Research Topics
| T SharmaSummaryAffiliation: Clinical Neuroscience Research Centre Country: UK Publications
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Detail Information
Publications
Social cognition and its neural correlates in schizophrenia and autismZeinab Abdi
Institute of Psychiatry, Kings College London, London, UK
CNS Spectr 9:335-43. 2004..We propose that deficits of social cognition may benefit from cognitive remediation therapy and pharmacological cognitive enhancers...- Quetiapine--efficacy in different domainsT Sharma
Clinical Neuroscience Research Centre, Stonehouse Hospital, Cotton Lane, Dartford, Kent, DA2 6AU, UK
Eur Neuropsychopharmacol 11:S385-90. 2001.... - Characterisation of cognitive impairment in schizophreniaTonmoy Sharma
Clinical Neuroscience Research Centre, 7 Twisleton Court, Priory Hill, Dartford, DA1 2EN, Kent, UK
Lancet Neurol 2:10. 2003 - Cognitive function in schizophrenia. Deficits, functional consequences, and future treatmentTonmoy Sharma
Clinical Neuroscience Research Centre, Stonehouse Hospital, Cotton Lane, Dartford, Kent DA2 6AU, UK
Psychiatr Clin North Am 26:25-40. 2003..Attempts at improving cognition in schizophrenia with specific cognitive enhancers pharmacologically and psychological therapies such as cognitive remediation might lead to better functional outcome in patients with schizophrenia... - Cognitive effects of adjunctive 24-weeks Rivastigmine treatment to antipsychotics in schizophrenia: a randomized, placebo-controlled, double-blind investigationTonmoy Sharma
Clinical Research, Clinical Neuroscience Research Centre, Priory Hill, Dartford, Kent, UK
Schizophr Res 85:73-83. 2006..Future studies should investigate the effects of other procholinergic drugs, such as Galantamine, which also act on the nicotine receptors and may produce stronger cognitive effects in schizophrenia... 
Insights and treatment options for psychiatric disorders guided by functional MRITonmoy Sharma
Clinical Neuroscience Research Center, Kent, United Kingdom
J Clin Invest 112:10-8. 2003- Effects of 10 mg and 15 mg oral procyclidine on critical flicker fusion threshold and cardiac functioning in healthy human subjectsT Sharma
Clinical Neuroscience Research Centre, Stonehouse Hospital, Dartford, Kent, UK
J Psychopharmacol 16:183-7. 2002..Further investigations are required to quantify the effects of procyclidine on CFFT and cardiac function in patients with schizophrenia... - Cognitive effects of olanzapine and clozapine treatment in chronic schizophreniaTonmoy Sharma
Clinical Neuroscience Research Centre, 7 Twisleton Court, Priory Hill, Dartford, DA1 2EN, Kent, UK
Psychopharmacology (Berl) 169:398-403. 2003..Typical antipsychotics, although effective in reducing positive symptoms of the illness, have not shown much effect on cognitive functions. Atypical antipsychotics have shown promise of improving some cognitive functions... - Impact on cognition of the use of antipsychoticsT Sharma
Clinical Neuroscience Research Centre, Dartford, UK
Curr Med Res Opin 18:s13-7. 2002.... - Disruption of learned irrelevance in acute schizophrenia in a novel continuous within-subject paradigm suitable for fMRIAndrew M J Young
School of Psychology, University of Leicester, University Road, Leicester LE1 7RH, UK
Behav Brain Res 156:277-88. 2005..These findings establish the likely value of the new paradigm for neuroimaging studies of attentional dysfunction in acute schizophrenia... - Lack of association between prepulse inhibition and antisaccadic deficits in chronic schizophrenia: implications for identification of schizophrenia endophenotypesVeena Kumari
Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
J Psychiatr Res 39:227-40. 2005..It is concluded that PPI and antisaccade abnormalities in schizophrenia represent separate endophenotypes, reflecting the functions of different genetic aetiologies and different or only partially overlapping neural systems... - Antipsychotic drug effects on brain morphology in first-episode psychosisJeffrey A Lieberman
Departments of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Arch Gen Psychiatry 62:361-70. 2005..This raises the possibility that antipsychotics might alter such pathomorphologic progression in early-stage schizophrenia... - A neuropsychological investigation into violence and mental illnessIan Barkataki
Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
Schizophr Res 74:1-13. 2005.... - Sex differences in prepulse inhibition deficits in chronic schizophreniaVeena Kumari
Department of Psychology Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Schizophr Res 69:219-35. 2004..Future studies of schizophrenia patients need to take sex and age of subjects into account to optimise the investigation of PPI deficits, and their clinical, neural, and pharmacological correlates... - Effects of rivastigmine on sustained attention in schizophrenia: an FMRI studyIngrid Aasen
Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
J Clin Psychopharmacol 25:311-7. 2005..Our results showed that rivastigmine treatment increased cerebellar activity and influenced attentional processes... - Volumetric neural correlates of antisaccade eye movements in first-episode psychosisUlrich Ettinger
Department of Psychology, McGill University, Stewart Biological Sciences Building, 1205 Dr Penfield Ave, Montreal, Quebec H3A 1B1 Canada
Am J Psychiatry 161:1918-21. 2004..The authors investigated the structural brain correlates of antisaccade performance... - A fMRI investigation of startle gating deficits in schizophrenia patients treated with typical or atypical antipsychoticsVeena Kumari
Department of Psychology, Institute of Psychiatry, King s College London, London, UK
Int J Neuropsychopharmacol 10:463-77. 2007..Imaging data buttress the validity of PPI as a useful animal model of schizophrenia... - Association between violent behaviour and impaired prepulse inhibition of the startle response in antisocial personality disorder and schizophreniaVeena Kumari
Department of Psychology, PO78, Institute of Psychiatry, Kings College London, De Crespigny Park, London SE5 8AF, UK
Behav Brain Res 158:159-66. 2005..The association between violent behaviour and impaired PPI suggests that neural structures and functions underlying PPI are implicated in (inhibition of) violence... - The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry studyElena Antonova
Department of Psychology, Institute of Psychiatry, London, UK
Biol Psychiatry 58:457-67. 2005..Region of interest studies have identified a number of structure-cognition associations in schizophrenia and revealed alterations in structure-cognition relationship in this population... - Does self-perceived mood predict more variance in cognitive performance than clinician-rated symptoms in schizophrenia?Rozmin Halari
Department of Psychology, Centre for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, PO 46, De Crespigny Park, London SE5 8AF, UK
Schizophr Bull 32:751-7. 2006..Self-perceived negative mood state may be a better predictor of cognitive deficits than clinician-rated symptoms in chronic schizophrenia patients... - Insight in first-episode psychosisJoseph P McEvoy
John Umstead Hospital, Duke University Department of Psychiatry, Butner, NC 27509, USA
Psychol Med 36:1385-93. 2006.... - Neural dysfunction and violence in schizophrenia: an fMRI investigationVeena Kumari
Department of Psychology, Institute of Psychiatry, King s College London, London, UK
Schizophr Res 84:144-64. 2006..It is concluded that reduced functional response in the frontal and inferior parietal regions leads to serious violence in schizophrenia perhaps via impaired executive functioning... - Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episodeDiana O Perkins
Department of Psychiatry, C.B.# 7160, University of North Carolina School of Medicine, Chapel Hill, 27599-7160, USA
Schizophr Res 83:53-63. 2006.... - Volumetric structural brain abnormalities in men with schizophrenia or antisocial personality disorderIan Barkataki
Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
Behav Brain Res 169:239-47. 2006.... - A behavioural and functional neuroimaging investigation into the effects of nicotine on sensorimotor gating in healthy subjects and persons with schizophreniaPeggy Postma
Department of Psychology, P078, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
