S Zammit

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint No association between schizophrenia and polymorphisms in COMT in two large samples
    Hywel J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 162:1736-8. 2005
  2. ncbi request reprint Stressful life events, 5-HTT genotype and risk of depression
    Stanley Zammit
    Br J Psychiatry 188:199-201. 2006
  3. pmc IQ and non-clinical psychotic symptoms in 12-year-olds: results from the ALSPAC birth cohort
    Jeremy Horwood
    Department of Social Medicine, University of Bristol, UK
    Br J Psychiatry 193:185-91. 2008
  4. pmc Cannabis use and depression: a longitudinal study of a national cohort of Swedish conscripts
    Edison Manrique-Garcia
    Department of Public Health Sciences, Division of Social Medicine, Karolinska Institutet, Norrbacka floor 6, Stockholm, S 17176, Sweden
    BMC Psychiatry 12:112. 2012
  5. ncbi request reprint Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study
    Stanley Zammit
    MRC Center for Neuropsychiatric Genetics and Genomics, Cardiff University, UK
    Am J Psychiatry 170:742-50. 2013
  6. doi request reprint A population-based study of shared genetic variation between premorbid IQ and psychosis among male twin pairs and sibling pairs from Sweden
    Tom Fowler
    Unit of Urologic and Genetic Epidemiology, University of Birmingham, and Heart of Birmingham Teaching Primary Care Trust, Birmingham, England
    Arch Gen Psychiatry 69:460-6. 2012
  7. ncbi request reprint A longitudinal study of premorbid IQ Score and risk of developing schizophrenia, bipolar disorder, severe depression, and other nonaffective psychoses
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales
    Arch Gen Psychiatry 61:354-60. 2004
  8. ncbi request reprint Examining interactions between risk factors for psychosis
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, UK
    Br J Psychiatry 197:207-11. 2010
  9. doi request reprint Misconceptions about gene-environment interactions in psychiatry
    Stanley Zammit
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, UK
    Evid Based Ment Health 13:65-8. 2010
  10. ncbi request reprint Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    J Psychiatr Res 40:622-6. 2006

Collaborators

Detail Information

Publications53

  1. ncbi request reprint No association between schizophrenia and polymorphisms in COMT in two large samples
    Hywel J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 162:1736-8. 2005
    ..The authors examined these hypotheses...
  2. ncbi request reprint Stressful life events, 5-HTT genotype and risk of depression
    Stanley Zammit
    Br J Psychiatry 188:199-201. 2006
    ..In this issue of the Journal an Australian study reports evidence of such an interaction on risk of depression. We discuss findings in this field in the context of the limitations inherent in studies of gene-environment interactions...
  3. pmc IQ and non-clinical psychotic symptoms in 12-year-olds: results from the ALSPAC birth cohort
    Jeremy Horwood
    Department of Social Medicine, University of Bristol, UK
    Br J Psychiatry 193:185-91. 2008
    ..There is a well-established association between pre-morbid low IQ score and schizophrenia. Psychosis-like symptoms in children may also be a risk factor for psychotic disorder but their relationship with IQ is unclear...
  4. pmc Cannabis use and depression: a longitudinal study of a national cohort of Swedish conscripts
    Edison Manrique-Garcia
    Department of Public Health Sciences, Division of Social Medicine, Karolinska Institutet, Norrbacka floor 6, Stockholm, S 17176, Sweden
    BMC Psychiatry 12:112. 2012
    ..We aim to assess whether risk of depression and other affective outcomes is increased among cannabis users...
  5. ncbi request reprint Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study
    Stanley Zammit
    MRC Center for Neuropsychiatric Genetics and Genomics, Cardiff University, UK
    Am J Psychiatry 170:742-50. 2013
    ....
  6. doi request reprint A population-based study of shared genetic variation between premorbid IQ and psychosis among male twin pairs and sibling pairs from Sweden
    Tom Fowler
    Unit of Urologic and Genetic Epidemiology, University of Birmingham, and Heart of Birmingham Teaching Primary Care Trust, Birmingham, England
    Arch Gen Psychiatry 69:460-6. 2012
    ..However, research in this area has generally used designs in which twin pairs are selected by case status and with assessment of IQ after the onset of psychosis rather than longitudinal population-based samples...
