Christopher S Potten

Summary

Affiliation: Christie Hospital NHS Trust
Country: UK

Publications

  1. ncbi request reprint The small intestine as a model for evaluating adult tissue stem cell drug targets
    Christopher S Potten
    EpiStem Limited, Manchester, UK
    Cell Prolif 36:115-29. 2003
  2. ncbi request reprint Radiation, the ideal cytotoxic agent for studying the cell biology of tissues such as the small intestine
    Christopher S Potten
    EpiStem Ltd, Manchester M13 9XX, United Kingdom
    Radiat Res 161:123-36. 2004
  3. doi request reprint The stem cells of small intestinal crypts: where are they?
    C S Potten
    EpiStem Ltd, Manchester, UK
    Cell Prolif 42:731-50. 2009
  4. ncbi request reprint Keratinocyte stem cells: a commentary
    Christopher S Potten
    Epithelial Biology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, U K
    J Invest Dermatol 119:888-99. 2002
  5. ncbi request reprint Keratinocyte stem cells, label-retaining cells and possible genome protection mechanisms
    Christopher S Potten
    EpiStem Ltd, Incubator Building, Manchester, UK
    J Investig Dermatol Symp Proc 9:183-95. 2004
  6. ncbi request reprint Identification of a putative intestinal stem cell and early lineage marker; musashi-1
    Christopher S Potten
    Epithelial Biology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Differentiation 71:28-41. 2003
  7. ncbi request reprint A putative human breast stem cell population is enriched for steroid receptor-positive cells
    Robert B Clarke
    Breast Biology Group, Cancer Research UK Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK
    Dev Biol 277:443-56. 2005
  8. ncbi request reprint Intestinal stem cells protect their genome by selective segregation of template DNA strands
    Christopher S Potten
    Epithelial Biology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M9 4BX, UK
    J Cell Sci 115:2381-8. 2002
  9. ncbi request reprint The intestinal epithelial stem cell
    Emma Marshman
    School of Biological Sciences, University of Manchester, Manchester, UK
    Bioessays 24:91-8. 2002
  10. ncbi request reprint Regulation of human breast epithelial stem cells
    Robert B Clarke
    Breast Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester, UK
    Cell Prolif 36:45-58. 2003

