Karl Swann

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection
    Karl Swann
    School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
    Fertil Steril 97:742-7. 2012
  2. doi request reprint The dynamics of calcium oscillations that activate mammalian eggs
    Karl Swann
    Department of Obstetrics and Gynaecology, School of Medicine, Cardiff University, Cardiff, UK
    Int J Dev Biol 52:585-94. 2008
  3. pmc Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility
    Michail Nomikos
    Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    Fertil Steril 99:76-85. 2013
  4. pmc Divergent effect of mammalian PLCζ in generating Ca²⁺ oscillations in somatic cells compared with eggs
    Sally V Phillips
    Department of Obstetrics and Gynaecology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Biochem J 438:545-53. 2011
  5. doi request reprint Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility
    Michail Nomikos
    Cell Signalling Laboratory, WHRI, Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, UK
    Bioessays 34:126-34. 2012
  6. pmc Novel regulation of PLCζ activity via its XY-linker
    Michail Nomikos
    Department of Obstetrics and Gynaecology, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Biochem J 438:427-32. 2011
  7. pmc Regulation of diacylglycerol production and protein kinase C stimulation during sperm- and PLCzeta-mediated mouse egg activation
    Yuansong Yu
    Department of Obstetrics and Gynaecology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, U K
    Biol Cell 100:633-43. 2008
  8. pmc The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs
    Jose Raul Gonzalez-Garcia
    Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff University, Cardiff, UK
    J Cell Physiol 228:110-9. 2013
  9. ncbi request reprint Role of phospholipase C-zeta domains in Ca2+-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic Ca2+ oscillations
    Michail Nomikos
    Cell Signalling Laboratory, Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN
    J Biol Chem 280:31011-8. 2005
  10. pmc Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region
    Michail Nomikos
    Cell Signalling Laboratory, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    J Cell Sci 124:2582-90. 2011

Collaborators

Detail Information

Publications15

  1. pmc Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection
    Karl Swann
    School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
    Fertil Steril 97:742-7. 2012
    ..To evaluate the imaging of cytoplasmic movements in human oocytes as a potential method to monitor the pattern of Ca(2+) oscillations during activation...
  2. doi request reprint The dynamics of calcium oscillations that activate mammalian eggs
    Karl Swann
    Department of Obstetrics and Gynaecology, School of Medicine, Cardiff University, Cardiff, UK
    Int J Dev Biol 52:585-94. 2008
    ..As yet we do not fully understand how the target of calcium in a mammalian egg might decode the patterns of calcium changes that can occur during egg activation...
  3. pmc Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility
    Michail Nomikos
    Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    Fertil Steril 99:76-85. 2013
    ....
  4. pmc Divergent effect of mammalian PLCζ in generating Ca²⁺ oscillations in somatic cells compared with eggs
    Sally V Phillips
    Department of Obstetrics and Gynaecology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Biochem J 438:545-53. 2011
    ..These data suggest that PLCζ-mediated Ca²⁺ oscillations may require specific factors that are only present within the egg cytoplasm or be inhibited by factors present only in somatic cell lines...
  5. doi request reprint Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility
    Michail Nomikos
    Cell Signalling Laboratory, WHRI, Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, UK
    Bioessays 34:126-34. 2012
    ..Recent advances have refined our understanding of how PLCζ induces Ca(2+) oscillations in the egg and also suggest its potential dysfunction as a cause of male infertility...
  6. pmc Novel regulation of PLCζ activity via its XY-linker
    Michail Nomikos
    Department of Obstetrics and Gynaecology, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Biochem J 438:427-32. 2011
    ....
  7. pmc Regulation of diacylglycerol production and protein kinase C stimulation during sperm- and PLCzeta-mediated mouse egg activation
    Yuansong Yu
    Department of Obstetrics and Gynaecology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, U K
    Biol Cell 100:633-43. 2008
    ..Fertilization-mediated increase in PKC activity has been demonstrated; however, its precise role is unclear...
  8. pmc The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs
    Jose Raul Gonzalez-Garcia
    Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff University, Cardiff, UK
    J Cell Physiol 228:110-9. 2013
    ..The results also suggest that Ca(2+) -induced DAG formation on intracellular membranes may stimulate PKC activity oscillations at fertilization...
  9. ncbi request reprint Role of phospholipase C-zeta domains in Ca2+-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic Ca2+ oscillations
    Michail Nomikos
    Cell Signalling Laboratory, Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN
    J Biol Chem 280:31011-8. 2005
    ..These data suggest that the exquisite Ca2+-dependent features of PLCzeta regulation are essential for it to generate inositol 1,4,5-trisphosphate and Ca2+ oscillations in intact mouse eggs...
  10. pmc Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region
    Michail Nomikos
    Cell Signalling Laboratory, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    J Cell Sci 124:2582-90. 2011
    ....
  11. pmc Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation
    Yuansong Yu
    Department of Obstetrics and Gynaecology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    J Cell Physiol 224:672-80. 2010
    ....
  12. doi request reprint Use of luciferase chimaera to monitor PLCzeta expression in mouse eggs
    Karl Swann
    Department of Obstetrics and Gynaecology, School of Medicine, Cardiff University, Cardiff, UK
    Methods Mol Biol 518:17-29. 2009
    ....
  13. doi request reprint PLCζ and the initiation of Ca(2+) oscillations in fertilizing mammalian eggs
    Karl Swann
    Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Cell Calcium 53:55-62. 2013
    ..This leads us to suggest that sperm PLCζ may be targeted to these cytoplasmic vesicles by directly interacting with a specific but as yet unidentified egg PLCζ-binding protein...
  14. doi request reprint Measuring Ca2+ oscillations in mammalian eggs
    Karl Swann
    School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Methods Mol Biol 957:231-48. 2013
    ..Either one of these dyes offers advantages over the more commonly used fura2. I describe the way that the fluorescence from dye-loaded eggs is measured with a conventional epifluorescence microscope and a CCD camera...
  15. ncbi request reprint Ca2+ oscillations stimulate an ATP increase during fertilization of mouse eggs
    Karen Campbell
    Department of Obstetrics and Gynaecology, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Dev Biol 298:225-33. 2006
    ..These data suggest that mammalian fertilization is associated with a sudden but transient increase in cytosolic ATP and that Ca(2+) oscillations are both necessary and sufficient to cause this increase in ATP levels...