Jonathan R S Arch

Summary

Affiliation: Clore Laboratory
Country: UK

Publications

  1. pmc Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification
    Jonathan R S Arch
    Clore Laboratory, University of Buckingham Buckingham, UK
    Front Physiol 4:64. 2013
  2. doi request reprint The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists
    Jonathan R S Arch
    Clore Laboratory, University of Buckingham, Buckingham, MK18 1EG, UK
    Naunyn Schmiedebergs Arch Pharmacol 378:225-40. 2008
  3. ncbi request reprint Some mathematical and technical issues in the measurement and interpretation of open-circuit indirect calorimetry in small animals
    J R S Arch
    Clore Laboratory, University of Buckingham, Buckingham, UK
    Int J Obes (Lond) 30:1322-31. 2006
  4. ncbi request reprint Central regulation of energy balance: inputs, outputs and leptin resistance
    Jonathan R S Arch
    Clore Laboratory, University of Buckingham, UK
    Proc Nutr Soc 64:39-46. 2005
  5. pmc Do low-affinity states of beta-adrenoceptors have roles in physiology and medicine?
    Jonathan R S Arch
    Clore Laboratory for Life Sciences, University of Buckingham, Buckingham, Bucks MK18 1EG
    Br J Pharmacol 143:517-8. 2004
  6. ncbi request reprint Lessons in obesity from transgenic animals
    J R S Arch
    Clore Laboratory, University of Buckingham, Buckingham, UK
    J Endocrinol Invest 25:867-75. 2002
  7. ncbi request reprint beta(3)-Adrenoceptor agonists: potential, pitfalls and progress
    Jonathan R S Arch
    GlaxoSmithKline, New Fontiers Science Park North, Coldharbour Road, Harlow, Essex CM19 5AD, UK
    Eur J Pharmacol 440:99-107. 2002
  8. doi request reprint Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content
    Mohamed Bellahcene
    Clore Laboratory, University of Buckingham, Buckingham MK18 1EG, UK
    Br J Nutr 109:1755-64. 2013
  9. ncbi request reprint Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers
    Claire J Stocker
    Clore Laboratory, Univ of Buckingham, Buckingham, UK
    Am J Physiol Regul Integr Comp Physiol 292:R1810-8. 2007
  10. doi request reprint Contrasts between the effects of zinc-α2-glycoprotein, a putative β3/2-adrenoceptor agonist and the β3/2-adrenoceptor agonist BRL35135 in C57Bl/6 (ob/ob) mice
    Edward T Wargent
    Clore Laboratory, University of Buckingham, Hunter Street, Buckingham MK18 1EG, UK
    J Endocrinol 216:157-68. 2013

