Michael J Owen

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi Genetic overlap between autism, schizophrenia and bipolar disorder
    Liam S Carroll
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Genome Med 1:102. 2009
  2. ncbi Methylenetetrahydrofolate reductase gene variant (MTHFR C677T) and migraine: a case control study and meta-analysis
    Zainab Samaan
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    BMC Neurol 11:66. 2011
  3. ncbi Dysbindin-1 and schizophrenia: from genetics to neuropathology
    Michael J Owen
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    J Clin Invest 113:1255-7. 2004
  4. ncbi The molecular genetics of schizophrenia: new findings promise new insights
    M J Owen
    Department of Psychological Medicine, Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Cardiff, UK
    Mol Psychiatry 9:14-27. 2004
  5. ncbi Genomic approaches to schizophrenia
    Michael J Owen
    Department of Psychological Medicine, School of Medicine, Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Clin Ther 27:S2-7. 2005
  6. ncbi Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13
    Marian L Hamshere
    Department of Psychological Medicine, School of Medicine, Cardiff University, Wales
    Arch Gen Psychiatry 62:1081-8. 2005
  7. ncbi No association between schizophrenia and polymorphisms in COMT in two large samples
    Hywel J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 162:1736-8. 2005
  8. ncbi Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    Biol Psychiatry 64:419-27. 2008
  9. ncbi Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 103:12469-74. 2006
  10. ncbi Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia
    Marian L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 156:929-40. 2011

