Michael J Owen

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint Recent advances in the genetics of schizophrenia
    Michael C O'Donovan
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
    Hum Mol Genet 12:R125-33. 2003
  2. ncbi request reprint No association between schizophrenia and polymorphisms in COMT in two large samples
    Hywel J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 162:1736-8. 2005
  3. ncbi request reprint Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK, and Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Schizophr Res 87:21-7. 2006
  4. ncbi request reprint Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia
    Timothy R Peirce
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, Wales
    Arch Gen Psychiatry 63:18-24. 2006
  5. ncbi request reprint Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder
    Elaine K Green
    Department of Psychological Medicine and Biostatics and Bioinformatics Unit, University of Wales College of Medicine, Cardiff
    Arch Gen Psychiatry 62:642-8. 2005
  6. ncbi request reprint Linkage disequilibrium mapping of bipolar affective disorder at 12q23-q24 provides evidence for association at CUX2 and FLJ32356
    Beate Glaser
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 132:38-45. 2005
  7. ncbi request reprint Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease
    Elaine Green
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK
    Am J Psychiatry 162:35-42. 2005
  8. pmc No evidence for association between polymorphisms in GRM3 and schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff, UK
    BMC Psychiatry 5:23. 2005
  9. ncbi request reprint Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 191:402-7. 2007
  10. ncbi request reprint No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Psychiatr Genet 13:107-10. 2003

Detail Information

Publications96

  1. ncbi request reprint Recent advances in the genetics of schizophrenia
    Michael C O'Donovan
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
    Hum Mol Genet 12:R125-33. 2003
    ....
  2. ncbi request reprint No association between schizophrenia and polymorphisms in COMT in two large samples
    Hywel J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 162:1736-8. 2005
    ..The authors examined these hypotheses...
  3. ncbi request reprint Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK, and Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Schizophr Res 87:21-7. 2006
    ..Our data do not support the hypothesis that an interaction between these genes influences susceptibility to schizophrenia...
  4. ncbi request reprint Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia
    Timothy R Peirce
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, Wales
    Arch Gen Psychiatry 63:18-24. 2006
    ..However, it is unclear whether the observed changes in the schizophrenic brain are primary or secondary...
  5. ncbi request reprint Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder
    Elaine K Green
    Department of Psychological Medicine and Biostatics and Bioinformatics Unit, University of Wales College of Medicine, Cardiff
    Arch Gen Psychiatry 62:642-8. 2005
    ..The most consistent finding has been that one particular haplotype (the "core" haplotype) is overrepresented in cases compared with control subjects...
  6. ncbi request reprint Linkage disequilibrium mapping of bipolar affective disorder at 12q23-q24 provides evidence for association at CUX2 and FLJ32356
    Beate Glaser
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 132:38-45. 2005
    ..Our data provide evidence for association between bipolar mood disorder and markers on chromosome 12q23-q24 but need replication in independent samples...
  7. ncbi request reprint Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease
    Elaine Green
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK
    Am J Psychiatry 162:35-42. 2005
    ..Here molecular genetic analyses aimed at localizing and identifying the susceptibility gene in this region are reported...
  8. pmc No evidence for association between polymorphisms in GRM3 and schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff, UK
    BMC Psychiatry 5:23. 2005
    ..Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3...
  9. ncbi request reprint Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 191:402-7. 2007
    ..Genetic variations might modify associations between schizophrenia and cannabis or tobacco use...
  10. ncbi request reprint No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Psychiatr Genet 13:107-10. 2003
    ..In an attempt to replicate these findings, we examined this polymorphism and a variable number tandem repeat in the second intron of 5-HTT for association with ADHD...
  11. ncbi request reprint Support for RGS4 as a susceptibility gene for schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:192-5. 2004
    ..Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples...
  12. ncbi request reprint Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria
    George Kirov
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:971-5. 2004
    ..We tried to replicate these findings in a sample of 488 parent-proband trios recruited in Bulgaria. Probands had a diagnosis of schizophrenia (n = 441) or schizoaffective disorder (n = 47)...
