management
    Graeme P Currie
    Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
    BMJ 332:1379-81. 2006
  32. pmc Chronic cough
    Graeme P Currie
    Chest Clinic C, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB252ZN
    BMJ 326:261. 2003
  33. pmc Systemic bioactivity of intranasal triamcinolone and mometasone in perennial allergic rhinitis
    Daniel K C Lee
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Br J Clin Pharmacol 55:310-3. 2003
    ..To evaluate the systemic bioactivity of triamcinolone acetonide (TA) 220 micro g or mometasone furoate (MF) 200 micro g over 3 weeks in perennial allergic rhinitis...
  34. pmc ABC of chronic obstructive pulmonary disease. Ventilatory support
    Gordon Christie
    Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
    BMJ 333:138-40. 2006
  35. ncbi request reprint Montelukast and theophylline: no use or some use in persistent asthma?
    Graeme P Currie
    Am J Respir Crit Care Med 175:1094; author reply 1094-5. 2007
  36. ncbi request reprint Evaluating the effects of "triple therapy" with inhaled corticosteroids, long-acting beta2-agonists, and leukotriene modifiers in asthma
    Graeme P Currie
    Chest 130:301-2. 2006
  37. ncbi request reprint Invalid and irrelevant comparisons: apples or oranges?
    Graeme P Currie
    Ann Allergy Asthma Immunol 96:379. 2006
  38. ncbi request reprint Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: a meta-analysis
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Ann Allergy Asthma Immunol 90:194-8. 2003
    ..There is a relatively steep dose-response curve for effects of inhaled corticosteroids on conventional airway markers of asthmatic disease control...
  39. ncbi request reprint Safety of long-acting beta-agonists
    Graeme P Currie
    Ann Intern Med 145:707-8; author reply 708-10. 2006
  40. ncbi request reprint Why SMART about second-line treatment when first-line treatment is being ignored?
    Graeme P Currie
    Chest 130:929; author reply 929. 2006
  41. ncbi request reprint Exhaled nitric oxide and asthma
    Graeme P Currie
    N Engl J Med 353:732-3; author reply 732-3. 2005
  42. ncbi request reprint Predictive parameters of dropout during inhaled corticosteroid tapering
    Daniel K C Lee
    Chest 121:1726-7. 2002
  43. ncbi request reprint Effects of high-dose inhaled fluticasone propionate on the hypothalamic-pituitary-adrenal axis in asthmatic patients with severely impaired lung function
    Daniel K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    Ann Allergy Asthma Immunol 93:253-8. 2004
    ..The effects of high-dose fluticasone propionate therapy on dynamic cortisol stimulation in severe asthma are unknown...
  44. pmc Comparison of combination inhalers vs inhaled corticosteroids alone in moderate persistent asthma
    Daniel K C Lee
    Asthma and Allergy Research Group, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY
    Br J Clin Pharmacol 56:494-500. 2003
    ....
  45. pmc Leukotriene C4 synthase polymorphisms and responsiveness to leukotriene antagonists in asthma
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Br J Clin Pharmacol 56:422-6. 2003
    ..Our aim is to evaluate whether responsiveness to leukotriene receptor antagonists was determined by expression of the variant (C) or wild-type (A) polymorphism of this enzyme...
  46. pmc Effects of fluticasone vs. fluticasone/salmeterol on airway calibre and airway hyperresponsiveness in mild persistent asthma
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Br J Clin Pharmacol 56:11-7. 2003
    ..We set out to evaluate effects on airway hyperresponsiveness (AHR) and airway calibre using hydrofluoroalkane fluticasone/salmeterol (FP/SM) vs. double the dose of fluticasone alone (FP)...
  47. ncbi request reprint Asthma exacerbations and sputum eosinophil counts
    Graeme P Currie
    Lancet 361:1302-3; author reply 1303. 2003
  48. ncbi request reprint Combined mediator blockade or topical corticosteroids for seasonal allergic rhinitis
    Brian J Lipworth
    J Allergy Clin Immunol 110:939; author reply 940. 2002
  49. ncbi request reprint Bronchoprotective effects of leukotriene receptor antagonists in asthma: a meta-analysis
    Graeme P Currie
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    Chest 122:146-50. 2002
    ..Since bronchial hyperresponsiveness is a noninvasive surrogate marker of asthmatic airway inflammation, we evaluated the bronchoprotection afforded by leukotriene receptor antagonists (LTRAs)...
