Research Topics
| D R OwensSummaryAffiliation: Cardiff University Country: UK Publications
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Detail Information
Publications
Stepwise intensification of insulin therapy in type 2 diabetes management--exploring the concept of the basal-plus approach in clinical practiceD R Owens
Institute of Molecular and Experimental Medicine, Cardiff University, University Hospital of Wales, Cardiff, UK
Diabet Med 30:276-88. 2013....- Evaluation of an online interactive Diabetes Needs Assessment Tool (DNAT) versus online self-directed learning: a randomised controlled trialSara Schroter
BMJ Editorial Office, BMJ Group, BMA House, Tavistock Square, London WC1H 9JR, UK
BMC Med Educ 11:35. 2011.... 
Increased prandial insulin secretion after administration of a single preprandial oral dose of repaglinide in patients with type 2 diabetesD R Owens
Diabetes Research Unit, University of Wales College of Medicine, South Glamorgan, U K
Diabetes Care 23:518-23. 2000..To examine the dose-related pharmacodynamics and pharmacokinetics of a single preprandial oral dose of repaglinide in patients with type 2 diabetes...
Beyond the era of NPH insulin--long-acting insulin analogs: chemistry, comparative pharmacology, and clinical applicationD R Owens
Diabetes Research Unit, Cardiff University, University Hospital Llandough, Penarth, United Kingdom
Diabetes Technol Ther 10:333-49. 2008....- Insulins today and beyondD R Owens
Diabetes Research Unit, Llandough Hospital, Penlan Road, Wales CF64 2XX, Penarth, UK
Lancet 358:739-46. 2001..Parallel developments in glucose-sensing technologies are welcomed as an integral part of safe and optimum implementation of insulin replacement therapy... - The quest for physiologic insulin replacementDavid R Owens
Diabetes Research Unit, Llandough Hospital, Penarth, Vale of Glamorgan, Cardiff, Wales CF64 2XX, United Kingdom
Postgrad Med 116:4-12. 2004..The molecular structures of these analogues have produced time-action profiles that better approach prandial and basal insulin secretion, thus allowing for easier, safer, and more flexible treatment regimens... - Repaglinide: prandial glucose regulation in clinical practiceD R Owens
Diabetes Research Unit, Llandough Hospital, Penarth, South Glamorgan, UK
Diabetes Obes Metab 2:S43-8. 2000..Given that most patients with type 2 diabetes require a multitherapy approach to achieve and sustain adequate glycaemic control, repaglinide will be an important element in future intensive therapy regimens... - Insulin preparations with prolonged effectDavid R Owens
Diabetes Research Unit, Cardiff University, University Hospital Llandough, Penarth, United Kingdom
Diabetes Technol Ther 13:S5-14. 2011..To date, the clinical experience with insulin degludec is limited but demonstrates it has comparable efficacy to insulin glargine... - Daytime variability of postprandial glucose tolerance and pancreatic B-cell function using 12-h profiles in persons with Type 2 diabetesR Peter
Diabetes Research Unit, University Hospital Llandough, Penarth, UK
Diabet Med 27:266-73. 2010..To study the variation in daytime glucose tolerance and pancreatic B-cell function at different levels of glycated haemoglobin (HbA(1c)) in subjects with Type 2 diabetes (T2DM)... - Performance of the revised '175' Modification of Diet in Renal Disease equation in patients with type 2 diabetesR A Chudleigh
Diabetes Research Unit, Llandough Hospital, Penlan Road, Llandough, Penarth CF64 2XX, UK
Diabetologia 51:1714-8. 2008..We studied performance of the traditional '186' Modification of Diet in Renal Disease (MDRD) equation, and the 2005 revised '175' MDRD equation in patients with type 2 diabetes... - Relative and absolute contributions of postprandial and fasting plasma glucose to daytime hyperglycaemia and HbA(1c) in subjects with Type 2 diabetesR Peter
Diabetes Research Unit, University Hospital Llandough, Penarth, UK
