Stephen R Sturzenbaum

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi Cadmium detoxification in earthworms: from genes to cells
    Stephen R Sturzenbaum
    Cardiff University, School of Biosciences, Main Building, Cardiff, CF10 3TL UK
    Environ Sci Technol 38:6283-9. 2004
  2. ncbi Identification of heavy metal induced changes in the expression patterns of the translationally controlled tumour protein (TCTP) in the earthworm Lumbricus rubellus1
    S R Stürzenbaum
    School of Molecular and Medical Biosciences, University of Wales, P O Box 911, Cardiff CF1 3US, Wales, UK
    Biochim Biophys Acta 1398:294-304. 1998
  3. pmc Molecular cloning and characterization of Cpn60 in the free-living nematode Plectus acuminatus
    S R Stürzenbaum
    Cardiff School of Biosciences, Cardiff University, PO Box 915, Cardiff CF10 3TL, Wales, UK
    Cell Stress Chaperones 10:79-85. 2005
  4. ncbi Metal ion trafficking in earthworms. Identification of a cadmium-specific metallothionein
    S R Stürzenbaum
    School of Biosciences, P O Box 911, Cardiff University, Cardiff CF1 3US, Wales, United Kingdom
    J Biol Chem 276:34013-8. 2001
  5. ncbi The identification, cloning and characterization of earthworm metallothionein
    S R Stürzenbaum
    School of Molecular and Medical Biosciences, University of Wales, Cardiff, UK
    FEBS Lett 431:437-42. 1998
  6. ncbi Characterisation and quantification of earthworm cyclophilins: identification of invariant and heavy metal responsive isoforms
    S R Stürzenbaum
    School of Biosciences, University of Wales, Cardiff, UK
    Biochim Biophys Acta 1489:467-73. 1999
  7. ncbi Developing a new method for soil pollution monitoring using molecular genetic biomarkers
    M Galay-Burgos
    Cardiff School of Biosciences, Cardiff University, PO Box 915, Cardiff, CF10 3TL, UK
    Biomarkers 8:229-39. 2003
  8. ncbi Accumulated metal speciation in earthworm populations with multigenerational exposure to metalliferous soils: cell fractionation and high-energy synchrotron analyses
    Jane Andre
    Cardiff School of Biosciences, Cardiff University, Park Place, Cardiff CF10 3US, UK
    Environ Sci Technol 43:6822-9. 2009
  9. doi Knock down of Caenorhabditis elegans cutc-1 exacerbates the sensitivity toward high levels of copper
    Sara Calafato
    School of Biosciences, University of Cardiff, Main Building, Park Place, Cardiff CF10 3TL, UK
    Toxicol Sci 106:384-91. 2008
  10. pmc Application of physiologically based modelling and transcriptomics to probe the systems toxicology of aldicarb for Caenorhabditis elegans (Maupas 1900)
    Jodie F Wren
    School of Biosciences, Cardiff University, Park Place, Cardiff, UK
    Ecotoxicology 20:397-408. 2011

