T Sharma

Summary

Affiliation: Clinical Neuroscience Research Centre
Country: UK

Publications

  1. ncbi request reprint Social cognition and its neural correlates in schizophrenia and autism
    Zeinab Abdi
    Institute of Psychiatry, Kings College London, London, UK
    CNS Spectr 9:335-43. 2004
  2. ncbi request reprint Quetiapine--efficacy in different domains
    T Sharma
    Clinical Neuroscience Research Centre, Stonehouse Hospital, Cotton Lane, Dartford, Kent, DA2 6AU, UK
    Eur Neuropsychopharmacol 11:S385-90. 2001
  3. ncbi request reprint Characterisation of cognitive impairment in schizophrenia
    Tonmoy Sharma
    Clinical Neuroscience Research Centre, 7 Twisleton Court, Priory Hill, Dartford, DA1 2EN, Kent, UK
    Lancet Neurol 2:10. 2003
  4. ncbi request reprint Cognitive function in schizophrenia. Deficits, functional consequences, and future treatment
    Tonmoy Sharma
    Clinical Neuroscience Research Centre, Stonehouse Hospital, Cotton Lane, Dartford, Kent DA2 6AU, UK
    Psychiatr Clin North Am 26:25-40. 2003
  5. ncbi request reprint Cognitive effects of adjunctive 24-weeks Rivastigmine treatment to antipsychotics in schizophrenia: a randomized, placebo-controlled, double-blind investigation
    Tonmoy Sharma
    Clinical Research, Clinical Neuroscience Research Centre, Priory Hill, Dartford, Kent, UK
    Schizophr Res 85:73-83. 2006
  6. pmc Insights and treatment options for psychiatric disorders guided by functional MRI
    Tonmoy Sharma
    Clinical Neuroscience Research Center, Kent, United Kingdom
    J Clin Invest 112:10-8. 2003
  7. ncbi request reprint Effects of 10 mg and 15 mg oral procyclidine on critical flicker fusion threshold and cardiac functioning in healthy human subjects
    T Sharma
    Clinical Neuroscience Research Centre, Stonehouse Hospital, Dartford, Kent, UK
    J Psychopharmacol 16:183-7. 2002
  8. ncbi request reprint Cognitive effects of olanzapine and clozapine treatment in chronic schizophrenia
    Tonmoy Sharma
    Clinical Neuroscience Research Centre, 7 Twisleton Court, Priory Hill, Dartford, DA1 2EN, Kent, UK
    Psychopharmacology (Berl) 169:398-403. 2003
  9. ncbi request reprint Impact on cognition of the use of antipsychotics
    T Sharma
    Clinical Neuroscience Research Centre, Dartford, UK
    Curr Med Res Opin 18:s13-7. 2002
  10. ncbi request reprint Disruption of learned irrelevance in acute schizophrenia in a novel continuous within-subject paradigm suitable for fMRI
    Andrew M J Young
    School of Psychology, University of Leicester, University Road, Leicester LE1 7RH, UK
    Behav Brain Res 156:277-88. 2005

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Social cognition and its neural correlates in schizophrenia and autism
    Zeinab Abdi
    Institute of Psychiatry, Kings College London, London, UK
    CNS Spectr 9:335-43. 2004
    ..We propose that deficits of social cognition may benefit from cognitive remediation therapy and pharmacological cognitive enhancers...
  2. ncbi request reprint Quetiapine--efficacy in different domains
    T Sharma
    Clinical Neuroscience Research Centre, Stonehouse Hospital, Cotton Lane, Dartford, Kent, DA2 6AU, UK
    Eur Neuropsychopharmacol 11:S385-90. 2001
    ....
