P N Durrington

Summary

Affiliation: Christie Hospital
Country: UK

Publications

  1. pmc An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia
    P N Durrington
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Heart 85:544-8. 2001
  2. ncbi request reprint Paraoxonase and atherosclerosis
    P N Durrington
    University of Manchester Department of Medicine, Manchester Royal Infirmary, Manchester, England
    Arterioscler Thromb Vasc Biol 21:473-80. 2001
  3. ncbi request reprint Human serum paraoxonase
    B Mackness
    University Department of Medicine, Manchester Royal Infirmary, United Kingdom
    Gen Pharmacol 31:329-36. 1998
  4. doi request reprint Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations
    J V Patel
    Clinical Epidemiology and Cardiovascular Medicine Group, University Department of Medicine, University of Manchester, UK
    Atherosclerosis 209:579-84. 2010
  5. ncbi request reprint Low paraoxonase activity in type II diabetes mellitus complicated by retinopathy
    B Mackness
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Clin Sci (Lond) 98:355-63. 2000
  6. ncbi request reprint Serum paraoxonase activity in patients with type 1 diabetes compared to healthy controls
    B Mackness
    University Department of Medicine, Manchester Royal Infirmary, Manchester, UK
    Eur J Clin Invest 32:259-64. 2002
  7. ncbi request reprint Low paraoxonase in Persian Gulf War Veterans self-reporting Gulf War Syndrome
    B Mackness
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, United Kingdom
    Biochem Biophys Res Commun 276:729-33. 2000
  8. ncbi request reprint Impact of migration on coronary heart disease risk factors: comparison of Gujaratis in Britain and their contemporaries in villages of origin in India
    J V Patel
    University Department of Medicine, University of Manchester, Division of Cardiovascular and Endocrine Science, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Atherosclerosis 185:297-306. 2006
  9. pmc Familial hypercholesterolaemia commonly presents with Achilles tenosynovitis
    D Beeharry
    University of Manchester, Division of Cardiovascular and Endocrine Science, Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13, UK
    Ann Rheum Dis 65:312-5. 2006
  10. ncbi request reprint Relationship between serum butyrylcholinesterase activity, hypertriglyceridaemia and insulin sensitivity in diabetes mellitus
    C A Abbott
    University Department of Medicine, Manchester Royal Infirmary, U K
    Clin Sci (Lond) 85:77-81. 1993