Diabet Med 26:974-80. 2009..To determine the relative and absolute contributions of postprandial glucose (PPG) and fasting or preprandial plasma glucose (FPG) to daytime hyperglycaemia and HbA(1c) respectively, in persons with type 2 diabetes (T2DM)... - Effects of initiation and titration of a single pre-prandial dose of insulin glulisine while continuing titrated insulin glargine in type 2 diabetes: a 6-month 'proof-of-concept' studyD R Owens
Diabetes Research Unit, Cardiff University, University Hospital Llandough, Penarth, UK
Diabetes Obes Metab 13:1020-7. 2011..The efficacy of initiating and titrating a single bolus dose of insulin glulisine to baseline insulin glargine plus oral hypoglycaemic agents (OHAs) was investigated... - Early-phase prandial insulin secretion: its role in the pathogenesis of type 2 diabetes mellitus and its modulation by repaglinideD R Owens
Diabetes Research Unit, Llandough Hospital, University of Wales, College of Medicine, Cardiff, UK
Diabetes Nutr Metab 15:19-27. 2002..Prandial glucose regulation with repaglinide could be associated with lower post-prandial glucose excursions and less risk of post-prandial hypoglycaemia than glibenclamide... - Comparison of the pharmacokinetics and pharmacodynamics of biphasic insulin aspart and insulin glargine in people with type 2 diabetesS Luzio
Diabetes Research Unit, Llandough Hospital, Penlan Road, Penarth, South Glamorgan, CF64 2XX, UK
Diabetologia 49:1163-8. 2006..The pharmacokinetic and pharmacodynamic properties of biphasic insulin aspart (BIAsp 30) (30% soluble, 70% protaminated insulin aspart [IAsp]) and insulin glargine (IGlarg) were compared... - Relationship between HbA1c and indices of glucose tolerance derived from a standardized meal test in newly diagnosed treatment naive subjects with Type 2 diabetesR Peter
Diabetes Research Unit, Academic Centre, Llandough Hospital, Penarth, UK
Diabet Med 23:990-5. 2006..To determine the relationship between HbA1c and other indices of glycaemic status derived during a standardized meal tolerance test (MTT) in newly diagnosed treatment-naive subjects with Type 2 diabetes (T2DM)... - Comparison of the subcutaneous absorption of insulin glargine (Lantus) and NPH insulin in patients with Type 2 diabetesS D Luzio
Diabetes Research Unit, Llandough Hospital and Community NHS Trust, Penlan Road, Penarth, Cardiff, UK
Horm Metab Res 35:434-8. 2003..Both insulin glargine and NPH insulin were well tolerated... - Effects of timing of administration and meal composition on the pharmacokinetic and pharmacodynamic characteristics of the short-acting oral hypoglycemic agent nateglinide in healthy subjectsS D Luzio
Diabetes Research Unit, Llandough Hospital, Penlan Road, Penarth, South Glam, CF64 2XX, UK
J Clin Endocrinol Metab 86:4874-80. 2001..Preprandial administration of nateglinide was more effective in reducing prandial glucose excursions, compared with postmeal dosing (+10 min), a consequence of the earlier insulin response... - Determining true glomerular filtration status in newly presenting type 2 diabetic subjects using age and sex adjustmentR Playle
Diabetes Research Unit, Llandough Hospital, Cardiff, Wales, UK
Diabetes Care 21:1893-6. 1998..To determine age- and sex-adjusted reference ranges (ASARRs) for glomerular filtration status using data from nondiabetic subjects and to apply these to newly presenting type 2 diabetic subjects... - Incidence of diabetic retinopathy in people with type 2 diabetes mellitus attending the Diabetic Retinopathy Screening Service for Wales: retrospective analysisR L Thomas
Diabetes Research Unit, Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff CF14 4XW, UK
BMJ 344:e874. 2012..To determine the incidence of any and referable diabetic retinopathy in people with type 2 diabetes mellitus attending an annual screening service for retinopathy and whose first screening episode indicated no evidence of retinopathy... - The glucose lowering effect of an oral insulin (Capsulin) during an isoglycaemic clamp study in persons with type 2 diabetesS D Luzio
