Nigel M Williams

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's disease
    Javier Simon-Sanchez
    Section of Medical Genomics, Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands
    PLoS ONE 7:e28787. 2012
  2. pmc Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3
    Nigel M Williams
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, and School of Medicine, Cardiff University, Cardiff, UK
    Am J Psychiatry 169:195-204. 2012
  3. ncbi request reprint Strong evidence that GNB1L is associated with schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:555-66. 2008
  4. ncbi request reprint Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?
    Nigel M Williams
    Department of Psychological Medicine, Cardiff University, UK
    Schizophr Bull 31:800-5. 2005
  5. pmc Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis
    Nigel M Williams
    MRC Centre in Neuropsychiatric Genetics and Genomics and Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, UK
    Lancet 376:1401-8. 2010
  6. pmc Molecular mechanisms in 22q11 deletion syndrome
    Nigel M Williams
    Department of Psychological Medicine and Neurology, MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Schizophr Bull 37:882-9. 2011
  7. ncbi request reprint Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 7:1092-100. 2002
  8. pmc Analysis of copy number variation using quantitative interspecies competitive PCR
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Nucleic Acids Res 36:e112. 2008
  9. pmc Genome scans and microarrays: converging on genes for schizophrenia?
    Nigel M Williams
    Department of Psychological Medicine, Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    Genome Biol 3:REVIEWS1011. 2002
  10. ncbi request reprint Genetic abnormalities of chromosome 22 and the development of psychosis
    Nigel M Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Curr Psychiatry Rep 6:176-82. 2004

Detail Information

Publications47

  1. pmc Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's disease
    Javier Simon-Sanchez
    Section of Medical Genomics, Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands
    PLoS ONE 7:e28787. 2012
    ..Although there might be other regions of interest apart from chromosome 19p13.3, we lack the power to detect them with this analysis...
  2. pmc Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3
    Nigel M Williams
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, and School of Medicine, Cardiff University, Cardiff, UK
    Am J Psychiatry 169:195-204. 2012
    ..Because of its multifactorial etiology, however, identifying the genes involved has been difficult. The authors followed up on recent findings suggesting that rare copy number variants (CNVs) may be important for ADHD etiology...
  3. ncbi request reprint Strong evidence that GNB1L is associated with schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:555-66. 2008
    ..However, other explanations are possible, and further analyses will be required to clarify the correct functional mechanism...
  4. ncbi request reprint Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?
    Nigel M Williams
    Department of Psychological Medicine, Cardiff University, UK
    Schizophr Bull 31:800-5. 2005
    ....
  5. pmc Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis
    Nigel M Williams
    MRC Centre in Neuropsychiatric Genetics and Genomics and Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, UK
    Lancet 376:1401-8. 2010
    ..We aimed to establish whether burden of CNVs was increased in ADHD, and to investigate whether identified CNVs were enriched for loci previously identified in autism and schizophrenia...
  6. pmc Molecular mechanisms in 22q11 deletion syndrome
    Nigel M Williams
    Department of Psychological Medicine and Neurology, MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Schizophr Bull 37:882-9. 2011
    ....
  7. ncbi request reprint Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 7:1092-100. 2002
    ..35, P = 0.006, P = 0.078 corrected for 13 alleles)...
  8. pmc Analysis of copy number variation using quantitative interspecies competitive PCR
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Nucleic Acids Res 36:e112. 2008
    ....
  9. pmc Genome scans and microarrays: converging on genes for schizophrenia?
    Nigel M Williams
    Department of Psychological Medicine, Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    Genome Biol 3:REVIEWS1011. 2002
    ..Microarray expression analysis may identify new candidate genes and pathways, and a number of intriguing preliminary findings have already been reported...
  10. ncbi request reprint Genetic abnormalities of chromosome 22 and the development of psychosis
    Nigel M Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Curr Psychiatry Rep 6:176-82. 2004
    ..However, although a number of genes have been implicated as possible schizophrenia susceptibility loci, further confirmatory studies are required...