  7. ncbi request reprint A longitudinal study of premorbid IQ Score and risk of developing schizophrenia, bipolar disorder, severe depression, and other nonaffective psychoses
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales
    Arch Gen Psychiatry 61:354-60. 2004
    ..To our knowledge, there are no prior population-based, longitudinal studies of premorbid IQ score and risk of developing severe depression requiring hospital admission...
  8. ncbi request reprint Examining interactions between risk factors for psychosis
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, UK
    Br J Psychiatry 197:207-11. 2010
    ..For complex multifactorial diseases it seems likely that co-exposure to two risk factors will show a greater than additive relationship on disease risk...
  9. doi request reprint Misconceptions about gene-environment interactions in psychiatry
    Stanley Zammit
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, UK
    Evid Based Ment Health 13:65-8. 2010
    ..In this article we discuss why, despite frequent claims to the contrary, studies of gene-environment interactions are very unlikely to enhance our understanding of disease aetiology or prevention...
  10. ncbi request reprint Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    J Psychiatr Res 40:622-6. 2006
    ....
  11. doi request reprint Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring
    Stanley Zammit
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK
    Br J Psychiatry 195:294-300. 2009
    ..Adverse effects of maternal substance use during pregnancy on fetal development may increase risk of psychopathology...
  12. ncbi request reprint Investigating if psychosis-like symptoms (PLIKS) are associated with family history of schizophrenia or paternal age in the ALSPAC birth cohort
    Stanley Zammit
    The Academic Unit of Psychiatry, University of Bristol, Bristol, UK
    Schizophr Res 104:279-86. 2008
    ..Whether future studies of PLIKS will increase our understanding of mechanisms underlying the development of schizophrenia, or prove useful in prediction of this disorder, remains to be seen...
  13. ncbi request reprint Investigating whether adverse prenatal and perinatal events are associated with non-clinical psychotic symptoms at age 12 years in the ALSPAC birth cohort
    S Zammit
    Academic Unit of Psychiatry, University of Bristol, UK
    Psychol Med 39:1457-67. 2009
    ....
  14. doi request reprint Effects of cannabis use on outcomes of psychotic disorders: systematic review
    Stanley Zammit
    Academic Unit of Psychiatry, University of Bristol, UK
    Br J Psychiatry 193:357-63. 2008
    ..It is unclear if research findings support clinical opinion that cannabis use leads to worse outcomes in people with psychosis, or whether this impression is confounded by other factors...
  15. pmc Schizophrenia and neural tube defects: comparisons from an epidemiological perspective
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Schizophr Bull 33:853-8. 2007
    ....
  16. ncbi request reprint Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 191:402-7. 2007
    ..Genetic variations might modify associations between schizophrenia and cannabis or tobacco use...
  17. ncbi request reprint Individuals, schools, and neighborhood: a multilevel longitudinal study of variation in incidence of psychotic disorders
    Stanley Zammit
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Wales, UK
    Arch Gen Psychiatry 67:914-22. 2010
    ..Few studies have examined whether both individual and neighborhood characteristics can explain this association. Furthermore, as has been shown for ethnicity, the effect of individual characteristics may depend on neighborhood context...
  18. ncbi request reprint Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 128:19-20. 2004
    ..These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior...
  19. ncbi request reprint Cannabis, COMT and psychotic experiences
    Stanley Zammit
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Psychiatry 199:380-5. 2011
    ..A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transferase (COMT) gene on psychosis has been reported, but not adequately replicated...
  20. ncbi request reprint Paternal age and risk for schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Br J Psychiatry 183:405-8. 2003
    ....
  21. ncbi request reprint Investigating the association between cigarette smoking and schizophrenia in a cohort study
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 160:2216-21. 2003
    ..Here, the authors investigated whether cigarette smoking alters the risk of subsequently developing schizophrenia. No longitudinal studies have previously examined this relationship...
  22. pmc Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: historical cohort study
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN
    BMJ 325:1199. 2002
    ..We performed a further analysis of this cohort to address these uncertainties while extending the follow up period to identify additional cases...
