Michael J Owen

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc Neurodevelopmental hypothesis of schizophrenia
    Michael J Owen
    MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, UK
    Br J Psychiatry 198:173-5. 2011
  2. pmc Implications of genetic findings for understanding schizophrenia
    Michael J Owen
    MRC Centre for Neuropsychiatric Genetics and Genomics, and Neuroscience and Mental Health Research Institute, Cardiff University School of Medicine, Cardiff, UK
    Schizophr Bull 38:904-7. 2012
  3. pmc The health informatics cohort enhancement project (HICE): using routinely collected primary care data to identify people with a lifetime diagnosis of psychotic disorder
    Alexis Economou
    Centre for Health Information Research and Evaluation, ILS2, College of Medicine, Swansea University, Swansea, SA2 8PP, UK
    BMC Res Notes 5:95. 2012
  4. pmc De novo mutation in schizophrenia
    Elliott Rees
    MRC Centre for Neuropsychiatric Genetics and Genomics, Mental Health Research Institute, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff, CF14 4XN, UK
    Schizophr Bull 38:377-81. 2012
  5. pmc The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study
    Anne Farmer
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    BMC Psychiatry 4:42. 2004
  6. ncbi request reprint Schizophrenia: genes at last?
    M J Owen
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Trends Genet 21:518-25. 2005
  7. pmc The genetic deconstruction of psychosis
    Michael J Owen
    Department of Psychological Medicine, The School of Medicine, Cardiff University, Cardiff, UK
    Schizophr Bull 33:905-11. 2007
  8. doi request reprint Schizophrenia genetics: advancing on two fronts
    Michael J Owen
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Curr Opin Genet Dev 19:266-70. 2009
  9. ncbi request reprint No association between schizophrenia and polymorphisms in COMT in two large samples
    Hywel J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 162:1736-8. 2005
  10. ncbi request reprint Association analysis of AKT1 and schizophrenia in a UK case control sample
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Res 93:58-65. 2007

Collaborators

Detail Information

Publications180 found, 100 shown here

  1. pmc Neurodevelopmental hypothesis of schizophrenia
    Michael J Owen
    MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, UK
    Br J Psychiatry 198:173-5. 2011
    ..This has important implications for future research and for the configuration of psychiatric services...
  2. pmc Implications of genetic findings for understanding schizophrenia
    Michael J Owen
    MRC Centre for Neuropsychiatric Genetics and Genomics, and Neuroscience and Mental Health Research Institute, Cardiff University School of Medicine, Cardiff, UK
    Schizophr Bull 38:904-7. 2012
    ....
  3. pmc The health informatics cohort enhancement project (HICE): using routinely collected primary care data to identify people with a lifetime diagnosis of psychotic disorder
    Alexis Economou
    Centre for Health Information Research and Evaluation, ILS2, College of Medicine, Swansea University, Swansea, SA2 8PP, UK
    BMC Res Notes 5:95. 2012
    ..abstract:..
  4. pmc De novo mutation in schizophrenia
    Elliott Rees
    MRC Centre for Neuropsychiatric Genetics and Genomics, Mental Health Research Institute, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff, CF14 4XN, UK
    Schizophr Bull 38:377-81. 2012
    ..However, these are very small in scale, and the results can only be considered as preliminary...
  5. pmc The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study
    Anne Farmer
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    BMC Psychiatry 4:42. 2004
    ..This study presents the method and socio-demographic details of the first 470 affected sibling pairs recruited from 8 different sites in Europe and the United States of America...
  6. ncbi request reprint Schizophrenia: genes at last?
    M J Owen
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Trends Genet 21:518-25. 2005
    ..The identification of these, and other susceptibility genes, will open up new avenues for research aimed at understanding the pathogenesis of schizophrenia, and will catalyse a re-appraisal of the classification of psychiatric disorders...
  7. pmc The genetic deconstruction of psychosis
    Michael J Owen
    Department of Psychological Medicine, The School of Medicine, Cardiff University, Cardiff, UK
    Schizophr Bull 33:905-11. 2007
    ....
