R Borrow

Summary

Affiliation: Central Public Health Laboratory
Country: UK

Publications

  1. ncbi request reprint Comparison of antibody kinetics following meningococcal serogroup C conjugate vaccine between healthy adults previously vaccinated with meningococcal A/C polysaccharide vaccine and vaccine-naïve controls
    R Borrow
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Nell Lane, West Didsbury, M20 2LR, Manchester, UK
    Vaccine 19:3043-50. 2001
  2. pmc Serological basis for use of meningococcal serogroup C conjugate vaccines in the United Kingdom: reevaluation of correlates of protection
    R Borrow
    PHLS Meningococcal Reference Unit, Withington Hospital, Manchester M20 2LR, London NW9 5EQ, United Kingdom
    Infect Immun 69:1568-73. 2001
  3. ncbi request reprint Reduced antibody response to revaccination with meningococcal serogroup A polysaccharide vaccine in adults
    R Borrow
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Nell Lane, West Didsbury, M20 2LR, Manchester, UK
    Vaccine 19:1129-32. 2000
  4. ncbi request reprint Prevalence of de-O-acetylated serogroup C meningococci before the introduction of meningococcal serogroup C conjugate vaccines in the United Kingdom
    R Borrow
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Nell Lane, West Didsbury, M20 2LR, Manchester, UK
    FEMS Immunol Med Microbiol 28:189-91. 2000
  5. ncbi request reprint Meningococcal serogroup C-specific IgG antibody responses and serum bactericidal titres in children following vaccination with a meningococcal A/C polysaccharide vaccine
    R Borrow
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Nell Lane, Manchester, UK
    FEMS Immunol Med Microbiol 28:79-85. 2000
  6. ncbi request reprint Evaluation of the Applied Biosystems automated Taqman polymerase chain reaction system for the detection of meningococcal DNA
    M Guiver
    Meningococcal Reference Unit, Withington Hospital, Nell Lane, Manchester, UK
    FEMS Immunol Med Microbiol 28:173-9. 2000
  7. pmc Evaluation of De-O-acetylated meningococcal C polysaccharide-tetanus toxoid conjugate vaccine in infancy: reactogenicity, immunogenicity, immunologic priming, and bactericidal activity against O-acetylated and De-O-acetylated serogroup C strains
    P Richmond
    Immunisation Division, Communicable Disease Surveillance Centre, Public Health Laboratory Service, London NW9 5EQ, United Kingdom
    Infect Immun 69:2378-82. 2001
  8. pmc Serologic responses to ACYW135 polysaccharide meningococcal vaccine in Saudi children under 5 years of age
    Y Al-Mazrou
    Meningococcal Reference Unit, HPA North West Laboratory, Manchester Royal Infirmary, Manchester, United Kingdom
    Infect Immun 73:2932-9. 2005
  9. ncbi request reprint Influence of prior meningococcal C polysaccharide vaccination on the response and generation of memory after meningococcal C conjugate vaccination in young children
    R Borrow
    Public Health Laboratory Service Meningococcal Reference Unit, Withington Hospital, Manchester, United Kingdom
    J Infect Dis 184:377-80. 2001
  10. ncbi request reprint Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory
    P Richmond
    Immunisation Division, Communicable Disease Surveillance Centre, Public Health Laboratory Service PHLS, London NW9 5EQ, United Kingdom
    J Infect Dis 179:1569-72. 1999

