Research Topics
| M CrowtherSummaryCountry: UK Publications
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Publications
Being underweight may reduce your ability to mobilise peripheral blood stem cellsMark Crowther
Department of Haematology, Worcestershire Royal Hospital, Worcester, UK
Transfus Apher Sci 43:365-7. 2010..Therefore being underweight may reduce a patient's ability to mobilise peripheral blood stem cells and, if confirmed, improving nutritional status may reduce the number of patients who fail to mobilise...- Systematic review and meta-analyses of studies of glutamine supplementation in haematopoietic stem cell transplantationM Crowther
Department of Haematology, Ward 16, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZD, UK
Bone Marrow Transplant 44:413-25. 2009..In conclusion, there may be beneficial effects of glutamine in HSCT but larger, well-designed studies are required to confirm the beneficial effects and investigate possible adverse effects... - Hot topics in parenteral nutrition. A review of the use of glutamine supplementation in the nutritional support of patients undergoing bone-marrow transplantation and traditional cancer therapyMark Crowther
Department of Haematology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZD, UK
Proc Nutr Soc 68:269-73. 2009..host disease, while intravenous glutamine may reduce infections but at the expense of an increased relapse rate. Good-quality studies are required in this area... - Intensity of warfarin coagulation in the antiphospholipid syndromeMark Crowther
Division of Hematology and Thromboembolism, McMaster University, St Joseph s Hospital, 50 Charlton Ave, East Hamilton, Ontario, Canada
Curr Rheumatol Rep 12:64-9. 2010..Care must be taken with all anticoagulants because of the increased risk of bleeding. Several other strategies are available if warfarin fails, including the addition of aspirin, increasing the warfarin target range, and use of heparin... - Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxisD Cook
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Crit Care 24:168-75. 2009.... 
Dalteparin versus warfarin for the prevention of recurrent venous thromboembolic events in cancer patients: a pharmacoeconomic analysisGeorge Dranitsaris
Augmentium Pharma Consulting, Toronto, Ontario, Canada
Pharmacoeconomics 24:593-607. 2006..002). A Canadian pharmacoeconomic analysis was conducted to measure the economic value of dalteparin for this indication...- Patients with a first symptomatic unprovoked deep vein thrombosis are at higher risk of recurrent venous thromboembolism than patients with a first unprovoked pulmonary embolismM J Kovacs
Department of Hematology, London Health Sciences Centre, Victoria Hospital, London, Ontario, Canada
J Thromb Haemost 8:1926-32. 2010.... - Does celecoxib potentiate the anticoagulant effect of warfarin? A randomized, double-blind, controlled trialFrancesco Dentali
Department of Medicine, McMaster University, Hamilton, ON, Canada
Ann Pharmacother 40:1241-7. 2006..Cyclooxygenase-2 selective NSAIDs such as celecoxib may be less likely to promote gastrointestinal bleeding; however, there are concerns that they could potentiate the anticoagulation effect of warfarin... - Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trialsFrancesco Dentali
Department of Medicine, McMaster University, and St Joseph s Healthcare, Hamilton, Ontario, Canada
Arch Intern Med 167:117-24. 2007..We performed a systematic review and meta-analysis of randomized controlled trials comparing these 2 treatment strategies (combined aspirin-OAC therapy vs OAC therapy alone) to assess the therapeutic benefits and risks... - Prevention of venous thromboembolism in critically ill surgery patients: a cross-sectional studyD Cook
Departments of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
J Crit Care 16:161-6. 2001..3, P =.001). CONCLUSIONS: VTE prevention for surgical ICU patients within the first postoperative week appear to be individualized, and influenced by current and future risks of thrombosis and bleeding... 
Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factorsDeborah Cook
Department of Medicine, 1200 Main Street, McMaster University, Hamilton, Canada
Crit Care 12:R32. 2008..The objective of the present study was to evaluate the prevalence, incidence and predictors of DVT and the incidence of bleeding in intensive care unit (ICU) patients with estimated creatinine clearance <30 ml/min...- Preventing and managing bleeding complications in anticoagulated patients: a case based approachMark Crowther
Division of Hematology, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 4A6
Thromb Res 123:S42-5. 2008..The paper is "case based" and narrative since there is little evidence to guide practice in this area... - Low molecular weight heparin and bleeding in patients with chronic renal failureMark Crowther
St Joseph s Hospital, Hamilton, Ontario, Canada
Curr Opin Pulm Med 13:409-13. 2007..Consequently, care should be employed when LMWH is administered to patients with impaired renal function as reduced clearance and bioaccumulation may cause bleeding... - Antiphospholipid syndrome: a challenging hypercoagulable state with systemic manifestationsMarco P Donadini
Division of Hematology and Thromboembolism, St Joseph s Hospital, McMaster University, Hamilton, ON, Canada
Hematol Oncol Clin North Am 24:669-76, vii. 2010..At present, there is no evidence to support or refute specific treatment strategies for primary prophylaxis of thrombosis... - Risk of recurrent venous thromboembolism after a first oestrogen-associated episode. Data from the REVERSE cohort studyGregoire Le Gal
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Thromb Haemost 104:498-503. 2010..The risk of recurrent VTE is low in women after a first otherwise unprovoked oestrogen-associated VTE. However, this risk is not significantly lower than in women whose VTE was not related to oestrogen use... - Thromboembolism in children with acute lymphoblastic leukaemia treated on Dana-Farber Cancer Institute protocols: effect of age and risk stratification of diseaseUma H Athale
Division of Hematology Oncology, Department of Pediatrics, McMaster University, Hamilton, ON, Canada
Br J Haematol 129:803-10. 2005..Age-related risk may partly reflect the effect of ALL-risk stratification. Higher dose steroids combined with ASP may lead to an increased risk of TE in HR patients... - Antiphospholipid antibodies in critical illnessFrancesco Dentali
St Joseph s Hospital, Hamilton, Ontario, Canada
Crit Care Med 38:S51-6. 2010..The optimal treatment of other clinical manifestations of antiphospholipid syndrome needs to be addressed in well-designed prospective studies... - Deep venous thrombosis in medical-surgical critically ill patients: prevalence, incidence, and risk factorsDeborah Cook
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Crit Care Med 33:1565-71. 2005..Further research is needed to evaluate the risks and benefits of more intense venous thromboembolism prophylaxis... - New anticoagulants: an updateMark Crowther
Division of Hematology, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada
Clin Adv Hematol Oncol 2:743-9. 2004.... - Low-molecular-weight heparin thromboprophylaxis in medical-surgical critically ill patients: a systematic reviewChristine Ribic
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Crit Care 24:197-205. 2009..The study aimed to systematically review the effect of low-molecular-weight heparin (LMWH) thromboprophylaxis in medical-surgical critically ill patients in the intensive care unit... - Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot studyDeborah J Cook
Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
J Crit Care 20:364-72. 2005..Its additional goals were to evaluate the suitability of the exclusion criteria and to document the range of research activities that precede accrual of patients into a trial to plan multisite management... - Measuring the anticoagulant effect of low molecular weight heparins in the critically illMark Crowther
St Joseph s Hospital, Hamilton, Ontario, Canada
Crit Care 10:150. 2006..These findings provide reassurance that subcutaneously administered medications may be used in critically ill patients with edema... - Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics: the DIRECT studyJames Douketis
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Arch Intern Med 168:1805-12. 2008..To challenge this premise, we evaluated if deep vein thrombosis (DVT) prophylaxis with dalteparin sodium confers an excessive anticoagulant effect in critically ill patients with severe renal insufficiency... - Direct thrombin inhibitorsJeffrey I Weitz
McMaster University and Henderson Research Centre, 711 Concession Street, Hamilton, Ontario, Canada, L8V 1C3
Thromb Res 106:V275-84. 2002..This review summarizes the clinical trial data with direct thrombin inhibitors and provides perspective on the role of direct thrombin inhibitors in the face of other new anticoagulants currently under development...