  13. ncbi request reprint A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder
    Darko Turic
    Department of Psychological Medicine, Cardiff University, School of Medicine, Heath Park, Cardiff, United Kingdom
    Biol Psychiatry 57:1461-6. 2005
    ..SLC1A3 is thus both a functional and positional candidate gene for ADHD...
  14. ncbi request reprint Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    J Psychiatr Res 40:622-6. 2006
    ....
  15. ncbi request reprint Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes
    Nicholas J Bray
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 13:2885-92. 2004
    ..02). Our data indicate that, in human brain, most of the cis-acting variance in APOE expression is accounted for by the epsilon4 haplotype, but there are additional, small, cis-acting influences associated with promoter genotype...
  16. doi request reprint Identification of loci associated with schizophrenia by genome-wide association and follow-up
    Michael C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 40:1053-5. 2008
    ..Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9))...
  17. ncbi request reprint Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 128:19-20. 2004
    ..These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior...
  18. ncbi request reprint Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease
    Paul Hollingworth
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    J Am Geriatr Soc 54:1348-54. 2006
    ..To investigate behavioral components of Alzheimer's disease (AD) and to analyze behavioral components in relation to disease severity, apolipoprotein E genotype (APOE), sex, years of education, age at onset, and cognitive impairment...
  19. pmc A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain
    Nicholas J Bray
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, CF14 4XN, Wales, UK
    Am J Hum Genet 73:152-61. 2003
    ....
  20. ncbi request reprint No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 58:78-80. 2005
    ..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()...
  21. ncbi request reprint A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease
    Denise Harold
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Pharmacogenet Genomics 16:75-7. 2006
    ..Treatment with acetylcholinesterase (AChE) inhibitors aims to reverse this deficit and does ameliorate the decline in cognition in some AD patients, although response is variable...
  22. pmc Support for the involvement of large copy number variants in the pathogenesis of schizophrenia
    George Kirov
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK
    Hum Mol Genet 18:1497-503. 2009
    ..2 and schizophrenia (P = 0.026). This study confirms the involvement of rare CNVs in the pathogenesis of schizophrenia and contributes to the growing list of specific CNVs that are implicated...
  23. ncbi request reprint Association analysis of the HOPA12bp polymorphism in schizophrenia and manic depressive illness
    George Kirov
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff CF144 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 118:16-9. 2003
    ..6%, P = 0.6. We conclude that the HOPA polymorphism is unlikely to be a major risk factor in the pathogenesis of these major psychiatric disorders although there could be a small effect in schizophrenia...
  24. pmc Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia
    Natalie Cope
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Am J Hum Genet 76:581-91. 2005
    ..006 in trios; 1-degree-of-freedom tests). Our data strongly implicate KIAA0319 as a susceptibility gene for dyslexia. The gene product is expressed in brain, but its specific function is currently unknown...
  25. ncbi request reprint Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder
    Deborah C Lawson
    Department of Psychologycal Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 116:84-9. 2003
    ..0, 95% CI = 1.09, 3.5), and TDT analysis indicated a statistical trend toward association. Our findings highlight the importance of phenotype definition and the need for the MAOA VNTR to be further examined...
  26. ncbi request reprint Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease
    Denise Harold
    Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK
    Hum Genet 113:258-67. 2003
    ..Levels of linkage disequilibrium were generally low across the CHAT locus but two of the coding variants, D7N and A120T, proved to be in complete linkage disequilibrium...
  27. ncbi request reprint Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasis
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
    Am J Med Genet 114:491-6. 2002
    ..Our data, therefore, do not support the hypothesis that genetic variation in MAOA and COMT is involved individually or in combination in the etiology of schizophrenia...
  28. doi request reprint Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder
    Tom Fowler
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Br J Psychiatry 194:62-7. 2009
    ..Children with attention-deficit hyperactivity disorder (ADHD) are thought to be at higher risk of psychopathy. Early biological and social adversity may contribute to this risk...
  29. ncbi request reprint Advances in genetic findings on attention deficit hyperactivity disorder
    Anita Thapar
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Psychol Med 37:1681-92. 2007
    ....