  23. pmc Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes
    M L Hamshere
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, CF14 4XN, UK
    J Med Genet 43:563-7. 2006
    ..Schizophrenia shows substantial clinical heterogeneity. One common important clinical variable in presentation is the occurrence of episodes of major depression...
  24. ncbi request reprint Screening the human protocadherin 8 (PCDH8) gene in schizophrenia
    N J Bray
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Genes Brain Behav 1:187-91. 2002
    ..These results suggest that any contribution of PCDH8 polymorphisms to schizophrenia susceptibility is likely to be weak, although the existence of rare variations of stronger effect cannot be excluded...
  25. ncbi request reprint Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1)
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales
    Arch Gen Psychiatry 61:336-44. 2004
    ..Recent research suggests that variation in the gene encoding dystrobrevin binding protein (DTNBP1) confers susceptibility to schizophrenia. Thus far, no specific risk haplotype has been identified in more than 1 study...
  26. ncbi request reprint Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia
    H J Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 120:42-6. 2003
    ..05 level. These results do not suggest that PRODH or PsPRODH contribute to the aetiology of schizophrenia, and that the putative schizophrenia susceptibility gene in 22q11 remains unknown...
  27. ncbi request reprint Mutation screening of the Homer gene family and association analysis in schizophrenia
    N Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 120:18-21. 2003
    ..05). Our results suggest it is unlikely that sequence variants in the Homer genes contribute to the aetiology of schizophrenia, but the variants we identified are plausible candidates for other neuropsychiatric phenotypes...
  28. pmc Association of measures of fetal and childhood growth with non-clinical psychotic symptoms in 12-year-olds: the ALSPAC cohort
    K Thomas
    Department of Social Medicine, University of Bristol, Bristol BS8 2PS, UK
    Br J Psychiatry 194:521-6. 2009
    ....
  29. pmc Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
    M C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 14:30-6. 2009
    ..17 (95% CI 1.06-1.29), P=0.0009). The SNP maps 85 kb from the nearest gene encoding fibroblast growth factor receptor 2 (FGFR2) making this a potential susceptibility gene for schizophrenia...
  30. pmc A systematic genomewide linkage study in 353 sib pairs with schizophrenia
    N M Williams
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Hum Genet 73:1355-67. 2003
    ..02) to 17p11.2-q25.1 in a single pedigree with schizophrenia. In our view, the evidence is now sufficiently compelling to undertake detailed mapping studies of these three regions...
  31. ncbi request reprint Height and body mass index in young adulthood and risk of schizophrenia: a longitudinal study of 1 347 520 Swedish men
    S Zammit
    Department of Psychological Medicine, Cardiff University, UK
    Acta Psychiatr Scand 116:378-85. 2007
    ..Measures of body size reflect genetic and environmental influences on growth and energy balance. Associations between such measures and risk of schizophrenia have been inconsistent...
  32. ncbi request reprint IGF1, growth pathway polymorphisms and schizophrenia: a pooling study
    D Gunnell
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    Am J Med Genet B Neuropsychiatr Genet 144:117-20. 2007
    ..SNP coverage of IGF1 was extensive, so our findings do not support a major role for IGF-I in the aetiology of schizophrenia...
  33. pmc Age- and puberty-dependent association between IQ score in early childhood and depressive symptoms in adolescence
    B Glaser
    The MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK
    Psychol Med 41:333-43. 2011
    ..Our study examines the relationship between total intelligence quotient (IQ) score at age 8 years, and depressive symptoms at 11, 13, 14 and 17 years...
  34. pmc Perinatal folate-related exposures and risk of psychotic symptoms in the ALSPAC birth cohort
    B Glaser
    The MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK
    Schizophr Res 120:177-83. 2010
    ..Our study examines the relationships between multiple determinants of perinatal folate-status and development of psychotic experiences in adolescence...
  35. ncbi request reprint Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales CF14 4XN, UK
    Mol Psychiatry 8:485-7. 2003
    ..6%; P=0.019). Our results therefore replicate the Icelandic findings in an out-bred Northern European population, although they suggest that the risk conferred by the haplotype is small...
  36. ncbi request reprint Birth order and the severity of illness in schizophrenia
    Fiona Gaughran
    Department of Psychological Medicine, King s College London, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, United Kingdom
    Psychiatry Res 150:205-10. 2007
    ..Further work is needed to explore the possibility of maternal-foetal genotype incompatibility as a risk factor for schizophrenia...
