Affiliation: Cognitive Drug Research
- Assessing cognitive function in clinical trials: latest developments and future directionsKeith Wesnes
Cognitive Drug Research, CDR House, 24 Portman Rd, Reading, UK RG30 1EA
Drug Discov Today 7:29-35. 2002..Data from a variety of topical areas in drug development are presented to illustrate the added value such techniques have brought. The latest developments in automation include remote testing via the Internet and telephone...
- The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteersK A Wesnes
Cognitive Drug Research Ltd, Reading, UK
Psychopharmacology (Berl) 152:353-61. 2000..This represents the first substantial demonstration of improvements to the memory of healthy middle-aged volunteers produced by a phytopharmaceutical...
- Breakfast reduces declines in attention and memory over the morning in schoolchildrenKeith A Wesnes
Cognitive Drug Research Ltd, Reading RG30 1EA, UK
Appetite 41:329-31. 2003..This study provides objective evidence that a typical breakfast of cereal rich in complex carbohydrates can help maintain mental performance over the morning...
- Benefits of rivastigmine on attention in dementia associated with Parkinson diseaseK A Wesnes
Cognitive Drug Research, Goring on Thames, United Kingdom
Neurology 65:1654-6. 2005..Significant benefits of rivastigmine over placebo were seen on all aspects of attention assessed: sustained attention, focused attention, consistence of responding, and central processing speed...
- Practice effects on cognitive tasks: a major problem?Keith Wesnes
Cognitive Drug Research Ltd, CDR House, 24 Portman Road, Reading RG30 1EA, UK
Lancet Neurol 1:473. 2002
- Effects of rivastigmine on cognitive function in dementia with lewy bodies: a randomised placebo-controlled international study using the cognitive drug research computerised assessment systemK A Wesnes
Cognitive Drug Research Ltd, Reading, University of Newcastle upon Tyne, UK
Dement Geriatr Cogn Disord 13:183-92. 2002..Three weeks after discontinuation of rivastigmine, most parameters of cognitive performance returned to predrug levels...
- Effects of hypertension on attention, memory, and executive function in older adultsBrian K Saxby
Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
Health Psychol 22:587-91. 2003..Using composite scores simplified data interpretation and suggested differential effects of hypertension on cognitive performance not clearly evident in individual test results...
- Subtle attentional deficits in the absence of dementia are associated with an increased risk of post-operative deliriumDavid P Lowery
University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Dement Geriatr Cogn Disord 23:390-4. 2007..Accurate prediction is imperative for clinical trials and prevention strategies...
- Rivastigmine tartrate with a focus on dementia associated with Parkinson's diseaseKeith Wesnes
Cognitive Drug Research, Ltd, Goring on Thames, and Human Cognitive Neuroscience Unit, Northumbria University, Newcastle on Tyne, UK
Drugs Today (Barc) 43:349-59. 2007..A treatment is now available for a previously unmet medical need...
- Quantifying the association between computerised measures of attention and confusion assessment method defined delirium: a prospective study of older orthopaedic surgical patients, free of dementiaDavid Peter Lowery
University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Int J Geriatr Psychiatry 23:1253-60. 2008..To determine whether attentional impairments are reliable neuropsychological markers of delirium...
- Cognitive performance in relapsing remitting multiple sclerosis: a longitudinal study in daily practice using a brief computerized cognitive batteryChris Edgar
United BioSource Corporation, 9 Gatehampton Road, Goring on Thames, RG8 0EN, UK
BMC Neurol 11:68. 2011....
- Cognitive associations of subcortical white matter lesions in older peopleJohn T O'Brien
Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle upon Tyne, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Ann N Y Acad Sci 977:436-44. 2002....
- Regulation of attention and response to therapy in dementia by butyrylcholinesteraseKirsty K O'Brien
MRC Building, MRC University of Newcastle Centre Development for Clinical Brain Ageing, Newcastle upon Tyne, NE1 3BZ, UK
Pharmacogenetics 13:231-9. 2003..Inhibitors of the enzyme acetylcholinesterase are an effective dementia treatment, though the role of the related enzyme butyrylcholinesterase is less well understood...