  11. doi request reprint Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    Biol Psychiatry 64:419-27. 2008
    ..We wished to investigate further the involvement of NRG1 in schizophrenia and bipolar disorder...
  12. ncbi request reprint No association between schizophrenia and polymorphisms in COMT in two large samples
    Hywel J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 162:1736-8. 2005
    ..The authors examined these hypotheses...
  13. ncbi request reprint Association analysis of AKT1 and schizophrenia in a UK case control sample
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Res 93:58-65. 2007
    ..Examination of our own data and those of other groups leads us to conclude that overall, the evidence for association of AKT1 as a susceptibility gene for schizophrenia is weakly positive, but not yet convincing...
  14. ncbi request reprint Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder
    Nigel M Williams
    Department of Psychological Medicine and Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University
    Arch Gen Psychiatry 63:366-73. 2006
    ..Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association...
  15. ncbi request reprint Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 141:96-101. 2006
    ....
  16. ncbi request reprint Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia
    Timothy R Peirce
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, Wales
    Arch Gen Psychiatry 63:18-24. 2006
    ..However, it is unclear whether the observed changes in the schizophrenic brain are primary or secondary...
  17. ncbi request reprint Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasis
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
    Am J Med Genet 114:491-6. 2002
    ..Our data, therefore, do not support the hypothesis that genetic variation in MAOA and COMT is involved individually or in combination in the etiology of schizophrenia...
  18. ncbi request reprint Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening
    Sunita Nair
    Institute of Nephrology, School of Medicine, Cardiff University, Cardiff, Wales, UK
    J Nephrol 21:400-5. 2008
    ..The ECM glycosaminoglycan hyaluronan (HA) influences TGF-b1 generation and can modulate its signal transduction activity; renal HA is synthesised by HA synthases HAS2 and HAS3...
  19. ncbi request reprint A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder
    Darko Turic
    Department of Psychological Medicine, Cardiff University, School of Medicine, Heath Park, Cardiff, United Kingdom
    Biol Psychiatry 57:1461-6. 2005
    ..SLC1A3 is thus both a functional and positional candidate gene for ADHD...
  20. pmc No evidence for association between polymorphisms in GRM3 and schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff, UK
    BMC Psychiatry 5:23. 2005
    ..Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3...
  21. ncbi request reprint Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression
    Nicholas J Bray
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, UK
    Hum Mol Genet 14:1947-54. 2005
    ..Our data indicate that variation in the DTNBP1 gene confers susceptibility to schizophrenia through reduced expression, and that this, therefore, represents a primary aetiological mechanism in the disorder...
  22. doi request reprint Identification of loci associated with schizophrenia by genome-wide association and follow-up
    Michael C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 40:1053-5. 2008
    ..Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9))...
  23. doi request reprint Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia
    Marian L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 156:929-40. 2011
    ..At present there are no genome-wide significant linkage results for these phenotypes, but a number of suggestive findings warrant further investigation...
  24. ncbi request reprint No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 58:78-80. 2005
    ..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()...
  25. pmc A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain
    Nicholas J Bray
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, CF14 4XN, Wales, UK
    Am J Hum Genet 73:152-61. 2003
    ....
  26. ncbi request reprint Support for RGS4 as a susceptibility gene for schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:192-5. 2004
    ..Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples...
  27. ncbi request reprint Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria
    George Kirov
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:971-5. 2004
    ..We tried to replicate these findings in a sample of 488 parent-proband trios recruited in Bulgaria. Probands had a diagnosis of schizophrenia (n = 441) or schizoaffective disorder (n = 47)...
  28. ncbi request reprint Identification and analysis of the promoter region of the human hyaluronan synthase 2 gene
    Jamie Monslow
    Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    J Biol Chem 279:20576-81. 2004
    ....
  29. ncbi request reprint Gene copy number variation in schizophrenia
    Smitha R Sutrala
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
    Schizophr Res 96:93-9. 2007
    ..No copy number variations were found for any of the genes in any samples. Our data suggests that more reliable methods need to be used to validate the existence of CNVs before full scale association studies are carried out...