  8. doi request reprint Schizophrenia genetics: advancing on two fronts
    Michael J Owen
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Curr Opin Genet Dev 19:266-70. 2009
    ..There is evidence both for an increased burden of CNVs in schizophrenia and that risk is conferred by specific large deletions at 1q21.1 and at 15q13.2 and by deletions of NRXN1 which encodes the synaptic scaffolding protein neurexin 1...
  9. ncbi request reprint No association between schizophrenia and polymorphisms in COMT in two large samples
    Hywel J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 162:1736-8. 2005
    ..The authors examined these hypotheses...
  10. ncbi request reprint Association analysis of AKT1 and schizophrenia in a UK case control sample
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Res 93:58-65. 2007
    ..Examination of our own data and those of other groups leads us to conclude that overall, the evidence for association of AKT1 as a susceptibility gene for schizophrenia is weakly positive, but not yet convincing...
  11. pmc Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 103:12469-74. 2006
    ..Our data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function...
  12. doi request reprint Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    Biol Psychiatry 64:419-27. 2008
    ..We wished to investigate further the involvement of NRG1 in schizophrenia and bipolar disorder...
  13. doi request reprint Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia
    Marian L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 156:929-40. 2011
    ..At present there are no genome-wide significant linkage results for these phenotypes, but a number of suggestive findings warrant further investigation...
  14. ncbi request reprint Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia
    Timothy R Peirce
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, Wales
    Arch Gen Psychiatry 63:18-24. 2006
    ..However, it is unclear whether the observed changes in the schizophrenic brain are primary or secondary...
  15. ncbi request reprint Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK, and Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Schizophr Res 87:21-7. 2006
    ..Our data do not support the hypothesis that an interaction between these genes influences susceptibility to schizophrenia...
  16. ncbi request reprint Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 141:96-101. 2006
    ....
  17. ncbi request reprint Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13
    Marian L Hamshere
    Department of Psychological Medicine, School of Medicine, Cardiff University, Wales
    Arch Gen Psychiatry 62:1081-8. 2005
    ..However, twin data suggest that, in addition to genes with specificity for these phenotypes, there exist genes that simultaneously influence susceptibility to schizophrenia, bipolar disorder, and schizoaffective disorder...
  18. doi request reprint Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia
    James T R Walters
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, Wales
    Arch Gen Psychiatry 67:692-700. 2010
    ..The Zinc Finger Protein 804A gene (ZNF804A) has been implicated in schizophrenia susceptibility by several genome-wide association studies. ZNF804A is brain expressed but of unknown function...
  19. ncbi request reprint Linkage disequilibrium mapping of bipolar affective disorder at 12q23-q24 provides evidence for association at CUX2 and FLJ32356
    Beate Glaser
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 132:38-45. 2005
    ..Our data provide evidence for association between bipolar mood disorder and markers on chromosome 12q23-q24 but need replication in independent samples...
  20. doi request reprint An association study of common variation at the MAPT locus with late-onset Alzheimer's disease
    Richard Abraham
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, UK
    Am J Med Genet B Neuropsychiatr Genet 150:1152-5. 2009
    ..In summary, we find no evidence for allelic or haplotypic association, with SNPs in the MAPT gene and LOAD. SNP rs242557 is nominally significant in the APOE4 positive individuals. None of the SNPs studied modified AAO for LOAD...
  21. ncbi request reprint Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK
    Elaine K Green
    Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK
    Br J Psychiatry 188:21-5. 2006
    ..Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder...
  22. ncbi request reprint Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 191:402-7. 2007
    ..Genetic variations might modify associations between schizophrenia and cannabis or tobacco use...
  23. pmc TCF4, schizophrenia, and Pitt-Hopkins Syndrome
    Derek J Blake
    Department of Psychological Medicine and Neurology, Medical Research Council Center for Neuropsychiatric Genetics and Genomics, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Bull 36:443-7. 2010
    ..These data suggest that TCF4, NRXN1, and CNTNAP2 may participate in a biological pathway that is altered in patients with schizophrenia and other neuropsychiatric disorders...
