Simon H Reed

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint Nucleotide excision repair in chromatin: the shape of things to come
    Simon H Reed
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    DNA Repair (Amst) 4:909-18. 2005
  2. doi request reprint Nucleotide excision repair in chromatin: damage removal at the drop of a HAT
    Simon H Reed
    Department of Medical Genetics, Haematology and Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    DNA Repair (Amst) 10:734-42. 2011
  3. ncbi request reprint Nucleotide excision repair and the ubiquitin proteasome pathway--do all roads lead to Rome?
    Simon H Reed
    The Department of Pathology, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    DNA Repair (Amst) 6:149-56. 2007
  4. pmc How chromatin is remodelled during DNA repair of UV-induced DNA damage in Saccharomyces cerevisiae
    Shirong Yu
    Department of Medical Genetics, Haematology, and Pathology, School of Medicine, Cardiff University, Cardiff, UK
    PLoS Genet 7:e1002124. 2011
  5. pmc Histone variant Htz1 promotes histone H3 acetylation to enhance nucleotide excision repair in Htz1 nucleosomes
    Yachuan Yu
    Institute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK and Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester M13 9PT, UK
    Nucleic Acids Res 41:9006-19. 2013
  6. pmc Saccharomyces cerevisiae Rad16 mediates ultraviolet-dependent histone H3 acetylation required for efficient global genome nucleotide-excision repair
    Yumin Teng
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    EMBO Rep 9:97-102. 2008
  7. ncbi request reprint Chromatin modifications and nucleotide excision repair
    Raymond Waters
    Pathology Department, Cardiff University, School of Medicine, Heath Park, Cardiff
    SEB Exp Biol Ser 59:189-201. 2008
  8. pmc ABF1-binding sites promote efficient global genome nucleotide excision repair
    Shirong Yu
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 284:966-73. 2009
  9. pmc Silenced yeast chromatin is maintained by Sir2 in preference to permitting histone acetylations for efficient NER
    Agurtzane Irizar
    Department of Pathology, School of Medicine, Cardiff University, Cardiff, UK
    Nucleic Acids Res 38:4675-86. 2010
  10. pmc UV irradiation stimulates histone acetylation and chromatin remodeling at a repressed yeast locus
    Yachuan Yu
    Department of Pathology, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 102:8650-5. 2005

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Nucleotide excision repair in chromatin: the shape of things to come
    Simon H Reed
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    DNA Repair (Amst) 4:909-18. 2005
    ..A number of recent studies have provided glimpses of a chromatin--NER connection. Here I review this literature and evaluate how it might aid our understanding, and shape our future research into NER...
  2. doi request reprint Nucleotide excision repair in chromatin: damage removal at the drop of a HAT
    Simon H Reed
    Department of Medical Genetics, Haematology and Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    DNA Repair (Amst) 10:734-42. 2011
    ....
  3. ncbi request reprint Nucleotide excision repair and the ubiquitin proteasome pathway--do all roads lead to Rome?
    Simon H Reed
    The Department of Pathology, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    DNA Repair (Amst) 6:149-56. 2007
    ....
  4. pmc How chromatin is remodelled during DNA repair of UV-induced DNA damage in Saccharomyces cerevisiae
    Shirong Yu
    Department of Medical Genetics, Haematology, and Pathology, School of Medicine, Cardiff University, Cardiff, UK
    PLoS Genet 7:e1002124. 2011
    ..Recent evidence suggests that GCN5 plays a role in NER in human cells. Our work provides important insight into how GG-NER operates in chromatin...
  5. pmc Histone variant Htz1 promotes histone H3 acetylation to enhance nucleotide excision repair in Htz1 nucleosomes
    Yachuan Yu
    Institute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK and Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester M13 9PT, UK
    Nucleic Acids Res 41:9006-19. 2013
    ..In summary, we have identified a novel aspect of chromatin that regulates efficient NER, and we provide a model for how Htz1 influences NER in Htz1 nucleosomes. ..
  6. pmc Saccharomyces cerevisiae Rad16 mediates ultraviolet-dependent histone H3 acetylation required for efficient global genome nucleotide-excision repair
    Yumin Teng
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    EMBO Rep 9:97-102. 2008
    ....
  7. ncbi request reprint Chromatin modifications and nucleotide excision repair
    Raymond Waters
    Pathology Department, Cardiff University, School of Medicine, Heath Park, Cardiff
    SEB Exp Biol Ser 59:189-201. 2008
    ..Surprisingly neither of these events require functional NER, but NER is needed to return the chromatin to its pre-UV state...
  8. pmc ABF1-binding sites promote efficient global genome nucleotide excision repair
    Shirong Yu
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 284:966-73. 2009
    ..We discuss how the GG-NER complex might facilitate GG-NER while preventing unregulated gene transcription during this process...
  9. pmc Silenced yeast chromatin is maintained by Sir2 in preference to permitting histone acetylations for efficient NER
    Agurtzane Irizar
    Department of Pathology, School of Medicine, Cardiff University, Cardiff, UK
    Nucleic Acids Res 38:4675-86. 2010
    ..Our experiments reveal that there are instances in the yeast genome where the maintenance of the existing chromatin structures dominates over the action of chromatin modifications associated with efficient NER...
  10. pmc UV irradiation stimulates histone acetylation and chromatin remodeling at a repressed yeast locus
    Yachuan Yu
    Department of Pathology, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 102:8650-5. 2005
    ..These experiments indicate that chromatin at a yeast repressed locus undergoes active change after UV radiation treatment and that failure to achieve histone H3 hyperacetylation impairs the repair of DNA damage...
  11. doi request reprint Lux ex tenebris: nucleotide resolution DNA repair and nucleosome mapping
    Yumin Teng
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Methods 48:23-34. 2009
    ..Here we describe two techniques developed in our laboratories which we hope have contributed to our understanding in this arena...
  12. doi request reprint Tilting at windmills? The nucleotide excision repair of chromosomal DNA
    Raymond Waters
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    DNA Repair (Amst) 8:146-52. 2009
    ....
  13. pmc A novel method for the genome-wide high resolution analysis of DNA damage
    Yumin Teng
    Department of Medical Genetics, Haematology and Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Nucleic Acids Res 39:e10. 2011
    ....
  14. ncbi request reprint Functional genome-wide analysis: a technical review, its developments and its relevance to cancer research
    James R Powell
    Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Recent Pat DNA Gene Seq 7:157-66. 2013
    ..We also offer insight into the potential clinical application of this technology in stratified medicine, particularly in the field of cancer therapy...
  15. ncbi request reprint The yeast Rad7/Rad16/Abf1 complex generates superhelical torsion in DNA that is required for nucleotide excision repair
    Shirong Yu
    Department of Pathology, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    DNA Repair (Amst) 3:277-87. 2004
    ..We conclude that in yeast the molecular mechanism of NER includes the generation of superhelical torsion in DNA...
  16. pmc Distinct functions of the ubiquitin-proteasome pathway influence nucleotide excision repair
    Thomas G Gillette
    The Center for Biomedical Inventions, Medicine and Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    EMBO J 25:2529-38. 2006
    ..These studies reveal that, following UV radiation, NER is mediated by nonproteolytic activities of the UPP, via the ubiquitin-like domain of Rad23 and UV radiation-induced ubiquitination of Rad4...