Seralynne D Vann

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc Dismantling the Papez circuit for memory in rats
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff, United Kingdom
    elife 2:e00736. 2013
  2. doi request reprint Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: implications for fornix function
    Seralynne D Vann
    School of Psychology, Cardiff University, United Kingdom
    Hippocampus 21:945-57. 2011
  3. pmc Impaired recollection but spared familiarity in patients with extended hippocampal system damage revealed by 3 convergent methods
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff CF10 3AT, United Kingdom
    Proc Natl Acad Sci U S A 106:5442-7. 2009
  4. ncbi request reprint Selective dysgranular retrosplenial cortex lesions in rats disrupt allocentric performance of the radial-arm maze task
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff, United Kingdom
    Behav Neurosci 119:1682-6. 2005
  5. doi request reprint Hippocampus and neocortex: recognition and spatial memory
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff, UK
    Curr Opin Neurobiol 21:440-5. 2011
  6. doi request reprint Memory loss resulting from fornix and septal damage: impaired supra-span recall but preserved recognition over a 24-hour delay
    Seralynne D Vann
    School of Psychology, Cardiff University, Park Place, Cardiff
    Neuropsychology 22:658-68. 2008
  7. doi request reprint Hippocampal, retrosplenial, and prefrontal hypoactivity in a model of diencephalic amnesia: Evidence towards an interdependent subcortical-cortical memory network
    Seralynne D Vann
    School of Psychology, Cardiff University, Wales, CF10 3AT, United Kingdom
    Hippocampus 19:1090-102. 2009
  8. doi request reprint Gudden's ventral tegmental nucleus is vital for memory: re-evaluating diencephalic inputs for amnesia
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff, CF10 3YG, UK
    Brain 132:2372-84. 2009
  9. doi request reprint What does the retrosplenial cortex do?
    Seralynne D Vann
    School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK
    Nat Rev Neurosci 10:792-802. 2009
  10. ncbi request reprint A role for the head-direction system in geometric learning
    Seralynne D Vann
    School of Psychology, Cardiff University, 70 Park Place, Cardiff, CF10 3AT, UK
    Behav Brain Res 224:201-6. 2011

Detail Information

Publications38

  1. pmc Dismantling the Papez circuit for memory in rats
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff, United Kingdom
    elife 2:e00736. 2013
    ..DOI:http://dx.doi.org/10.7554/eLife.00736.001. ..
  2. doi request reprint Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: implications for fornix function
    Seralynne D Vann
    School of Psychology, Cardiff University, United Kingdom
    Hippocampus 21:945-57. 2011
    ..This new evidence for independent functions shows that the mammillary bodies are more than just a hippocampal relay...
  3. pmc Impaired recollection but spared familiarity in patients with extended hippocampal system damage revealed by 3 convergent methods
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff CF10 3AT, United Kingdom
    Proc Natl Acad Sci U S A 106:5442-7. 2009
    ..The convergent evidence that mammillary body atrophy impairs recall but spares familiarity-based recognition appears irreconcilable with single-process models...
  4. ncbi request reprint Selective dysgranular retrosplenial cortex lesions in rats disrupt allocentric performance of the radial-arm maze task
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff, United Kingdom
    Behav Neurosci 119:1682-6. 2005
    ..This change in strategy is consistent with anatomical data showing that the dysgranular region is the primary recipient of visual inputs to the rat retrosplenial cortex...
  5. doi request reprint Hippocampus and neocortex: recognition and spatial memory
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff, UK
    Curr Opin Neurobiol 21:440-5. 2011
    ..Future models of spatial and recognition memory will have to extend beyond the hippocampus and perirhinal cortex to incorporate a wider network of cortical and subcortical structures...
  6. doi request reprint Memory loss resulting from fornix and septal damage: impaired supra-span recall but preserved recognition over a 24-hour delay
    Seralynne D Vann
    School of Psychology, Cardiff University, Park Place, Cardiff
    Neuropsychology 22:658-68. 2008
    ..This recall/recognition dissociation provides further evidence for neuroanatomical divisions within recognition memory processes...
