E A Gould

Summary

Affiliation: Centre for Ecology and Hydrology
Country: UK

Publications

  1. ncbi request reprint Complete sequence of two tick-borne flaviviruses isolated from Siberia and the UK: analysis and significance of the 5' and 3'-UTRs
    T S Gritsun
    Institute of Virology and Environmental Microbiology, Oxford, UK
    Virus Res 49:27-39. 1997
  2. ncbi request reprint The 3' untranslated region of tick-borne flaviviruses originated by the duplication of long repeat sequences within the open reading frame
    T S Gritsun
    Centre for Ecology and Hydrology, Mansfield Rd, Oxford 0X1 3SR, UK
    Virology 350:269-75. 2006
  3. ncbi request reprint Does antiviral therapy have a role in the control of Japanese encephalitis?
    E A Gould
    Unite des Virus Emergents, Faculte de Medecine, 27 Boulevard Jean Moulin, 13005 Marseille, France
    Antiviral Res 78:140-9. 2008
  4. pmc Potential arbovirus emergence and implications for the United Kingdom
    Ernest Andrew Gould
    Centre for Ecology and Hydrology Oxford, Oxford, UK
    Emerg Infect Dis 12:549-55. 2006
  5. doi request reprint First case of rabbit haemorrhagic disease in Canada: contaminated flying insect, vs. long-term infection hypothesis
    E A Gould
    Unite des Virus Emergents, Faculte de Medecine Timone, 27 Bd Jean Moulin, Marseille Cedex 05, France
    Mol Ecol 21:1042-7. 2012
  6. pmc Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?
    Xavier de Lamballerie
    Institut de Recherche pour le Développement UMR190 Unité des Virus Emergents, Universite de la Mediterranee, Marseille, France
    Virol J 5:33. 2008
  7. pmc Detection of seroconversion to West Nile virus, Usutu virus and Sindbis virus in UK sentinel chickens
    Alan Buckley
    CEH Oxford, Mansfield Road, Oxford OX1 3SR, UK
    Virol J 3:71. 2006
  8. pmc Universal primers that amplify RNA from all three flavivirus subgroups
    Sheryl L Maher-Sturgess
    Australian Biosecurity CRC, University of Queensland, St Lucia, QLD 4067, Australia
    Virol J 5:16. 2008
  9. ncbi request reprint Pathogenic flaviviruses
    E A Gould
    CEH Oxford, Mansfield Road, Oxford, UK
    Lancet 371:500-9. 2008
  10. pmc Impact of climate change and other factors on emerging arbovirus diseases
    E A Gould
    Unite des Virus Emergents, Faculte de Medecine Timone, 13385 Marseille, Cedex 05, France
    Trans R Soc Trop Med Hyg 103:109-21. 2009

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Complete sequence of two tick-borne flaviviruses isolated from Siberia and the UK: analysis and significance of the 5' and 3'-UTRs
    T S Gritsun
    Institute of Virology and Environmental Microbiology, Oxford, UK
    Virus Res 49:27-39. 1997
    ..The possible implications of these findings are discussed...
  2. ncbi request reprint The 3' untranslated region of tick-borne flaviviruses originated by the duplication of long repeat sequences within the open reading frame
    T S Gritsun
    Centre for Ecology and Hydrology, Mansfield Rd, Oxford 0X1 3SR, UK
    Virology 350:269-75. 2006
    ..We propose that the 3'UTR, and possibly the open reading frame, evolved through multiple duplications, deletions and mutations of a primordial sequence element...
  3. ncbi request reprint Does antiviral therapy have a role in the control of Japanese encephalitis?
    E A Gould
    Unite des Virus Emergents, Faculte de Medecine, 27 Boulevard Jean Moulin, 13005 Marseille, France
    Antiviral Res 78:140-9. 2008
    ..Here we briefly review the epidemiological problems presented by this virus, the present state of drug development and the contributory role that antiviral therapy might play in developing future control strategies for JE...
  4. pmc Potential arbovirus emergence and implications for the United Kingdom
    Ernest Andrew Gould
    Centre for Ecology and Hydrology Oxford, Oxford, UK
    Emerg Infect Dis 12:549-55. 2006
    ..While other arboviruses, such as West Nile virus, Sindbis virus, Tahyna virus, and Louping ill virus, apparently circulate in the United Kingdom, they do not appear to present an imminent threat to humans or animals...
