Patricia A Nuttall

Summary

Affiliation: Centre for Ecology and Hydrology
Country: UK

Publications

  1. ncbi request reprint Molecular characterization of tick-virus interactions
    Patricia A Nuttall
    NERC Centre for Ecology and Hydrology, Maclean Building, Crowmarsh Gifford, Wallingford, OX108BB, United Kingdom
    Front Biosci (Landmark Ed) 14:2466-83. 2009
  2. ncbi request reprint Exposed and concealed antigens as vaccine targets for controlling ticks and tick-borne diseases
    P A Nuttall
    Centre for Ecology and Hydrology, Oxford, UK
    Parasite Immunol 28:155-63. 2006
  3. ncbi request reprint Tick-host interactions: saliva-activated transmission
    P A Nuttall
    Centre for Ecology and Hydrology, Mansfield Rd, Oxford, OX1 3SR, UK
    Parasitology 129:S177-89. 2004
  4. ncbi request reprint Vector-host interactions in disease transmission
    P A Nuttall
    CEH Institute of Virology and Environmental Microbiology, Oxford, UK
    J Mol Microbiol Biotechnol 2:381-6. 2000
  5. doi request reprint An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure
    Guido C Paesen
    CEH Oxford, Mansfield Road, Oxford OX1 3SR, UK
    J Mol Biol 389:734-47. 2009
  6. pmc Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses
    Stephen G Preston
    Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Pathog 9:e1003450. 2013
  7. ncbi request reprint Dual action ectoparasite vaccine targeting 'exposed' and 'concealed' antigens
    Adama R Trimnell
    CEH Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK
    Vaccine 20:3560-8. 2002
  8. ncbi request reprint A tick protein with a modified Kunitz fold inhibits human tryptase
    Guido C Paesen
    CEH, Mansfield Road, Oxford, OX1 3SR, UK
    J Mol Biol 368:1172-86. 2007
  9. ncbi request reprint Complement inhibitor of C5 activation from the soft tick Ornithodoros moubata
    Miles A Nunn
    Centre for Ecology and Hydrology, Oxford, Oxford, United Kingdom
    J Immunol 174:2084-91. 2005
  10. ncbi request reprint Tick-borne viruses
    M Labuda
    Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 845 06 Bratislava, Slovakia
    Parasitology 129:S221-45. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Molecular characterization of tick-virus interactions
    Patricia A Nuttall
    NERC Centre for Ecology and Hydrology, Maclean Building, Crowmarsh Gifford, Wallingford, OX108BB, United Kingdom
    Front Biosci (Landmark Ed) 14:2466-83. 2009
    ..As the tick proteome is unravelled, its interaction with the viral proteome should help explain the interactions between ticks and the many important viruses they transmit...
  2. ncbi request reprint Exposed and concealed antigens as vaccine targets for controlling ticks and tick-borne diseases
    P A Nuttall
    Centre for Ecology and Hydrology, Oxford, UK
    Parasite Immunol 28:155-63. 2006
    ..With the proliferation of molecular techniques and their application to vaccine development, there are high hopes for new and effective antitick vaccines that also control tick-borne diseases...
  3. ncbi request reprint Tick-host interactions: saliva-activated transmission
    P A Nuttall
    Centre for Ecology and Hydrology, Mansfield Rd, Oxford, OX1 3SR, UK
    Parasitology 129:S177-89. 2004
    ..Whatever they turn out to be, the quest to identify the tick molecules that mediate SAT is an exciting one, and offers new insights to controlling ticks and tick-borne diseases...
  4. ncbi request reprint Vector-host interactions in disease transmission
    P A Nuttall
    CEH Institute of Virology and Environmental Microbiology, Oxford, UK
    J Mol Microbiol Biotechnol 2:381-6. 2000
    ..Understanding the key events at the tick vector-host interface, that promote spirochete infection and transmission, will provide a better understanding of the epidemiology and ecology of these important human pathogens...
  5. doi request reprint An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure
    Guido C Paesen
    CEH Oxford, Mansfield Road, Oxford OX1 3SR, UK
    J Mol Biol 389:734-47. 2009
    ....
  6. pmc Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses
    Stephen G Preston
    Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Pathog 9:e1003450. 2013
    ..Our results suggest a previously unknown mechanism for parasite-induced subversion of adaptive immunity, one which may also facilitate pathogen transmission. ..
  7. ncbi request reprint Dual action ectoparasite vaccine targeting 'exposed' and 'concealed' antigens
    Adama R Trimnell
    CEH Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK
    Vaccine 20:3560-8. 2002
    ..This dual action, acting at the feeding site and in the midgut, offers a self-sustaining strategy for ectoparasite control boosted by natural infestations...
  8. ncbi request reprint A tick protein with a modified Kunitz fold inhibits human tryptase
    Guido C Paesen
    CEH, Mansfield Road, Oxford, OX1 3SR, UK
    J Mol Biol 368:1172-86. 2007
    ..TdPI accumulates in the cytosolic granules of mast cells, presumably suppressing inflammation in the host animal's skin by tryptase inhibition...
  9. ncbi request reprint Complement inhibitor of C5 activation from the soft tick Ornithodoros moubata
    Miles A Nunn
    Centre for Ecology and Hydrology, Oxford, Oxford, United Kingdom
    J Immunol 174:2084-91. 2005
    ..OmCI is the first lipocalin family member shown to inhibit C and also the first natural inhibitor that specifically targets the C5 activation step...
  10. ncbi request reprint Tick-borne viruses
    M Labuda
    Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 845 06 Bratislava, Slovakia
    Parasitology 129:S221-45. 2004
    ..Key challenges are to determine the molecular adaptations that allow tick-borne viruses to infect and replicate in both tick and vertebrate cells, and to identify the principal ecological determinants of tick-borne virus survival...
  11. ncbi request reprint Tick-borne Great Island Virus: (I) Identification of seabird host and evidence for co-feeding and viraemic transmission
    M A Nunn
