D R Owens

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc Clinical evidence for the earlier initiation of insulin therapy in type 2 diabetes
    David R Owens
    Diabetes Research Group, Institute of Life Sciences College of Medicine, Swansea University, Swansea SA2 8PP, United Kingdom
    Diabetes Technol Ther 15:776-85. 2013
  2. ncbi request reprint Differential effects of GLP-1 receptor agonists on components of dysglycaemia in individuals with type 2 diabetes mellitus
    D R Owens
    Diabetes Research Group, Institute of Life Sciences College of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, UK Electronic address
    Diabetes Metab 39:485-96. 2013
  3. pmc Stepwise intensification of insulin therapy in type 2 diabetes management--exploring the concept of the basal-plus approach in clinical practice
    D R Owens
    Institute of Molecular and Experimental Medicine, Cardiff University, University Hospital of Wales, Cardiff, UK
    Diabet Med 30:276-88. 2013
  4. pmc Evaluation of an online interactive Diabetes Needs Assessment Tool (DNAT) versus online self-directed learning: a randomised controlled trial
    Sara Schroter
    BMJ Editorial Office, BMJ Group, BMA House, Tavistock Square, London WC1H 9JR, UK
    BMC Med Educ 11:35. 2011
  5. ncbi request reprint Increased prandial insulin secretion after administration of a single preprandial oral dose of repaglinide in patients with type 2 diabetes
    D R Owens
    Diabetes Research Unit, University of Wales College of Medicine, South Glamorgan, U K
    Diabetes Care 23:518-23. 2000
  6. doi request reprint The quest for physiologic insulin replacement
    David R Owens
    Diabetes Research Unit, Llandough Hospital, Penarth, Vale of Glamorgan, Cardiff, Wales CF64 2XX, United Kingdom
    Postgrad Med 116:4-12. 2004
  7. ncbi request reprint Insulins today and beyond
    D R Owens
    Diabetes Research Unit, Llandough Hospital, Penlan Road, Wales CF64 2XX, Penarth, UK
    Lancet 358:739-46. 2001
  8. doi request reprint Insulin preparations with prolonged effect
    David R Owens
    Diabetes Research Unit, Cardiff University, University Hospital Llandough, Penarth, United Kingdom
    Diabetes Technol Ther 13:S5-14. 2011
  9. ncbi request reprint Repaglinide: prandial glucose regulation in clinical practice
    D R Owens
    Diabetes Research Unit, Llandough Hospital, Penarth, South Glamorgan, UK
    Diabetes Obes Metab 2:S43-8. 2000
  10. doi request reprint Beyond the era of NPH insulin--long-acting insulin analogs: chemistry, comparative pharmacology, and clinical application
    D R Owens
    Diabetes Research Unit, Cardiff University, University Hospital Llandough, Penarth, United Kingdom
    Diabetes Technol Ther 10:333-49. 2008

Collaborators

Detail Information

Publications45

  1. pmc Clinical evidence for the earlier initiation of insulin therapy in type 2 diabetes
    David R Owens
    Diabetes Research Group, Institute of Life Sciences College of Medicine, Swansea University, Swansea SA2 8PP, United Kingdom
    Diabetes Technol Ther 15:776-85. 2013
    ..As such, early initiation of insulin therapy may not only help to avoid the effects of prolonged glycemic burden, but may also positively alter the course of disease progression...
  2. ncbi request reprint Differential effects of GLP-1 receptor agonists on components of dysglycaemia in individuals with type 2 diabetes mellitus
    D R Owens
    Diabetes Research Group, Institute of Life Sciences College of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, UK Electronic address
    Diabetes Metab 39:485-96. 2013
    ....
  3. pmc Stepwise intensification of insulin therapy in type 2 diabetes management--exploring the concept of the basal-plus approach in clinical practice
    D R Owens
    Institute of Molecular and Experimental Medicine, Cardiff University, University Hospital of Wales, Cardiff, UK
    Diabet Med 30:276-88. 2013
    ....
  4. pmc Evaluation of an online interactive Diabetes Needs Assessment Tool (DNAT) versus online self-directed learning: a randomised controlled trial
    Sara Schroter
    BMJ Editorial Office, BMJ Group, BMA House, Tavistock Square, London WC1H 9JR, UK
    BMC Med Educ 11:35. 2011
    ....