  30. doi request reprint Mood-incongruent psychosis in bipolar disorder: conditional linkage analysis shows genome-wide suggestive linkage at 1q32.3, 7p13 and 20q13.31
    Marian L Hamshere
    Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research in Wales, Cardiff, CF14 4XN, UK
    Bipolar Disord 11:610-20. 2009
    ..Findings in recent association studies at two specific genes suggest that the occurrence of mood-incongruent psychotic features may indicate a relatively homogeneous subset of the bipolar phenotype. We examined this hypothesis...
  31. pmc No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study
    Sophie Mills
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    BMC Psychiatry 4:15. 2004
    ..Two studies showed that subjects with the low activity Met allele performed better on the Wisconsin Card Sorting Test (WCST) and another study found an effect on processing speed and attention...
  32. ncbi request reprint Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)
    Rachel Raybould
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, Wales, UK
    Biol Psychiatry 57:696-701. 2005
    ..We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample...
  33. pmc The genetic deconstruction of psychosis
    Michael J Owen
    Department of Psychological Medicine, The School of Medicine, Cardiff University, Cardiff, UK
    Schizophr Bull 33:905-11. 2007
    ....
  34. doi request reprint Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Eur Child Adolesc Psychiatry 18:26-32. 2009
    ....
  35. pmc Dysbindin-1 and schizophrenia: from genetics to neuropathology
    Michael J Owen
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    J Clin Invest 113:1255-7. 2004
    ..Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia...
  36. ncbi request reprint DNA pooling as a tool for large-scale association studies in complex traits
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Ann Med 36:146-52. 2004
    ..Here, we consider the main points in study design, and illustrate the application of pooling using psychiatric phenotypes as an example...
  37. ncbi request reprint An update on the genetics of schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Curr Opin Psychiatry 19:158-64. 2006
    ..This paper reviews recent molecular genetic studies of schizophrenia and evaluates claims implicating specific genes as susceptibility loci...
  38. pmc Finding schizophrenia genes
    George Kirov
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    J Clin Invest 115:1440-8. 2005
    ..These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it...
  39. pmc A comparison of four clustering methods for brain expression microarray data
    Alexander L Richards
    Department of Psychological Medicine, School of Medicine, University Hospital Wales, Heath Park, Cardiff, Wales, UK
    BMC Bioinformatics 9:490. 2008
    ..The results are compared on speed, gene coverage and GO enrichment. The effects of combining the clusters produced by each method are also assessed...
  40. ncbi request reprint Chromosome 22 deletion syndrome and schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, College of Medicine, Cardiff University, Cardiff, United Kingdom
    Int Rev Neurobiol 73:1-27. 2006
  41. ncbi request reprint Familiality of symptom dimensions in depression
    Ania Korszun
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Arch Gen Psychiatry 61:468-74. 2004
    ..A dimensional rather than a categorical approach to depressive phenotype definition may be more useful for identification of susceptibility genes...
  42. ncbi request reprint Genetic abnormalities of chromosome 22 and the development of psychosis
    Nigel M Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Curr Psychiatry Rep 6:176-82. 2004
    ..However, although a number of genes have been implicated as possible schizophrenia susceptibility loci, further confirmatory studies are required...
  43. doi request reprint New findings from genetic association studies of schizophrenia
    Hywel J Williams
    Department of Psychological Medicine, School of Medicine, Cardiff Universty, Heath Park, Cardiff, UK
    J Hum Genet 54:9-14. 2009
    ....
  44. pmc Analysis of copy number variation using quantitative interspecies competitive PCR
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Nucleic Acids Res 36:e112. 2008
    ....
  45. ncbi request reprint Association analysis of AKT1 and schizophrenia in a UK case control sample
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Res 93:58-65. 2007
    ..Examination of our own data and those of other groups leads us to conclude that overall, the evidence for association of AKT1 as a susceptibility gene for schizophrenia is weakly positive, but not yet convincing...
  46. ncbi request reprint Strong evidence that GNB1L is associated with schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:555-66. 2008
    ..However, other explanations are possible, and further analyses will be required to clarify the correct functional mechanism...