  7. doi request reprint Hippocampal, retrosplenial, and prefrontal hypoactivity in a model of diencephalic amnesia: Evidence towards an interdependent subcortical-cortical memory network
    Seralynne D Vann
    School of Psychology, Cardiff University, Wales, CF10 3AT, United Kingdom
    Hippocampus 19:1090-102. 2009
    ..This account suggests a role for the mammillary bodies that is independent of their hippocampal inputs...
  8. doi request reprint Gudden's ventral tegmental nucleus is vital for memory: re-evaluating diencephalic inputs for amnesia
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff, CF10 3YG, UK
    Brain 132:2372-84. 2009
    ..This study provides the first clear evidence that the VTNg is critical for memory, and consequently indicates that diencephalic-hippocampal models of memory should be extended to incorporate the limbic midbrain...
  9. doi request reprint What does the retrosplenial cortex do?
    Seralynne D Vann
    School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK
    Nat Rev Neurosci 10:792-802. 2009
    ....
  10. ncbi request reprint A role for the head-direction system in geometric learning
    Seralynne D Vann
    School of Psychology, Cardiff University, 70 Park Place, Cardiff, CF10 3AT, UK
    Behav Brain Res 224:201-6. 2011
    ..From the pattern of impairments it also appears that, with training, rats with lateral mammillary body lesions are able to recruit other navigational systems or that there is some degree of redundancy within the head-direction system...
  11. doi request reprint Re-evaluating the role of the mammillary bodies in memory
    Seralynne D Vann
    School of Psychology, Cardiff University, Tower Building, Cardiff, UK
    Neuropsychologia 48:2316-27. 2010
    ....
  12. ncbi request reprint Transient spatial deficit associated with bilateral lesions of the lateral mammillary nuclei
    Seralynne D Vann
    School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, UK
    Eur J Neurosci 21:820-4. 2005
    ..At the same time, the remaining mammillary nuclei also contribute to spatial learning, though this may be in a qualitatively different manner...
  13. ncbi request reprint Testing the importance of the retrosplenial guidance system: effects of different sized retrosplenial cortex lesions on heading direction and spatial working memory
    Seralynne D Vann
    School of Psychology, Cardiff University, Park Place, PO Box 901, Cardiff CF10 3YG, UK
    Behav Brain Res 155:97-108. 2004
    ..These findings show that lesion size is a critical factor and may explain why some studies have failed to find comparable deficits after retrosplenial cortex lesions...
  14. ncbi request reprint Evidence of a spatial encoding deficit in rats with lesions of the mammillary bodies or mammillothalamic tract
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff, CF10 3YG, United Kingdom
    J Neurosci 23:3506-14. 2003
    ..Together, these results suggest that mammillary body damage causes an encoding deficit when learning new spatial tasks, resulting in a suboptimal mode of performance, which may reflect a loss of directional heading information...
  15. ncbi request reprint Lesions of the mammillothalamic tract impair the acquisition of spatial but not nonspatial contextual conditional discriminations
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff CF10 3YG, UK
    Eur J Neurosci 18:2413-6. 2003
    ..These results provide support for the suggestion that mammillothalamic tract lesions disrupt visuo-spatial encoding...
  16. doi request reprint Granular and dysgranular retrosplenial cortices provide qualitatively different contributions to spatial working memory: evidence from immediate-early gene imaging in rats
    Helen H J Pothuizen
    School of Psychology, Tower Building, Cardiff University, Cardiff, UK
    Eur J Neurosci 30:877-88. 2009
    ....
  17. doi request reprint Effects of selective granular retrosplenial cortex lesions on spatial working memory in rats
    Helen H J Pothuizen
    School of Psychology, Cardiff University, Cardiff, UK
    Behav Brain Res 208:566-75. 2010
    ..Combining these findings with the results of previous functional and anatomical studies suggests that the granular and dysgranular retrosplenial subregions function in close conjunction to support spatial learning...
