Keith Wesnes

..Data from a variety of topical areas in drug development are presented to illustrate the added value such techniques have brought. The latest developments in automation include remote testing via the Internet and telephone...

..This represents the first substantial demonstration of improvements to the memory of healthy middle-aged volunteers produced by a phytopharmaceutical...

..This study provides objective evidence that a typical breakfast of cereal rich in complex carbohydrates can help maintain mental performance over the morning...

..Significant benefits of rivastigmine over placebo were seen on all aspects of attention assessed: sustained attention, focused attention, consistence of responding, and central processing speed...

..Three weeks after discontinuation of rivastigmine, most parameters of cognitive performance returned to predrug levels...

..Using composite scores simplified data interpretation and suggested differential effects of hypertension on cognitive performance not clearly evident in individual test results...

..Accurate prediction is imperative for clinical trials and prevention strategies...

..A treatment is now available for a previously unmet medical need...

..To determine whether attentional impairments are reliable neuropsychological markers of delirium...

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..Inhibitors of the enzyme acetylcholinesterase are an effective dementia treatment, though the role of the related enzyme butyrylcholinesterase is less well understood...

..Improved attention may have positive effects on cognitive and functional outcomes for AD patients, although this hypothesis requires further study and validation...

..These results further differentiate the physiological responses involved during memory for affective and neutral material...

..Furthermore, coadministration of dapoxetine did not affect the pharmacokinetics of ethanol or potentiate the cognitive and subjective effects of ethanol...

..We examined attention-enhancing effects of the cholinesterase inhibitor donepezil in Dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) by means of open label study...

..A complete absence of negative interactions on measures of safety and cognitive function supports the absence of a contraindication to co-administration of acamprosate and naltrexone in clinical practice...

..Given this large disparity, prospective studies to clarify the utility of different criteria as a predictor of subsequent dementia are a priority...

..In this study we evaluated the effect of darifenacin, an M3 selective antagonist, on cognitive function in elderly volunteers without clinical dementia...

..No acute effects of Ginkgo biloba were found for any of the memory tests examined. The findings suggest that 120 mg of Ginkgo biloba has no acute nootropic effects in healthy older humans...

..A larger study is warranted to confirm these preliminary findings...

..These findings suggest that daily perceived stress in children may impoverish cognitive performance via its modulating effects on the HPA axis activity...

..To determine whether APOE genotype explained variability in short-term recovery from predominantly mild traumatic brain injury (TBI)...

..These findings indicate that the olfactory properties of these essential oils can produce objective effects on cognitive performance, as well as subjective effects on mood...

..They are discussed with reference to possible pharmacological and psychological modes of influence...

..The diagnostic tool also proves to be very effective in discriminating between Alzheimer's disease and dementia with Lewy bodies...

..To compare executive, memory and visuospatial functioning of DSM-IV anorexia nervosa (AN), bulimia nervosa (BN), and normal controls (NC)...

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..These effects may be a consequence of galantamine's potentiating action at nicotinic receptors...

..The apolipoprotein E (APOE) epsilon4 allele has been implicated as a significant risk factor in the development of late-onset Alzheimer disease, but the evidence of cognitive sequelae in healthy individuals has been mixed...

..CONCLUSION: The findings emphasize the importance of identifying early cognitive impairments to optimize rehabilitation, care planning, and secondary prevention of dementia in stroke patients...

..The epsilon4 allele may modulate the effect of lorazepam on p5-HIAA, but further studies are needed to confirm this finding and elucidate its possible significance...