  47. ncbi request reprint The future of psychiatric genetics
    Marianne B M van den Bree
    Department of Psychological Medicine, University of Wales, College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Ann Med 35:122-34. 2003
    ..In this article, we consider the difficulties that complex diseases pose to genetic research, discuss progress and make suggestions regarding future directions...
  48. ncbi request reprint Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?
    Nigel M Williams
    Department of Psychological Medicine, Cardiff University, UK
    Schizophr Bull 31:800-5. 2005
    ....
  49. pmc Genetic overlap between autism, schizophrenia and bipolar disorder
    Liam S Carroll
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Genome Med 1:102. 2009
    ....
  50. ncbi request reprint HTR2A: association and expression studies in neuropsychiatric genetics
    Nadine Norton
    Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Ann Med 37:121-9. 2005
    ..In this review we examine and summarize these findings in various neuropsychiatric phenotypes...
  51. pmc Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis
    Nigel M Williams
    MRC Centre in Neuropsychiatric Genetics and Genomics and Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, UK
    Lancet 376:1401-8. 2010
    ..We aimed to establish whether burden of CNVs was increased in ADHD, and to investigate whether identified CNVs were enriched for loci previously identified in autism and schizophrenia...
  52. doi request reprint Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder
    Elaine K Green
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 153:1347-9. 2010
    ..Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide Pā€‰=ā€‰0.0058; experiment-wide corrected significance Pā€‰=ā€‰0.052)...
  53. doi request reprint Genetics of psychosis; insights from views across the genome
    Michael C O'Donovan
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Heath Park, Cardiff CF23 6BQ, UK
    Hum Genet 126:3-12. 2009
    ..They also provide grounds for optimism that larger studies will reveal more about the origins of these disorders, although currently, very little of the genetic risk of either disorder is explained...
  54. ncbi request reprint Cis-acting variation in the expression of a high proportion of genes in human brain
    Nicholas J Bray
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Hum Genet 113:149-53. 2003
    ....
  55. pmc Genome scans and microarrays: converging on genes for schizophrenia?
    Nigel M Williams
    Department of Psychological Medicine, Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    Genome Biol 3:REVIEWS1011. 2002
    ..Microarray expression analysis may identify new candidate genes and pathways, and a number of intriguing preliminary findings have already been reported...
  56. ncbi request reprint Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Hum Genet 110:471-8. 2002
    ..Our assay conditions are generalisable, universal, robust and, therefore, for the first time, permit high-throughput association analysis at a realistic cost...
  57. ncbi request reprint Genomic approaches to schizophrenia
    Michael J Owen
    Department of Psychological Medicine, School of Medicine, Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Clin Ther 27:S2-7. 2005
    ..However, like other common disorders, the mode of transmission is complex and probably reflects oligogenic inheritance against a polygenic background...
  58. ncbi request reprint Memory for new information as a cognitive marker of liability to Alzheimer's disease in a high risk group: a research note
    Frances Rice
    Department of Psychological Medicine, 4th Floor, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Int J Geriatr Psychiatry 18:155-60. 2003
    ..The development of Alzheimer's disease (AD) is often insidious and there is evidence that pre-morbid neuropsychological deficits exist...
  59. ncbi request reprint Bipolar disorder among an isolated island community in Ethiopia
    Abebaw Fekadu
    Department of Psychological Medicine, University of Wales College Medicine, Cardiff, UK
    J Affect Disord 80:1-10. 2004
    ..The Zeway islanders have lived in geographic and cultural isolation for over three centuries...
  60. pmc Analysis of copy number variations at 15 schizophrenia-associated loci
    Elliott Rees
    Elliott Rees, MRes, James T R Walters, PhD, MRCPsych, Lyudmila Georgieva, PhD, Anthony R Isles, PhD, MRC, Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK Kimberly D Chambert, MS, Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachuetts, USA Alexander L Richards, PhD, Gerwyn Mahoney Davies, Bsc, Sophie E Legge, Bsc, Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK Jennifer L Moran, PhD, Steven A McCarroll, PhD, Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge
    Br J Psychiatry 204:108-14. 2014
    ..A number of copy number variants (CNVs) have been suggested as susceptibility factors for schizophrenia. For some of these the data remain equivocal, and the frequency in individuals with schizophrenia is uncertain...