  5. doi request reprint First case of rabbit haemorrhagic disease in Canada: contaminated flying insect, vs. long-term infection hypothesis
    E A Gould
    Unite des Virus Emergents, Faculte de Medecine Timone, 27 Bd Jean Moulin, Marseille Cedex 05, France
    Mol Ecol 21:1042-7. 2012
    ..The flying insect hypothesis of Peacock et al. is based on circumstantial evidence and, I believe, has a lower probability of being correct than my evidence-based long-term infection proposal...
  6. pmc Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?
    Xavier de Lamballerie
    Institut de Recherche pour le Développement UMR190 Unité des Virus Emergents, Universite de la Mediterranee, Marseille, France
    Virol J 5:33. 2008
    ..This disconcerting and current unique example of "evolutionary convergence" occurring in nature illustrates rapid pathogen adaptation to ecological perturbation, driven directly as a consequence of human activities...
  7. pmc Detection of seroconversion to West Nile virus, Usutu virus and Sindbis virus in UK sentinel chickens
    Alan Buckley
    CEH Oxford, Mansfield Road, Oxford OX1 3SR, UK
    Virol J 3:71. 2006
    ..The proportion of seropositive chickens was higher for WNV than for Usutu virus or Sindbis virus. Attempts to isolate infectious virus or to detect viral RNA in the sera, failed...
  8. pmc Universal primers that amplify RNA from all three flavivirus subgroups
    Sheryl L Maher-Sturgess
    Australian Biosecurity CRC, University of Queensland, St Lucia, QLD 4067, Australia
    Virol J 5:16. 2008
    ..Here we review the specificity of published primers, and describe a new universal primer pair that can detect a wide range of flaviviruses, including viruses from each of the recognised subgroups...
  9. ncbi request reprint Pathogenic flaviviruses
    E A Gould
    CEH Oxford, Mansfield Road, Oxford, UK
    Lancet 371:500-9. 2008
    ....
  10. pmc Impact of climate change and other factors on emerging arbovirus diseases
    E A Gould
    Unite des Virus Emergents, Faculte de Medecine Timone, 13385 Marseille, Cedex 05, France
    Trans R Soc Trop Med Hyg 103:109-21. 2009
    ..In this brief review we ask the question, are these diseases emerging because of climate change or do other factors play an equal or even more important role in their emergence?..
  11. ncbi request reprint Understanding the alphaviruses: recent research on important emerging pathogens and progress towards their control
    E A Gould
    Institut de Recherche pour le Développement UMR190 Unité des Virus Emergents, Universite de la Mediterranee, Marseille, France
    Antiviral Res 87:111-24. 2010
    ....
  12. doi request reprint Co-circulation of widely disparate strains of rabbit haemorrhagic disease virus could explain localised epidemicity in the United Kingdom
    N L Forrester
    Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK
    Virology 393:42-8. 2009
    ....
  13. ncbi request reprint Long-term survival of New Zealand rabbit haemorrhagic disease virus RNA in wild rabbits, revealed by RT-PCR and phylogenetic analysis
    N L Forrester
    Centre for Ecology and Hydrology formerly Institute of Virology, Mansfield Road, Oxford OX1 3SR, UK
    J Gen Virol 84:3079-86. 2003
    ..Moreover, the co-circulation of other strains of RHDV in the same rabbit population, such as the Spanish strain, might also impact on their susceptibility to the bio-control agent...
  14. ncbi request reprint Phylogenetic analysis of rabbit haemorrhagic disease virus strains from the Arabian Peninsula: did RHDV emerge simultaneously in Europe and Asia?
    N L Forrester
    Centre for Ecology and Hydrology formerly Institute of Virology, Mansfield Road, Oxford OX1 3SR, UK
    Virology 344:277-82. 2006
    ....
  15. ncbi request reprint Benign circulation of rabbit haemorrhagic disease virus on Lambay Island, Eire
    N L Forrester
    Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK
    Virology 358:18-22. 2007
    ....
  16. ncbi request reprint Direct repeats in the 3' untranslated regions of mosquito-borne flaviviruses: possible implications for virus transmission
    T S Gritsun
    Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK
    J Gen Virol 87:3297-305. 2006
    ....