Collaborators

Detail Information

Publications23

  1. pmc An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia
    P N Durrington
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Heart 85:544-8. 2001
    ..These fatty acids can decrease serum triglyceride concentrations, but so far the doses used in trials examining their effects on coronary end points have had only minimal triglyceride lowering effects...
  2. ncbi request reprint Paraoxonase and atherosclerosis
    P N Durrington
    University of Manchester Department of Medicine, Manchester Royal Infirmary, Manchester, England
    Arterioscler Thromb Vasc Biol 21:473-80. 2001
    ....
  3. ncbi request reprint Human serum paraoxonase
    B Mackness
    University Department of Medicine, Manchester Royal Infirmary, United Kingdom
    Gen Pharmacol 31:329-36. 1998
    ....
  4. doi request reprint Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations
    J V Patel
    Clinical Epidemiology and Cardiovascular Medicine Group, University Department of Medicine, University of Manchester, UK
    Atherosclerosis 209:579-84. 2010
    ..Coronary heart disease (CHD) is exceptionally prevalent amongst globally dispersed migrant groups originating from the Indian subcontinent, but the contribution of dyslipidaemia to their increased risk remains poorly defined...
  5. ncbi request reprint Low paraoxonase activity in type II diabetes mellitus complicated by retinopathy
    B Mackness
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Clin Sci (Lond) 98:355-63. 2000
    ....
  6. ncbi request reprint Serum paraoxonase activity in patients with type 1 diabetes compared to healthy controls
    B Mackness
    University Department of Medicine, Manchester Royal Infirmary, Manchester, UK
    Eur J Clin Invest 32:259-64. 2002
    ..High-density lipoprotein (HDL) associated paraoxonase (PON1) can retard the oxidation of LDL...
  7. ncbi request reprint Low paraoxonase in Persian Gulf War Veterans self-reporting Gulf War Syndrome
    B Mackness
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, United Kingdom
    Biochem Biophys Res Commun 276:729-33. 2000
    ..2 +/- 4.1 micromol/min/ml vs 9.86 +/- 4.4, P = NS). A decreased capacity to detoxify OP insecticides resulting from low serum PON1 activity may have contributed to the development of Gulf War Syndrome...
  8. ncbi request reprint Impact of migration on coronary heart disease risk factors: comparison of Gujaratis in Britain and their contemporaries in villages of origin in India
    J V Patel
    University Department of Medicine, University of Manchester, Division of Cardiovascular and Endocrine Science, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Atherosclerosis 185:297-306. 2006
    ..Strategies to improve nutrition and to identify and treat cardiovascular risk factors such as dyslipidaemia and hypertension are urgently required...
  9. pmc Familial hypercholesterolaemia commonly presents with Achilles tenosynovitis
    D Beeharry
    University of Manchester, Division of Cardiovascular and Endocrine Science, Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13, UK
    Ann Rheum Dis 65:312-5. 2006
    ..Even before tendons are chronically enlarged, tenosynovitis may occur and medical advice be sought. Untreated HeFH carries a high risk of premature coronary heart disease, which can be ameliorated by early diagnosis...
  10. ncbi request reprint Relationship between serum butyrylcholinesterase activity, hypertriglyceridaemia and insulin sensitivity in diabetes mellitus
    C A Abbott
    University Department of Medicine, Manchester Royal Infirmary, U K
    Clin Sci (Lond) 85:77-81. 1993
    ..6. These results are consistent with the view that butyrylcholinesterase may have a role in the altered lipoprotein metabolism in hypertriglyceridaemia associated with insulin insensitivity or insulin deficiency in diabetes mellitus...
  11. ncbi request reprint Omega-3 fatty acids: their role in the prevention and treatment of atherosclerosis related risk factors and complications
    D Bhatnagar
    University of Manchester, Department of Medicine, Manchester Royal Infirmary, UK
    Int J Clin Pract 57:305-14. 2003
    ..Omacor is also useful in the treatment of hypertriglyceridaemia, both as monotherapy and in combination with statins...
  12. doi request reprint Protection Against Nephropathy in Diabetes with Atorvastatin (PANDA): a randomized double-blind placebo-controlled trial of high- vs. low-dose atorvastatin(1)
    M K Rutter
    Cardiovascular Medicine Research Group, School of Biomedicine, University of Manchester, Manchester, UK
    Diabet Med 28:100-8. 2011
    ..To compare the renal effects of low- vs. high-dose atorvastatin in patients with Type 2 diabetes mellitus and optimally managed early renal disease...
  13. ncbi request reprint Preventing cardiovascular disease in hypertension: effects of lowering blood pressure and cholesterol
    R Green
    Department of Medicine, Manchester Royal Infirmary, Manchester, UK
    QJM 95:821-6. 2002
    ..Aim: To compare the potential benefits of antihypertensive medication and statin therapy in hypertensive patients, and examine whether this policy is rational...
  14. ncbi request reprint Paraoxonase status in coronary heart disease: are activity and concentration more important than genotype?
    B Mackness
    University Department of Medicine, School of Epidemiology and Health Sciences, University of Manchester, Manchester, UK
    Arterioscler Thromb Vasc Biol 21:1451-7. 2001
    ..These results indicate that lower PON1 activity and concentration and, therefore, the reduced ability to prevent LDL lipid peroxidation may be more important in determining the presence of CHD than paraoxonase genetic polymorphisms...
  15. pmc Squalene synthase inhibitors
    V C Menys
    Medicine and Surgery Central Clinical Academic Group, Medicine, Manchester Royal Infirmary, Oxford Road, Manchester Ml3 9WL
    Br J Pharmacol 139:881-2. 2003
  16. ncbi request reprint Costs of aspirin and statins in general practice
    A Drummond
    Department of Medicine, Manchester Royal Infirmary, Manchester, UK
    QJM 95:23-6. 2002
    ..Aspirin and statins are the two drugs most commonly indicated for secondary prevention of atherosclerotic disease in the UK. Statin treatment, which is more expensive, is under-prescribed...
  17. pmc Clinical, biochemical, and immunohistochemical features of necrobiotic xanthogranulomatosis
    M Jeziorska
    Department of Medicine, University of Manchester, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    J Clin Pathol 56:64-8. 2003
    ..To describe the clinical features of two patients with paraproteinaemia and necrobiotic xanthogranulomatosis together with detailed immunohistochemistry of the lesions in one...
  18. ncbi request reprint Prevention of cardiovascular disease in systemic lupus erythematosus--proposed guidelines for risk factor management
    J Wajed
    The University of Manchester, Rheumatism Research Centre, Central Manchester and Manchester Children s University Hospitals NHS Trust, Oxford Road, Manchester M13 9WL, UK
    Rheumatology (Oxford) 43:7-12. 2004
  19. ncbi request reprint Paraoxonase polymorphisms and coronary heart disease
    P N Durrington
    Lancet 364:579-80; author reply 580. 2004
  20. ncbi request reprint Paraoxonase polymorphisms and self-reported chronic ill-health in farmers dipping sheep
    A C Povey
    Centre for Occupational and Environmental Health, University of Manchester, Manchester M13 9PL, UK
    Occup Med (Lond) 55:282-6. 2005
    ....
  21. ncbi request reprint The hunt for nutritional and pharmacological modulators of paraoxonase
    P N Durrington
    Arterioscler Thromb Vasc Biol 22:1248-50. 2002
  22. ncbi request reprint Comparison of the risk of fatal coronary heart disease in treated xanthomatous and non-xanthomatous heterozygous familial hypercholesterolaemia: a prospective registry study
    H A W Neil
    Division Public Health and Primary Health Care, Institute for Health Sciences, University of Oxford, Headington, Oxford, UK
    Atherosclerosis 170:73-8. 2003
    ..The prognosis of treated non-xanthomatous (TX-) FH is uncertain and the objective of this study was to compare mortality from coronary heart disease (CHD) in patients with treated TX+ (definite) and TX- (possible) heterozygous FH...
  23. ncbi request reprint Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel
    P J Barter
    Heart Research Institute, Camperdown, Sydney, NSW, Australia
    J Intern Med 259:247-58. 2006
    ..The evidence also indicates that the apo B/apo A-I ratio is superior to any of the conventional cholesterol ratios in patients without symptomatic vascular disease or diabetes to evaluate the lipoprotein-related risk of vascular disease...