  3. ncbi request reprint Characterisation of cognitive impairment in schizophrenia
    Tonmoy Sharma
    Clinical Neuroscience Research Centre, 7 Twisleton Court, Priory Hill, Dartford, DA1 2EN, Kent, UK
    Lancet Neurol 2:10. 2003
  4. ncbi request reprint Cognitive function in schizophrenia. Deficits, functional consequences, and future treatment
    Tonmoy Sharma
    Clinical Neuroscience Research Centre, Stonehouse Hospital, Cotton Lane, Dartford, Kent DA2 6AU, UK
    Psychiatr Clin North Am 26:25-40. 2003
    ..Attempts at improving cognition in schizophrenia with specific cognitive enhancers pharmacologically and psychological therapies such as cognitive remediation might lead to better functional outcome in patients with schizophrenia...
  5. ncbi request reprint Cognitive effects of adjunctive 24-weeks Rivastigmine treatment to antipsychotics in schizophrenia: a randomized, placebo-controlled, double-blind investigation
    Tonmoy Sharma
    Clinical Research, Clinical Neuroscience Research Centre, Priory Hill, Dartford, Kent, UK
    Schizophr Res 85:73-83. 2006
    ..Future studies should investigate the effects of other procholinergic drugs, such as Galantamine, which also act on the nicotine receptors and may produce stronger cognitive effects in schizophrenia...
  6. pmc Insights and treatment options for psychiatric disorders guided by functional MRI
    Tonmoy Sharma
    Clinical Neuroscience Research Center, Kent, United Kingdom
    J Clin Invest 112:10-8. 2003
  7. ncbi request reprint Effects of 10 mg and 15 mg oral procyclidine on critical flicker fusion threshold and cardiac functioning in healthy human subjects
    T Sharma
    Clinical Neuroscience Research Centre, Stonehouse Hospital, Dartford, Kent, UK
    J Psychopharmacol 16:183-7. 2002
    ..Further investigations are required to quantify the effects of procyclidine on CFFT and cardiac function in patients with schizophrenia...
  8. ncbi request reprint Cognitive effects of olanzapine and clozapine treatment in chronic schizophrenia
    Tonmoy Sharma
    Clinical Neuroscience Research Centre, 7 Twisleton Court, Priory Hill, Dartford, DA1 2EN, Kent, UK
    Psychopharmacology (Berl) 169:398-403. 2003
    ..Typical antipsychotics, although effective in reducing positive symptoms of the illness, have not shown much effect on cognitive functions. Atypical antipsychotics have shown promise of improving some cognitive functions...
  9. ncbi request reprint Impact on cognition of the use of antipsychotics
    T Sharma
    Clinical Neuroscience Research Centre, Dartford, UK
    Curr Med Res Opin 18:s13-7. 2002
    ....
  10. ncbi request reprint Disruption of learned irrelevance in acute schizophrenia in a novel continuous within-subject paradigm suitable for fMRI
    Andrew M J Young
    School of Psychology, University of Leicester, University Road, Leicester LE1 7RH, UK
    Behav Brain Res 156:277-88. 2005
    ..These findings establish the likely value of the new paradigm for neuroimaging studies of attentional dysfunction in acute schizophrenia...
  11. ncbi request reprint Lack of association between prepulse inhibition and antisaccadic deficits in chronic schizophrenia: implications for identification of schizophrenia endophenotypes
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    J Psychiatr Res 39:227-40. 2005
    ..It is concluded that PPI and antisaccade abnormalities in schizophrenia represent separate endophenotypes, reflecting the functions of different genetic aetiologies and different or only partially overlapping neural systems...
  12. ncbi request reprint Antipsychotic drug effects on brain morphology in first-episode psychosis
    Jeffrey A Lieberman
    Departments of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Arch Gen Psychiatry 62:361-70. 2005
    ..This raises the possibility that antipsychotics might alter such pathomorphologic progression in early-stage schizophrenia...
  13. ncbi request reprint A neuropsychological investigation into violence and mental illness
    Ian Barkataki
    Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Schizophr Res 74:1-13. 2005
    ....
  14. ncbi request reprint Sex differences in prepulse inhibition deficits in chronic schizophrenia
    Veena Kumari
    Department of Psychology Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 69:219-35. 2004
    ..Future studies of schizophrenia patients need to take sex and age of subjects into account to optimise the investigation of PPI deficits, and their clinical, neural, and pharmacological correlates...