Collaborators

Detail Information

Publications17

  1. ncbi request reprint The small intestine as a model for evaluating adult tissue stem cell drug targets
    Christopher S Potten
    EpiStem Limited, Manchester, UK
    Cell Prolif 36:115-29. 2003
    ..Some of the regulatory networks governing stem and transit cell behaviour are beginning to be understood and it is postulated that p53 plays a crucial role in these processes...
  2. ncbi request reprint Radiation, the ideal cytotoxic agent for studying the cell biology of tissues such as the small intestine
    Christopher S Potten
    EpiStem Ltd, Manchester M13 9XX, United Kingdom
    Radiat Res 161:123-36. 2004
    ..Such studies have allowed the cell lineages and genome protection mechanisms operating the small intestinal crypts to be defined...
  3. doi request reprint The stem cells of small intestinal crypts: where are they?
    C S Potten
    EpiStem Ltd, Manchester, UK
    Cell Prolif 42:731-50. 2009
    ..There could be a distinct and as yet undiscovered relationship between these observed traits, with stem cell properties both in cells of the crypt base and those at cell position 4...
  4. ncbi request reprint Keratinocyte stem cells: a commentary
    Christopher S Potten
    Epithelial Biology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, U K
    J Invest Dermatol 119:888-99. 2002
    ..This commentary assesses the data generated to date and critically discusses the conclusions that have been drawn. Our current level of understanding, or lack of understanding, of the keratinocyte stem cell is reviewed...
  5. ncbi request reprint Keratinocyte stem cells, label-retaining cells and possible genome protection mechanisms
    Christopher S Potten
    EpiStem Ltd, Incubator Building, Manchester, UK
    J Investig Dermatol Symp Proc 9:183-95. 2004
    ..Experiments in the small intestine indicate that the stem cells here are selectively sorting their DNA and becoming LRCs. A possible role for p53 in stem cell biology is presented...
  6. ncbi request reprint Identification of a putative intestinal stem cell and early lineage marker; musashi-1
    Christopher S Potten
    Epithelial Biology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Differentiation 71:28-41. 2003
    ..These observations suggest that Musashi-1 is a marker of stem and early lineage progenitor cells in murine intestinal tissue...
  7. ncbi request reprint A putative human breast stem cell population is enriched for steroid receptor-positive cells
    Robert B Clarke
    Breast Biology Group, Cancer Research UK Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK
    Dev Biol 277:443-56. 2005
    ..The data suggest a model where scattered steroid receptor-positive cells are stem cells that self-renew through asymmetric cell division and generate patches of transit amplifying and differentiated cells...
  8. ncbi request reprint Intestinal stem cells protect their genome by selective segregation of template DNA strands
    Christopher S Potten
    Epithelial Biology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M9 4BX, UK
    J Cell Sci 115:2381-8. 2002
    ..The presence of these protective mechanisms ensures that the small intestine rarely develops cancer and that stem cells can sustain the extensive cell proliferation needed during life...
  9. ncbi request reprint The intestinal epithelial stem cell
    Emma Marshman
    School of Biological Sciences, University of Manchester, Manchester, UK
    Bioessays 24:91-8. 2002
    ....
  10. ncbi request reprint Regulation of human breast epithelial stem cells
    Robert B Clarke
    Breast Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester, UK
    Cell Prolif 36:45-58. 2003
    ..ERalpha/PR+ breast cancers exhibit loss of the two key regulators of asymmetric cell division, Musashi-1 and Notch-1 and thus may arise from symmetric division of the ERalpha/PR+ stem cell...
  11. pmc Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo
    Satoshi Ishizuka
    School of Clinical Medical Sciences Gerontology, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
    Nucleic Acids Res 31:6198-205. 2003
    ..Our results thus establish that PARP-1 acts as a survival factor for intestinal stem cells in vivo and suggest a functional link with early p53 and p21(CIP1/WAF1) responses...
  12. ncbi request reprint HIV enteropathy: crypt stem and transit cell hyperproliferation induces villous atrophy in HIV/Microsporidia-infected jejunal mucosa
    Philip A Batman
    Department of Histopathology, Bradford Teaching Hospitals Foundation Trust, Bradford, UK
    AIDS 21:433-9. 2007
    ..The study aim was to analyse the kinetics of stem and transit cells in the crypts of jejunal mucosa infected with HIV and Microsporidia...
  13. ncbi request reprint Crowd control in the crypt
    Catherine Booth
    Nat Med 8:1360-1. 2002
  14. ncbi request reprint Repeated ultraviolet exposure affords the same protection against DNA photodamage and erythema in human skin types II and IV but is associated with faster DNA repair in skin type IV
    John M Sheehan
    Department of Environmental Dermatology, St John s Institute of Dermatology, Guy s, King s, and St Thomas School of Medicine, King s College London, St Thomas Hospital, UK
    J Invest Dermatol 118:825-9. 2002
    ..This provides further indirect evidence that DNA is a chromophore for erythema, but also suggests that a tan may not be the major factor in natural photoprotection...
  15. ncbi request reprint Helicobacter pylori regulates the expression of inhibitors of DNA binding (Id) proteins by gastric epithelial cells
    Barbara Ada Manzo
    Research Centre for Gastroenterology, Institute of Cell and Molecular Sciences, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, 4 Newark Street, London E1 2AT, UK
    Microbes Infect 8:1064-74. 2006
    ..In conclusion, H. pylori alters the expression of Id proteins, in vitro and in vivo; it is hypothesised that these changes contribute to H. pylori-associated pathologies...
  16. pmc An increase in epithelial cell apoptosis is associated with chronic intestinal nematode infection
    Laura J Cliffe
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M139PT, United Kingdom
    Infect Immun 75:1556-64. 2007
    ..It is proposed that the generation of proinflammatory cytokines during chronic T. muris infection may play a positive role, by promoting intestinal epithelial cell apoptosis, to counter infection-induced epithelial hyperplasia...
  17. ncbi request reprint Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast
    Kai C Chan
    Department of Surgery, University Hospital of South Manchester, United Kingdom
    Cancer Res 62:122-8. 2002
    ..3; P = 0.0005]. EGFR-TK inhibition with ZD1839 offers a novel approach to the treatment of EGFR-positive DCIS, regardless of ER status, and provides a potential new chemopreventative approach in patients at high risk of breast cancer...