  37. ncbi request reprint Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype
    G Jones
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales, UK
    Br J Psychiatry 179:351-5. 2001
    ..Although the aetiology of aggression is multifactorial, three studies have reported associations between polymorphisms of the catechol-O-methyltransferase (COMT) gene and aggression in schizophrenia...
  38. ncbi request reprint Characterisation, mutation detection, and association analysis of alternative promoters and 5' UTRs of the human dopamine D3 receptor gene in schizophrenia
    R J Anney
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Mol Psychiatry 7:493-502. 2002
    ..The results from this study imply that neither the coding nor the regulatory region of DRD3 plays a major role in predisposition to schizophrenia...
  39. ncbi request reprint Cannabis and suicide: longitudinal study
    Ceri Price
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Psychiatry 195:492-7. 2009
    ..Some studies suggest that cannabis use is associated with suicidal ideation, but no detailed longitudinal study has examined suicide as an outcome...
  40. ncbi request reprint Support for RGS4 as a susceptibility gene for schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:192-5. 2004
    ..Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples...
  41. ncbi request reprint Self-reported psychotic symptoms in the general population: results from the longitudinal study of the British National Psychiatric Morbidity Survey
    Nicola J Wiles
    Academic Unit of Psychiatry, Department of Community Based Medicine, University of Bristol, The Grange, 1 Woodland Road, Bristol BS8 1AU, UK
    Br J Psychiatry 188:519-26. 2006
    ..Scarce longitudinal data exist on the occurrence of psychotic symptoms in the general population...
  42. pmc Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 103:12469-74. 2006
    ..Our data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function...
  43. doi request reprint Identification of loci associated with schizophrenia by genome-wide association and follow-up
    Michael C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 40:1053-5. 2008
    ..Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9))...
  44. pmc No evidence for association between polymorphisms in GRM3 and schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff, UK
    BMC Psychiatry 5:23. 2005
    ..Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3...
  45. doi request reprint Individual- and area-level influence on suicide risk: a multilevel longitudinal study of Swedish schoolchildren
    S Zammit
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK
    Psychol Med 44:267-77. 2014
    ..No studies have examined whether area characteristics during childhood are associated with subsequent suicide, or whether risk associated with individual characteristics varies according to childhood neighbourhood context...
  46. ncbi request reprint A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 135:2-4. 2005
    ..Larger studies of this issue are required, together with studies of maternal genotype which could identify whether maternal folate status during pregnancy is important...
  47. ncbi request reprint Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
    Theresa H M Moore
    Academic Unit of Psychiatry, University of Bristol, Bristol, UK
    Lancet 370:319-28. 2007
    ..We systematically reviewed the evidence pertaining to cannabis use and occurrence of psychotic or affective mental health outcomes...
  48. ncbi request reprint Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 141:96-101. 2006
    ....
  49. doi request reprint Commentary on 'The case for gene-environment interactions in psychiatry'
    Stanley Zammit
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff UK
    Curr Opin Psychiatry 21:326-7. 2008
  50. ncbi request reprint Common versus psychopathology-specific risk factors for psychotic experiences and depression during adolescence
    D Kounali
    School of Social and Community Medicine, University of Bristol, UK
    Psychol Med 44:2557-66. 2014
    ..However, PEs often co-occur with depression, and no study has explicitly tested whether risk factors for schizophrenia are shared between PEs and depression, or are psychopathology specific, while jointly modelling both outcomes...
  51. doi request reprint Pre-conception inter-pregnancy interval and risk of schizophrenia
    Lihini Gunawardana
    Department of Psychological Medicine and Neurology, Cardiff University, Heath Park, UK
    Br J Psychiatry 199:338-9. 2011
    ..These findings support the hypothesis that folate (or other micronutrient) deficiency during fetal development may be an important risk factor for schizophrenia...
  52. ncbi request reprint Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder
    Nigel M Williams
    Department of Psychological Medicine and Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University
    Arch Gen Psychiatry 63:366-73. 2006
    ..Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association...
  53. ncbi request reprint Exploring the relationship between cannabis use and psychosis
    Stanley Zammit
    Addiction 99:1353-5. 2004