  5. ncbi request reprint Increased prandial insulin secretion after administration of a single preprandial oral dose of repaglinide in patients with type 2 diabetes
    D R Owens
    Diabetes Research Unit, University of Wales College of Medicine, South Glamorgan, U K
    Diabetes Care 23:518-23. 2000
    ..To examine the dose-related pharmacodynamics and pharmacokinetics of a single preprandial oral dose of repaglinide in patients with type 2 diabetes...
  6. doi request reprint The quest for physiologic insulin replacement
    David R Owens
    Diabetes Research Unit, Llandough Hospital, Penarth, Vale of Glamorgan, Cardiff, Wales CF64 2XX, United Kingdom
    Postgrad Med 116:4-12. 2004
    ..The molecular structures of these analogues have produced time-action profiles that better approach prandial and basal insulin secretion, thus allowing for easier, safer, and more flexible treatment regimens...
  7. ncbi request reprint Insulins today and beyond
    D R Owens
    Diabetes Research Unit, Llandough Hospital, Penlan Road, Wales CF64 2XX, Penarth, UK
    Lancet 358:739-46. 2001
    ..Parallel developments in glucose-sensing technologies are welcomed as an integral part of safe and optimum implementation of insulin replacement therapy...
  8. doi request reprint Insulin preparations with prolonged effect
    David R Owens
    Diabetes Research Unit, Cardiff University, University Hospital Llandough, Penarth, United Kingdom
    Diabetes Technol Ther 13:S5-14. 2011
    ..To date, the clinical experience with insulin degludec is limited but demonstrates it has comparable efficacy to insulin glargine...
  9. ncbi request reprint Repaglinide: prandial glucose regulation in clinical practice
    D R Owens
    Diabetes Research Unit, Llandough Hospital, Penarth, South Glamorgan, UK
    Diabetes Obes Metab 2:S43-8. 2000
    ..Given that most patients with type 2 diabetes require a multitherapy approach to achieve and sustain adequate glycaemic control, repaglinide will be an important element in future intensive therapy regimens...
  10. doi request reprint Beyond the era of NPH insulin--long-acting insulin analogs: chemistry, comparative pharmacology, and clinical application
    D R Owens
    Diabetes Research Unit, Cardiff University, University Hospital Llandough, Penarth, United Kingdom
    Diabetes Technol Ther 10:333-49. 2008
    ....
  11. doi request reprint Daytime variability of postprandial glucose tolerance and pancreatic B-cell function using 12-h profiles in persons with Type 2 diabetes
    R Peter
    Diabetes Research Unit, University Hospital Llandough, Penarth, UK
    Diabet Med 27:266-73. 2010
    ..To study the variation in daytime glucose tolerance and pancreatic B-cell function at different levels of glycated haemoglobin (HbA(1c)) in subjects with Type 2 diabetes (T2DM)...
  12. doi request reprint Performance of the revised '175' Modification of Diet in Renal Disease equation in patients with type 2 diabetes
    R A Chudleigh
    Diabetes Research Unit, Llandough Hospital, Penlan Road, Llandough, Penarth CF64 2XX, UK
    Diabetologia 51:1714-8. 2008
    ..We studied performance of the traditional '186' Modification of Diet in Renal Disease (MDRD) equation, and the 2005 revised '175' MDRD equation in patients with type 2 diabetes...
  13. doi request reprint Relative and absolute contributions of postprandial and fasting plasma glucose to daytime hyperglycaemia and HbA(1c) in subjects with Type 2 diabetes
    R Peter
    Diabetes Research Unit, University Hospital Llandough, Penarth, UK
    Diabet Med 26:974-80. 2009
    ..To determine the relative and absolute contributions of postprandial glucose (PPG) and fasting or preprandial plasma glucose (FPG) to daytime hyperglycaemia and HbA(1c) respectively, in persons with type 2 diabetes (T2DM)...
  14. pmc Effects of initiation and titration of a single pre-prandial dose of insulin glulisine while continuing titrated insulin glargine in type 2 diabetes: a 6-month 'proof-of-concept' study
    D R Owens
    Diabetes Research Unit, Cardiff University, University Hospital Llandough, Penarth, UK
    Diabetes Obes Metab 13:1020-7. 2011
    ..The efficacy of initiating and titrating a single bolus dose of insulin glulisine to baseline insulin glargine plus oral hypoglycaemic agents (OHAs) was investigated...