  24. ncbi request reprint Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease
    Elaine Green
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK
    Am J Psychiatry 162:35-42. 2005
    ..Here molecular genetic analyses aimed at localizing and identifying the susceptibility gene in this region are reported...
  25. pmc Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia
    Marian L Hamshere
    Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Br J Psychiatry 203:107-11. 2013
    ..There is recent evidence of some degree of shared genetic susceptibility between adult schizophrenia and childhood attention-deficit hyperactivity disorder (ADHD) for rare chromosomal variants...
  26. ncbi request reprint The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease
    Amy Gerrish
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
    J Alzheimers Dis 28:377-87. 2012
    ..However, the gene-wide effect observed at MAPT indicates a possible contribution to disease risk which requires further study...
  27. pmc Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain
    Hywel J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, UK
    Am J Med Genet B Neuropsychiatr Genet 156:781-4. 2011
    ....
  28. pmc Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping
    Irina Zaharieva
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    BMC Psychiatry 8:11. 2008
    ..Several linkage studies suggest that chromosome 5q31-32 might contain risk loci for schizophrenia (SZ). We wanted to identify susceptibility genes for schizophrenia within this region...
  29. doi request reprint Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 196:235-40. 2010
    ..Attention-deficit hyperactivity disorder (ADHD) is recognised as a common, disabling condition. Little information is available regarding the long-term outcomes for individuals with ADHD in the UK...
  30. doi request reprint Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity
    Tom Fowler
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Psychiatr Genet 19:312-9. 2009
    ..The aims of this study were to test whether these gene variants are linked to psychopathy traits in attention-deficit hyperactivity disorder (ADHD)...
  31. ncbi request reprint Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria
    George Kirov
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:971-5. 2004
    ..We tried to replicate these findings in a sample of 488 parent-proband trios recruited in Bulgaria. Probands had a diagnosis of schizophrenia (n = 441) or schizoaffective disorder (n = 47)...
  32. doi request reprint Genotype link with extreme antisocial behavior: the contribution of cognitive pathways
    Kate Langley
    Department of Psychological Medicine and Neurology, Cardiff University, Wales, England
    Arch Gen Psychiatry 67:1317-23. 2010
    ..The same genotype has also been implicated in affecting cognitive function in healthy individuals. Impaired cognitive function might therefore lie on the risk pathway from genotype to clinical outcome...
  33. ncbi request reprint Support for RGS4 as a susceptibility gene for schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:192-5. 2004
    ..Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples...
  34. doi request reprint Identification of loci associated with schizophrenia by genome-wide association and follow-up
    Michael C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 40:1053-5. 2008
    ..Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9))...
  35. pmc No evidence for association between polymorphisms in GRM3 and schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff, UK
    BMC Psychiatry 5:23. 2005
    ..Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3...
  36. ncbi request reprint Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 16:2703-12. 2007
    ..Where samples overlapped, the genotyping consistency was high, estimated to average at 97.3%. Our large-scale linkage analysis consolidates clear evidence for a susceptibility locus for LOAD on 10q21.2...
  37. ncbi request reprint Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    J Psychiatr Res 40:622-6. 2006
    ....
  38. ncbi request reprint A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder
    Darko Turic
    Department of Psychological Medicine, Cardiff University, School of Medicine, Heath Park, Cardiff, United Kingdom
    Biol Psychiatry 57:1461-6. 2005
    ..SLC1A3 is thus both a functional and positional candidate gene for ADHD...
  39. doi request reprint Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches
    Masashi Ikeda
    MRC, Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 67:263-9. 2010
    ..Pharmacogenomic approaches based on genomewide sets of single nucleotide polymorphisms (SNPs) are now feasible and offer the potential to uncover variants that influence drug response...
  40. ncbi request reprint Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 128:19-20. 2004
    ..These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior...
  41. ncbi request reprint Strong evidence that GNB1L is associated with schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:555-66. 2008
    ..However, other explanations are possible, and further analyses will be required to clarify the correct functional mechanism...