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Comparison of antibody kinetics following meningococcal serogroup C conjugate vaccine between healthy adults previously vaccinated with meningococcal A/C polysaccharide vaccine and vaccine-naïve controls
    R Borrow
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Nell Lane, West Didsbury, M20 2LR, Manchester, UK
    Vaccine 19:3043-50. 2001
    ..Putative protective SBA titres (> or =8, 32 or 128) were observed by day 10 following MCC vaccination regardless of MACP history...
  2. pmc Serological basis for use of meningococcal serogroup C conjugate vaccines in the United Kingdom: reevaluation of correlates of protection
    R Borrow
    PHLS Meningococcal Reference Unit, Withington Hospital, Manchester M20 2LR, London NW9 5EQ, United Kingdom
    Infect Immun 69:1568-73. 2001
    ..These results indicated that the majority of toddlers with an rSBA titer between 8 and 64, and some of those with an hSBA result of <4, have mounted a protective immune response with the induction of immunological memory...
  3. ncbi request reprint Reduced antibody response to revaccination with meningococcal serogroup A polysaccharide vaccine in adults
    R Borrow
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Nell Lane, West Didsbury, M20 2LR, Manchester, UK
    Vaccine 19:1129-32. 2000
    ..Repeated vaccination with MACP vaccine may be ineffective and development and use of meningococcal serogroup A conjugate vaccines should be encouraged...
  4. ncbi request reprint Prevalence of de-O-acetylated serogroup C meningococci before the introduction of meningococcal serogroup C conjugate vaccines in the United Kingdom
    R Borrow
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Nell Lane, West Didsbury, M20 2LR, Manchester, UK
    FEMS Immunol Med Microbiol 28:189-91. 2000
    ..The acetylation status of serogroup C isolates needs to be monitored throughout and after the introduction of MCC vaccines...
  5. ncbi request reprint Meningococcal serogroup C-specific IgG antibody responses and serum bactericidal titres in children following vaccination with a meningococcal A/C polysaccharide vaccine
    R Borrow
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Nell Lane, Manchester, UK
    FEMS Immunol Med Microbiol 28:79-85. 2000
    ..The importance of standardised assays is paramount at a time where immunogenicity trials are replacing efficacy trials for the introduction of MCC vaccines...
  6. ncbi request reprint Evaluation of the Applied Biosystems automated Taqman polymerase chain reaction system for the detection of meningococcal DNA
    M Guiver
    Meningococcal Reference Unit, Withington Hospital, Nell Lane, Manchester, UK
    FEMS Immunol Med Microbiol 28:173-9. 2000
    ..The developed Taqman assays for the diagnosis of meningococcal disease enables a high throughput, rapid turnaround of samples with considerable reduced risk of contamination...
  7. pmc Evaluation of De-O-acetylated meningococcal C polysaccharide-tetanus toxoid conjugate vaccine in infancy: reactogenicity, immunogenicity, immunologic priming, and bactericidal activity against O-acetylated and De-O-acetylated serogroup C strains
    P Richmond
    Immunisation Division, Communicable Disease Surveillance Centre, Public Health Laboratory Service, London NW9 5EQ, United Kingdom
    Infect Immun 69:2378-82. 2001
    ..MCC-TT vaccine is highly immunogenic and primes for immunologic memory against OAc+ and OAc- MenC strains in infancy...
  8. pmc Serologic responses to ACYW135 polysaccharide meningococcal vaccine in Saudi children under 5 years of age
    Y Al-Mazrou
    Meningococcal Reference Unit, HPA North West Laboratory, Manchester Royal Infirmary, Manchester, United Kingdom
    Infect Immun 73:2932-9. 2005
    ..However, for menC and menW poor levels of putative protection were still evident at 4 years of age...
  9. ncbi request reprint Influence of prior meningococcal C polysaccharide vaccination on the response and generation of memory after meningococcal C conjugate vaccination in young children
    R Borrow
    Public Health Laboratory Service Meningococcal Reference Unit, Withington Hospital, Manchester, United Kingdom
    J Infect Dis 184:377-80. 2001
    ....
  10. ncbi request reprint Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory
    P Richmond
    Immunisation Division, Communicable Disease Surveillance Centre, Public Health Laboratory Service PHLS, London NW9 5EQ, United Kingdom
    J Infect Dis 179:1569-72. 1999
    ..01) than in the 2-microgram dose cohort but were lower after polysaccharide boosting (P=.02). This meningococcal conjugate vaccine was well tolerated and immunogenic and induced immunologic memory in infants...
  11. pmc Contamination and sensitivity issues with a real-time universal 16S rRNA PCR
    C E Corless
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester M20 2LR, United Kingdom
    J Clin Microbiol 38:1747-52. 2000
    ....
  12. ncbi request reprint IgG antibody subclass responses determined by immunoblot in infants' sera following vaccination with a meningococcal recombinant hexavalent PorA OMV vaccine
    S Martin
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Nell Lane, West Didsbury, M20 2LR, Manchester, UK
    Vaccine 19:4404-8. 2001
    ..The recombinant hexavalent PorA OMV vaccine stimulates both IgG(1) and IgG(3) subclass antibodies, the subclasses that are most effective in activating the complement system...