Psychopharmacology (Berl) 184:589-99. 2006..CONCLUSIONS: Nicotine enhances tactile PPI in both healthy and schizophrenia groups. Our preliminary fMRI findings reveal that this effect is modulated by increased limbic activity... - Cognitive impairment but preservation of sexual dimorphism in cognitive abilities in chronic schizophreniaRozmin Halari
Centre for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, PO 46, De Crespigny Park, London SE5 8AF, UK
Psychiatry Res 141:129-39. 2006..It is concluded that normal sexual dimorphism is undisturbed on both spatial and verbal tasks by the schizophrenia disease process... - Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidolRobert B Zipursky
Schizophrenia Programme, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Br J Psychiatry 187:537-43. 2005..Substantial weight gain is common with many atypical antipsychotics... - Comparable fMRI activity with differential behavioural performance on mental rotation and overt verbal fluency tasks in healthy men and womenRozmin Halari
Centre for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, De Crespigny Park, P O Box 46, London SE5 8AF, UK
Exp Brain Res 169:1-14. 2006..Our results demonstrate comparable brain activation in men and women in association with mental rotation and verbal fluency function with differential performance, and provide support for sex differences in brain-behaviour relationships... - Neural correlates of adjunctive rivastigmine treatment to antipsychotics in schizophrenia: a randomized, placebo-controlled, double-blind fMRI studyVeena Kumari
Department of Psychology, Institute of Psychiatry, King s College London, London, UK
Neuroimage 29:545-56. 2006.... - Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosisRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA
Biol Psychiatry 59:97-105. 2006..Neurocognitive deficits are severe in first-episode psychosis... - Saccadic eye movements, schizotypy, and the role of neuroticismUlrich Ettinger
Department of Psychology, McGill University, Stewart Biological Sciences Building, 1205 Dr Penfield Ave, Montreal, Que, Canada H3A 1B1
Biol Psychol 68:61-78. 2005..We conclude that saccadic performance patterns in schizotypy are not due to negative emotionality or general psychopathology, but specific to schizophrenia spectrum signs and symptoms... - Neurological soft signs and their relationship to cognitive and clinical efficacy of atypical antipsychotics in schizophreniaMrigendra Das
Institute of Psychiatry, London, UK
Schizophr Bull 30:241-53. 2004..The presence of high NSS in schizophrenia patients impedes the improvement in cognitive function with atypical antipsychotics treatment... - Effects of typical and atypical antipsychotics on prepulse inhibition in schizophrenia: a critical evaluation of current evidence and directions for future researchVeena Kumari
Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Psychopharmacology (Berl) 162:97-101. 2002.... - Effects of acute procyclidine administration on prepulse inhibition of the startle response in schizophrenia: a double-blind, placebo-controlled studyVeena Kumari
Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, UK
J Psychopharmacol 17:89-95. 2003..The use of anticholinergics needs to be carefully controlled/examined in investigations of information processing deficits using a PPI model and reduced to the minimum level in clinical care of schizophrenia... - N100 and P300 amplitude to Go and No-Go variants of the auditory oddball in siblings discordant for schizophreniaAlex Sumich
King s College London, Institute of Psychiatry, BIAU, Centre for Neuroimaging Sciences, London SE5 8AF, UK
Schizophr Res 98:265-77. 2008..P300 amplitude reduction is reliably seen in schizophrenia. Inconsistent reports of isolated frontal and/or parietal deficits in unaffected family members may be clarified using a task that places greater load on frontal function... - Longitudinal study of symptoms and cognitive function in chronic schizophreniaCatherine Hughes
Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Schizophr Res 59:137-46. 2003..The results do not suggest a causal relationship between the course of symptoms and neuropsychological functioning in chronic schizophrenia... 