  15. ncbi request reprint Effects of rivastigmine on sustained attention in schizophrenia: an FMRI study
    Ingrid Aasen
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    J Clin Psychopharmacol 25:311-7. 2005
    ..Our results showed that rivastigmine treatment increased cerebellar activity and influenced attentional processes...
  16. ncbi request reprint Volumetric neural correlates of antisaccade eye movements in first-episode psychosis
    Ulrich Ettinger
    Department of Psychology, McGill University, Stewart Biological Sciences Building, 1205 Dr Penfield Ave, Montreal, Quebec H3A 1B1 Canada
    Am J Psychiatry 161:1918-21. 2004
    ..The authors investigated the structural brain correlates of antisaccade performance...
  17. ncbi request reprint A fMRI investigation of startle gating deficits in schizophrenia patients treated with typical or atypical antipsychotics
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Int J Neuropsychopharmacol 10:463-77. 2007
    ..Imaging data buttress the validity of PPI as a useful animal model of schizophrenia...
  18. ncbi request reprint Association between violent behaviour and impaired prepulse inhibition of the startle response in antisocial personality disorder and schizophrenia
    Veena Kumari
    Department of Psychology, PO78, Institute of Psychiatry, Kings College London, De Crespigny Park, London SE5 8AF, UK
    Behav Brain Res 158:159-66. 2005
    ..The association between violent behaviour and impaired PPI suggests that neural structures and functions underlying PPI are implicated in (inhibition of) violence...
  19. ncbi request reprint The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study
    Elena Antonova
    Department of Psychology, Institute of Psychiatry, London, UK
    Biol Psychiatry 58:457-67. 2005
    ..Region of interest studies have identified a number of structure-cognition associations in schizophrenia and revealed alterations in structure-cognition relationship in this population...
  20. pmc Does self-perceived mood predict more variance in cognitive performance than clinician-rated symptoms in schizophrenia?
    Rozmin Halari
    Department of Psychology, Centre for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, PO 46, De Crespigny Park, London SE5 8AF, UK
    Schizophr Bull 32:751-7. 2006
    ..Self-perceived negative mood state may be a better predictor of cognitive deficits than clinician-rated symptoms in chronic schizophrenia patients...
  21. ncbi request reprint Insight in first-episode psychosis
    Joseph P McEvoy
    John Umstead Hospital, Duke University Department of Psychiatry, Butner, NC 27509, USA
    Psychol Med 36:1385-93. 2006
    ....
  22. ncbi request reprint Neural dysfunction and violence in schizophrenia: an fMRI investigation
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Schizophr Res 84:144-64. 2006
    ..It is concluded that reduced functional response in the frontal and inferior parietal regions leads to serious violence in schizophrenia perhaps via impaired executive functioning...
  23. ncbi request reprint Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episode
    Diana O Perkins
    Department of Psychiatry, C B 7160, University of North Carolina School of Medicine, Chapel Hill, 27599 7160, USA
    Schizophr Res 83:53-63. 2006
    ..Factors associated with treatment adherence in patients with chronic schizophrenia include beliefs about severity of illness and need for treatment, treatment with typical versus atypical antipsychotic and medication side effects...
  24. ncbi request reprint Volumetric structural brain abnormalities in men with schizophrenia or antisocial personality disorder
    Ian Barkataki
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Behav Brain Res 169:239-47. 2006
    ....
  25. ncbi request reprint A behavioural and functional neuroimaging investigation into the effects of nicotine on sensorimotor gating in healthy subjects and persons with schizophrenia
    Peggy Postma
    Department of Psychology, P078, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Psychopharmacology (Berl) 184:589-99. 2006
    ..No previous study has examined the neural mechanisms of the effect of nicotine on PPI in humans...
  26. ncbi request reprint Cognitive impairment but preservation of sexual dimorphism in cognitive abilities in chronic schizophrenia
    Rozmin Halari
    Centre for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, PO 46, De Crespigny Park, London SE5 8AF, UK
    Psychiatry Res 141:129-39. 2006
    ..It is concluded that normal sexual dimorphism is undisturbed on both spatial and verbal tasks by the schizophrenia disease process...