Diabetes Research Unit, University Hospital Llandough, Penlan Road, Penarth, South Glamorgan, CF64 2XX, UK
Diabetes Obes Metab 12:82-7. 2010..Randomized, open, single-centre, two-way crossover study comparing the pharmacokinetic (PK) and pharmacodynamic (PD) properties of subcutaneous (sc) regular human insulin (Actrapid) and oral insulin in a capsule form (Capsulin)... - Glucose dependent insulinotropic polypeptide (GIP) infused intravenously is insulinotropic in the fasting state in type 2 (non-insulin dependent) diabetes mellitusI R Jones
Department of Medicine, University of Wales, College of Medicine, Heath Park, Cardiff, United Kingdom
Horm Metab Res 21:23-6. 1989..At 4 min when a significant beta-cell response was observed GIP levels were well within the physiological range.(ABSTRACT TRUNCATED AT 250 WORDS).. - Visual function in young IDDM patients over 8 years of age. A 4-year longitudinal studyR V North
Department of Optometry and Vision Sciences, University of Wales, Cardiff, U K
Diabetes Care 20:1724-30. 1997..To carry out a longitudinal study of visual functions in young patients over the age of 8 years with IDDM and to assess the impact of metabolic control on the presence of diabetic retinopathy... - Insulin resistance and inflammation - A further systemic complication of COPDC E Bolton
Department of Respiratory Medicine, School of Medicine, Cardiff University, Llandough Hospital, Vale of Glamorgan, UK
COPD 4:121-6. 2007..This relationship may indicate a contributory factor in the excess risk of cardiovascular disease and type II diabetes in COPD... - Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized studyD R Owens
University Hospital Llandough, Cardiff, UK
Diabet Med 28:1352-61. 2011..0-10.0%)] by metformin and sulphonylurea combination treatment... - Day-to-day variability of fasting plasma glucose in newly diagnosed type 2 diabetic subjectsR L Ollerton
Diabetes Research Unit, Llandough Hospital, Cardiff, Wales, U K
Diabetes Care 22:394-8. 1999..To determine the day-to-day intraindividual variability of fasting plasma glucose (FPG) in newly diagnosed Caucasian type 2 diabetic subjects... - Importance of validation of immunoassays for intact proinsulinS D Luzio
Diabetes Research Unit, Llandough Hospital, Penarth, UK
Clin Chem Lab Med 39:631-3. 2001..This study underlines the importance of the use of validation procedures which demonstrate quantitative analytical recoveries from a variety of specimens over the working range of the assay method in question... - Acute effects of valsartan on insulin sensitivity in obese, non-hypertensive subjects with and without type 2 diabetesS D Luzio
Diabetes Research Unit, Llandough Hospital, Penlan Road, Penarth, S Glam CF64 2XX, Wales, UK
Horm Metab Res 34:271-4. 2002..Two studies were designed to determine whether a single dose (80 mg) of the angiotensin II receptor blocker (ARB), valsartan, alters insulin sensitivity in obese, non-hypertensive subjects with and without Type 2 diabetes... - Alternative routes of insulin deliveryD R Owens
University of Wales College of Medicine, Cardiff, UK
Diabet Med 20:886-98. 2003..True insulin independence will require further advances in the combined fields of cell biology and genetics to ensure freedom from both the need for lifelong administration of insulin and the complications of diabetes... - Insulin glargine (Lantus)D R Owens
Diabetes Research Unit, University of Wales College of Medicine, Cardiff, UK
Int J Clin Pract 56:460-6. 2002..In patients where oral hypoglycaemic agents are failing, insulin glargine can be added. The early introduction of insulin in patients with type 2 diabetes is to be encouraged... - Diabetic retinopathy screening: perspectives of people with diabetes, screening intervals and costs of attending screeningS T Yeo