  15. ncbi request reprint Early-phase prandial insulin secretion: its role in the pathogenesis of type 2 diabetes mellitus and its modulation by repaglinide
    D R Owens
    Diabetes Research Unit, Llandough Hospital, University of Wales, College of Medicine, Cardiff, UK
    Diabetes Nutr Metab 15:19-27. 2002
    ..Prandial glucose regulation with repaglinide could be associated with lower post-prandial glucose excursions and less risk of post-prandial hypoglycaemia than glibenclamide...
  16. ncbi request reprint Comparison of the pharmacokinetics and pharmacodynamics of biphasic insulin aspart and insulin glargine in people with type 2 diabetes
    S Luzio
    Diabetes Research Unit, Llandough Hospital, Penlan Road, Penarth, South Glamorgan, CF64 2XX, UK
    Diabetologia 49:1163-8. 2006
    ..The pharmacokinetic and pharmacodynamic properties of biphasic insulin aspart (BIAsp 30) (30% soluble, 70% protaminated insulin aspart [IAsp]) and insulin glargine (IGlarg) were compared...
  17. doi request reprint Estimates of the relative and absolute diurnal contributions of fasting and post-prandial plasma glucose over a range of hyperglycaemia in type 2 diabetes
    R Peter
    Diabetes Research Group, Swansea University, Swansea, United Kingdom Electronic address
    Diabetes Metab 39:337-42. 2013
    ..To re-examine the relative and absolute contributions of fasting/pre-prandial glucose (FPG) and post-prandial glucose (PPG) to 24-h hyperglycaemia and HbA1c respectively in non-insulin treated subjects with type 2 diabetes (T2DM)...
  18. ncbi request reprint Relationship between HbA1c and indices of glucose tolerance derived from a standardized meal test in newly diagnosed treatment naive subjects with Type 2 diabetes
    R Peter
    Diabetes Research Unit, Academic Centre, Llandough Hospital, Penarth, UK
    Diabet Med 23:990-5. 2006
    ..To determine the relationship between HbA1c and other indices of glycaemic status derived during a standardized meal tolerance test (MTT) in newly diagnosed treatment-naive subjects with Type 2 diabetes (T2DM)...
  19. ncbi request reprint Comparison of the subcutaneous absorption of insulin glargine (Lantus) and NPH insulin in patients with Type 2 diabetes
    S D Luzio
    Diabetes Research Unit, Llandough Hospital and Community NHS Trust, Penlan Road, Penarth, Cardiff, UK
    Horm Metab Res 35:434-8. 2003
    ..Both insulin glargine and NPH insulin were well tolerated...
  20. ncbi request reprint Effects of timing of administration and meal composition on the pharmacokinetic and pharmacodynamic characteristics of the short-acting oral hypoglycemic agent nateglinide in healthy subjects
    S D Luzio
    Diabetes Research Unit, Llandough Hospital, Penlan Road, Penarth, South Glam, CF64 2XX, UK
    J Clin Endocrinol Metab 86:4874-80. 2001
    ..Preprandial administration of nateglinide was more effective in reducing prandial glucose excursions, compared with postmeal dosing (+10 min), a consequence of the earlier insulin response...
  21. ncbi request reprint Determining true glomerular filtration status in newly presenting type 2 diabetic subjects using age and sex adjustment
    R Playle
    Diabetes Research Unit, Llandough Hospital, Cardiff, Wales, UK
    Diabetes Care 21:1893-6. 1998
    ..To determine age- and sex-adjusted reference ranges (ASARRs) for glomerular filtration status using data from nondiabetic subjects and to apply these to newly presenting type 2 diabetic subjects...
  22. pmc Incidence of diabetic retinopathy in people with type 2 diabetes mellitus attending the Diabetic Retinopathy Screening Service for Wales: retrospective analysis
    R L Thomas
    Diabetes Research Unit, Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff CF14 4XW, UK
    BMJ 344:e874. 2012
    ..To determine the incidence of any and referable diabetic retinopathy in people with type 2 diabetes mellitus attending an annual screening service for retinopathy and whose first screening episode indicated no evidence of retinopathy...
  23. ncbi request reprint Glucose dependent insulinotropic polypeptide (GIP) infused intravenously is insulinotropic in the fasting state in type 2 (non-insulin dependent) diabetes mellitus
    I R Jones
    Department of Medicine, University of Wales, College of Medicine, Heath Park, Cardiff, United Kingdom
    Horm Metab Res 21:23-6. 1989
    ..At 4 min when a significant beta-cell response was observed GIP levels were well within the physiological range.(ABSTRACT TRUNCATED AT 250 WORDS)..
