Brian Eyden

Summary

Affiliation: Christie Hospital
Country: UK

Publications

  1. doi The myofibroblast and its tumours
    B Eyden
    Department of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, UK
    J Clin Pathol 62:236-49. 2009
  2. doi A structure resembling basal/external lamina on the surface of plasma cells, and a discussion on intercellular contacts between hemolymphoid cells
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, UK
    Ultrastruct Pathol 33:16-20. 2009
  3. doi Fibronexus junctions associated with in vivo human endothelium
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, UK
    Ultrastruct Pathol 33:28-32. 2009
  4. doi Carcinoma versus cytokeratin-positive lymphoma: a case report emphasizing the diagnostic role of electron microscopy
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, UK
    Ultrastruct Pathol 33:33-8. 2009
  5. doi Pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation: a single case report
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, United Kingdom
    Ultrastruct Pathol 34:42-7. 2010
  6. doi Ultrastructurally confirmed myofibrosarcoma: a series of 10 new cases, with a discussion on diagnostic criteria
    Patrick Shenjere
    the Christie NHS Foundation Trust, Manchester, UK
    Int J Surg Pathol 21:29-36. 2013
  7. doi Epithelioid sarcoma: a case report with ultrastructural confirmation of myofibroblastic differentiation based on fibronexus junctions
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, UK
    Ultrastruct Pathol 33:61-6. 2009
  8. ncbi Leiomyosarcoma showing partial synthetic-phase differentiation
    Brian Eyden
    Christie Hospital NHS Trust, Manchester, United Kingdom
    Ultrastruct Pathol 26:335-40. 2002
  9. doi Alveolar rhabdomyosarcoma with neuroendocrine/neuronal differentiation: report of 3 cases
    M Adib Houreih
    Department of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
    Int J Surg Pathol 17:135-41. 2009
  10. ncbi Metastatic small cell malignant melanoma: a case requiring immunoelectronmicroscopy for the demonstration of lattice-deficient melanosomes
    Brian Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK
    Ultrastruct Pathol 29:71-8. 2005