  17. ncbi request reprint Genome sequence analysis of Tamana bat virus and its relationship with the genus Flavivirus
    X De Lamballerie
    Unite des Virus Emergents, EA3292 IFR48, Universite de la Mediterranee, Faculte de Medecine, 27 Bd J Moulin, F13005 Marseille, France
    J Gen Virol 83:2443-54. 2002
    ....
  18. ncbi request reprint Biological consequences of deletions within the 3'-untranslated region of flaviviruses may be due to rearrangements of RNA secondary structure
    V Proutski
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, South Parks Road, Oxford, UK
    Virus Res 64:107-23. 1999
    ..The functional significance of certain structural elements and their possible effect on the efficiency of viral replication in different cells are also discussed...
  19. ncbi request reprint The degree of attenuation of tick-borne encephalitis virus depends on the cumulative effects of point mutations
    T S Gritsun
    Institute of Virology and Environmental Microbiology, Mansfield Road, Oxford OX1 3SR, UK
    J Gen Virol 82:1667-75. 2001
    ..In terms of developing flavivirus vaccines, the impact of accumulating apparently minor mutations should be assessed in detail...
  20. ncbi request reprint Complete coding sequence of the Alkhurma virus, a tick-borne flavivirus causing severe hemorrhagic fever in humans in Saudi Arabia
    R N Charrel
    Unité des Virus Emergents EA 3292, Universite de la Mediterranee, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille 13005, France
    Biochem Biophys Res Commun 287:455-61. 2001
    ....
  21. ncbi request reprint Origin and evolution of flavivirus 5'UTRs and panhandles: trans-terminal duplications?
    T S Gritsun
    Centre for Ecology and Hydrology, Mansfield Rd, Oxford, 0X1 3SR, UK
    Virology 366:8-15. 2007
    ..Analysis of the alignments revealed that the panhandles represent evolutionary remnants of a long cyclisation domain that probably emerged through duplication of one of the UTR termini...
  22. ncbi request reprint Louping ill virus envelope protein expressed by recombinant baculovirus and vaccinia virus fails to stimulate protective immunity
    S Y Shiu
    NERC Institute of Virology and Environmental Microbiology, Oxford, UK
    Virus Res 26:213-29. 1992
    ....
  23. ncbi request reprint Tick-borne virus diseases of human interest in Europe
    R N Charrel
    Unite des Virus Emergents, Faculte de Medecine, Marseille, France
    Clin Microbiol Infect 10:1040-55. 2004
    ..Their ability to cause severe disease in man means that these viruses, as well as any clinical samples suspected of containing them, must be handled with specific and stringent precautions...
  24. ncbi request reprint Molecular epidemiology of Rabbit haemorrhagic disease virus
    S R Moss
    Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK
    J Gen Virol 83:2461-7. 2002
    ..The high stability of RHDV RNA is also demonstrated by showing that it can be amplified and sequenced from rabbit bone marrow samples collected at least 7 weeks after the animal has died...
  25. ncbi request reprint The 3' untranslated regions of Kamiti River virus and Cell fusing agent virus originated by self-duplication
    T S Gritsun
    Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK
    J Gen Virol 87:2615-9. 2006
    ..These data provide new insights into the evolution of the flavivirus 3'UTR...
  26. ncbi request reprint Evolution of the Japanese encephalitis serocomplex viruses
    E A Gould
    Institute of Virology and Environmental Microbiology, Mansfield Road, Oxford, OX1 3SR, UK
    Curr Top Microbiol Immunol 267:391-404. 2002
  27. ncbi request reprint The 3' untranslated region of tick-borne flaviviruses originated by the duplication of long repeat sequences within the open reading frame
    T S Gritsun
    Centre for Ecology and Hydrology, Mansfield Rd, Oxford 0X1 3SR, UK
    Virology 354:217-23. 2006
    ..We propose that the 3'UTR, and possibly the open reading frame, evolved through multiple duplications, deletions and mutations of a primordial sequence element...
  28. ncbi request reprint Direct repeats in the flavivirus 3' untranslated region; a strategy for survival in the environment?
    T S Gritsun
    Centre for Ecology and Hydrology, Mansfield Rd, Oxford 0X1 3SR, UK
    Virology 358:258-65. 2007
    ..We propose that short DRs represent the evolutionary remnants of LRSs rather than distinct molecular duplications. The relevance of DRs to virus replication enhancer function, and thus survival, is discussed...
