Keith Wesnes

Summary

Affiliation: Cognitive Drug Research
Country: UK

Publications

  1. ncbi request reprint Assessing cognitive function in clinical trials: latest developments and future directions
    Keith Wesnes
    Cognitive Drug Research, CDR House, 24 Portman Rd, Reading, UK RG30 1EA
    Drug Discov Today 7:29-35. 2002
  2. ncbi request reprint The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers
    K A Wesnes
    Cognitive Drug Research Ltd, Reading, UK
    Psychopharmacology (Berl) 152:353-61. 2000
  3. ncbi request reprint Breakfast reduces declines in attention and memory over the morning in schoolchildren
    Keith A Wesnes
    Cognitive Drug Research Ltd, Reading RG30 1EA, UK
    Appetite 41:329-31. 2003
  4. ncbi request reprint Benefits of rivastigmine on attention in dementia associated with Parkinson disease
    K A Wesnes
    Cognitive Drug Research, Goring on Thames, United Kingdom
    Neurology 65:1654-6. 2005
  5. ncbi request reprint Practice effects on cognitive tasks: a major problem?
    Keith Wesnes
    Cognitive Drug Research Ltd, CDR House, 24 Portman Road, Reading RG30 1EA, UK
    Lancet Neurol 1:473. 2002
  6. ncbi request reprint Effects of rivastigmine on cognitive function in dementia with lewy bodies: a randomised placebo-controlled international study using the cognitive drug research computerised assessment system
    K A Wesnes
    Cognitive Drug Research Ltd, Reading, University of Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 13:183-92. 2002
  7. ncbi request reprint Effects of hypertension on attention, memory, and executive function in older adults
    Brian K Saxby
    Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Health Psychol 22:587-91. 2003
  8. ncbi request reprint Subtle attentional deficits in the absence of dementia are associated with an increased risk of post-operative delirium
    David P Lowery
    University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 23:390-4. 2007
  9. ncbi request reprint Rivastigmine tartrate with a focus on dementia associated with Parkinson's disease
    Keith Wesnes
    Cognitive Drug Research, Ltd, Goring on Thames, and Human Cognitive Neuroscience Unit, Northumbria University, Newcastle on Tyne, UK
    Drugs Today (Barc) 43:349-59. 2007
  10. doi request reprint Quantifying the association between computerised measures of attention and confusion assessment method defined delirium: a prospective study of older orthopaedic surgical patients, free of dementia
    David Peter Lowery
    University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 23:1253-60. 2008

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Assessing cognitive function in clinical trials: latest developments and future directions
    Keith Wesnes
    Cognitive Drug Research, CDR House, 24 Portman Rd, Reading, UK RG30 1EA
    Drug Discov Today 7:29-35. 2002
    ..Data from a variety of topical areas in drug development are presented to illustrate the added value such techniques have brought. The latest developments in automation include remote testing via the Internet and telephone...
  2. ncbi request reprint The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers
    K A Wesnes
    Cognitive Drug Research Ltd, Reading, UK
    Psychopharmacology (Berl) 152:353-61. 2000
    ..This represents the first substantial demonstration of improvements to the memory of healthy middle-aged volunteers produced by a phytopharmaceutical...
  3. ncbi request reprint Breakfast reduces declines in attention and memory over the morning in schoolchildren
    Keith A Wesnes
    Cognitive Drug Research Ltd, Reading RG30 1EA, UK
    Appetite 41:329-31. 2003
    ..This study provides objective evidence that a typical breakfast of cereal rich in complex carbohydrates can help maintain mental performance over the morning...
  4. ncbi request reprint Benefits of rivastigmine on attention in dementia associated with Parkinson disease
    K A Wesnes
    Cognitive Drug Research, Goring on Thames, United Kingdom
    Neurology 65:1654-6. 2005
    ..Significant benefits of rivastigmine over placebo were seen on all aspects of attention assessed: sustained attention, focused attention, consistence of responding, and central processing speed...