Collaborators

Detail Information

Publications24

  1. pmc Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification
    Jonathan R S Arch
    Clore Laboratory, University of Buckingham Buckingham, UK
    Front Physiol 4:64. 2013
    ..How and under what conditions a genetic modification or compound increases energy expenditure influences the decision on whether to seek drugs for the target or take a candidate drug into clinical studies...
  2. doi request reprint The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists
    Jonathan R S Arch
    Clore Laboratory, University of Buckingham, Buckingham, MK18 1EG, UK
    Naunyn Schmiedebergs Arch Pharmacol 378:225-40. 2008
    ....
  3. ncbi request reprint Some mathematical and technical issues in the measurement and interpretation of open-circuit indirect calorimetry in small animals
    J R S Arch
    Clore Laboratory, University of Buckingham, Buckingham, UK
    Int J Obes (Lond) 30:1322-31. 2006
    ..75 or 0.66), is similarly flawed. It is best to use analysis of covariance to determine the relationship of EE to body mass or fat-free mass within each group, and then test whether this relationship differs between groups...
  4. ncbi request reprint Central regulation of energy balance: inputs, outputs and leptin resistance
    Jonathan R S Arch
    Clore Laboratory, University of Buckingham, UK
    Proc Nutr Soc 64:39-46. 2005
    ..In the long term it may be possible to customise obesity therapies according to those inputs and outputs that are most disturbed and most amenable to intervention in individual subjects...
  5. pmc Do low-affinity states of beta-adrenoceptors have roles in physiology and medicine?
    Jonathan R S Arch
    Clore Laboratory for Life Sciences, University of Buckingham, Buckingham, Bucks MK18 1EG
    Br J Pharmacol 143:517-8. 2004
    ..This work raises the possibility that low-affinity states of beta-adrenoceptors have physiological roles, and suggests that they might be drug targets...
  6. ncbi request reprint Lessons in obesity from transgenic animals
    J R S Arch
    Clore Laboratory, University of Buckingham, Buckingham, UK
    J Endocrinol Invest 25:867-75. 2002
    ..The perspectives into obesity offered by transgenic mouse models should assist clinical researchers in the design and interpretation of their studies in human obesity...
  7. ncbi request reprint beta(3)-Adrenoceptor agonists: potential, pitfalls and progress
    Jonathan R S Arch
    GlaxoSmithKline, New Fontiers Science Park North, Coldharbour Road, Harlow, Essex CM19 5AD, UK
    Eur J Pharmacol 440:99-107. 2002
    ..This may deactivate those protein kinase C isoenzymes that inhibit insulin signalling...
  8. doi request reprint Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content
    Mohamed Bellahcene
    Clore Laboratory, University of Buckingham, Buckingham MK18 1EG, UK
    Br J Nutr 109:1755-64. 2013
    ..These results suggest that the absence of GPR41 increases body fat content in male mice. Gut-derived SCFA may raise energy expenditure and help to protect against obesity by activating GPR41...
  9. ncbi request reprint Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers
    Claire J Stocker
    Clore Laboratory, Univ of Buckingham, Buckingham, UK
    Am J Physiol Regul Integr Comp Physiol 292:R1810-8. 2007
    ..A similar trend was seen for male rats fed on the obesogenic diet. Thus leptin levels during pregnancy and lactation can affect the development of energy balance regulatory systems in their offspring...
  10. doi request reprint Contrasts between the effects of zinc-α2-glycoprotein, a putative β3/2-adrenoceptor agonist and the β3/2-adrenoceptor agonist BRL35135 in C57Bl/6 (ob/ob) mice
    Edward T Wargent
    Clore Laboratory, University of Buckingham, Hunter Street, Buckingham MK18 1EG, UK
    J Endocrinol 216:157-68. 2013
    ..ZAG does not behave as a typical β(3/2)-adrenoceptor agonist...
  11. doi request reprint Identification of a novel agonist of peroxisome proliferator-activated receptors alpha and gamma that may contribute to the anti-diabetic activity of guggulipid in Lep(ob)/Lep(ob) mice
    Claire L Cornick
    Clore Laboratory for Life Sciences, University of Buckingham, MK18 1EG Buckingham, UK
    J Nutr Biochem 20:806-15. 2009
    ..Another component may contribute to guggulipid's anti-diabetic and hypocholesterolaemic activity by stimulating LXRalpha...
  12. ncbi request reprint Orexins and the treatment of obesity
    Darren Smart
    Neurology CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Eur J Pharmacol 440:199-212. 2002
    ....
  13. pmc Improved glucose tolerance in acyl CoA:diacylglycerol acyltransferase 1-null mice is dependent on diet
    Steven J Y Wang
    Clore Laboratory, University of Buckingham, Buckingham MK18 1EG, UK
    Lipids Health Dis 6:2. 2007
    ..Studies so far have focussed on male null mice fed a high fat diet and there are few data on heterozygotes. We compared male and female Dgat1-/-, Dgat1+/- and Dgat1+/+ C57Bl/6 mice fed on either standard chow or a high fat diet...
  14. pmc Beta2-adrenoceptors and non-beta-adrenoceptors mediate effects of BRL37344 and clenbuterol on glucose uptake in soleus muscle: studies using knockout mice
    Robert A Ngala
    Clore Laboratory, University of Buckingham, Buckingham, UK
    Br J Pharmacol 158:1676-82. 2009
    ..Effects of beta-adrenoceptor antagonists on responses to the agonists have been studied further using muscles from wild-type mice...
  15. doi request reprint Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids
    Mohamed S Zaibi
    Clore Laboratory, University of Buckingham, Buckingham, UK
    FEBS Lett 584:2381-6. 2010
    ..Pertussis toxin prevented stimulation of leptin secretion by propionate in epididymal adipocytes, implicating Galpha(i) signalling mediated by GPR43 in SCFA-stimulated leptin secretion...
  16. ncbi request reprint Fetal origins of insulin resistance and obesity
    Claire J Stocker
    Clore Laboratory, University of Buckingham, Hunter Street, Buckingham MK18 1EG, UK
    Proc Nutr Soc 64:143-51. 2005
    ..Leptin administration to protein-restricted dams inhibits the suppression of 11beta-HSD-2 and may be one mechanism by which the metabolic syndrome is prevented...
  17. ncbi request reprint Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter
    Nigel J Pearce
    Department of Vascular Biology, GlaxoSmithKline, Harlow, UK
    Metabolism 53:1322-30. 2004
    ....
  18. pmc Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation
    Ed Wargent
    Clore Laboratory for Life Sciences, University of Buckingham, Buckingham, MK18 1EG, UK
    Lipids Health Dis 4:3. 2005
    ..We have conducted three experiments with CLA in obese mice over three weeks, and one over eleven weeks. We have also investigated the effects of CLA isomers in PPARgamma and PPARalpha reporter gene assays...
  19. ncbi request reprint Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice
    Andrea C Haynes
    GlaxoSmithKline, Third Avenue, Harlow, Essex, CM19 5AW, UK
    Regul Pept 104:153-9. 2002
    ..OX1 receptor mRNA was detected in BAT, and its expression was increased by 58% by treatment with SB-334867-A. This is the first demonstration that OX1 receptor antagonists have potential as both anti-obesity and anti-diabetic agents...
  20. doi request reprint Targeting thermogenesis and related pathways in anti-obesity drug discovery
    John C Clapham
    AstraZeneca R and D, Alderley Park, Macclesfield and Clore Laboratory, University of Buckingham, Buckingham, UK
    Pharmacol Ther 131:295-308. 2011
    ..We will then explore a number of approaches that potentially increase thermogenesis in humans. The challenge we have is in accumulating enough human data to validate this approach using drugs...
  21. ncbi request reprint Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 reduces food intake and weight gain but maintains energy expenditure in diet-induced obese mice
    S J Y Wang
    Clore Laboratory, University of Buckingham, Buckingham, MK18 1EG, UK
    Diabetologia 49:1333-7. 2006
    ..2733 lowers blood glucose and insulin in mutant mouse models of obesity and diabetes. Its effects on energy balance and body composition, and their contribution to improved glucose homeostasis have received little attention...
  22. ncbi request reprint Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation
    C Stocker
    Clore Laboratory, University of Buckingham, Buckingham, UK
    Int J Obes Relat Metab Disord 28:129-36. 2004
    ....
  23. ncbi request reprint Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone
    E Wargent
    Clore Laboratory, University of Buckingham, Buckingham, UK
    Diabetes Obes Metab 7:170-81. 2005
    ....
  24. ncbi request reprint Orexins and feeding: special occasions or everyday occurrence?
    Xue J Cai
    Department of Medicine, Diabetes and Endocrinology Research Group, University of Liverpool, L69 3GA, Liverpool, United Kingdom
    Regul Pept 104:1-9. 2002
    ....