Brian Eyden

Summary

Affiliation: Christie Hospital
Country: UK

Publications

  1. ncbi The myofibroblast: an assessment of controversial issues and a definition useful in diagnosis and research
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    Ultrastruct Pathol 25:39-50. 2001
  2. ncbi Foci of amorphous/granulofilamentous matrix in the extracellular domain of tumours: a study of 34 cases. 1. Ultrastructural characterisation
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK
    J Submicrosc Cytol Pathol 35:99-109. 2003
  3. ncbi Ultrastructural preservation of ovarian cortical tissue cryopreserved in dimethylsulfoxide for subsequent transplantation into young female cancer patients
    Brian Eyden
    Department of Histopathology, Christie Hospital, Manchester, UK
    Ultrastruct Pathol 28:239-45. 2004
  4. ncbi Fibroblast phenotype plasticity: relevance for understanding heterogeneity in "fibroblastic" tumors
    Brian Eyden
    Department of Histopathology, Christie Hospital, Manchester, UK
    Ultrastruct Pathol 28:307-19. 2004
  5. ncbi Metastatic small cell malignant melanoma: a case requiring immunoelectronmicroscopy for the demonstration of lattice-deficient melanosomes
    Brian Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK
    Ultrastruct Pathol 29:71-8. 2005
  6. ncbi Foci of amorphous/granulofilamentous matrix in the extracellular domain of tumours. 2. Immunohistochemical and immunogold characterization of a fibronectin-rich matrix component
    B Eyden
    Department of Histopathology, Christie Hospital, Manchester, United Kingdom
    J Submicrosc Cytol Pathol 37:1-11. 2005
  7. ncbi Malignant melanoma with neuroendocrine differentiation: clinical, histological, immunohistochemical and ultrastructural features of three cases
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK
    Histopathology 47:402-9. 2005
  8. ncbi The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. Part 1--normal and reactive cells
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    J Submicrosc Cytol Pathol 37:109-204. 2005
  9. ncbi The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. part 2 - tumours and tumour-like lesions
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    J Submicrosc Cytol Pathol 37:231-96. 2005
  10. ncbi Electron microscopy in the study of myofibroblastic lesions
    Brian Eyden
    Department of Histopathology, Christie Hospital National Health Service Trust, Manchester, United Kingdom
    Semin Diagn Pathol 20:13-24. 2003