  29. ncbi request reprint Molecular epidemiology of dengue virus type 3 in Venezuela
    N Y Uzcategui
    Centre for Ecology and Hydrology CEH Oxford, Formerly the Institute of Virology and Environmental Microbiology, Mansfield Road, UK
    J Gen Virol 84:1569-75. 2003
    ..Finally, no evidence of the re-emergence of the strain that circulated in Venezuela in the late 1960s and 1970s (genotype V) was found...
  30. doi request reprint The European Virus Archive: a new resource for virology research
    E A Gould
    Unite des Virus Emergents, Faculte de Medecine Timone, 5ème étage Aile Bleu, 27, Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Antiviral Res 95:167-71. 2012
    ..Organizations or individuals who would like to be considered as contributors are invited to contact the EVA coordinator, Jean-Louis Romette, at jean-louis.romette@univmed.fr...
  31. ncbi request reprint Cytotoxic T-cell activity is not detectable in Venezuelan equine encephalitis virus-infected mice
    L D Jones
    CEH Institute of Virology, Mansfield Road, OX1 3SR, Oxford, UK
    Virus Res 91:255-9. 2003
    ..These data suggest that VEEV infection of mice does not elicit detectable CTL activity, and that CTL are unlikely to play a role in protection against virulent VEEV...
  32. ncbi request reprint Phylogeny of the genus flavivirus using complete coding sequences of arthropod-borne viruses and viruses with no known vector
    F Billoir
    Laboratoire de Virologie Moleculaire, Tropicale et Transfusionnelle, Unite des Virus Emergents, Faculte de Medecine de Marseille, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    J Gen Virol 81:781-90. 2000
    ..In contrast, branching patterns at the deeper nodes of the tree were different from those reported in the previous study of NS5 sequences. The significance of these observations is discussed...
  33. ncbi request reprint Tick-borne encephalitis
    T S Gritsun
    CEH Institute of Virology and Environmental Microbiology, Mansfield Road, Oxford OX1 3SR, UK
    Antiviral Res 57:129-46. 2003
    ..This review also contains a brief history of vaccination against TBE including trials with live attenuated vaccine and modern tendencies in developing of vaccine virus strains...
  34. ncbi request reprint Detection of Louping ill virus in clinical specimens from mammals and birds using TaqMan RT-PCR
    L Marriott
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Virol Methods 137:21-8. 2006
    ....
  35. ncbi request reprint Molecular epidemiology of dengue type 2 virus in Venezuela: evidence for in situ virus evolution and recombination
    N Y Uzcategui
    Centre for Ecology and Hydrology (CEH) Oxford, Oxford OX1 3SR, UK
    J Gen Virol 82:2945-53. 2001
    ....
  36. ncbi request reprint Rapid subgroup identification of the flaviviruses using degenerate primer E-gene RT-PCR and site specific restriction enzyme analysis
    M W Gaunt
    Pathogen Molecular Biology and Biochemistry Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    J Virol Methods 128:113-27. 2005
    ..Ninety percent of the known vector-borne flaviviruses with published full length E-gene sequences could be identified within 10 h...
  37. ncbi request reprint Recombination in rabbit haemorrhagic disease virus: possible impact on evolution and epidemiology
    N L Forrester
    Centre for Ecology and Hydrology, formerly Institute of Virology Mansfield Road Oxford OX1 3SR, United Kingdom
    Virology 376:390-6. 2008
    ..These observations imply that recombination may play a significant role in the evolution, epidemiology and diversity of RHDV...
  38. pmc The relationships between West Nile and Kunjin viruses
    J H Scherret
    Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia
    Emerg Infect Dis 7:697-705. 2001
    ..Our results suggest that KUN and WN viruses comprise a group of closely related viruses that can be differentiated into subgroups on the basis of genetic and antigenic analyses...
  39. ncbi request reprint Evolution of base composition and codon usage bias in the genus Flavivirus
    G M Jenkins
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    J Mol Evol 52:383-90. 2001
    ....
  40. ncbi request reprint The VIZIER project: preparedness against pathogenic RNA viruses
    B Coutard
    Architecture et Fonction des Macromolecules Biologiques, CNRS, and Universités d Aix Marseille I et II, UMR 6098, ESIL case 925, 13288 Marseille Cedex 09, France
    Antiviral Res 78:37-46. 2008
    ....