  42. ncbi request reprint Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression
    Nicholas J Bray
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, UK
    Hum Mol Genet 14:1947-54. 2005
    ..Our data indicate that variation in the DTNBP1 gene confers susceptibility to schizophrenia through reduced expression, and that this, therefore, represents a primary aetiological mechanism in the disorder...
  43. ncbi request reprint Copy number variation in schizophrenia in the Japanese population
    Masashi Ikeda
    Medical Research Council MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Biol Psychiatry 67:283-6. 2010
    ..Copy number variants (CNVs) have been shown to increase the risk to develop schizophrenia. The best supported findings are at 1q21.1, 15q11.2, 15q13.3, and 22q11.2 and deletions at the gene neurexin 1 (NRXN1)...
  44. doi request reprint The role of the major histocompatibility complex region in cognition and brain structure: a schizophrenia GWAS follow-up
    James T R Walters
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, Wales
    Am J Psychiatry 170:877-85. 2013
    ..Follow-up of these results has the potential to provide insights into the pathophysiology of schizophrenia and cognition. ..
  45. ncbi request reprint Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes
    Nicholas J Bray
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 13:2885-92. 2004
    ..02). Our data indicate that, in human brain, most of the cis-acting variance in APOE expression is accounted for by the epsilon4 haplotype, but there are additional, small, cis-acting influences associated with promoter genotype...
  46. ncbi request reprint Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease
    Paul Hollingworth
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    J Am Geriatr Soc 54:1348-54. 2006
    ..To investigate behavioral components of Alzheimer's disease (AD) and to analyze behavioral components in relation to disease severity, apolipoprotein E genotype (APOE), sex, years of education, age at onset, and cognitive impairment...
  47. ncbi request reprint Risk of psychopathology in adolescent offspring of mothers with psychopathology and recurrent depression
    Ruth Sellers
    Child and Adolescent Psychiatry Section, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 202:108-14. 2013
    ..Offspring of mothers with depression are at heightened risk of psychiatric disorder. Many mothers with depression have comorbid psychopathology. How these co-occurring problems affect child outcomes has rarely been considered...
  48. doi request reprint Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder
    Tom Fowler
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Br J Psychiatry 194:62-7. 2009
    ..Children with attention-deficit hyperactivity disorder (ADHD) are thought to be at higher risk of psychopathy. Early biological and social adversity may contribute to this risk...
  49. ncbi request reprint Advances in genetic findings on attention deficit hyperactivity disorder
    Anita Thapar
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Psychol Med 37:1681-92. 2007
    ....
  50. pmc Pooled DNA genotyping on Affymetrix SNP genotyping arrays
    George Kirov
    Department of Psychological Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    BMC Genomics 7:27. 2006
    ..However, thus far, this conclusion is based upon published data concerning only a small number of SNPs...
  51. ncbi request reprint A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease
    Denise Harold
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Pharmacogenet Genomics 16:75-7. 2006
    ..Treatment with acetylcholinesterase (AChE) inhibitors aims to reverse this deficit and does ameliorate the decline in cognition in some AD patients, although response is variable...
  52. pmc Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
    Lesley Jones
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom
    PLoS ONE 5:e13950. 2010
    ..We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes...
  53. pmc Support for the involvement of large copy number variants in the pathogenesis of schizophrenia
    George Kirov
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK
    Hum Mol Genet 18:1497-503. 2009
    ..2 and schizophrenia (P = 0.026). This study confirms the involvement of rare CNVs in the pathogenesis of schizophrenia and contributes to the growing list of specific CNVs that are implicated...
  54. pmc A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain
    Nicholas J Bray
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, CF14 4XN, Wales, UK
    Am J Hum Genet 73:152-61. 2003
    ....
  55. doi request reprint Mood-incongruent psychosis in bipolar disorder: conditional linkage analysis shows genome-wide suggestive linkage at 1q32.3, 7p13 and 20q13.31
    Marian L Hamshere
    Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research in Wales, Cardiff, CF14 4XN, UK
    Bipolar Disord 11:610-20. 2009
    ..Findings in recent association studies at two specific genes suggest that the occurrence of mood-incongruent psychotic features may indicate a relatively homogeneous subset of the bipolar phenotype. We examined this hypothesis...