  61. ncbi request reprint Wake-up call for British psychiatry
    Nick Craddock
    Department of Psychological Medicine, Medical School, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 193:6-9. 2008
    ..On the 200th birthday of psychiatry, it is fitting to reconsider the specialty's core values and renew efforts to use psychiatric skills for the maximum benefit of patients...
  62. ncbi request reprint Paternal age and risk for schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Br J Psychiatry 183:405-8. 2003
    ....
  63. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  64. ncbi request reprint Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease
    Hao Li
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Arch Neurol 65:45-53. 2008
    ..To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs...
  65. ncbi request reprint Mutational analysis of two positional candidate susceptibility genes for bipolar disorder on chromosome 12q23-q24: phenylalanine hydroxylase and human LIM-homeobox LHX5
    Elaine K Green
    Molecular Psychiatry Group, Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham, UK
    Psychiatr Genet 13:97-101. 2003
    ..1; pedigree 5501, maximum LOD=3.6)...
  66. pmc A network of dopaminergic gene variations implicated as risk factors for schizophrenia
    Michael E Talkowski
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hum Mol Genet 17:747-58. 2008
    ..Our data suggest that a network of dopaminergic polymorphisms increase risk for SZ...
  67. ncbi request reprint Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 17:759-67. 2008
    ..These data implicate NEDD9 as a novel susceptibility gene for LOAD and possibly PD...
  68. doi request reprint A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder
    Avshalom Caspi
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 65:203-10. 2008
    ..Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous neurodevelopmental disorder that in some cases is accompanied by antisocial behavior...
  69. pmc Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kindgdom
    PLoS Genet 4:e28. 2008
    ..58 (p = 8.8 x 10(-7); p = 1.6 x 10(-5) for gene-sex interaction). The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease...
  70. pmc Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping
    Irina Zaharieva
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    BMC Psychiatry 8:11. 2008
    ..Several linkage studies suggest that chromosome 5q31-32 might contain risk loci for schizophrenia (SZ). We wanted to identify susceptibility genes for schizophrenia within this region...
  71. doi request reprint Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    Biol Psychiatry 64:419-27. 2008
    ..We wished to investigate further the involvement of NRG1 in schizophrenia and bipolar disorder...
  72. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  73. ncbi request reprint Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 141:96-101. 2006
    ....
  74. ncbi request reprint Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13
    Marian L Hamshere
    Department of Psychological Medicine, School of Medicine, Cardiff University, Wales
    Arch Gen Psychiatry 62:1081-8. 2005
    ..However, twin data suggest that, in addition to genes with specificity for these phenotypes, there exist genes that simultaneously influence susceptibility to schizophrenia, bipolar disorder, and schizoaffective disorder...
  75. ncbi request reprint Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression
    Nicholas J Bray
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, UK
    Hum Mol Genet 14:1947-54. 2005
    ..Our data indicate that variation in the DTNBP1 gene confers susceptibility to schizophrenia through reduced expression, and that this, therefore, represents a primary aetiological mechanism in the disorder...
  76. ncbi request reprint Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme
    Petra Nowotny
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 136:62-8. 2005
    ..Although our results are not universally negative, we were unable to replicate the results of previous studies and conclude that common variants or haplotypes of these variants in IDE are not major risk factors for LOAD...
  77. ncbi request reprint No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:739-41. 2002
    ..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
  78. ncbi request reprint Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease
    Victoria Busby
    Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Neuromolecular Med 5:133-46. 2004
    ..None of these SNPs was associated with disease. Although an excellent candidate, we conclude that CTNNA3 is unlikely to account for the AD susceptibility locus on chromosome 10...
  79. ncbi request reprint Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD
    Amanda J Myers
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Med Genet B Neuropsychiatr Genet 124:29-37. 2004
    ..Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data...
