A Tonks

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia
    A Tonks
    Department of Haematology, School of Medicine, Cardiff University, Cardiff, UK
    Leukemia 21:2495-505. 2007
  2. ncbi request reprint Optimized retroviral transduction protocol which preserves the primitive subpopulation of human hematopoietic cells
    Alex Tonks
    Department of Haematology and Department of Medical Microbiology, Cardiff University, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Biotechnol Prog 21:953-8. 2005
  3. ncbi request reprint Surfactant phospholipid DPPC downregulates monocyte respiratory burst via modulation of PKC
    Alex Tonks
    Dept of Haematology, School of Medicine, Wales College of Medicine, Cardiff Univ, Heath Park, Cardiff CF14 4XN, UK
    Am J Physiol Lung Cell Mol Physiol 288:L1070-80. 2005
  4. ncbi request reprint Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal
    A Tonks
    Department of Haematology, University of Wales College of Medicine, Cardiff, UK
    Leukemia 18:1238-45. 2004
  5. ncbi request reprint Honey stimulates inflammatory cytokine production from monocytes
    A J Tonks
    Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, Wales CF14 4XN, UK
    Cytokine 21:242-7. 2003
  6. ncbi request reprint The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells
    Alex Tonks
    Department of Haematology, University of Wales College of Medicine, Cardiff, United Kingdom
    Blood 101:624-32. 2003
  7. pmc Dipalmitoylphosphatidylcholine modulates inflammatory functions of monocytic cells independently of mitogen activated protein kinases
    A Tonks
    School of Applied Sciences, University of Wales Institute, Cardiff, UK
    Clin Exp Immunol 124:86-94. 2001
  8. ncbi request reprint Prostaglandin E(2) and tumour necrosis factor-alpha release by monocytes are modulated by phospholipids
    R H Morris
    School of Applied Sciences, University of Wales Institute, Cardiff, Wales, UK
    Cytokine 12:1717-9. 2000
  9. ncbi request reprint A 5.8-kDa component of manuka honey stimulates immune cells via TLR4
    A J Tonks
    Department of Medical Microbiology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    J Leukoc Biol 82:1147-55. 2007
  10. ncbi request reprint Stimulation of TNF-alpha release in monocytes by honey
    A Tonks
    School of Applied Sciences, University of Wales Institute Cardiff, Western Ave, Cardiff, CF5 2YB, UK
    Cytokine 14:240-2. 2001

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia
    A Tonks
    Department of Haematology, School of Medicine, Cardiff University, Cardiff, UK
    Leukemia 21:2495-505. 2007
    ..These data provide the most comprehensive and pertinent assessment of the effect of RUNX1-RUNX1T1 on gene expression and demonstrate the highly context-dependent effects of this fusion gene...
  2. ncbi request reprint Optimized retroviral transduction protocol which preserves the primitive subpopulation of human hematopoietic cells
    Alex Tonks
    Department of Haematology and Department of Medical Microbiology, Cardiff University, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Biotechnol Prog 21:953-8. 2005
    ..In summary, we demonstrate a high-frequency transduction protocol which preserves the therapeutically relevant primitive subpopulation of human hematopoietic cells...
  3. ncbi request reprint Surfactant phospholipid DPPC downregulates monocyte respiratory burst via modulation of PKC
    Alex Tonks
    Dept of Haematology, School of Medicine, Wales College of Medicine, Cardiff Univ, Heath Park, Cardiff CF14 4XN, UK
    Am J Physiol Lung Cell Mol Physiol 288:L1070-80. 2005
    ..These results suggest that DPPC, the major component of pulmonary surfactant, plays a role in modulating leukocyte inflammatory responses in the lung via downregulation of PKC, a mechanism that may involve the PKCdelta isoform...