Collaborators

Detail Information

Publications38

  1. ncbi The myofibroblast: an assessment of controversial issues and a definition useful in diagnosis and research
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    Ultrastruct Pathol 25:39-50. 2001
    ..Illustrations of the usefulness of these criteria in the diagnosis of soft-tissue lesions (myofibrosarcoma, so-called myofibroblastoma) are given...
  2. ncbi Foci of amorphous/granulofilamentous matrix in the extracellular domain of tumours: a study of 34 cases. 1. Ultrastructural characterisation
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK
    J Submicrosc Cytol Pathol 35:99-109. 2003
    ..Material of similar substructure and density was also associated with some vessels. FEAM were mostly found in tumours showing mesenchymal differentiation. The nature and origin of FEAM is discussed...
  3. ncbi Ultrastructural preservation of ovarian cortical tissue cryopreserved in dimethylsulfoxide for subsequent transplantation into young female cancer patients
    Brian Eyden
    Department of Histopathology, Christie Hospital, Manchester, UK
    Ultrastruct Pathol 28:239-45. 2004
    ....
  4. ncbi Fibroblast phenotype plasticity: relevance for understanding heterogeneity in "fibroblastic" tumors
    Brian Eyden
    Department of Histopathology, Christie Hospital, Manchester, UK
    Ultrastruct Pathol 28:307-19. 2004
    ..Ultimately, our understanding of the molecular events controlling differentiation in cancer will lead to control, cure and prevention...
  5. ncbi Metastatic small cell malignant melanoma: a case requiring immunoelectronmicroscopy for the demonstration of lattice-deficient melanosomes
    Brian Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK
    Ultrastruct Pathol 29:71-8. 2005
    ..This is also the first case of small cell melanoma to be studied by electron microscopy...
  6. ncbi Foci of amorphous/granulofilamentous matrix in the extracellular domain of tumours. 2. Immunohistochemical and immunogold characterization of a fibronectin-rich matrix component
    B Eyden
    Department of Histopathology, Christie Hospital, Manchester, United Kingdom
    J Submicrosc Cytol Pathol 37:1-11. 2005
    ..There is little support light microscopically for a relationship to immune-complexes or cryoglobulins...
  7. ncbi Malignant melanoma with neuroendocrine differentiation: clinical, histological, immunohistochemical and ultrastructural features of three cases
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK
    Histopathology 47:402-9. 2005
    ..To document the clinical, histological, immunohistochemical and ultrastructural features of three malignant melanomas showing neuroendocrine differentiation...
  8. ncbi The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. Part 1--normal and reactive cells
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    J Submicrosc Cytol Pathol 37:109-204. 2005
    ..The mechanism by which myofibroblasts arise in granulation tissue and promote tumour progression is discussed briefly, and an appendix provides summaries of the involvement of myofibroblasts in non-neoplastic diseases...
  9. ncbi The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. part 2 - tumours and tumour-like lesions
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    J Submicrosc Cytol Pathol 37:231-96. 2005
    ....
  10. ncbi Electron microscopy in the study of myofibroblastic lesions
    Brian Eyden
    Department of Histopathology, Christie Hospital National Health Service Trust, Manchester, United Kingdom
    Semin Diagn Pathol 20:13-24. 2003
    ..Myofibroblastoma is among many lesions described as myofibroblastic which, however, appear to show a kind of smooth-muscle differentiation. Some spindle-cell malignancies express myofibroblastic features...
  11. ncbi Intranodal myofibroblastoma: study of a case suggesting smooth-muscle differentiation
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    J Submicrosc Cytol Pathol 33:157-63. 2001
    ..The findings confirm earlier observations suggesting that some intranodal myofibroblastomas are not myofibroblastic, but show a form of smooth-muscle differentiation...
  12. ncbi Giant-cell fibroblastoma: a case report emphasising the presence of hyperplastic subplasmalemmal linear densities in continuity with granular matrices in the extracellular space
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK
    J Submicrosc Cytol Pathol 32:509-14. 2000
    ....
  13. ncbi Basement-membrane-related peri-vascular matrices not organised as a basal lamina: distribution in malignant tumours and benign lesions
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    J Submicrosc Cytol Pathol 32:515-23. 2000
    ..This paper briefly discusses the possible functions of these matrices as modulators of cell biological processes...
  14. ncbi Spindle-cell squamous carcinoma exhibiting myofibroblastic differentiation. A study of two cases showing fibronexus junctions
    Brian Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    Virchows Arch 440:36-44. 2002
    ..It extends the known distribution of the fibronexus and expands the ultrastructural spectrum of squamous carcinoma...
  15. ncbi Contribution of electron microscopy to understanding cellular differentiation in mesenchymal tumors of the gastrointestinal tract: a study of 82 tumors
    Brian Eyden
    Department of Histopathology, Christie Hospital, Manchester, United Kingdom
    Ultrastruct Pathol 26:269-85. 2002
    ..Results indicated overlap between poorly differentiated leiomyosarcoma and GIST, and between GIST and GANT. GANT is emphasized as a neuronal tumor identifiable by electron microscopy, and thereby distinguishable from GIST...
  16. ncbi Amphicrine carcinoma of breast with giant granules: an immunohistochemical, histochemical and ultrastructural study
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    J Submicrosc Cytol Pathol 34:27-36. 2002
    ..The exceptional size of these exocrine granules is emphasised, and the nature of both the small and giant granules discussed in this amphicrine carcinoma...
  17. doi Ultrastructurally confirmed myofibrosarcoma: a series of 10 new cases, with a discussion on diagnostic criteria
    Patrick Shenjere
    the Christie NHS Foundation Trust, Manchester, UK
    Int J Surg Pathol 21:29-36. 2013
    ..However, given the right histological appearance, use of a panel of antibodies that includes α-smooth muscle actin, desmin, and h-caldesmon, serves as an acceptable practical way of diagnosing myofibrosarcoma...
  18. doi Pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation: a single case report
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, United Kingdom
    Ultrastruct Pathol 34:42-7. 2010
    ..Given the four lines of differentiation--striated muscle, smooth muscle, fibroblastic, and histiocytic--a name reflecting its phenotype would be pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation...