  80. ncbi request reprint Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia
    Lyudmila Georgieva
    Department of Medical Genetics, Medical University Sofia, Sofia, Bulgaria
    Psychiatr Genet 13:103-6. 2003
    ..31, a region in which evidence for linkage to schizophrenia has been reported. The gene has an unusually large first exon of 3544 nucleotides, which encodes the signal peptide and all nine ectodomains in the protein...
  81. ncbi request reprint Association between a promoter variant in the monoamine oxidase A gene and schizophrenia
    Erik G Jonsson
    Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institute and Hospital, R5 00, SE 171 76 Stockholm, Sweden
    Schizophr Res 61:31-7. 2003
    ..05). In women, no significant differences were found. The present results support the involvement of the MAOA gene in men with schizophrenia in the investigated Swedish population but should be interpreted with caution until replicated...
  82. ncbi request reprint Genes for schizophrenia? Recent findings and their pathophysiological implications
    Paul J Harrison
    University of Oxford Department of Psychiatry, Neurosciences Building, Warneford Hospital, OX3 7JX, Oxford, UK
    Lancet 361:417-9. 2003
    ..Identifying the genes is essential if the pathogenesis and pathophysiology of schizophrenia is finally to be understood, and to give the prospect of more effective treatment...
  83. ncbi request reprint Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease
    Scott Smemo
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Street, St Louis, MO 63110, USA
    Ann Neurol 59:21-6. 2006
    ..We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD...
  84. ncbi request reprint Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK
    Elaine K Green
    Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK
    Br J Psychiatry 188:21-5. 2006
    ..Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder...
  85. ncbi request reprint Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 16:2703-12. 2007
    ..Where samples overlapped, the genotyping consistency was high, estimated to average at 97.3%. Our large-scale linkage analysis consolidates clear evidence for a susceptibility locus for LOAD on 10q21.2...
  86. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  87. ncbi request reprint Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci
    Gillian Hamilton
    MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, Kings College London, Denmark Hill, London, UK
    Am J Med Genet B Neuropsychiatr Genet 144:508-16. 2007
    ..In particular, our data suggest that the effect of variants within these genes might be influenced by gender...
  88. pmc Is COMT a susceptibility gene for schizophrenia?
    Hywel J Williams
    Department of Psychological Medicine, School of Medicine, Cardiff Uniiversity, Henry Wellcome Building, Health Park, Cardiff CF14 4XN, UK
    Schizophr Bull 33:635-41. 2007
    ....
  89. ncbi request reprint Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants
    Andrew Grupe
    Celera Diagnostics, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 16:865-73. 2007
    ..This is a missense mutation in the galanin-like peptide precursor gene (P = 0.00005, OR = 1.2, false positive rate = 0.87)...
  90. pmc Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 103:12469-74. 2006
    ..Our data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function...
  91. ncbi request reprint Effects of differential genotyping error rate on the type I error probability of case-control studies
    Valentina Moskvina
    Bioinformatics and Biostatistics Unit, School of Medicine, Wales College of Medicine, Cardiff University, Cardiff, UK
    Hum Hered 61:55-64. 2006
    ....
  92. ncbi request reprint Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder
    Nigel M Williams
    Department of Psychological Medicine and Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University
    Arch Gen Psychiatry 63:366-73. 2006
    ..Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association...
  93. ncbi request reprint Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease
    Gillian Hamilton
    MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, Kings College London, Denmark Hill, London SE5 8AF, UK
    Neurosci Lett 401:77-80. 2006
    ..Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD...
  94. pmc Pooled DNA genotyping on Affymetrix SNP genotyping arrays
    George Kirov
    Department of Psychological Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    BMC Genomics 7:27. 2006
    ..However, thus far, this conclusion is based upon published data concerning only a small number of SNPs...
  95. ncbi request reprint Major psychiatric disorders and the serotonin transporter gene (SLC6A4): family-based association studies
    Albena Dimitrova
    Department of Medical Genetics, Medical University Sofia, University Hospital Maichin Dom, Sofia, Bulgaria
    Psychiatr Genet 12:137-41. 2002
    ..2). The VNTR polymorphism in the 5-HTT gene does not appear to be a major risk factor for increasing susceptibility to major psychiatric disorders...