  18. pmc Medial temporal lobe projections to the retrosplenial cortex of the macaque monkey
    John P Aggleton
    School of Psychology, Cardiff University, Cardiff, Wales, United Kingdom CF10 3AT
    Hippocampus 22:1883-900. 2012
    ..The findings also suggest further functional differences within retrosplenial subregions as area 29 received the large majority of efferents from the subiculum...
  19. ncbi request reprint Anterior thalamic lesions stop immediate early gene activation in selective laminae of the retrosplenial cortex: evidence of covert pathology in rats?
    Trisha A Jenkins
    School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, Wales CF10 3YG, UK
    Eur J Neurosci 19:3291-304. 2004
    ..This selective effect of anterior thalamic damage upon retrosplenial activity may both amplify the disruptive effects of anterior thalamic lesions and help to explain the posterior cingulate hypoactivity found in Alzheimer's disease...
  20. doi request reprint Lesions of the fornix and anterior thalamic nuclei dissociate different aspects of hippocampal-dependent spatial learning: implications for the neural basis of scene learning
    John P Aggleton
    School of Psychology, Cardiff University, Cardiff, Wales, UK
    Behav Neurosci 123:504-19. 2009
    ..Consequently, the findings suggest that structural learning is heavily dependent on cortico-hippocampal interactions. In contrast, subcortical inputs (such as those from the anterior thalamus) contribute to geometric learning...
  21. doi request reprint Segregation of parallel inputs to the anteromedial and anteroventral thalamic nuclei of the rat
    Nicholas F Wright
    School of Psychology, Cardiff University, Cardiff, United Kingdom
    J Comp Neurol 521:2966-86. 2013
    ....
  22. ncbi request reprint Testing the importance of the caudal retrosplenial cortex for spatial memory in rats
    Seralynne D Vann
    School of Psychology, Cardiff University of Wales, Park Place, P O Box 901, UK
    Behav Brain Res 140:107-18. 2003
    ..These results show a subtle impairment in spatial memory performance that is not as severe as that seen when more complete lesions of the retrosplenial cortex are made...
  23. doi request reprint Do rats with retrosplenial cortex lesions lack direction?
    Helen H J Pothuizen
    School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, UK
    Eur J Neurosci 28:2486-98. 2008
    ....
  24. doi request reprint Parallel but separate inputs from limbic cortices to the mammillary bodies and anterior thalamic nuclei in the rat
    Nicholas F Wright
    School of Psychology, Cardiff University, Cardiff, CF10 3AT, United Kingdom
    J Comp Neurol 518:2334-54. 2010
    ..These limbic projections to the mammillary bodies and anterior thalamus comprise a circuit that is vital for memory, within which the two major components could convey parallel, independent information...
  25. pmc Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions
    John P Aggleton
    School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, Wales CF10 3AT, UK
    Eur J Neurosci 31:2292-307. 2010
    ..Such distal effects challenge more traditional views of neuropathology as they reveal how extensive covert pathology might accompany localised overt pathology, and so impair memory...
  26. ncbi request reprint Extensive cytotoxic lesions of the rat retrosplenial cortex reveal consistent deficits on tasks that tax allocentric spatial memory
    Seralynne D Vann
    School of Psychology, Cardiff University, Wales
    Behav Neurosci 116:85-94. 2002
    ..The present study not only demonstrates a role for the retrosplenial cortex in allocentric spatial memory, but also explains why previous excitotoxic lesions have failed to detect any deficits...
  27. ncbi request reprint Distinct, parallel pathways link the medial mammillary bodies to the anterior thalamus in macaque monkeys
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff, Wales, CF10 3AT, UK
    Eur J Neurosci 26:1575-86. 2007
    ..g. nucleus reuniens. These anatomical findings not only reveal novel ways of grouping the neurons within the medial mammillary nucleus, but also indicate that the mammillothalamic connections support cognition in multiple ways...