  27. ncbi request reprint Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol
    Robert B Zipursky
    Schizophrenia Programme, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Br J Psychiatry 187:537-43. 2005
    ..Substantial weight gain is common with many atypical antipsychotics...
  28. ncbi request reprint Comparable fMRI activity with differential behavioural performance on mental rotation and overt verbal fluency tasks in healthy men and women
    Rozmin Halari
    Centre for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, De Crespigny Park, P O Box 46, London SE5 8AF, UK
    Exp Brain Res 169:1-14. 2006
    ..Our results demonstrate comparable brain activation in men and women in association with mental rotation and verbal fluency function with differential performance, and provide support for sex differences in brain-behaviour relationships...
  29. ncbi request reprint Neural correlates of adjunctive rivastigmine treatment to antipsychotics in schizophrenia: a randomized, placebo-controlled, double-blind fMRI study
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Neuroimage 29:545-56. 2006
    ....
  30. ncbi request reprint Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosis
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA
    Biol Psychiatry 59:97-105. 2006
    ..Neurocognitive deficits are severe in first-episode psychosis...
  31. ncbi request reprint Saccadic eye movements, schizotypy, and the role of neuroticism
    Ulrich Ettinger
    Department of Psychology, McGill University, Stewart Biological Sciences Building, 1205 Dr Penfield Ave, Montreal, Que, Canada H3A 1B1
    Biol Psychol 68:61-78. 2005
    ..We conclude that saccadic performance patterns in schizotypy are not due to negative emotionality or general psychopathology, but specific to schizophrenia spectrum signs and symptoms...
  32. ncbi request reprint Neurological soft signs and their relationship to cognitive and clinical efficacy of atypical antipsychotics in schizophrenia
    Mrigendra Das
    Institute of Psychiatry, London, UK
    Schizophr Bull 30:241-53. 2004
    ..The presence of high NSS in schizophrenia patients impedes the improvement in cognitive function with atypical antipsychotics treatment...
  33. ncbi request reprint Effects of typical and atypical antipsychotics on prepulse inhibition in schizophrenia: a critical evaluation of current evidence and directions for future research
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Psychopharmacology (Berl) 162:97-101. 2002
    ....
  34. ncbi request reprint Effects of acute procyclidine administration on prepulse inhibition of the startle response in schizophrenia: a double-blind, placebo-controlled study
    Veena Kumari
    Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, UK
    J Psychopharmacol 17:89-95. 2003
    ..The use of anticholinergics needs to be carefully controlled/examined in investigations of information processing deficits using a PPI model and reduced to the minimum level in clinical care of schizophrenia...
  35. ncbi request reprint N100 and P300 amplitude to Go and No-Go variants of the auditory oddball in siblings discordant for schizophrenia
    Alex Sumich
    King s College London, Institute of Psychiatry, BIAU, Centre for Neuroimaging Sciences, London SE5 8AF, UK
    Schizophr Res 98:265-77. 2008
    ..P300 amplitude reduction is reliably seen in schizophrenia. Inconsistent reports of isolated frontal and/or parietal deficits in unaffected family members may be clarified using a task that places greater load on frontal function...
  36. ncbi request reprint Longitudinal study of symptoms and cognitive function in chronic schizophrenia
    Catherine Hughes
    Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 59:137-46. 2003
    ..The results do not suggest a causal relationship between the course of symptoms and neuropsychological functioning in chronic schizophrenia...
  37. doi request reprint Neuropsychological function-brain structure relationships and stage of illness: an investigation into chronic and first-episode schizophrenia
    Preethi Premkumar
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Psychiatry Res 162:195-204. 2008
    ..A similar dissociation between young and older subjects of both healthy and patient groups suggests that a 'bigger-is-better' relationship style is present in older individuals regardless of a diagnosis of schizophrenia...
  38. doi request reprint Neural correlates of deficient response inhibition in mentally disordered violent individuals
    Ian Barkataki
    Department of Psychology, School of HumanSciences, University of Surrey, Guildford GU2 7HX, UK
    Behav Sci Law 26:51-64. 2008
    ..In addition, caudate dysfunction may contribute, given its role in timing and temporal processing as well as suppression of motor actions, to deficient inhibition and violent behaviour in schizophrenia...