  5. ncbi request reprint Practice effects on cognitive tasks: a major problem?
    Keith Wesnes
    Cognitive Drug Research Ltd, CDR House, 24 Portman Road, Reading RG30 1EA, UK
    Lancet Neurol 1:473. 2002
  6. ncbi request reprint Effects of rivastigmine on cognitive function in dementia with lewy bodies: a randomised placebo-controlled international study using the cognitive drug research computerised assessment system
    K A Wesnes
    Cognitive Drug Research Ltd, Reading, University of Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 13:183-92. 2002
    ..Three weeks after discontinuation of rivastigmine, most parameters of cognitive performance returned to predrug levels...
  7. ncbi request reprint Effects of hypertension on attention, memory, and executive function in older adults
    Brian K Saxby
    Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Health Psychol 22:587-91. 2003
    ..Using composite scores simplified data interpretation and suggested differential effects of hypertension on cognitive performance not clearly evident in individual test results...
  8. ncbi request reprint Subtle attentional deficits in the absence of dementia are associated with an increased risk of post-operative delirium
    David P Lowery
    University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 23:390-4. 2007
    ..Accurate prediction is imperative for clinical trials and prevention strategies...
  9. ncbi request reprint Rivastigmine tartrate with a focus on dementia associated with Parkinson's disease
    Keith Wesnes
    Cognitive Drug Research, Ltd, Goring on Thames, and Human Cognitive Neuroscience Unit, Northumbria University, Newcastle on Tyne, UK
    Drugs Today (Barc) 43:349-59. 2007
    ..A treatment is now available for a previously unmet medical need...
  10. doi request reprint Quantifying the association between computerised measures of attention and confusion assessment method defined delirium: a prospective study of older orthopaedic surgical patients, free of dementia
    David Peter Lowery
    University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 23:1253-60. 2008
    ..To determine whether attentional impairments are reliable neuropsychological markers of delirium...
  11. pmc Cognitive performance in relapsing remitting multiple sclerosis: a longitudinal study in daily practice using a brief computerized cognitive battery
    Chris Edgar
    United BioSource Corporation, 9 Gatehampton Road, Goring on Thames, RG8 0EN, UK
    BMC Neurol 11:68. 2011
    ....
  12. ncbi request reprint Cognitive associations of subcortical white matter lesions in older people
    John T O'Brien
    Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle upon Tyne, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Ann N Y Acad Sci 977:436-44. 2002
    ....
  13. ncbi request reprint Regulation of attention and response to therapy in dementia by butyrylcholinesterase
    Kirsty K O'Brien
    MRC Building, MRC University of Newcastle Centre Development for Clinical Brain Ageing, Newcastle upon Tyne, NE1 3BZ, UK
    Pharmacogenetics 13:231-9. 2003
    ..Inhibitors of the enzyme acetylcholinesterase are an effective dementia treatment, though the role of the related enzyme butyrylcholinesterase is less well understood...
  14. doi request reprint Effects of galantamine on measures of attention: results from 2 clinical trials in Alzheimer disease patients with comparisons to donepezil
    James E Galvin
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Alzheimer Dis Assoc Disord 22:30-8. 2008
    ..Improved attention may have positive effects on cognitive and functional outcomes for AD patients, although this hypothesis requires further study and validation...
  15. ncbi request reprint Chewing gum selectively improves aspects of memory in healthy volunteers
    Lucy Wilkinson
    Human Cognitive Neuroscience Unit, Division of Psychology, University of Northumbria, Newcastle upon Tyne, NE1 8ST, UK
    Appetite 38:235-6. 2002
  16. ncbi request reprint The effect of glucose administration and the emotional content of words on heart rate and memory
    Claire E Ford
    Human Cognitive Neuroscience Unit, University of Northumbria, Newcastle upon Tyne, UK
    J Psychopharmacol 16:241-4. 2002
    ..These results further differentiate the physiological responses involved during memory for affective and neutral material...