  28. ncbi request reprint Sparing of the familiarity component of recognition memory in a patient with hippocampal pathology
    John P Aggleton
    School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, Wales CF10 3AT, UK
    Neuropsychologia 43:1810-23. 2005
    ....
  29. ncbi request reprint The mammillary bodies: two memory systems in one?
    Seralynne D Vann
    School of Psychology, Cardiff University, PO Box 901, Cardiff CF10 3YG, UK
    Nat Rev Neurosci 5:35-44. 2004
  30. ncbi request reprint Projections from the hippocampal region to the mammillary bodies in macaque monkeys
    John P Aggleton
    School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, Wales CF10 3AT UK
    Eur J Neurosci 22:2519-30. 2005
    ..Other comparisons revealed underlying similarities with the corresponding projections in the rat brain...
  31. pmc New behavioral protocols to extend our knowledge of rodent object recognition memory
    Mathieu M Albasser
    School of Psychology, Cardiff University, Cardiff, CF10 3AT Wales, United Kingdom
    Learn Mem 17:407-19. 2010
    ..The overall findings demonstrate the efficacy of this new behavioral task and advance our understanding of object recognition...
  32. ncbi request reprint Dysgranular retrosplenial cortex lesions in rats disrupt cross-modal object recognition
    Emma L Hindley
    School of Psychology, Cardiff University, Cardiff CF10 3AT, United Kingdom
    Learn Mem 21:171-9. 2014
    ..The present findings suggest a role for the dysgranular retrosplenial cortex in mediating the integration of information across multiple cue types, a role that potentially applies to both spatial and nonspatial domains. ..
  33. doi request reprint The origin of projections from the posterior cingulate and retrosplenial cortices to the anterior, medial dorsal and laterodorsal thalamic nuclei of macaque monkeys
    John P Aggleton
    School of Psychology, Cardiff University, 70, Park Place, Cardiff, Wales, CF10 3AT, UK
    Eur J Neurosci 39:107-23. 2014
    ..While the lack of retrosplenial connections singled out the medial dorsal nucleus, the very similar connection patterns shown by the anterior ventral and laterodorsal nuclei point to common roles in cognition. ..
  34. ncbi request reprint A novel role for the rat retrosplenial cortex in cognitive control
    Andrew J D Nelson
    School of Psychology, Cardiff University, Cardiff CF10 3AT, United Kingdom
    Learn Mem 21:90-7. 2014
    ..Rather, these data reveal the selective involvement of the rat retrosplenial cortex in response conflict, and so extend the frontal system underlying cognitive control...
  35. pmc Patients with hippocampal amnesia cannot imagine new experiences
    Demis Hassabis
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 104:1726-31. 2007
    ..Given how closely imagined experiences match episodic memories, the absence of this function mediated by the hippocampus, may also fundamentally affect the ability to vividly re-experience the past...
  36. pmc Impaired spatial and non-spatial configural learning in patients with hippocampal pathology
    Dharshan Kumaran
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuropsychologia 45:2699-711. 2007
    ....
  37. ncbi request reprint Testing the importance of the retrosplenial navigation system: lesion size but not strain matters: a reply to Harker and Whishaw
    John P Aggleton
    Neurosci Biobehav Rev 28:525-31. 2004
    ..There is, however, growing evidence that when interpreting the effects of retrosplenial lesions, account should be given of the lesion method and its interaction with lesion size...
  38. doi request reprint A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory
    Dimitris Tsivilis
    School of Psychological Sciences, Zochonis Building, University of Manchester, Brunswick Street, Manchester, M13 9PL, UK
    Nat Neurosci 11:834-42. 2008
    ..No other structure was consistently associated with memory. These findings support models of diencephalic memory mechanisms that require hippocampal inputs for recall, but not for key elements of recognition...