Neuropsychological function-brain structure relationships and stage of illness: an investigation into chronic and first-episode schizophreniaPreethi Premkumar
Department of Psychology, Institute of Psychiatry, King s College London, London, UK
Psychiatry Res 162:195-204. 2008..A similar dissociation between young and older subjects of both healthy and patient groups suggests that a 'bigger-is-better' relationship style is present in older individuals regardless of a diagnosis of schizophrenia...- Neural correlates of deficient response inhibition in mentally disordered violent individualsIan Barkataki
Department of Psychology, School of HumanSciences, University of Surrey, Guildford GU2 7HX, UK
Behav Sci Law 26:51-64. 2008..In addition, caudate dysfunction may contribute, given its role in timing and temporal processing as well as suppression of motor actions, to deficient inhibition and violent behaviour in schizophrenia... - Atypical antipsychotics and cognition in schizophreniaTonmoy Sharma
Arch Gen Psychiatry 59:571-2; author reply 573-5. 2002 - Prepulse inhibition of the startle response in risperidone-treated patients: comparison with typical antipsychoticsVeena Kumari
Section of Cognitive Psychopharmacology, Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Schizophr Res 55:139-46. 2002.... - Effects of oral procyclidine administration on cognitive functions in healthy subjects: implications for schizophreniaElizabeth Zachariah
J Clin Psychopharmacol 22:224-6. 2002 - Cognitive effects of nicotine in humans: an fMRI studyVeena Kumari
Department of Psychology, Institute of Psychiatry, King s College, London, UK
Neuroimage 19:1002-13. 2003.... - Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine versus haloperidolJeffrey A Lieberman
Department of Psychiatry, University of North Carolina School of Medicine, NC 27599 7160, USA
Am J Psychiatry 160:1396-404. 2003..This study compared the acute and long-term effectiveness of haloperidol with that of olanzapine in patients with first-episode psychosis in a large, controlled clinical trial... - Identifying vulnerability markers in prodromal patients: a step in the right direction for schizophrenia preventionLucy Knowles
Collaborative Therapy Unit, The Mental Health Research Institute, Parkville, Australia
CNS Spectr 9:595-602. 2004..It is hoped that identification of such markers may improve the predictive potency of prodromal criteria, and perhaps pave the way for future screening and primary prevention strategies... - Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disordersDiana Perkins
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, 27599 7160
Br J Psychiatry 185:18-24. 2004..Duration of untreated psychosis (DUP) may contribute to the observed heterogeneity of the treatment response in first-episode schizophrenia... - Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: a randomized, double-blind trial of olanzapine versus low doses of haloperidolRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
Am J Psychiatry 161:985-95. 2004..This study compares the neurocognitive effects of olanzapine and low doses of haloperidol in patients with first-episode psychosis... - Neuropsychologic functioning and structural MRI of the brain in patients with schizophreniaPreethi Premkumar
Royal College of Psychiatrists, College Research Unit, London, UK
Expert Rev Neurother 5:85-94. 2005..Understanding the roles of the neurodevelopmental and neurodegenerative models of schizophrenia is important in deciding intervention strategies... - Effects of procyclidine on eye movements in schizophreniaUlrich Ettinger
Division of Psychological Medicine, Institute of Psychiatry, UK
Neuropsychopharmacology 28:2199-208. 2003..Effects of order of administration and practice on the antisaccade task suggest that these factors need to be taken into consideration in future pharmacological studies... - De-coupling of cognitive performance and cerebral functional response during working memory in schizophreniaGarry D Honey
Section of Cognitive Psychopharmacology, Institute of Psychiatry, London SE5 8AF, UK
Schizophr Res 53:45-56. 2002..This deficit, apparent within the performance capacity of the patients, may represent a fundamental abnormality in schizophrenia, and may compromise performance at higher cognitive loads... - Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI)Geoffrey C Dunbar
Clinical Development and Regulatory Affairs, Targacept Inc, Winston Salem, NC 27101, USA
J Psychopharmacol 21:171-8. 2007..Ispronicline also had a beneficial effect on cognition in subjects with AAMI. This was seen most strongly in a Cmax range that had been predicted from pre-clinical animal studies... - Neuroticism and brain responses to anticipatory fearVeena Kumari