  24. ncbi request reprint Visual function in young IDDM patients over 8 years of age. A 4-year longitudinal study
    R V North
    Department of Optometry and Vision Sciences, University of Wales, Cardiff, U K
    Diabetes Care 20:1724-30. 1997
    ..To carry out a longitudinal study of visual functions in young patients over the age of 8 years with IDDM and to assess the impact of metabolic control on the presence of diabetic retinopathy...
  25. ncbi request reprint Insulin resistance and inflammation - A further systemic complication of COPD
    C E Bolton
    Department of Respiratory Medicine, School of Medicine, Cardiff University, Llandough Hospital, Vale of Glamorgan, UK
    COPD 4:121-6. 2007
    ..This relationship may indicate a contributory factor in the excess risk of cardiovascular disease and type II diabetes in COPD...
  26. doi request reprint The glucose lowering effect of an oral insulin (Capsulin) during an isoglycaemic clamp study in persons with type 2 diabetes
    S D Luzio
    Diabetes Research Unit, University Hospital Llandough, Penlan Road, Penarth, South Glamorgan, CF64 2XX, UK
    Diabetes Obes Metab 12:82-7. 2010
    ..Randomized, open, single-centre, two-way crossover study comparing the pharmacokinetic (PK) and pharmacodynamic (PD) properties of subcutaneous (sc) regular human insulin (Actrapid) and oral insulin in a capsule form (Capsulin)...
  27. ncbi request reprint A comparison of the pharmacodynamic profiles of insulin detemir and insulin glargine: a single dose clamp study in people with type 2 diabetes
    S D Luzio
    Diabetes Research Group, Swansea University, Swansea, United Kingdom Electronic address
    Diabetes Metab 39:537-42. 2013
    ..The pharmacodynamic properties of a single dose of 0.5 U/kg insulin detemir and insulin glargine were compared during two 24-h isoglycaemic clamps, one week apart...
  28. ncbi request reprint Day-to-day variability of fasting plasma glucose in newly diagnosed type 2 diabetic subjects
    R L Ollerton
    Diabetes Research Unit, Llandough Hospital, Cardiff, Wales, U K
    Diabetes Care 22:394-8. 1999
    ..To determine the day-to-day intraindividual variability of fasting plasma glucose (FPG) in newly diagnosed Caucasian type 2 diabetic subjects...
  29. doi request reprint Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study
    D R Owens
    University Hospital Llandough, Cardiff, UK
    Diabet Med 28:1352-61. 2011
    ..0-10.0%)] by metformin and sulphonylurea combination treatment...
  30. ncbi request reprint Alternative routes of insulin delivery
    D R Owens
    University of Wales College of Medicine, Cardiff, UK
    Diabet Med 20:886-98. 2003
    ..True insulin independence will require further advances in the combined fields of cell biology and genetics to ensure freedom from both the need for lifelong administration of insulin and the complications of diabetes...
  31. ncbi request reprint Insulin glargine (Lantus)
    D R Owens
    Diabetes Research Unit, University of Wales College of Medicine, Cardiff, UK
    Int J Clin Pract 56:460-6. 2002
    ..In patients where oral hypoglycaemic agents are failing, insulin glargine can be added. The early introduction of insulin in patients with type 2 diabetes is to be encouraged...
  32. ncbi request reprint Acute effects of valsartan on insulin sensitivity in obese, non-hypertensive subjects with and without type 2 diabetes
    S D Luzio
    Diabetes Research Unit, Llandough Hospital, Penlan Road, Penarth, S Glam CF64 2XX, Wales, UK
    Horm Metab Res 34:271-4. 2002
    ..Two studies were designed to determine whether a single dose (80 mg) of the angiotensin II receptor blocker (ARB), valsartan, alters insulin sensitivity in obese, non-hypertensive subjects with and without Type 2 diabetes...
  33. ncbi request reprint Importance of validation of immunoassays for intact proinsulin
    S D Luzio
    Diabetes Research Unit, Llandough Hospital, Penarth, UK
    Clin Chem Lab Med 39:631-3. 2001
    ..This study underlines the importance of the use of validation procedures which demonstrate quantitative analytical recoveries from a variety of specimens over the working range of the assay method in question...