  39. ncbi request reprint Atypical antipsychotics and cognition in schizophrenia
    Tonmoy Sharma
    Arch Gen Psychiatry 59:571-2; author reply 573-5. 2002
  40. ncbi request reprint Prepulse inhibition of the startle response in risperidone-treated patients: comparison with typical antipsychotics
    Veena Kumari
    Section of Cognitive Psychopharmacology, Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 55:139-46. 2002
    ....
  41. ncbi request reprint Effects of oral procyclidine administration on cognitive functions in healthy subjects: implications for schizophrenia
    Elizabeth Zachariah
    J Clin Psychopharmacol 22:224-6. 2002
  42. ncbi request reprint Cognitive effects of nicotine in humans: an fMRI study
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, King s College, London, UK
    Neuroimage 19:1002-13. 2003
    ....
  43. ncbi request reprint Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine versus haloperidol
    Jeffrey A Lieberman
    Department of Psychiatry, University of North Carolina School of Medicine, NC 27599 7160, USA
    Am J Psychiatry 160:1396-404. 2003
    ..This study compared the acute and long-term effectiveness of haloperidol with that of olanzapine in patients with first-episode psychosis in a large, controlled clinical trial...
  44. ncbi request reprint Identifying vulnerability markers in prodromal patients: a step in the right direction for schizophrenia prevention
    Lucy Knowles
    Collaborative Therapy Unit, The Mental Health Research Institute, Parkville, Australia
    CNS Spectr 9:595-602. 2004
    ..It is hoped that identification of such markers may improve the predictive potency of prodromal criteria, and perhaps pave the way for future screening and primary prevention strategies...
  45. ncbi request reprint Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders
    Diana Perkins
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, 27599 7160
    Br J Psychiatry 185:18-24. 2004
    ..Duration of untreated psychosis (DUP) may contribute to the observed heterogeneity of the treatment response in first-episode schizophrenia...
  46. ncbi request reprint Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: a randomized, double-blind trial of olanzapine versus low doses of haloperidol
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Am J Psychiatry 161:985-95. 2004
    ..This study compares the neurocognitive effects of olanzapine and low doses of haloperidol in patients with first-episode psychosis...
  47. ncbi request reprint Neuropsychologic functioning and structural MRI of the brain in patients with schizophrenia
    Preethi Premkumar
    Royal College of Psychiatrists, College Research Unit, London, UK
    Expert Rev Neurother 5:85-94. 2005
    ..Understanding the roles of the neurodevelopmental and neurodegenerative models of schizophrenia is important in deciding intervention strategies...
  48. ncbi request reprint Effects of procyclidine on eye movements in schizophrenia
    Ulrich Ettinger
    Division of Psychological Medicine, Institute of Psychiatry, UK
    Neuropsychopharmacology 28:2199-208. 2003
    ..Effects of order of administration and practice on the antisaccade task suggest that these factors need to be taken into consideration in future pharmacological studies...
  49. ncbi request reprint De-coupling of cognitive performance and cerebral functional response during working memory in schizophrenia
    Garry D Honey
    Section of Cognitive Psychopharmacology, Institute of Psychiatry, London SE5 8AF, UK
    Schizophr Res 53:45-56. 2002
    ..This deficit, apparent within the performance capacity of the patients, may represent a fundamental abnormality in schizophrenia, and may compromise performance at higher cognitive loads...
  50. ncbi request reprint Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI)
    Geoffrey C Dunbar
    Clinical Development and Regulatory Affairs, Targacept Inc, Winston Salem, NC 27101, USA
    J Psychopharmacol 21:171-8. 2007
    ..Ispronicline also had a beneficial effect on cognition in subjects with AAMI. This was seen most strongly in a Cmax range that had been predicted from pre-clinical animal studies...