  30. ncbi request reprint Gene copy number variation in schizophrenia
    Smitha R Sutrala
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 147:606-11. 2008
    ....
  31. ncbi request reprint DNA pooling as a tool for large-scale association studies in complex traits
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Ann Med 36:146-52. 2004
    ..Here, we consider the main points in study design, and illustrate the application of pooling using psychiatric phenotypes as an example...
  32. doi request reprint Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease
    Laura L Kilarski
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Neurology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Mov Disord 27:1522-9. 2012
    ..The overall frequency of mutations in known EOPD genes was lower than previously estimated. Our study shows an increased likelihood of mutations in patients with lower AAO, family history, or parental consanguinity...
  33. doi request reprint Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1
    Nicholas J Bray
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:1169-74. 2008
    ..Our data provide complementary evidence for chromosome 8p as a susceptibility locus for schizophrenia, and suggest that genetic variation within this region may influence risk, at least in part, through effects on DTNBP1 expression...
  34. doi request reprint Familial frontotemporal dementia with amyotrophic lateral sclerosis and a shared haplotype on chromosome 9p
    Justin P Pearson
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, CF14 4XN, UK
    J Neurol 258:647-55. 2011
    ..Sequencing of this region did not identify any evidence of a pathogenic exonic mutation. This suggests that the pathogenic change affects non-coding DNA and that the disease is caused by variation in gene or protein expression...
  35. ncbi request reprint Chromosome 22 deletion syndrome and schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, College of Medicine, Cardiff University, Cardiff, United Kingdom
    Int Rev Neurobiol 73:1-27. 2006
  36. pmc Dysbindin-1 and schizophrenia: from genetics to neuropathology
    Michael J Owen
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    J Clin Invest 113:1255-7. 2004
    ..Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia...
  37. ncbi request reprint Recent advances in the genetics of schizophrenia
    Michael C O'Donovan
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
    Hum Mol Genet 12:R125-33. 2003
    ....
  38. ncbi request reprint Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Hum Genet 110:471-8. 2002
    ..Our assay conditions are generalisable, universal, robust and, therefore, for the first time, permit high-throughput association analysis at a realistic cost...
  39. pmc A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease
    Peter Holmans
    Department of Psychological Medicine and Neurology, Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Hum Mol Genet 22:1039-49. 2013
    ....
  40. ncbi request reprint The human hyaluronan synthase genes: genomic structures, proximal promoters and polymorphic microsatellite markers
    Jamie Monslow
    Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Int J Biochem Cell Biol 35:1272-83. 2003
    ..We thus present a comprehensive resource for mutation detection screening of all HAS exons and/or linkage analysis of each HAS gene in a variety of disorders for which they are attractive candidates...
  41. doi request reprint The genetic aetiology of late-onset chronic progressive cerebellar ataxia. A population-based study
    Mark Wardle
    Dept of Neurology, Ophthalmology and Audiological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    J Neurol 256:343-8. 2009
    ..Furthermore, there is marked geographic and ethnic variation in the relative importance of these individual disorders and the cause of such observed variation remains unexplained...
  42. doi request reprint Recent advances in the genetics of the ALS-FTLD complex
    Huw R Morris
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Curr Neurol Neurosci Rep 12:243-50. 2012
    ..The identification of mutations in these genes represents an important step forward in our understanding of the clinical, pathological, and genetic spectrum of ALS/FTLD diseases...
  43. ncbi request reprint Experimental approaches for identifying schizophrenia risk genes
    Kiran K Mantripragada
    Department of Psychological Medicine and Neurology, MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Curr Top Behav Neurosci 4:587-610. 2010
    ..This approach has the potential to provide a clarified picture of the majority of the genetic variation underlying disease pathogenesis...
  44. pmc Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples
    Michael E Talkowski
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 60:152-62. 2006
    ..Yet, similar to other SCZ candidate genes, studies have been inconsistent with respect to the associated alleles...
  45. ncbi request reprint No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:739-41. 2002
    ..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
  46. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
    Cathryn M Lewis
    Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Am J Hum Genet 73:34-48. 2003
    ..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...