Department of Psychology, Institute of Psychiatry, King s College London, De Crespigny Park, London, United Kingdom
Behav Neurosci 121:643-52. 2007..The observations support recent psychophysiological research that has demonstrated reduced processing of pain in subjects with higher levels of neuroticism, especially the anxiety component of this trait... - A large scale (N=400) investigation of gray matter differences in schizophrenia using optimized voxel-based morphometryShashwath A Meda
Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, CT 06106, USA
Schizophr Res 101:95-105. 2008..However, results from these studies vary widely, likely due to different methodological or statistical approaches... - Regional cortical thinning in subjects with violent antisocial personality disorder or schizophreniaVeena M Narayan
Laboratory of Neuro Imaging, Ahmanson Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Am J Psychiatry 164:1418-27. 2007.... - Frontal lobe volumes in schizophrenia: effects of stage and duration of illnessPreethi Premkumar
King s College London, Institute of Psychiatry, Department of Psychology, PO78, De Crespigny Park, London SE5 8AF, UK
J Psychiatr Res 40:627-37. 2006..The enlargement of the premotor cortex and putamen are likely to be a result of antipsychotic medication... - Increases in regional subarachnoid CSF without apparent cortical gray matter deficits in schizophrenia: modulating effects of sex and ageKatherine L Narr
Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA
Am J Psychiatry 160:2169-80. 2003..Cortical gray matter reductions show aging effects but are below the threshold of significance in schizophrenia... - Neuroimaging in schizophrenia: from theory to practiceJessica Sheringham
Zeus Research Ltd, London
Hosp Med 63:328-31. 2002..Neuroimaging has long contributed to our understanding of schizophrenia but recent developments suggest it may ultimately play a practical role in its early detection and management... - Procedural learning in schizophrenia: a functional magnetic resonance imaging investigationVeena Kumari
Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
Schizophr Res 57:97-107. 2002.... - Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relativesKatja Schulze
Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 53:562-70. 2003..CONCLUSIONS: We failed to find evidence that hippocampal volume loss is associated with familial liability to schizophrenia but have confirmed the association between hippocampal volume reduction and exposure to obstetric complications... - Neural correlates of tactile prepulse inhibition: a functional MRI study in normal and schizophrenic subjectsVeena Kumari
Section of Cognitive Psychopharmacology, Institute of Psychiatry, King s College, De Crespigny Park, London SE5 8AF, UK
Psychiatry Res 122:99-113. 2003..The findings demonstrate involvement of the striatum, hippocampus, thalamus, and frontal and parietal cortical regions in PPI. Dysfunctions in any of these regions may underlie observations of reduced PPI in schizophrenia... - Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophreniaDominic Fannon
Section of General Psychiatry, Institute of Psychiatry, London, UK
Biol Psychiatry 54:587-98. 2003..Further investigation of the influence of medication at this stage of illness is warranted... - Neural abnormalities during cognitive generation of affect in treatment-resistant depressionVeena Kumari
Section of Cognitive Psychopharmacology, Institute of Psychiatry, King's College, London, UK
Biol Psychiatry 54:777-91. 2003..The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and nonresponsiveness to treatment in depression... - The relationship between brain structure and neurocognition in schizophrenia: a selective reviewElena Antonova
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Schizophr Res 70:117-45. 2004..Finally, the methodological limitations of the reviewed studies are discussed and suggestions for future research are offered... - A controlled study of brain structure in monozygotic twins concordant and discordant for schizophreniaNeeltje E M van Haren
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
Biol Psychiatry 56:454-61. 2004..We examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities... - Temporal lobe abnormalities in first-episode psychosisAlex Sumich
Clinical Neuroscience Research Centre, Stonehouse Hospital, Cotton Lane, Dartford, Kent DA2 6AU, UK
Am J Psychiatry 159:1232-5. 2002..Paranoid and nonparanoid patients differed in left amygdala volume. CONCLUSIONS: The authors conclude that bilateral hippocampal and left planum temporale abnormalities are present near the onset of psychosis...