Centre for Health Economics and Medicines Evaluation, IMSCaR, College of Health and Behavioural Sciences, Bangor University, Bangor, UK
Diabet Med 29:878-85. 2012..To obtain the views of people with diabetes about the provision of diabetic retinopathy screening services; and the interval of screening... - Comparison of subcutaneous soluble human insulin and insulin analogues (AspB9, GluB27; AspB10; AspB28) on meal-related plasma glucose excursions in type I diabetic subjectsS Kang
Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
Diabetes Care 14:571-7. 1991..All three analogues given immediately before the meal are at least as effective as soluble human insulin given 30 min earlier. These analogues are promising potential candidates for short-acting insulins of the future... - Use of cystatin C-based estimations of glomerular filtration rate in patients with type 2 diabetesR A Chudleigh
Diabetes Research Unit, Llandough University Hospital, Penlan Road, Llandough, Penarth, Cardiff, UK
Diabetologia 52:1274-8. 2009..Equations based on cystatin C provide an alternative method. We compared performance of the MDRD equation with a selection of cystatin C-based formulae for estimation of GFR in normoalbuminuric patients with type 2 diabetes... - The influence of plasma glucose upon pulsatile ocular blood flow in subjects with type II diabetes mellitusR L Perrott
Department of Optometry and Vision Sciences, Cardiff University, UK
Diabetologia 44:700-5. 2001.... - Results of the pilot study of DIADEM: a comprehensive disease management programme for type 2 diabetesS Luzio
University of Wales College of Medicine, Cardiff, UK
Diabetes Res Clin Pract 76:410-7. 2007..The purpose of the study was to evaluate the feasibility and preliminary clinical effects of the DIADEM disease management programme for type 2 diabetic patients... - Preferences of people with diabetes for diabetic retinopathy screening: a discrete choice experimentS T Yeo
Centre for Health Economics and Medicines Evaluation, IMSCaR, College of Health and Behavioural Sciences, Bangor University, Bangor, UK
Diabet Med 29:869-77. 2012..As the first study of its kind, we aimed to determine preferences for diabetic retinopathy screening in people with diabetes and to examine the trade-offs between frequency of screening and other service attributes... - Feasibility of using the TOSCA telescreening procedures for diabetic retinopathyS Luzio
Diabetes Research Unit, Penarth, Cardiff, UK
Diabet Med 21:1121-8. 2004.... - Effect of darkness on inner retinal hypoxia in diabetesN Drasdo
Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cathays Park, Cardiff CF10 3NB, UK
Lancet 359:2251-3. 2002..Oscillatory potentials in the controls were unaffected by oxygen. This finding strengthens support for the suggestion that diabetic patients might benefit from sleeping with night-time illumination... - Type 2 diabetes: a well-characterised but suboptimally controlled disease. Can we bridge the divide?L Monnier
Laboratory of Human Nutrition, University Institute of Clinical Research, 34093 Montpellier Cedex 5, France
Diabetes Metab 34:207-16. 2008.... - A placebo-controlled crossover study comparing the effects of nateglinide and glibenclamide on postprandial hyperglycaemia and hyperinsulinaemia in patients with type 2 diabetesA H Barnett
Department of Medicine, Birmingham Heartlands Hospital, University of Birmingham, Birmingham, UK
Diabetes Obes Metab 6:104-13. 2004.... - Contribution of fasting and postprandial plasma glucose to HbA1cR L Ollerton
Diabet Med 22:954-5. 2005 - Perceptions of diabetic retinopathy and screening procedures among diabetic peopleM Trento
Centro Retinopatia Diabetica, Department of Internal Medicine, University of Turin, Turin, Italy
Diabet Med 19:810-3. 2002..To assess how diabetic patients perceive retinopathy, screening for sight-threatening lesions and their own role in preventing blindness...