  41. pmc Characterization of a siberian virus isolated from a patient with progressive chronic tick-borne encephalitis
    T S Gritsun
    CEH Institute of Virology and Environmental Microbiology, Oxford OX1 3SR, United Kingdom
    J Virol 77:25-36. 2003
    ..These studies suggest that the patient from whom Za virus was isolated died due to increased pathogenicity of the latent virus following spontaneous mutagenesis...
  42. ncbi request reprint Characterization of tick-borne encephalitis virus-specific human T lymphocyte responses by stimulation with structural TBEV proteins expressed in a recombinant baculovirus
    I Gomez
    Institute for Biomedical Ageing Research, Austrian Academy of Sciences, Innsbruck, Austria
    Viral Immunol 16:407-14. 2003
    ..These lines were CD4+ and had a TH0 cytokine production pattern. Our results demonstrate the utility of recombinant viral proteins to study the generation and characterization of TBEV specific T cell responses...
  43. ncbi request reprint Dengue virus type 2 in Cuba, 1997: conservation of E gene sequence in isolates obtained at different times during the epidemic
    R Rodriguez-Roche
    Department of Virology, PAHO WHO Collaborating Center for Viral Diseases, Pedro Kouri Tropical Medicine Institute, Havana, Cuba
    Arch Virol 150:415-25. 2005
    ..This "American/Asian" genotype has therefore gradually dispersed across the Caribbean region during the past 5 years...
  44. ncbi request reprint Pseudocowpox virus: the etiological agent of contagious ecthyma (Auzdyk) in camels (Camelus dromedarius) in the Arabian peninsula
    M I Abubakr
    West Riffa, Kingdom of Bahrain
    Vector Borne Zoonotic Dis 7:257-60. 2007
    ..The phylogeny also demonstrated that PCPV in Arabian camels was phylogenetically distinct from, and circulates independently of, ruminant-associated PCPV from Europe...
  45. ncbi request reprint Origin and evolution of 3'UTR of flaviviruses: long direct repeats as a basis for the formation of secondary structures and their significance for virus transmission
    T S Gritsun
    Centre for Ecology and Hydrology, Oxford, 0X1 3SR, United Kingdom
    Adv Virus Res 69:203-48. 2007
    ..The relevance of these flavivirus DRs to evolution, diversity, 3'UTR enhancer function, and virus transmission is reviewed...
  46. pmc Epidemiology of rabbit haemorrhagic disease virus in the United Kingdom: evidence for seasonal transmission by both virulent and avirulent modes of infection
    P J White
    Institute of Biological Science, University of Stirling, Stirling FK9 4LA, UK
    Epidemiol Infect 132:555-67. 2004
    ..These findings suggest that many--perhaps most--strains of RHDV may be propagated through both 'pathogenic' and 'non-pathogenic' modes of behaviour. Transmission occurred predominantly during and just after the breeding season...
  47. ncbi request reprint T cells from elderly persons respond to neoantigenic stimulation with an unimpaired IL-2 production and an enhanced differentiation into effector cells
    I Gomez
    Institute for Biomedical Ageing Research, Austrian Academy of Sciences, Rennweg 10, A 6020 Innsbruck, Austria
    Exp Gerontol 39:597-605. 2004
    ..Rapid generation of effector cells from naïve cells may at least partly counterbalance the decreasing size of the naïve T cell pool in elderly persons...
  48. ncbi request reprint Phylogeny and molecular epidemiology of West Nile and Kunjin viruses
    J H Scherret
    Center for Tropical Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Curr Top Microbiol Immunol 267:373-90. 2002
  49. ncbi request reprint Comparative analysis of the NS 1 gene sequences of dengue-1 viruses prototype Hawaii strain and Thai isolate TH-Sman, and determination of the intratypic variation of NS 1 protein among dengue-1 viruses
    S Y Shiu
    Department of Microbiology, University of Hong Kong
    Arch Virol 131:447-54. 1993
    ..1% to 3.1% difference in the NS 1 protein among dengue-1 strains, which is comparable to that reported for dengue-1 envelope protein (0.2% to 3.6% difference) but less than that of dengue-2 NS 1 protein (0.6% to 7.4% difference)...
  50. ncbi request reprint Susceptibility of mosquito and tick cell lines to infection with various flaviviruses
    C H Lawrie
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, UK
    Med Vet Entomol 18:268-74. 2004
    ....