  56. pmc A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk
    Jade Chapman
    MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Hum Mol Genet 22:816-24. 2013
    ..Thus, in contrast to diseases such as schizophrenia, autism and attention deficit/hyperactivity disorder, CNVs do not appear to make a significant contribution to the development of AD...
  57. ncbi request reprint Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasis
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
    Am J Med Genet 114:491-6. 2002
    ..Our data, therefore, do not support the hypothesis that genetic variation in MAOA and COMT is involved individually or in combination in the etiology of schizophrenia...
  58. ncbi request reprint Association analysis of the HOPA12bp polymorphism in schizophrenia and manic depressive illness
    George Kirov
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff CF144 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 118:16-9. 2003
    ..6%, P = 0.6. We conclude that the HOPA polymorphism is unlikely to be a major risk factor in the pathogenesis of these major psychiatric disorders although there could be a small effect in schizophrenia...
  59. pmc Is COMT a susceptibility gene for schizophrenia?
    Hywel J Williams
    Department of Psychological Medicine, School of Medicine, Cardiff Uniiversity, Henry Wellcome Building, Health Park, Cardiff CF14 4XN, UK
    Schizophr Bull 33:635-41. 2007
    ....
  60. pmc Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD
    Evangelia Stergiakouli
    MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, Wales
    Am J Psychiatry 169:186-94. 2012
    ..The authors undertook a GWAS of ADHD and examined whether associated SNPs, including those below conventional levels of significance, influenced the same biological pathways affected by CNVs...
  61. ncbi request reprint Effects of differential genotyping error rate on the type I error probability of case-control studies
    Valentina Moskvina
    Bioinformatics and Biostatistics Unit, School of Medicine, Wales College of Medicine, Cardiff University, Cardiff, UK
    Hum Hered 61:55-64. 2006
    ....
  62. pmc A comparison of four clustering methods for brain expression microarray data
    Alexander L Richards
    Department of Psychological Medicine, School of Medicine, University Hospital Wales, Heath Park, Cardiff, Wales, UK
    BMC Bioinformatics 9:490. 2008
    ..The results are compared on speed, gene coverage and GO enrichment. The effects of combining the clusters produced by each method are also assessed...
  63. ncbi request reprint No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 58:78-80. 2005
    ..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()...
  64. doi request reprint Analysis of neurogranin (NRGN) in schizophrenia
    Rhodri Ll Smith
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine, School of Medicine, Cardiff University, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 156:532-5. 2011
    ..Finally, analysis of a brain expression dataset of at least 130 individuals did not identify any eQTLs that were correlated with associated SNP rs12807809 following correction for multiple testing...
  65. pmc Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
    ..5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86)...
  66. doi request reprint Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
    Hywel J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 20:387-91. 2011
    ..7 × 10(-5)). Including earlier reported data for trans-disorder effects for ZNF804A and CACNA1C, six out of eight of the most robustly associated loci for either disorder show trans-disorder effects...
  67. doi request reprint Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder
    Elaine K Green
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 153:1347-9. 2010
    ..Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052)...
  68. doi request reprint Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1
    Nicholas J Bray
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:1169-74. 2008
    ..Our data provide complementary evidence for chromosome 8p as a susceptibility locus for schizophrenia, and suggest that genetic variation within this region may influence risk, at least in part, through effects on DTNBP1 expression...
  69. ncbi request reprint Cannabis, COMT and psychotic experiences
    Stanley Zammit
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Psychiatry 199:380-5. 2011
    ..A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transferase (COMT) gene on psychosis has been reported, but not adequately replicated...
  70. pmc Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    Paul Hollingworth
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 43:429-35. 2011
    ..0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10))...
  71. ncbi request reprint Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 7:1092-100. 2002
    ..35, P = 0.006, P = 0.078 corrected for 13 alleles)...