Collaborators

Detail Information

Publications18

  1. ncbi Cadmium detoxification in earthworms: from genes to cells
    Stephen R Sturzenbaum
    Cardiff University, School of Biosciences, Main Building, Cardiff, CF10 3TL UK
    Environ Sci Technol 38:6283-9. 2004
    ..In summary, this paper provides a detailed dissection of the genetic, molecular, and cellular basis of a sophisticated pathway that facilitates the uptake, accumulation, transport, and excretion of cadmium...
  2. ncbi Identification of heavy metal induced changes in the expression patterns of the translationally controlled tumour protein (TCTP) in the earthworm Lumbricus rubellus1
    S R Stürzenbaum
    School of Molecular and Medical Biosciences, University of Wales, P O Box 911, Cardiff CF1 3US, Wales, UK
    Biochim Biophys Acta 1398:294-304. 1998
    ....
  3. pmc Molecular cloning and characterization of Cpn60 in the free-living nematode Plectus acuminatus
    S R Stürzenbaum
    Cardiff School of Biosciences, Cardiff University, PO Box 915, Cardiff CF10 3TL, Wales, UK
    Cell Stress Chaperones 10:79-85. 2005
    ..In conclusion, this first account of molecular genetic similarities and differences of Cpn60 in a neglected nematode taxon provides a valuable insight into its potential uses in gene-based ecotoxicological risk assessment exercises...
  4. ncbi Metal ion trafficking in earthworms. Identification of a cadmium-specific metallothionein
    S R Stürzenbaum
    School of Biosciences, P O Box 911, Cardiff University, Cardiff CF1 3US, Wales, United Kingdom
    J Biol Chem 276:34013-8. 2001
    ..The structure-function relationship of wMT-2 and its role in cadmium detoxification through sequestration and compartmentalization is discussed...
  5. ncbi The identification, cloning and characterization of earthworm metallothionein
    S R Stürzenbaum
    School of Molecular and Medical Biosciences, University of Wales, Cardiff, UK
    FEBS Lett 431:437-42. 1998
    ..Possible implications for intracellular metal trafficking are discussed...
  6. ncbi Characterisation and quantification of earthworm cyclophilins: identification of invariant and heavy metal responsive isoforms
    S R Stürzenbaum
    School of Biosciences, University of Wales, Cardiff, UK
    Biochim Biophys Acta 1489:467-73. 1999
    ..This intriguing observation has profound implications regarding cyclophilin's use as an invariant control and highlights the fact that it is essential to treat cyclophilin isoforms as separate entities, rather than one functional unit...
  7. ncbi Developing a new method for soil pollution monitoring using molecular genetic biomarkers
    M Galay-Burgos
    Cardiff School of Biosciences, Cardiff University, PO Box 915, Cardiff, CF10 3TL, UK
    Biomarkers 8:229-39. 2003
    ..This study demonstrates that it is now technically feasible to use gene expression as an index of pollution exposure in environmentally relevant organisms...
  8. ncbi Accumulated metal speciation in earthworm populations with multigenerational exposure to metalliferous soils: cell fractionation and high-energy synchrotron analyses
    Jane Andre
    Cardiff School of Biosciences, Cardiff University, Park Place, Cardiff CF10 3US, UK
    Environ Sci Technol 43:6822-9. 2009
    ..These observations are highly significant in the challenging exercise of interpreting holistic biomarker data delivered by "omic" technologies...
  9. doi Knock down of Caenorhabditis elegans cutc-1 exacerbates the sensitivity toward high levels of copper
    Sara Calafato
    School of Biosciences, University of Cardiff, Main Building, Park Place, Cardiff CF10 3TL, UK
    Toxicol Sci 106:384-91. 2008
    ..This indicates that cutc-1 plays a crucial role in the protection from excess copper...
  10. pmc Application of physiologically based modelling and transcriptomics to probe the systems toxicology of aldicarb for Caenorhabditis elegans (Maupas 1900)
    Jodie F Wren
    School of Biosciences, Cardiff University, Park Place, Cardiff, UK
    Ecotoxicology 20:397-408. 2011
    ..These effects, coupled to the effect on biotransformation enzymes also seen, represent the materialisation of the maintenance costs indicated by DEBtox modelling...
  11. ncbi Cu and Cd effects on the earthworm Lumbricus rubellus in the laboratory: multivariate statistical analysis of relationships between exposure, biomarkers, and ecologically relevant parameters
    Malyka Galay Burgos
    School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
    Environ Sci Technol 39:1757-63. 2005
    ..It is proposed that the use of such a suite of biomarkers could serve as indicators of the "health" of the soil environment and provide early warning signals of potential danger to the biota or as a means of monitoring soil remediation...
  12. ncbi C. elegans metallothioneins: new insights into the phenotypic effects of cadmium toxicosis
    S C Swain
    Cardiff University, School of Biosciences, Wales, UK
    J Mol Biol 341:951-59. 2004
    ..elegans upon exposure to cadmium, the results providing further evidence that the transcriptional control of metallothioneins is fundamentally divergent in lower invertebrates and not mediated via MTF-1 as in more complex organisms...
  13. ncbi Differential metallothionein expression in earthworm (Lumbricus rubellus) tissues
    A J Morgan
    Cardiff School of Biosciences, Cardiff University, PO Box 915, Cardiff Wales, CF10 3TL, UK
    Ecotoxicol Environ Saf 57:11-9. 2004
    ....
  14. ncbi Control genes in quantitative molecular biological techniques: the variability of invariance
    S R Stürzenbaum
    Cardiff University, School of Biosciences BIOSI 2, P O Box 911, Wales, Cardiff, UK
    Comp Biochem Physiol B Biochem Mol Biol 130:281-9. 2001
    ..Finally, different approaches undertaken to assess the invariance of control genes are critically analysed to generate a procedure that will help to discern the best control for novel experiments...
  15. doi Molecular genetic differentiation in earthworms inhabiting a heterogeneous Pb-polluted landscape
    J Andre
    Cardiff School of Biosciences, Cardiff University, BIOSI 1, Museum Avenue, Cardiff CF10 3TL, UK
    Environ Pollut 158:883-90. 2010
    ..We recommend the mandatory genotyping of all individuals prior to field-based ecotoxicological assays, particularly those using discriminating genomic technologies...
  16. ncbi Earthworm pre-procarboxypeptidase: a copper responsive enzyme
    S R Stürzenbaum
    School of Biosciences, University of Wales, Cardiff, UK
    Biometals 14:85-94. 2001
    ..Finally, the significance of these observations in terms of risk assessment and biomonitoring of contaminated soils is discussed...
  17. ncbi Single and double metallothionein knockout in the nematode C. elegans reveals cadmium dependent and independent toxic effects on life history traits
    Sam Hughes
    School of Biosciences, Cardiff University, Main Building, Park Place, Cardiff CF10 3TL, UK
    Environ Pollut 145:395-400. 2007
    ..In summary, metallothionein is undoubtedly an important player in cadmium detoxification, but evidently also an important factor in cadmium independent pathways...
  18. ncbi Microevolution and ecotoxicology of metals in invertebrates
    A John Morgan
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    Environ Sci Technol 41:1085-96. 2007
    ....