  4. ncbi request reprint Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal
    A Tonks
    Department of Haematology, University of Wales College of Medicine, Cardiff, UK
    Leukemia 18:1238-45. 2004
    ..Taken together, these results suggest that expression of AML1-ETO selectively inhibits the differentiation of granulocytic cells and promoted extensive self-renewal, supporting a causal role for t(8;21) translocations in leukaemogenesis...
  5. ncbi request reprint Honey stimulates inflammatory cytokine production from monocytes
    A J Tonks
    Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, Wales CF14 4XN, UK
    Cytokine 21:242-7. 2003
    ..These results suggest that the effect of honey on wound healing may in part be related to the stimulation of inflammatory cytokines from monocytic cells. Such cell types are known to play an important role in healing and tissue repair...
  6. ncbi request reprint The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells
    Alex Tonks
    Department of Haematology, University of Wales College of Medicine, Cardiff, United Kingdom
    Blood 101:624-32. 2003
    ..These data demonstrate the capacity of AML1-ETO to promote the self-renewal of human hematopoietic cells and therefore support a causal role for t(8;21) translocations in leukemogenesis...
  7. pmc Dipalmitoylphosphatidylcholine modulates inflammatory functions of monocytic cells independently of mitogen activated protein kinases
    A Tonks
    School of Applied Sciences, University of Wales Institute, Cardiff, UK
    Clin Exp Immunol 124:86-94. 2001
    ..This may in part be related to membrane effects but does not include alterations in p44/p42 or p38 MAPK signalling...
  8. ncbi request reprint Prostaglandin E(2) and tumour necrosis factor-alpha release by monocytes are modulated by phospholipids
    R H Morris
    School of Applied Sciences, University of Wales Institute, Cardiff, Wales, UK
    Cytokine 12:1717-9. 2000
    ..This indicates a role for these lipids in alveolar immunoregulation...
  9. ncbi request reprint A 5.8-kDa component of manuka honey stimulates immune cells via TLR4
    A J Tonks
    Department of Medical Microbiology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    J Leukoc Biol 82:1147-55. 2007
    ..These findings reveal mechanisms and components involved in honey stimulation of cytokine induction and could potentially lead to the development of novel therapeutics to improve wound healing for patients with acute and chronic wounds...
  10. ncbi request reprint Stimulation of TNF-alpha release in monocytes by honey
    A Tonks
    School of Applied Sciences, University of Wales Institute Cardiff, Western Ave, Cardiff, CF5 2YB, UK
    Cytokine 14:240-2. 2001
    ..001) in unprimed MM6 cells by manuka and pasture honey but was not altered in primed cells. These results could explain the suggested therapeutic properties of honey in promoting wound healing...
  11. pmc γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin
    R G Morgan
    Department of Hematology, Institute of Cancer and Genetics, School of Medicine, Cardiff University, Wales, Cardiff, UK
    Leukemia 27:336-43. 2013
    ....
  12. doi request reprint DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB
    R H K Morris
    Cardiff School of Health Sciences, University of Wales Institute Cardiff, Western Avenue, Llandaff, Cardiff, Wales CF5 2YB, UK
    Biochem Biophys Res Commun 370:174-8. 2008
    ..This study provides new evidence for the anti-inflammatory activity of DPPC and that this activity is at least in part mediated via CREB activation of COX-2...
  13. pmc CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia
    S J Coles
    Department of Medical Genetics, Haematology and Pathology, Cardiff University, Cardiff, UK
    Leukemia 25:792-9. 2011
    ..Together, these findings provide the first evidence that CD200 has a direct and significant suppressive influence on NK cell activity in AML patients and may contribute to the increased relapse rate in CD200(+) patients...
  14. doi request reprint OGG1 is a novel prognostic indicator in acute myeloid leukaemia
    K Liddiard
    Department of Haematology, School of Medicine, Cardiff University, Cardiff, UK
    Oncogene 29:2005-12. 2010
    ....
  15. ncbi request reprint CD200 as a prognostic factor in acute myeloid leukaemia
    A Tonks
    Leukemia 21:566-8. 2007