D P Ramji

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc A critical role for the Sp1-binding sites in the transforming growth factor-beta-mediated inhibition of lipoprotein lipase gene expression in macrophages
    Scott A Irvine
    Cardiff School of Biosciences, Cardiff University Museum Avenue, Cardiff CF10 3US, UK
    Nucleic Acids Res 33:1423-34. 2005
  2. pmc The anti-atherogenic cytokine interleukin-33 inhibits the expression of a disintegrin and metalloproteinase with thrombospondin motifs-1, -4 and -5 in human macrophages: Requirement of extracellular signal-regulated kinase, c-Jun N-terminal kinase and pho
    Tim G Ashlin
    Cardiff School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AX, United Kingdom
    Int J Biochem Cell Biol 46:113-23. 2014
  3. pmc Regulation of ADAMTS-1, -4 and -5 expression in human macrophages: differential regulation by key cytokines implicated in atherosclerosis and novel synergism between TL1A and IL-17
    Tim G Ashlin
    Cardiff School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AX, United Kingdom
    Cytokine 64:234-42. 2013
  4. pmc The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-β and requires Smads, p38 mitogen-activated protein kinase and c-Jun
    Rebecca C Salter
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, United Kingdom
    Int J Biochem Cell Biol 43:805-11. 2011
  5. pmc Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes
    Saira Ali
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Int J Biochem Cell Biol 42:113-9. 2010
  6. pmc The interferon-gamma-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3
    Sandra M Harris
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Cell Signal 20:2296-301. 2008
  7. pmc A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression
    Etimad A Huwait
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Cell Signal 23:542-9. 2011
  8. pmc CCAAT/enhancer-binding proteins: structure, function and regulation
    Dipak P Ramji
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, U K
    Biochem J 365:561-75. 2002
  9. ncbi request reprint Transforming growth factor-beta-regulated expression of genes in macrophages implicated in the control of cholesterol homoeostasis
    D P Ramji
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Biochem Soc Trans 34:1141-4. 2006
  10. pmc Analysis of the Xenopus laevis CCAAT-enhancer binding protein alpha gene promoter demonstrates species-specific differences in the mechanisms for both auto-activation and regulation by Sp1
    F T Kockar
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff CF10 3US, UK
    Nucleic Acids Res 29:362-72. 2001