  17. ncbi request reprint Dapoxetine has no pharmacokinetic or cognitive interactions with ethanol in healthy male volunteers
    Nishit B Modi
    ALZA Corporation, 1900 Charleston Road, Building M11 4A, Mountain View, CA 94043, USA
    J Clin Pharmacol 47:315-22. 2007
    ..Furthermore, coadministration of dapoxetine did not affect the pharmacokinetics of ethanol or potentiate the cognitive and subjective effects of ethanol...
  18. ncbi request reprint Effects of donepezil on central processing speed and attentional measures in Parkinson's disease with dementia and dementia with Lewy bodies
    Elise Rowan
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 23:161-7. 2007
    ..We examined attention-enhancing effects of the cholinesterase inhibitor donepezil in Dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) by means of open label study...
  19. ncbi request reprint A pharmacokinetic and pharmacodynamic drug interaction study of acamprosate and naltrexone
    Barbara J Mason
    Division of Substance Abuse, Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL, USA
    Neuropsychopharmacology 27:596-606. 2002
    ..A complete absence of negative interactions on measures of safety and cognitive function supports the absence of a contraindication to co-administration of acamprosate and naltrexone in clinical practice...
  20. ncbi request reprint Mild cognitive impairment and vascular cognitive impairment in stroke patients
    Clive Ballard
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle, UK
    Int Psychogeriatr 15:123-6. 2003
    ..Given this large disparity, prospective studies to clarify the utility of different criteria as a predictor of subsequent dementia are a priority...
  21. ncbi request reprint Assessment of cognitive function of the elderly population: effects of darifenacin
    Richard B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Urol 173:493-8. 2005
    ..In this study we evaluated the effect of darifenacin, an M3 selective antagonist, on cognitive function in elderly volunteers without clinical dementia...
  22. ncbi request reprint The acute nootropic effects of Ginkgo biloba in healthy older human subjects: a preliminary investigation
    Pradeep J Nathan
    Neuropharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Australia
    Hum Psychopharmacol 17:45-9. 2002
    ..No acute effects of Ginkgo biloba were found for any of the memory tests examined. The findings suggest that 120 mg of Ginkgo biloba has no acute nootropic effects in healthy older humans...
  23. ncbi request reprint Increased anticholinergic challenge-induced memory impairment associated with the APOE-epsilon4 allele in the elderly: a controlled pilot study
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Neuropsychopharmacology 29:403-9. 2004
    ..A larger study is warranted to confirm these preliminary findings...
  24. ncbi request reprint Cognitive performance and morning levels of salivary cortisol and alpha-amylase in children reporting high vs. low daily stress perception
    Enrique F Maldonado
    Department of Psychobiology and Methodology of the Behavioral Sciences, Universidad de Malaga, Spain
    Span J Psychol 11:3-15. 2008
    ..These findings suggest that daily perceived stress in children may impoverish cognitive performance via its modulating effects on the HPA axis activity...
  25. ncbi request reprint Apolipoprotein E epsilon 4 and short-term recovery from predominantly mild brain injury
    Joshua N Liberman
    Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
    Neurology 58:1038-44. 2002
    ..To determine whether APOE genotype explained variability in short-term recovery from predominantly mild traumatic brain injury (TBI)...
  26. ncbi request reprint Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults
    Mark Moss
    Human Cognitive Neuroscience Unit, Division of Psychology, Northumberland Building, University of Northumbria, Newcastle upon Tyne, NE1 8ST, UK
    Int J Neurosci 113:15-38. 2003
    ..These findings indicate that the olfactory properties of these essential oils can produce objective effects on cognitive performance, as well as subjective effects on mood...