- Effects of galantamine on measures of attention: results from 2 clinical trials in Alzheimer disease patients with comparisons to donepezilJames E Galvin
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Alzheimer Dis Assoc Disord 22:30-8. 2008..Improved attention may have positive effects on cognitive and functional outcomes for AD patients, although this hypothesis requires further study and validation...
- Chewing gum selectively improves aspects of memory in healthy volunteersLucy Wilkinson
Human Cognitive Neuroscience Unit, Division of Psychology, University of Northumbria, Newcastle upon Tyne, NE1 8ST, UK
Appetite 38:235-6. 2002
- The effect of glucose administration and the emotional content of words on heart rate and memoryClaire E Ford
Human Cognitive Neuroscience Unit, University of Northumbria, Newcastle upon Tyne, UK
J Psychopharmacol 16:241-4. 2002..These results further differentiate the physiological responses involved during memory for affective and neutral material...
- Dapoxetine has no pharmacokinetic or cognitive interactions with ethanol in healthy male volunteersNishit B Modi
ALZA Corporation, 1900 Charleston Road, Building M11 4A, Mountain View, CA 94043, USA
J Clin Pharmacol 47:315-22. 2007..Furthermore, coadministration of dapoxetine did not affect the pharmacokinetics of ethanol or potentiate the cognitive and subjective effects of ethanol...
- Effects of donepezil on central processing speed and attentional measures in Parkinson's disease with dementia and dementia with Lewy bodiesElise Rowan
Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
Dement Geriatr Cogn Disord 23:161-7. 2007..We examined attention-enhancing effects of the cholinesterase inhibitor donepezil in Dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) by means of open label study...
- A pharmacokinetic and pharmacodynamic drug interaction study of acamprosate and naltrexoneBarbara J Mason
Division of Substance Abuse, Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL, USA
Neuropsychopharmacology 27:596-606. 2002..A complete absence of negative interactions on measures of safety and cognitive function supports the absence of a contraindication to co-administration of acamprosate and naltrexone in clinical practice...
- Mild cognitive impairment and vascular cognitive impairment in stroke patientsClive Ballard
Institute for Ageing and Health, Newcastle General Hospital, Newcastle, UK
Int Psychogeriatr 15:123-6. 2003..Given this large disparity, prospective studies to clarify the utility of different criteria as a predictor of subsequent dementia are a priority...
- Assessment of cognitive function of the elderly population: effects of darifenacinRichard B Lipton
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
J Urol 173:493-8. 2005..In this study we evaluated the effect of darifenacin, an M3 selective antagonist, on cognitive function in elderly volunteers without clinical dementia...
- The acute nootropic effects of Ginkgo biloba in healthy older human subjects: a preliminary investigationPradeep J Nathan
Neuropharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Australia
Hum Psychopharmacol 17:45-9. 2002..No acute effects of Ginkgo biloba were found for any of the memory tests examined. The findings suggest that 120 mg of Ginkgo biloba has no acute nootropic effects in healthy older humans...
- Increased anticholinergic challenge-induced memory impairment associated with the APOE-epsilon4 allele in the elderly: a controlled pilot studyNunzio Pomara
Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
Neuropsychopharmacology 29:403-9. 2004..A larger study is warranted to confirm these preliminary findings...
- Cognitive performance and morning levels of salivary cortisol and alpha-amylase in children reporting high vs. low daily stress perceptionEnrique F Maldonado
Department of Psychobiology and Methodology of the Behavioral Sciences, Universidad de Malaga, Spain
Span J Psychol 11:3-15. 2008..These findings suggest that daily perceived stress in children may impoverish cognitive performance via its modulating effects on the HPA axis activity...
- Apolipoprotein E epsilon 4 and short-term recovery from predominantly mild brain injuryJoshua N Liberman
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
Neurology 58:1038-44. 2002..To determine whether APOE genotype explained variability in short-term recovery from predominantly mild traumatic brain injury (TBI)...
- Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adultsMark Moss
Human Cognitive Neuroscience Unit, Division of Psychology, Northumberland Building, University of Northumbria, Newcastle upon Tyne, NE1 8ST, UK
Int J Neurosci 113:15-38. 2003..These findings indicate that the olfactory properties of these essential oils can produce objective effects on cognitive performance, as well as subjective effects on mood...
- Modulation of cognitive performance and mood by aromas of peppermint and ylang-ylangMark Moss
Human Cognitive Neuroscience Unit, Division of Psychology, University of Northumbria, Newcastle upon Tyne, United Kingdom
Int J Neurosci 118:59-77. 2008..They are discussed with reference to possible pharmacological and psychological modes of influence...
- Reliable diagnoses of dementia by the naive credal classifier inferred from incomplete cognitive dataMarco Zaffalon
IDSIA, Galleria 2, 6928 Manno, Lugano, Switzerland
Artif Intell Med 29:61-79. 2003..The diagnostic tool also proves to be very effective in discriminating between Alzheimer's disease and dementia with Lewy bodies...
- Neuropsychological study of underweight and "weight-recovered" anorexia nervosa compared with bulimia nervosa and normal controlsPeter Bosanac
Department of Psychiatry, University of Melbourne, Austin Hospital, Studley Road, Heidelberg 3084, Melbourne, Australia
Int J Eat Disord 40:613-21. 2007..To compare executive, memory and visuospatial functioning of DSM-IV anorexia nervosa (AN), bulimia nervosa (BN), and normal controls (NC)...
- Neuropsychological deficits in older stroke patientsClive Ballard
Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle NE4 6BE, United Kingdom
Ann N Y Acad Sci 977:179-82. 2002....
- The psychopharmacology of herbal extracts: issues and challengesAndrew Scholey
Psychopharmacology (Berl) 179:705-7; author reply 708-11. 2005
- White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patientsEmma J Burton
Institute for Ageing and Health, Newcastle General Hospital, Newcastle, UK
Stroke 35:1270-5. 2004....
- A review of cognitive impairment and cerebral metabolite abnormalities in patients with hepatitis C infectionDaniel M Forton
Liver Unit, Division of Medicine, Faculty of Medicine, Imperial College London, St Mary s Hospital Campus, London, UK
AIDS 19:S53-63. 2005....
- Early onset effects of galantamine treatment on attention in patients with Alzheimer's diseaseBruno Vellas
Memory Research Resource Center for Alzheimer's Disease, , , Toulouse, France
Curr Med Res Opin 21:1423-9. 2005..These effects may be a consequence of galantamine's potentiating action at nicotinic receptors...
- The acute effects of combined administration of Ginkgo biloba and Bacopa monniera on cognitive function in humansBronya F G Maher
Hum Psychopharmacol 17:163-4. 2002
- Apolipoprotein E epsilon4 allele and lorazepam effects on memory in high-functioning older adultsNunzio Pomara
Geriatric Psychiatry Program, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Arch Gen Psychiatry 62:209-16. 2005..The apolipoprotein E (APOE) epsilon4 allele has been implicated as a significant risk factor in the development of late-onset Alzheimer disease, but the evidence of cognitive sequelae in healthy individuals has been mixed...
- Association between mild vascular cognitive impairment and impaired activities of daily living in older stroke survivors without dementiaSally Stephens
University of Newcastle, UK
J Am Geriatr Soc 53:103-7. 2005..CONCLUSION: The findings emphasize the importance of identifying early cognitive impairments to optimize rehabilitation, care planning, and secondary prevention of dementia in stroke patients...
- Effects of acute lorazepam administration on aminergic activity in normal elderly subjects: relationship to performance effects and apolipoprotein genotypeNunzio Pomara
Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Neurochem Res 29:1391-8. 2004..The epsilon4 allele may modulate the effect of lorazepam on p5-HIAA, but further studies are needed to confirm this finding and elucidate its possible significance...