  19. doi Epithelioid sarcoma: a case report with ultrastructural confirmation of myofibroblastic differentiation based on fibronexus junctions
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, UK
    Ultrastruct Pathol 33:61-6. 2009
    ..The findings are discussed in relation to the unusually varied differentiation reported for this tumor...
  20. ncbi Leiomyosarcoma showing partial synthetic-phase differentiation
    Brian Eyden
    Christie Hospital NHS Trust, Manchester, United Kingdom
    Ultrastruct Pathol 26:335-40. 2002
    ..In a subset of cells myofilaments were absent, but structures resembling solitary focal densities were identified. These are discussed as possible indicators of a primitive level of smooth-muscle differentiation...
  21. doi Fibronexus junctions associated with in vivo human endothelium
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, UK
    Ultrastruct Pathol 33:28-32. 2009
    ..They might also function as mechanotransducers of extracellular stress in the extracellular milieu. The present observations constitute a further, rare example of endothelium-associated fibronexuses in reactive human vessels...
  22. doi Alveolar rhabdomyosarcoma with neuroendocrine/neuronal differentiation: report of 3 cases
    M Adib Houreih
    Department of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
    Int J Surg Pathol 17:135-41. 2009
    ..PAX:FKHR fusion transcript was identified in case 2, case 3 had a variant PAX3 transcript, and case 1 was negative. The data presented expands the known differentiation of alveolar rhabdomyosarcoma...
  23. doi A structure resembling basal/external lamina on the surface of plasma cells, and a discussion on intercellular contacts between hemolymphoid cells
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, UK
    Ultrastruct Pathol 33:16-20. 2009
    ..Its function remains uncertain, although it may implement adhesion to other cells, as part of the immune functions that plasma cells and other hemolymphoid cells perform in the gut, for example, and elsewhere...
  24. ncbi A case of fibroblastic low-grade malignant peripheral nerve sheath tumor--a true neurofibrosarcoma
    Mohammad Adib Houreih
    Department of Histopathology, Christie Hospital, Manchester, UK
    Ultrastruct Pathol 31:347-56. 2007
    ..The present case represents an unambiguous demonstration of the co-expression within individual tumor cells of Schwannian and fibroblastic differentiation in a low-grade MPNST. The literature on this subject is reviewed...
  25. ncbi Rhabdomyoblastic differentiation in malignant melanoma in adults: report of 2 cases
    Deepa Gharpuray-Pandit
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    Int J Surg Pathol 15:20-5. 2007
    ..Both cases reported here were confirmed by immunohistochemistry. Both cases were also studied by electron microscopy, and one showed distinctive ultrastructural features of striated muscle...
  26. doi Stromal cells in the human gut show ultrastructural features of fibroblasts and smooth muscle cells but not myofibroblasts
    Brian Eyden
    Department of Histopathology, Christie NHS Foundation Trust, Manchester, UK
    J Cell Mol Med 15:1483-91. 2011
    ..The recognition that these cells are showing smooth-muscle or fibroblastic but not true myofibroblastic differentiation should inform our understanding of the function of these cells...
  27. ncbi Case for the panel of ultrastructural pathology--uterine leiomyoma
    Brian Eyden
    Christie Hospital, Manchester, UK
    Ultrastruct Pathol 28:115-7. 2004
  28. doi Carcinoma versus cytokeratin-positive lymphoma: a case report emphasizing the diagnostic role of electron microscopy
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, UK
    Ultrastruct Pathol 33:33-8. 2009
    ..This is one of the occasions where dewaxing (of an immunohistochemically defined wax block) offers positive advantages, despite compromised structural preservation, in the search for diagnostically important organelles...
  29. doi Pseudo-Gaucher cells in multiple myeloma
    Patrick Shenjere
    Department of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
    Int J Surg Pathol 16:176-9. 2008
    ..The patient had no clinical evidence of inherited Gaucher's disease. These pseudo-Gaucher cells obscured neoplastic plasma cells causing diagnostic difficulty...
  30. ncbi Soft-tissue extrarenal rhabdoid tumor with a unique long-term survival
    Aurelie Fabre
    Histopathology Department, St Mary s Hospital, London, UK
    Ultrastruct Pathol 28:49-52. 2004
    ..The features of this case are documented, with a brief summary of histological, immunohistochemical, ultrastructural, and genetic characteristics of this entity...
  31. ncbi TGF-beta1 drives partial myofibroblastic differentiation in chondromyxoid fibroma of bone
    Salvatore Romeo
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    J Pathol 208:26-34. 2006
    ..Fibronectin-EDA levels were low. We have therefore substantiated the presence of morphological, immunohistochemical, and immuno-electron microscopic partial myofibroblastic differentiation in CMF, driven by TGF-beta1 signalling...
  32. ncbi Primary small cell malignant melanoma of the rectum: case report of a very rare tumor
    Guofeng Wang
    Department of Pathology, Second Affiliated Hospital to the Medical School of Zhejiang University, Hangzhou, China
    Ultrastruct Pathol 31:315-20. 2007
    ..Documentation of these unusual morphological variants is important for identifying any distinctive outcome they might exhibit compared with conventional malignant melanoma...
  33. ncbi An immunohistochemical and ultrastructural study of pancreatic microcystic serous cyst adenoma with special reference to tumor-associated microvasculature and vascular endothelial growth factor in tumor cells
    Kazuto Yamazaki
    Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
    Ultrastruct Pathol 30:119-28. 2006
    ....
  34. ncbi Structural characterization of myofibroblasts in the bladder
    Marcus J Drake
    School of Surgical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    BJU Int 97:29-32. 2006
  35. ncbi Gastrointestinal autonomic nerve tumor
    Brian Eyden
    Am J Surg Pathol 26:396-7; author reply 397-8. 2002
  36. ncbi An ultrastructural and immunohistochemical study of microcystic meningioma with emphasis on matrix proteins and connexin 26 type gap junctions
    Kazuto Yamazaki
    Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
    Ultrastruct Pathol 28:247-53. 2004
    ....
  37. ncbi Re: Med Electron Microsc (2004) 37: 119-129
    Brian Eyden
    Med Electron Microsc 37:256; author reply 257-8. 2004
  38. ncbi Epithelioid leiomyosarcoma of the external deep soft tissue
    Brian Eyden
    Arch Pathol Lab Med 127:402-4; author reply 404. 2003