  13. ncbi request reprint siaD PCR ELISA for confirmation and identification of serogroup Y and W135 meningococcal infections
    R Borrow
    Manchester Public Health Laboratory, Withington Hospital, Didsbury, UK
    FEMS Microbiol Lett 159:209-14. 1998
    ..The serogroup-specific W135 and Y PCR ELISA is a useful addition to currently available serogroup B and C assay for non-culture diagnosis of meningococcal infection and outbreak investigation...
  14. ncbi request reprint Analysis of the human Ig isotype response to individual transferrin binding proteins A and B from Neisseria meningitidis
    A S Johnson
    Manchester Public Health Laboratory, Withington Hospital, UK
    FEMS Immunol Med Microbiol 19:159-67. 1997
    ..The variability of immune responses to each Tbp from the two strains suggests that a successful vaccine would need to include TbpA and TbpB from a number of strains...
  15. pmc Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR
    C E Corless
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester M20 2LR, United Kingdom
    J Clin Microbiol 39:1553-8. 2001
    ..The ctrA primer set used in the multiplex PCR was found to be more sensitive (P < 0.0001) than the ctrA primers that had been used for meningococcal PCR testing at that time...
  16. pmc Measurement and interpretation of pneumococcal IgG levels for clinical management
    P Balmer
    Manchester Public Health Laboratory, Withington Hospital, Manchester, UK
    Clin Exp Immunol 133:364-9. 2003
    ..A tool that allows the interpretation of the results of the serotype-specific assay is provided and its potential for assessing individual susceptibility levels to vaccine preventable pneumococcal infection is discussed...
  17. ncbi request reprint Impact of meningococcal C conjugate vaccine in the UK
    P Balmer
    Meningococcal Reference Unit, Manchester PHL, Withington Hospital
    J Med Microbiol 51:717-22. 2002
    ..Surveillance of the genotypic and phenotypic characteristics of invasive and carriage isolates has shown no evidence to date of capsular switching from serogroup C to serogroup B...
  18. pmc Genetic analysis of capsular status of meningococcal carrier isolates
    F Sadler
    PHLS Meningococcal Reference Unit, Public Health Laboratory, Withington Hospital, Manchester M20 2LR
    Epidemiol Infect 130:59-70. 2003
    ..This as implications for assessment of the benefits of mass antibiotic and vaccination programmes for outbreak control. Previously expressed concerns of increased risk due to removal of protective ora may have been overstated...
  19. ncbi request reprint Immunogenicity of one, two or three doses of a meningococcal C conjugate vaccine conjugated to tetanus toxoid, given as a three-dose primary vaccination course in UK infants at 2, 3 and 4 months of age with acellular pertussis-containing DTP/Hib vaccine
    J Southern
    Immunisation Department, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    Vaccine 24:215-9. 2006
    ..These results suggest that a reduced number of doses of MCC-TT would be adequate in infancy if given concomitantly with an acellular pertussis-containing vaccine...
  20. pmc Failure of antibody response to polysaccharide antigen in treated panhypopituitary adults
    A Mukherjee
    Department of Endocrinology, Christie Hospital, Manchester, UK
    Clin Exp Immunol 156:271-7. 2009
    ..Significant humoral immune deficiency is seen in panhypopituitarism and may contribute to morbidity...
  21. pmc Investigation of different group A immunoassays following one dose of meningococcal group A conjugate vaccine or A/C polysaccharide vaccine in adults
    H Findlow
    Vaccine Evaluation Unit, Health Protection Agency North West, Clinical Sciences Building, Manchester Royal Infirmary, Manchester, UK
    Clin Vaccine Immunol 16:969-77. 2009
    ..The two OPA methods correlated weakly and achieved only a low correlation with the other immunoassays. The correlation between hSBA and group A-specific IgG was higher for the PsA-TT group than for the PsA/C group...
  22. ncbi request reprint Analysis of the human Ig isotype response to lactoferrin binding protein A from Neisseria meningitidis
    A S Johnson
    Manchester Public Health Laboratory, Withington Hospital, UK
    FEMS Immunol Med Microbiol 25:349-54. 1999
    ..This study demonstrates that LbpA does not induce a highly cross-reactive antibody response, indicating that it is unlikely to be an effective vaccine antigen...
  23. ncbi request reprint Genotyping of Enterocytozoon bieneusi in AIDS patients from the north west of England
    F Sadler
    Manchester Public Health Laboratory, Withington Hospital, Manchester, UK
    J Infect 44:39-42. 2002
    ..In this study Enterocytozoon bieneusi -positive faeces samples from AIDS patients in the north west of England were investigated by polymerase chain reaction (PCR) and DNA sequencing for potential zoonotic origins...
  24. ncbi request reprint An interleukin-1 genotype is associated with fatal outcome of meningococcal disease
    R C Read
    1Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, and 2Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester, United Kingdom
    J Infect Dis 182:1557-60. 2000
    ..018; OR, 7.78 [95% CI, 1. 05-59.05]). There was no association between TNF genotype and fatal outcome. These data suggest that IL-1 genotype influences the severity of meningococcal disease...