    NERC Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR
    Parasitology 132:233-40. 2006
    ..Virus infection of adult ticks feeding on guillemots was highly efficient and may involve both viraemic transmission and transmission from infected to uninfected ticks feeding together on birds that do not develop a patent viraemia...
  12. ncbi request reprint Impact of climate change on health: what is required of climate modellers?
    C Huntingford
    Centre for Ecology and Hydrology, Wallingford, Oxfordshire OX10 8BB, UK
    Trans R Soc Trop Med Hyg 101:97-103. 2007
    ..However we are optimistic that climate-health model simulations, including uncertainty bounds, will provide much needed estimates of the likely impacts of climate change on human health...
  13. ncbi request reprint Tick-borne Great Island Virus: (II) Impact of age-related acquired immunity on transmission in a natural seabird host
    M A Nunn
    NERC Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR
    Parasitology 132:241-53. 2006
    ..The results indicate age-related acquired immunity is a key factor in GIV transmission and highlight the need to consider age-related effects and host immunity when undertaking quantitative studies of tick-borne pathogen transmission...
  14. ncbi request reprint Antigenic profile of Ixodes ricinus: effect of developmental stage, feeding time and the response of different host species
    C H Lawrie
    CEH Institute of Virology and Environmental Microbiology, Oxford, UK
    Parasite Immunol 23:549-56. 2001
    ..The pattern of antigenic tick-molecules recognized by infested host species varies with the period of feeding, developmental stage and the particular host species parasitized...
  15. doi request reprint Immunomodulatory arsenal of nymphal ticks
    K Peterková
    Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia
    Med Vet Entomol 22:167-71. 2008
    ..These data show that nymphs, which epidemiologically are usually more important than adults as disease vectors, possess a range of anti-cytokine activities that may facilitate pathogen transmission...
  16. ncbi request reprint Differential anti-chemokine activity of Amblyomma variegatum adult ticks during blood-feeding
    I Vancova
    Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia
    Parasite Immunol 29:169-77. 2007
    ..They support the concept of 'mate guarding', in which males help their mates to engorge by controlling their host's immune response, and the possibility that ticks benefit from feeding together by exploiting molecular individuality...
  17. ncbi request reprint Manipulation of host cytokine network by ticks: a potential gateway for pathogen transmission
    V Hajnicka
    Institute of Virology, Slovak Academy of Sciences, 842 05 Bratislava, Slovakia
    Parasitology 130:333-42. 2005
    ....
  18. ncbi request reprint Tick-borne flaviviruses
    T S Gritsun
    CEH Institute of Virology and Environmental Microbiology, Oxford, OX1 3SR, United Kingdom
    Adv Virus Res 61:317-71. 2003
    ..This chapter contains a brief history of vaccination against TBE including the trials with live attenuated vaccine and reviews the modern trends in development of vaccine virus strains...
  19. ncbi request reprint Dynamics of infection in tick vectors and at the tick-host interface
    P A Nuttall
    CEH Institute of Virology and Environmental Microbiology, Oxford, OX1 3SR, United Kingdom
    Adv Virus Res 60:233-72. 2003
    ..Here we speculate that exploitation of the tick pharmacopeia, rather than development of viremia, is the key step in successful tick-borne flavivirus transmission...
  20. ncbi request reprint Vasodilatory activity in horsefly and deerfly salivary glands
    P Rajská
    Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia
    Med Vet Entomol 17:395-402. 2003
    ..did not induce relaxation. The kinetics of vasodilation induced by SGE of four horsefly species differed from the deerfly. These results indicate that tabanid species may produce more than one type of vasodilator to aid blood feeding...
  21. ncbi request reprint Anticoagulant activities in salivary glands of tabanid flies
    M Kazimirova
    Institute of Zoology, Slovak Academy of Sciences, Bratislava
    Med Vet Entomol 16:301-9. 2002
    ..Electrophoretic profiles of SGE proteins differed between genera and species. Overall, the results suggest that tabanids have evolved at least two antihaemostatic strategies...
  22. ncbi request reprint Anti-interleukin-8 activity of tick salivary gland extracts
    V Hajnicka
    Institute of Preventive and Clinical Medicine, Bratislava, Slovakia
    Parasite Immunol 23:483-9. 2001
    ..Future isolation and characterization of the active molecules will enable determination of their functional roles in bloodfeeding and effect on tick-borne pathogen transmission...
  23. ncbi request reprint Large RNA segment of Dugbe nairovirus encodes the putative RNA polymerase
    A C Marriott
    NERC Institute of Virology and Environmental Microbiology, Oxford, UK
    J Gen Virol 77:1775-80. 1996
    ..However, the core polymerase was the only function that could be assigned to a region of the DUG L gene...
  24. ncbi request reprint A tick homologue of the human DNA helicase II 70-kDa subunit
    G C Paesen
    NERC Institute of Virology and Environmental Microbiology, Oxford, UK
    Biochim Biophys Acta 1305:120-4. 1996
    ..The tick homologue appears to be more closely related to the mammalian protein than to the only other p70 homologue reported in arthropods, the inverted repeat binding protein (IRBP) in the fruitfly, Drosophila melanogaster...
  25. ncbi request reprint Dugbe Nairovirus M RNA: nucleotide sequence and coding strategy
    A C Marriott
    NERC Institute of Virology and Environmental Microbiology, Oxford, United Kingdom
    Virology 190:606-15. 1992
    ..The region between the carboxyl terminus of G2 and the 5' end of the long open reading frame apparently encodes a nonstructural protein of about 70 kDa, which is a precursor of the G2 protein...