  72. ncbi request reprint Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Mol Psychiatry 7:508-14. 2002
    ..2). These SNPs will therefore be suitable for studying neuropsychiatric phenotypes that are putatively related to NMDA dysfunction. Pooled analysis provided no support for association between any of the GRIN genes and schizophrenia...
  73. pmc No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study
    Sophie Mills
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    BMC Psychiatry 4:15. 2004
    ..Two studies showed that subjects with the low activity Met allele performed better on the Wisconsin Card Sorting Test (WCST) and another study found an effect on processing speed and attention...
  74. doi request reprint Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia
    Detelina Grozeva
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, UK
    Arch Gen Psychiatry 67:318-27. 2010
    ..The possible involvement of copy number variants (CNVs) in bipolar disorder has received little attention to date...
  75. ncbi request reprint Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)
    Rachel Raybould
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, Wales, UK
    Biol Psychiatry 57:696-701. 2005
    ..We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample...
  76. doi request reprint Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Eur Child Adolesc Psychiatry 18:26-32. 2009
    ....
  77. ncbi request reprint Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease
    Denise Harold
    Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK
    Hum Genet 113:258-67. 2003
    ..Levels of linkage disequilibrium were generally low across the CHAT locus but two of the coding variants, D7N and A120T, proved to be in complete linkage disequilibrium...
  78. ncbi request reprint Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease
    A R Morgan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 144:762-70. 2007
    ..Two SNPs in SGPL1 demonstrated marginal evidence of association, with uncorrected P values of 0.042 and 0.056, suggesting that variation in SGPL1 may confer susceptibility to LOAD...
  79. ncbi request reprint An update on the genetics of schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Curr Opin Psychiatry 19:158-64. 2006
    ..This paper reviews recent molecular genetic studies of schizophrenia and evaluates claims implicating specific genes as susceptibility loci...
  80. ncbi request reprint No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Psychiatr Genet 13:107-10. 2003
    ..In an attempt to replicate these findings, we examined this polymorphism and a variable number tandem repeat in the second intron of 5-HTT for association with ADHD...
  81. ncbi request reprint Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia
    George Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:458-65. 2008
    ..Both genes have been affected by CNVs in patients with autism and mental retardation, but neither has been previously implicated in SZ...
  82. pmc Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia
    Natalie Cope
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Am J Hum Genet 76:581-91. 2005
    ..006 in trios; 1-degree-of-freedom tests). Our data strongly implicate KIAA0319 as a susceptibility gene for dyslexia. The gene product is expressed in brain, but its specific function is currently unknown...
  83. ncbi request reprint Mutation screening of the Homer gene family and association analysis in schizophrenia
    N Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 120:18-21. 2003
    ..05). Our results suggest it is unlikely that sequence variants in the Homer genes contribute to the aetiology of schizophrenia, but the variants we identified are plausible candidates for other neuropsychiatric phenotypes...
  84. ncbi request reprint Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability
    D W Morris
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 129:97-103. 2004
    ..As these are the only clear cut functional candidate genes in the region, identification of the putative susceptibility locus for RD on 15q will require more methodical non-hypothesis driven positional cloning approaches...
  85. ncbi request reprint Association analysis of the glial cell line-derived neurotrophic factor (GDNF) gene in schizophrenia
    H J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Schizophr Res 97:271-6. 2007
    ..We conclude that our sample does not provide independent statistically significant evidence for association between GDNF and schizophrenia, nor does it replicate previous specific reports of association...
  86. ncbi request reprint Linkage analysis of the genetic loci for high myopia on 18p, 12q, and 17q in 51 U.K. families
    Jane E Farbrother
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 45:2879-85. 2004
    ..To determine the extent to which high myopia in a cohort of 51 U.K. families can be attributed to currently identified genetic loci...
  87. pmc Analysis of copy number variation using quantitative interspecies competitive PCR
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Nucleic Acids Res 36:e112. 2008
    ....
  88. ncbi request reprint A full genome scan for late onset Alzheimer's disease
    P Kehoe
    Neuropsychiatric Genetics Unit, Tenovus Building, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
    Hum Mol Genet 8:237-45. 1999
    ..Moreover, our data will be of interest to those hoping to identify positional candidate genes using information emerging from neurobiological studies of AD...