  27. ncbi request reprint Modulation of cognitive performance and mood by aromas of peppermint and ylang-ylang
    Mark Moss
    Human Cognitive Neuroscience Unit, Division of Psychology, University of Northumbria, Newcastle upon Tyne, United Kingdom
    Int J Neurosci 118:59-77. 2008
    ..They are discussed with reference to possible pharmacological and psychological modes of influence...
  28. ncbi request reprint Reliable diagnoses of dementia by the naive credal classifier inferred from incomplete cognitive data
    Marco Zaffalon
    IDSIA, Galleria 2, 6928 Manno, Lugano, Switzerland
    Artif Intell Med 29:61-79. 2003
    ..The diagnostic tool also proves to be very effective in discriminating between Alzheimer's disease and dementia with Lewy bodies...
  29. ncbi request reprint Neuropsychological study of underweight and "weight-recovered" anorexia nervosa compared with bulimia nervosa and normal controls
    Peter Bosanac
    Department of Psychiatry, University of Melbourne, Austin Hospital, Studley Road, Heidelberg 3084, Melbourne, Australia
    Int J Eat Disord 40:613-21. 2007
    ..To compare executive, memory and visuospatial functioning of DSM-IV anorexia nervosa (AN), bulimia nervosa (BN), and normal controls (NC)...
  30. ncbi request reprint Neuropsychological deficits in older stroke patients
    Clive Ballard
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle NE4 6BE, United Kingdom
    Ann N Y Acad Sci 977:179-82. 2002
    ....
  31. ncbi request reprint The psychopharmacology of herbal extracts: issues and challenges
    Andrew Scholey
    Psychopharmacology (Berl) 179:705-7; author reply 708-11. 2005
  32. ncbi request reprint White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patients
    Emma J Burton
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle, UK
    Stroke 35:1270-5. 2004
    ..We hypothesized that processing speed and executive dysfunction will be associated with frontal WMH whereas impaired memory will be associated with temporal WMH...
  33. ncbi request reprint A review of cognitive impairment and cerebral metabolite abnormalities in patients with hepatitis C infection
    Daniel M Forton
    Liver Unit, Division of Medicine, Faculty of Medicine, Imperial College London, St Mary s Hospital Campus, London, UK
    AIDS 19:S53-63. 2005
    ....
  34. ncbi request reprint Early onset effects of galantamine treatment on attention in patients with Alzheimer's disease
    Bruno Vellas
    Memory Research Resource Center for Alzheimer s Disease, Service de Geriatrie, CHU Hôpital Lagrave Casselardit, Toulouse, France
    Curr Med Res Opin 21:1423-9. 2005
    ..This study was designed to test the effects of galantamine on attention in patients with mild-to-moderate Alzheimer's disease (AD) and to see how changes in attention affected their caregivers...
  35. ncbi request reprint The acute effects of combined administration of Ginkgo biloba and Bacopa monniera on cognitive function in humans
    Bronya F G Maher
    Hum Psychopharmacol 17:163-4. 2002
  36. ncbi request reprint Apolipoprotein E epsilon4 allele and lorazepam effects on memory in high-functioning older adults
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 62:209-16. 2005
    ..The apolipoprotein E (APOE) epsilon4 allele has been implicated as a significant risk factor in the development of late-onset Alzheimer disease, but the evidence of cognitive sequelae in healthy individuals has been mixed...
  37. ncbi request reprint Association between mild vascular cognitive impairment and impaired activities of daily living in older stroke survivors without dementia
    Sally Stephens
    University of Newcastle, UK
    J Am Geriatr Soc 53:103-7. 2005
    ..To determine the relationship between mild vascular cognitive impairment (mVCI) and functional disability in older stroke survivors without dementia...
  38. ncbi request reprint Effects of acute lorazepam administration on aminergic activity in normal elderly subjects: relationship to performance effects and apolipoprotein genotype
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Neurochem Res 29:1391-8. 2004
    ..The epsilon4 allele may modulate the effect of lorazepam on p5-HIAA, but further studies are needed to confirm this finding and elucidate its possible significance...