  34. doi request reprint Diabetic retinopathy screening: perspectives of people with diabetes, screening intervals and costs of attending screening
    S T Yeo
    Centre for Health Economics and Medicines Evaluation, IMSCaR, College of Health and Behavioural Sciences, Bangor University, Bangor, UK
    Diabet Med 29:878-85. 2012
    ..To obtain the views of people with diabetes about the provision of diabetic retinopathy screening services; and the interval of screening...
  35. ncbi request reprint Comparison of subcutaneous soluble human insulin and insulin analogues (AspB9, GluB27; AspB10; AspB28) on meal-related plasma glucose excursions in type I diabetic subjects
    S Kang
    Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Diabetes Care 14:571-7. 1991
    ..All three analogues given immediately before the meal are at least as effective as soluble human insulin given 30 min earlier. These analogues are promising potential candidates for short-acting insulins of the future...
  36. ncbi request reprint The influence of plasma glucose upon pulsatile ocular blood flow in subjects with type II diabetes mellitus
    R L Perrott
    Department of Optometry and Vision Sciences, Cardiff University, UK
    Diabetologia 44:700-5. 2001
    ....
  37. doi request reprint Use of cystatin C-based estimations of glomerular filtration rate in patients with type 2 diabetes
    R A Chudleigh
    Diabetes Research Unit, Llandough University Hospital, Penlan Road, Llandough, Penarth, Cardiff, UK
    Diabetologia 52:1274-8. 2009
    ..Equations based on cystatin C provide an alternative method. We compared performance of the MDRD equation with a selection of cystatin C-based formulae for estimation of GFR in normoalbuminuric patients with type 2 diabetes...
  38. ncbi request reprint Results of the pilot study of DIADEM: a comprehensive disease management programme for type 2 diabetes
    S Luzio
    University of Wales College of Medicine, Cardiff, UK
    Diabetes Res Clin Pract 76:410-7. 2007
    ..The purpose of the study was to evaluate the feasibility and preliminary clinical effects of the DIADEM disease management programme for type 2 diabetic patients...
  39. doi request reprint Preferences of people with diabetes for diabetic retinopathy screening: a discrete choice experiment
    S T Yeo
    Centre for Health Economics and Medicines Evaluation, IMSCaR, College of Health and Behavioural Sciences, Bangor University, Bangor, UK
    Diabet Med 29:869-77. 2012
    ..As the first study of its kind, we aimed to determine preferences for diabetic retinopathy screening in people with diabetes and to examine the trade-offs between frequency of screening and other service attributes...
  40. ncbi request reprint Effect of darkness on inner retinal hypoxia in diabetes
    N Drasdo
    Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cathays Park, Cardiff CF10 3NB, UK
    Lancet 359:2251-3. 2002
    ..Oscillatory potentials in the controls were unaffected by oxygen. This finding strengthens support for the suggestion that diabetic patients might benefit from sleeping with night-time illumination...
  41. ncbi request reprint Feasibility of using the TOSCA telescreening procedures for diabetic retinopathy
    S Luzio
    Diabetes Research Unit, Penarth, Cardiff, UK
    Diabet Med 21:1121-8. 2004
    ....
  42. ncbi request reprint Type 2 diabetes: a well-characterised but suboptimally controlled disease. Can we bridge the divide?
    L Monnier
    Laboratory of Human Nutrition, University Institute of Clinical Research, 34093 Montpellier Cedex 5, France
    Diabetes Metab 34:207-16. 2008
    ....
  43. ncbi request reprint A placebo-controlled crossover study comparing the effects of nateglinide and glibenclamide on postprandial hyperglycaemia and hyperinsulinaemia in patients with type 2 diabetes
    A H Barnett
    Department of Medicine, Birmingham Heartlands Hospital, University of Birmingham, Birmingham, UK
    Diabetes Obes Metab 6:104-13. 2004
    ....
  44. ncbi request reprint Perceptions of diabetic retinopathy and screening procedures among diabetic people
    M Trento
    Centro Retinopatia Diabetica, Department of Internal Medicine, University of Turin, Turin, Italy
    Diabet Med 19:810-3. 2002
    ..To assess how diabetic patients perceive retinopathy, screening for sight-threatening lesions and their own role in preventing blindness...
  45. ncbi request reprint Contribution of fasting and postprandial plasma glucose to HbA1c
    R L Ollerton
    Diabet Med 22:954-5. 2005