  89. ncbi request reprint Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia
    T Bowen
    Division of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Psychiatr Genet 10:33-7. 2000
    ..No evidence for association of CTG18.1, ERDA1 and/or TGC13-7a with schizophrenia was found. The combined data accounted for only 54% of the CAG/CTG arrays of > 40 repeats found in our previous RED analysis...
  90. ncbi request reprint Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia
    H J Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 120:42-6. 2003
    ..05 level. These results do not suggest that PRODH or PsPRODH contribute to the aetiology of schizophrenia, and that the putative schizophrenia susceptibility gene in 22q11 remains unknown...
  91. pmc Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes
    M L Hamshere
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, CF14 4XN, UK
    J Med Genet 43:563-7. 2006
    ..Schizophrenia shows substantial clinical heterogeneity. One common important clinical variable in presentation is the occurrence of episodes of major depression...
  92. ncbi request reprint CUX2, a potential regulator of NCAM expression: genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder
    N J Jacobsen
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet 105:295-300. 2001
    ..No evidence was found for the involvement of variants within the CUX2 coding, or 5' UTR sequence in producing susceptibility to bipolar disorder...
  93. ncbi request reprint No association between apolipoprotein E polymorphisms and general cognitive ability in children
    D Turic
    Neuropsychiatric Genetics Unit, Psychological Medicine, Tenovus Building, Heat Park, UWCM, Cardiff CF14 4XN, UK
    Neurosci Lett 299:97-100. 2001
    ..No evidence of association between these polymorphisms and g was found. We conclude that variation at these loci is not a factor with a measurable impact on general cognitive ability in the healthy population...
  94. ncbi request reprint Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD
    D Turic
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 127:68-72. 2004
    ..All were tested for possible association with ADHD using a combination of pooled and individual genotyping. The results of our study do not suggest that polymorphisms in these genes contribute to susceptibility to ADHD...
  95. ncbi request reprint Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine
    M J Arranz
    Department of Psychological Medicine, Institute of Psychiatry, Denmark Hill, London, UK
    Mol Psychiatry 3:61-6. 1998
    ..These results provide further evidence suggesting that genetic variation at 5-HT2A receptors may influence clozapine response and strengthen the candidacy of these receptors as important therapeutic targets...
  96. ncbi request reprint Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis. Molecular genetic study
    D Ivanov
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Br J Psychiatry 183:409-13. 2003
    ..About 30% of patients with VCFS have psychosis, and the rate of these deletions in schizophrenia has been reported to be about 1%. Even higher rates of VCFS deletions have been reported for childhood-onset schizophrenia...
  97. pmc Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept
    M L Hamshere
    Biostatistics and Bioinformatics Unit and Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Psychiatry 195:23-9. 2009
    ..Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research...
  98. ncbi request reprint Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease
    D Harold
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 144:448-52. 2007
    ..The most significant statistical interaction is between rs3740473, a synonymous single nucleotide polymorphism (SNP) in SH3MD1 and rs11244787, an intronic SNP in ADAM12 (effect size = 2.1 for interaction term, P = 0.006)...
  99. ncbi request reprint Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease
    R Abraham
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Hum Genet 109:646-52. 2001
    ..We conclude that IDE does not make a substantial contribution to the aetiology of LOAD and therefore cannot account for the linkage between LOAD and 10q...
  100. ncbi request reprint Genetic abnormalities of chromosome 22 and the development of psychosis
    Nigel M Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Curr Psychiatry Rep 6:176-82. 2004
    ..However, although a number of genes have been implicated as possible schizophrenia susceptibility loci, further confirmatory studies are required...
  101. ncbi request reprint Bipolar disorder among an isolated island community in Ethiopia
    Abebaw Fekadu
    Department of Psychological Medicine, University of Wales College Medicine, Cardiff, UK
    J Affect Disord 80:1-10. 2004
    ..The Zeway islanders have lived in geographic and cultural isolation for over three centuries...