  50. ncbi request reprint Step-down therapy with low-dose fluticasone-salmeterol combination or medium-dose hydrofluoroalkane 134a-beclomethasone alone
    Stephen J Fowler
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutic, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    J Allergy Clin Immunol 109:929-35. 2002
    ..Options for step-down therapy include use of inhaled corticosteroids alone or in combination with a long-acting beta2-agonist...
  51. ncbi request reprint Histamine and indirect bronchoprovocation with adenosine monophosphate in asthma
    Daniel K C Lee
    Respir Med 99:515; author reply 516. 2005
  52. ncbi request reprint What about add-on second-line controller therapy?
    Graeme P Currie
    Chest 127:1077; author reply 1077-8. 2005
  53. ncbi request reprint In vitro synergism of inhaled corticosteroid and long-acting beta2-agonist is not translated clinically in vivo
    Daniel K C Lee
    J Allergy Clin Immunol 115:880; author reply 880-1. 2005
  54. ncbi request reprint The GOAL study: designed to favor a long-acting beta2-agonist?
    Graeme P Currie
    Am J Respir Crit Care Med 171:1060-1; author reply 1061. 2005
  55. ncbi request reprint Sputum eosinophils and bronchodilator reversibility: COPD or asthma?
    Graeme P Currie
    Chest 127:2292-3. 2005
  56. ncbi request reprint Combination therapy with a long-acting beta2-agonist and an inhaled corticosteroid as initial maintenance treatment in asthma
    Daniel K C Lee
    Ann Allergy Asthma Immunol 94:410-1; author reply 411-2. 2005
  57. ncbi request reprint Effects of montelukast in patients with persistent asthma using inhaled corticosteroids plus additional second-line therapy
    Graeme P Currie
    J Allergy Clin Immunol 116:230. 2005
  58. ncbi request reprint Therapeutic ratio of hydrofluoroalkane and chlorofluorocarbon formulations of fluticasone propionate
    Stephen J Fowler
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Chest 122:618-23. 2002
    ..To compare the therapeutic ratio of chlorofluorocarbon (CFC) and hydrofluoroalkane-134a (HFA) formulations of fluticasone propionate (FP)...
  59. ncbi request reprint beta(2)-Adrenergic receptor polymorphism in asthma: prospective versus retrospective perspective
    Daniel K C Lee
    J Allergy Clin Immunol 117:222; author reply 222-3. 2006
  60. ncbi request reprint Determinants of airway hyperresponsiveness in mild asthma
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells University Hospital and Medical School, Dundee, Scotland
    Ann Allergy Asthma Immunol 90:560-3. 2003
    ..Patients with mild asthma may have coexisting severe airway hyperresponsiveness (AHR), although the reasons for this are uncertain...
  61. ncbi request reprint Recovery time following bronchial challenge
    Graeme P Currie
    Respir Med 99:653. 2005
  62. ncbi request reprint Beneficial antiinflammatory effects of leukotriene receptor antagonists in asthma
    Graeme P Currie
    Chest 127:1458. 2005
  63. ncbi request reprint Dose-response effects of inhaled corticosteroids in asthma: what endpoint should we measure?
    Graeme P Currie
    Respir Med 101:191; author reply 192. 2007
  64. ncbi request reprint Intranasal corticosteroid therapy and bronchial hyperresponsiveness in the unified airway
    Graeme P Currie
    Ann Allergy Asthma Immunol 93:206; author reply 206-7. 2004
  65. ncbi request reprint A case of self-inflicted bilateral pneumothorax
    David R Miller
    Resuscitation 71:122-3. 2006
  66. ncbi request reprint H1-antihistamines
    Daniel K C Lee
    N Engl J Med 352:1155-7; author reply 1155-7. 2005
  67. ncbi request reprint Uncertain biologic relevance of polymorphisms of leukotriene C4 synthase in asthma
    Graeme P Currie
    J Allergy Clin Immunol 115:205. 2005
  68. ncbi request reprint Are colonial Haemophilus influenzae responsible for exacerbations of chronic obstructive pulmonary disease after all?
    Daniel K C Lee
    Am J Respir Crit Care Med 171:194; author reply 194-5. 2005
  69. ncbi request reprint Omalizumab and changes in airway hyperresponsiveness
    Graeme P Currie
    Am J Respir Crit Care Med 171:88-9; author reply 89. 2005