Collaborators

Detail Information

Publications19

  1. doi The myofibroblast and its tumours
    B Eyden
    Department of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, UK
    J Clin Pathol 62:236-49. 2009
    ..Immunohistochemistry and electron microscopy, used together, are emphasised as being important for maximum diagnostic confidence in some myofibroblastic lesions...
  2. doi A structure resembling basal/external lamina on the surface of plasma cells, and a discussion on intercellular contacts between hemolymphoid cells
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, UK
    Ultrastruct Pathol 33:16-20. 2009
    ..Its function remains uncertain, although it may implement adhesion to other cells, as part of the immune functions that plasma cells and other hemolymphoid cells perform in the gut, for example, and elsewhere...
  3. doi Fibronexus junctions associated with in vivo human endothelium
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, UK
    Ultrastruct Pathol 33:28-32. 2009
    ..They might also function as mechanotransducers of extracellular stress in the extracellular milieu. The present observations constitute a further, rare example of endothelium-associated fibronexuses in reactive human vessels...
  4. doi Carcinoma versus cytokeratin-positive lymphoma: a case report emphasizing the diagnostic role of electron microscopy
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, UK
    Ultrastruct Pathol 33:33-8. 2009
    ..This is one of the occasions where dewaxing (of an immunohistochemically defined wax block) offers positive advantages, despite compromised structural preservation, in the search for diagnostically important organelles...
  5. doi Pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation: a single case report
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, United Kingdom
    Ultrastruct Pathol 34:42-7. 2010
    ..Given the four lines of differentiation--striated muscle, smooth muscle, fibroblastic, and histiocytic--a name reflecting its phenotype would be pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation...
  6. doi Ultrastructurally confirmed myofibrosarcoma: a series of 10 new cases, with a discussion on diagnostic criteria
    Patrick Shenjere
    the Christie NHS Foundation Trust, Manchester, UK
    Int J Surg Pathol 21:29-36. 2013
    ..However, given the right histological appearance, use of a panel of antibodies that includes α-smooth muscle actin, desmin, and h-caldesmon, serves as an acceptable practical way of diagnosing myofibrosarcoma...
  7. doi Epithelioid sarcoma: a case report with ultrastructural confirmation of myofibroblastic differentiation based on fibronexus junctions
    Brian Eyden
    Department of Histopathology, the Christie NHS Foundation Trust, Manchester, UK
    Ultrastruct Pathol 33:61-6. 2009
    ..The findings are discussed in relation to the unusually varied differentiation reported for this tumor...
  8. ncbi Leiomyosarcoma showing partial synthetic-phase differentiation
    Brian Eyden
    Christie Hospital NHS Trust, Manchester, United Kingdom
    Ultrastruct Pathol 26:335-40. 2002
    ..In a subset of cells myofilaments were absent, but structures resembling solitary focal densities were identified. These are discussed as possible indicators of a primitive level of smooth-muscle differentiation...
  9. doi Alveolar rhabdomyosarcoma with neuroendocrine/neuronal differentiation: report of 3 cases
    M Adib Houreih
    Department of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
    Int J Surg Pathol 17:135-41. 2009
    ..PAX:FKHR fusion transcript was identified in case 2, case 3 had a variant PAX3 transcript, and case 1 was negative. The data presented expands the known differentiation of alveolar rhabdomyosarcoma...
  10. ncbi Metastatic small cell malignant melanoma: a case requiring immunoelectronmicroscopy for the demonstration of lattice-deficient melanosomes
    Brian Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK
    Ultrastruct Pathol 29:71-8. 2005
    ..This is also the first case of small cell melanoma to be studied by electron microscopy...
  11. ncbi Contribution of electron microscopy to understanding cellular differentiation in mesenchymal tumors of the gastrointestinal tract: a study of 82 tumors
    Brian Eyden
    Department of Histopathology, Christie Hospital, Manchester, United Kingdom
    Ultrastruct Pathol 26:269-85. 2002
    ..Results indicated overlap between poorly differentiated leiomyosarcoma and GIST, and between GIST and GANT. GANT is emphasized as a neuronal tumor identifiable by electron microscopy, and thereby distinguishable from GIST...
  12. doi Stromal cells in the human gut show ultrastructural features of fibroblasts and smooth muscle cells but not myofibroblasts
    Brian Eyden
    Department of Histopathology, Christie NHS Foundation Trust, Manchester, UK
    J Cell Mol Med 15:1483-91. 2011
    ..The recognition that these cells are showing smooth-muscle or fibroblastic but not true myofibroblastic differentiation should inform our understanding of the function of these cells...
  13. doi Pseudo-Gaucher cells in multiple myeloma
    Patrick Shenjere
    Department of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
    Int J Surg Pathol 16:176-9. 2008
    ..The patient had no clinical evidence of inherited Gaucher's disease. These pseudo-Gaucher cells obscured neoplastic plasma cells causing diagnostic difficulty...
  14. ncbi A case of fibroblastic low-grade malignant peripheral nerve sheath tumor--a true neurofibrosarcoma
    Mohammad Adib Houreih
    Department of Histopathology, Christie Hospital, Manchester, UK
    Ultrastruct Pathol 31:347-56. 2007
    ..The present case represents an unambiguous demonstration of the co-expression within individual tumor cells of Schwannian and fibroblastic differentiation in a low-grade MPNST. The literature on this subject is reviewed...
  15. ncbi Rhabdomyoblastic differentiation in malignant melanoma in adults: report of 2 cases
    Deepa Gharpuray-Pandit
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    Int J Surg Pathol 15:20-5. 2007
    ..Both cases reported here were confirmed by immunohistochemistry. Both cases were also studied by electron microscopy, and one showed distinctive ultrastructural features of striated muscle...
  16. ncbi Case for the panel of ultrastructural pathology--uterine leiomyoma
    Brian Eyden
    Christie Hospital, Manchester, UK
    Ultrastruct Pathol 28:115-7. 2004
  17. ncbi Electron microscopy in the study of myofibroblastic lesions
    Brian Eyden
    Department of Histopathology, Christie Hospital National Health Service Trust, Manchester, United Kingdom
    Semin Diagn Pathol 20:13-24. 2003
    ..Myofibroblastoma is among many lesions described as myofibroblastic which, however, appear to show a kind of smooth-muscle differentiation. Some spindle-cell malignancies express myofibroblastic features...
  18. ncbi Fibroblast phenotype plasticity: relevance for understanding heterogeneity in "fibroblastic" tumors
    Brian Eyden
    Department of Histopathology, Christie Hospital, Manchester, UK
    Ultrastruct Pathol 28:307-19. 2004
    ..Ultimately, our understanding of the molecular events controlling differentiation in cancer will lead to control, cure and prevention...
  19. ncbi Spindle-cell squamous carcinoma exhibiting myofibroblastic differentiation. A study of two cases showing fibronexus junctions
    Brian Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    Virchows Arch 440:36-44. 2002
    ..It extends the known distribution of the fibronexus and expands the ultrastructural spectrum of squamous carcinoma...