Collaborators

Detail Information

Publications27

  1. pmc A critical role for the Sp1-binding sites in the transforming growth factor-beta-mediated inhibition of lipoprotein lipase gene expression in macrophages
    Scott A Irvine
    Cardiff School of Biosciences, Cardiff University Museum Avenue, Cardiff CF10 3US, UK
    Nucleic Acids Res 33:1423-34. 2005
    ..These results, therefore, suggest a novel mechanism for the TGF-beta-mediated repression of LPL gene transcription that involves regulation of the action of Sp1 and Sp3...
  2. pmc The anti-atherogenic cytokine interleukin-33 inhibits the expression of a disintegrin and metalloproteinase with thrombospondin motifs-1, -4 and -5 in human macrophages: Requirement of extracellular signal-regulated kinase, c-Jun N-terminal kinase and pho
    Tim G Ashlin
    Cardiff School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AX, United Kingdom
    Int J Biochem Cell Biol 46:113-23. 2014
    ..These studies provide novel insights into the expression of ADAMTS-1, -4 and -5 in human atherosclerotic lesions and the regulation of their expression in human macrophages by the key anti-atherogenic cytokine IL-33. ..
  3. pmc Regulation of ADAMTS-1, -4 and -5 expression in human macrophages: differential regulation by key cytokines implicated in atherosclerosis and novel synergism between TL1A and IL-17
    Tim G Ashlin
    Cardiff School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AX, United Kingdom
    Cytokine 64:234-42. 2013
    ..These studies provide new insight into the regulation of key ADAMTS family members in human macrophages by major cytokines in relation to atherosclerosis...
  4. pmc The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-β and requires Smads, p38 mitogen-activated protein kinase and c-Jun
    Rebecca C Salter
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, United Kingdom
    Int J Biochem Cell Biol 43:805-11. 2011
    ..The inhibition of macrophage ADAMTS-4 expression is likely to contribute to the anti-atherogenic, plaque stabilisation action of TGF-β...
  5. pmc Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes
    Saira Ali
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Int J Biochem Cell Biol 42:113-9. 2010
    ..Taken together, these results suggest a potentially crucial role for NF-kappaB in the IL-1-induced expression of C/EBPdelta, and thereby downstream APP genes regulated by this transcription factor...
  6. pmc The interferon-gamma-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3
    Sandra M Harris
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Cell Signal 20:2296-301. 2008
    ..Taken together, these results suggest a key role for CK2 and PI3K signalling pathways in the IFN-gamma-mediated inhibition of macrophage LPL gene transcription through the regulation of Sp1/Sp3 binding...
  7. pmc A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression
    Etimad A Huwait
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Cell Signal 23:542-9. 2011
    ..These studies reveal a novel role for JNK and PI3K/AKT signaling in the LXR-regulated expression in macrophages of several key genes implicated in atherosclerosis...
  8. pmc CCAAT/enhancer-binding proteins: structure, function and regulation
    Dipak P Ramji
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, U K
    Biochem J 365:561-75. 2002
    ..This review deals with the structure, biological function and the regulation of the C/EBP family...
  9. ncbi request reprint Transforming growth factor-beta-regulated expression of genes in macrophages implicated in the control of cholesterol homoeostasis
    D P Ramji
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Biochem Soc Trans 34:1141-4. 2006
    ....
  10. pmc Analysis of the Xenopus laevis CCAAT-enhancer binding protein alpha gene promoter demonstrates species-specific differences in the mechanisms for both auto-activation and regulation by Sp1
    F T Kockar
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff CF10 3US, UK
    Nucleic Acids Res 29:362-72. 2001
    ..In addition, we demonstrate a novel species-specific action of Sp1 in the regulation of C/EBPalpha expression, with the factor able to repress the murine promoter but activate the XENOPUS: gene...
  11. ncbi request reprint Molecular characterization of the Xenopus CCAAT-enhancer binding protein beta gene promoter
    P Foka
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, Wales, UK
    Biochem Biophys Res Commun 285:430-6. 2001
    ..However, a comparison of C/EBPbeta gene promoters characterized to date does indicate the existence of species-specific differences in autoregulation...
  12. ncbi request reprint Characterisation and developmental regulation of the Xenopus laevis CCAAT-enhancer binding protein beta gene
    S Kousteni
    School of Molecular and Medical Biosciences, Cardiff University, P O Box 911, Cardiff, CF1 3US, UK
    Mech Dev 77:143-8. 1998
    ..The expression domain becomes almost ubiquitous during later embryonic development, and includes the brain, spinal cord, somites and regions that give rise to the liver and the heart...
  13. ncbi request reprint The role of transforming growth factor-beta in atherosclerosis
    Nishi N Singh
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, United Kingdom
    Cytokine Growth Factor Rev 17:487-99. 2006
    ..This review will discuss the role of TGF-beta in atherosclerosis along with the molecular mechanisms underlying its action during the pathogenesis of the disease...
  14. doi request reprint ADAMTS proteases: key roles in atherosclerosis?
    Rebecca C Salter
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK CF10 3AX
    J Mol Med (Berl) 88:1203-11. 2010
    ..In this review, we introduce the structure and function of the ADAMTS family of proteases and review the literature that links them with inflammation and atherosclerosis...
  15. ncbi request reprint The ovine CCAAT-enhancer binding protein delta gene: cloning, characterization, and species-specific autoregulation
    G E Davies
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF1 3US, United Kingdom
    Biochem Biophys Res Commun 271:346-52. 2000
    ..These results suggest that, in common with C/EBPalpha, the C/EBPdelta genes may also be subject to autoregulation by distinct species-specific mechanisms...
  16. ncbi request reprint Critical role for casein kinase 2 and phosphoinositide-3-kinase in the interferon-gamma-induced expression of monocyte chemoattractant protein-1 and other key genes implicated in atherosclerosis
    Elizabeth J Harvey
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Arterioscler Thromb Vasc Biol 27:806-12. 2007
    ..The mechanisms underlying the actions of IFN-gamma signaling in macrophages were investigated using monocyte chemoattractant protein (MCP)-1 as a model gene...
  17. ncbi request reprint A novel role of Sp1 and Sp3 in the interferon-gamma -mediated suppression of macrophage lipoprotein lipase gene transcription
    Timothy R Hughes
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, United Kingdom
    J Biol Chem 277:11097-106. 2002
    ..In contrast, the cytokine decreased the DNA binding activity of Sp1 without affecting the protein levels. These studies therefore reveal a novel mechanism for IFN-gamma-mediated regulation of macrophage gene transcription...
  18. ncbi request reprint The pivotal role of lipoprotein lipase in atherosclerosis
    James R Mead
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, CF10 3US, Cardiff, UK
    Cardiovasc Res 55:261-9. 2002
  19. doi request reprint IL-33 reduces macrophage foam cell formation
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    J Immunol 185:1222-9. 2010
    ..In conclusion, IL-33 has a protective role in atherosclerosis by reducing macrophage foam cell formation suggesting that IL-33 maybe a potential therapeutic agent against atherosclerosis...
  20. pmc The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    J Immunol 184:5827-34. 2010
    ..We show, for the first time, a novel proatherogenic role for both TL1A and DR3 that implicates this pathway as a target for the therapeutic intervention of atherosclerosis...
  21. ncbi request reprint Lipoprotein lipase: structure, function, regulation, and role in disease
    James R Mead
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, UK
    J Mol Med (Berl) 80:753-69. 2002
    ..This review summarises recent findings in relation to the structure, function, and regulation of LPL along with its important role in disease...
  22. doi request reprint Interferon gamma: a master regulator of atherosclerosis
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Cytokine Growth Factor Rev 20:125-35. 2009
    ..This review will focus on evaluating the contribution of IFN-gamma to atherosclerosis and, in particular, how it regulates immune responses to the disease...
  23. ncbi request reprint Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription
    James R Mead
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, United Kingdom
    J Biol Chem 278:17741-51. 2003
    ....
  24. doi request reprint Protein kinase CK2, an important regulator of the inflammatory response?
    Nishi N Singh
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    J Mol Med (Berl) 86:887-97. 2008
    ..This review will give an overview of CK2 and its regulation and describe the evidence implicating its role in inflammation...
  25. ncbi request reprint The key role of apolipoprotein E in atherosclerosis
    Kirsty Greenow
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, UK
    J Mol Med (Berl) 83:329-42. 2005
    ....
  26. ncbi request reprint Interferon-gamma and atherosclerosis: pro- or anti-atherogenic?
    Elizabeth J Harvey
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Cardiovasc Res 67:11-20. 2005
    ..This review will discuss these actions of the cytokine along with recent findings that have emerged from mouse models of atherosclerosis that are deficient in IFN-gamma signaling...
  27. ncbi request reprint Transforming growth factor-beta-induced expression of the apolipoprotein E gene requires c-Jun N-terminal kinase, p38 kinase, and casein kinase 2
    Nishi N Singh
    School of Biosciences, Cardiff University, United Kingdom
    Arterioscler Thromb Vasc Biol 26:1323-9. 2006
    ..Despite such importance, the mechanisms underlying the regulation of apoE expression by TGF-beta have not been characterized and were therefore investigated...