  51. ncbi request reprint Neuroticism and brain responses to anticipatory fear
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, King s College London, De Crespigny Park, London, United Kingdom
    Behav Neurosci 121:643-52. 2007
    ..The observations support recent psychophysiological research that has demonstrated reduced processing of pain in subjects with higher levels of neuroticism, especially the anxiety component of this trait...
  52. pmc A large scale (N=400) investigation of gray matter differences in schizophrenia using optimized voxel-based morphometry
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, CT 06106, USA
    Schizophr Res 101:95-105. 2008
    ..However, results from these studies vary widely, likely due to different methodological or statistical approaches...
  53. pmc Regional cortical thinning in subjects with violent antisocial personality disorder or schizophrenia
    Veena M Narayan
    Laboratory of Neuro Imaging, Ahmanson Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Am J Psychiatry 164:1418-27. 2007
    ....
  54. ncbi request reprint Frontal lobe volumes in schizophrenia: effects of stage and duration of illness
    Preethi Premkumar
    King s College London, Institute of Psychiatry, Department of Psychology, PO78, De Crespigny Park, London SE5 8AF, UK
    J Psychiatr Res 40:627-37. 2006
    ..The enlargement of the premotor cortex and putamen are likely to be a result of antipsychotic medication...
  55. ncbi request reprint Increases in regional subarachnoid CSF without apparent cortical gray matter deficits in schizophrenia: modulating effects of sex and age
    Katherine L Narr
    Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Am J Psychiatry 160:2169-80. 2003
    ....
  56. ncbi request reprint Neuroimaging in schizophrenia: from theory to practice
    Jessica Sheringham
    Zeus Research Ltd, London
    Hosp Med 63:328-31. 2002
    ..Neuroimaging has long contributed to our understanding of schizophrenia but recent developments suggest it may ultimately play a practical role in its early detection and management...
  57. ncbi request reprint Procedural learning in schizophrenia: a functional magnetic resonance imaging investigation
    Veena Kumari
    Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
    Schizophr Res 57:97-107. 2002
    ....
  58. ncbi request reprint Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives
    Katja Schulze
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 53:562-70. 2003
    ..The aim of our study was to assess the contribution of familial liability and obstetric complications to hippocampal volume reduction in schizophrenia...
  59. ncbi request reprint Neural correlates of tactile prepulse inhibition: a functional MRI study in normal and schizophrenic subjects
    Veena Kumari
    Section of Cognitive Psychopharmacology, Institute of Psychiatry, King s College, De Crespigny Park, London SE5 8AF, UK
    Psychiatry Res 122:99-113. 2003
    ..The findings demonstrate involvement of the striatum, hippocampus, thalamus, and frontal and parietal cortical regions in PPI. Dysfunctions in any of these regions may underlie observations of reduced PPI in schizophrenia...
  60. ncbi request reprint Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophrenia
    Dominic Fannon
    Section of General Psychiatry, Institute of Psychiatry, London, UK
    Biol Psychiatry 54:587-98. 2003
    ..There is mounting evidence that antipsychotic medication influences N-acetylaspartate...
  61. ncbi request reprint Neural abnormalities during cognitive generation of affect in treatment-resistant depression
    Veena Kumari
    Section of Cognitive Psychopharmacology, Institute of Psychiatry, King s College, London, UK
    Biol Psychiatry 54:777-91. 2003
    ..Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness...
  62. ncbi request reprint The relationship between brain structure and neurocognition in schizophrenia: a selective review
    Elena Antonova
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Schizophr Res 70:117-45. 2004
    ..Finally, the methodological limitations of the reviewed studies are discussed and suggestions for future research are offered...
  63. ncbi request reprint A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 56:454-61. 2004
    ..We examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities...
  64. ncbi request reprint Temporal lobe abnormalities in first-episode psychosis
    Alex Sumich
    Clinical Neuroscience Research Centre, Stonehouse Hospital, Cotton Lane, Dartford, Kent DA2 6AU, UK
    Am J Psychiatry 159:1232-5. 2002
    ..Confounds include disease chronicity, gender, and handedness. The present study investigated temporal substructures in right-handed male patients experiencing their first episode of psychotic illness...