Detail Information

Publications168 found, 100 shown here

  1. ncbi Genetic overlap between autism, schizophrenia and bipolar disorder
    Liam S Carroll
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Genome Med 1:102. 2009
    ....
  2. ncbi Methylenetetrahydrofolate reductase gene variant (MTHFR C677T) and migraine: a case control study and meta-analysis
    Zainab Samaan
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    BMC Neurol 11:66. 2011
    ..We aim to investigate the effect of this variant on propensity for migraine and to perform a systematic review and meta-analysis of studies of MTHFR and migraine to date...
  3. ncbi Dysbindin-1 and schizophrenia: from genetics to neuropathology
    Michael J Owen
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    J Clin Invest 113:1255-7. 2004
    ..Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia...
  4. ncbi The molecular genetics of schizophrenia: new findings promise new insights
    M J Owen
    Department of Psychological Medicine, Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Cardiff, UK
    Mol Psychiatry 9:14-27. 2004
    ..The ability of positional genetics to implicate novel genes and pathways will open up new vistas for neurobiological research, and all the signs are that it is now poised to deliver crucial insights into the nature of schizophrenia...
  5. ncbi Genomic approaches to schizophrenia
    Michael J Owen
    Department of Psychological Medicine, School of Medicine, Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Clin Ther 27:S2-7. 2005
    ..However, like other common disorders, the mode of transmission is complex and probably reflects oligogenic inheritance against a polygenic background...
  6. ncbi Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13
    Marian L Hamshere
    Department of Psychological Medicine, School of Medicine, Cardiff University, Wales
    Arch Gen Psychiatry 62:1081-8. 2005
    ..Follow-up of this region should use samples enriched for cases of schizoaffective disorder. Our findings have similar implications for the search for genetic variation on chromosome 22q11 that influences susceptibility to psychosis...
  7. ncbi No association between schizophrenia and polymorphisms in COMT in two large samples
    Hywel J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 162:1736-8. 2005
    ..The authors examined these hypotheses...
  8. ncbi Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    Biol Psychiatry 64:419-27. 2008
    ..We wished to investigate further the involvement of NRG1 in schizophrenia and bipolar disorder...
  9. ncbi Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 103:12469-74. 2006
    ..Our data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function...
  10. ncbi Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia
    Marian L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 156:929-40. 2011
    ..At present there are no genome-wide significant linkage results for these phenotypes, but a number of suggestive findings warrant further investigation...
  11. ncbi Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia
    Timothy R Peirce
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, Wales
    Arch Gen Psychiatry 63:18-24. 2006
    ..However, it is unclear whether the observed changes in the schizophrenic brain are primary or secondary...
  12. ncbi Association analysis of AKT1 and schizophrenia in a UK case control sample
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Res 93:58-65. 2007
    ..Examination of our own data and those of other groups leads us to conclude that overall, the evidence for association of AKT1 as a susceptibility gene for schizophrenia is weakly positive, but not yet convincing...
  13. ncbi Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder
    Elaine K Green
    Department of Psychological Medicine and Biostatics and Bioinformatics Unit, University of Wales College of Medicine, Cardiff
    Arch Gen Psychiatry 62:642-8. 2005
    ..The most consistent finding has been that one particular haplotype (the "core" haplotype) is overrepresented in cases compared with control subjects...
  14. ncbi Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 141:96-101. 2006
    ....
  15. ncbi Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK, and Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Schizophr Res 87:21-7. 2006
    ..Our data do not support the hypothesis that an interaction between these genes influences susceptibility to schizophrenia...
  16. ncbi Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK
    Elaine K Green
    Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK
    Br J Psychiatry 188:21-5. 2006
    ..Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder...
  17. ncbi Linkage disequilibrium mapping of bipolar affective disorder at 12q23-q24 provides evidence for association at CUX2 and FLJ32356
    Beate Glaser
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 132:38-45. 2005
    ..Our data provide evidence for association between bipolar mood disorder and markers on chromosome 12q23-q24 but need replication in independent samples...
  18. ncbi An association study of common variation at the MAPT locus with late-onset Alzheimer's disease
    Richard Abraham
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, UK
    Am J Med Genet B Neuropsychiatr Genet 150:1152-5. 2009
    ..In summary, we find no evidence for allelic or haplotypic association, with SNPs in the MAPT gene and LOAD. SNP rs242557 is nominally significant in the APOE4 positive individuals. None of the SNPs studied modified AAO for LOAD...
  19. ncbi Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia
    James T R Walters
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, Wales
    Arch Gen Psychiatry 67:692-700. 2010
    ..The Zinc Finger Protein 804A gene (ZNF804A) has been implicated in schizophrenia susceptibility by several genome-wide association studies. ZNF804A is brain expressed but of unknown function...
  20. ncbi Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 191:402-7. 2007
    ..Genetic variations might modify associations between schizophrenia and cannabis or tobacco use...
  21. ncbi Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria
    George Kirov
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:971-5. 2004
    ..We tried to replicate these findings in a sample of 488 parent-proband trios recruited in Bulgaria. Probands had a diagnosis of schizophrenia (n = 441) or schizoaffective disorder (n = 47)...
  22. ncbi TCF4, schizophrenia, and Pitt-Hopkins Syndrome
    Derek J Blake
    Department of Psychological Medicine and Neurology, Medical Research Council Center for Neuropsychiatric Genetics and Genomics, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Bull 36:443-7. 2010
    ..These data suggest that TCF4, NRXN1, and CNTNAP2 may participate in a biological pathway that is altered in patients with schizophrenia and other neuropsychiatric disorders...
  23. ncbi No evidence for association between polymorphisms in GRM3 and schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff, UK
    BMC Psychiatry 5:23. 2005
    ..Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3...
  24. ncbi Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping
    Irina Zaharieva
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    BMC Psychiatry 8:11. 2008
    ..Several linkage studies suggest that chromosome 5q31-32 might contain risk loci for schizophrenia (SZ). We wanted to identify susceptibility genes for schizophrenia within this region...
  25. ncbi Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 196:235-40. 2010
    ..Attention-deficit hyperactivity disorder (ADHD) is recognised as a common, disabling condition. Little information is available regarding the long-term outcomes for individuals with ADHD in the UK...
  26. ncbi Identification of loci associated with schizophrenia by genome-wide association and follow-up
    Michael C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 40:1053-5. 2008
    ..Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9))...
  27. ncbi Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity
    Tom Fowler
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Psychiatr Genet 19:312-9. 2009
    ..The aims of this study were to test whether these gene variants are linked to psychopathy traits in attention-deficit hyperactivity disorder (ADHD)...
  28. ncbi No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Psychiatr Genet 13:107-10. 2003
    ..In an attempt to replicate these findings, we examined this polymorphism and a variable number tandem repeat in the second intron of 5-HTT for association with ADHD...
  29. ncbi Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain
    Hywel J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, UK
    Am J Med Genet B Neuropsychiatr Genet 156:781-4. 2011
    ....
  30. ncbi The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease
    Amy Gerrish
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
    J Alzheimers Dis 28:377-87. 2012
    ..However, the gene-wide effect observed at MAPT indicates a possible contribution to disease risk which requires further study...
  31. ncbi Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches
    Masashi Ikeda
    MRC, Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 67:263-9. 2010
    ..Pharmacogenomic approaches based on genomewide sets of single nucleotide polymorphisms (SNPs) are now feasible and offer the potential to uncover variants that influence drug response...
  32. ncbi Support for RGS4 as a susceptibility gene for schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:192-5. 2004
    ..Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples...
  33. ncbi Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease
    Paul Hollingworth
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    J Am Geriatr Soc 54:1348-54. 2006
    ..CONCLUSION: Four behavioral components were identified that were comparable with those observed previously. Future analysis of these components will strengthen understanding of the underlying pathology of behavioral symptoms and AD...
  34. ncbi Strong evidence that GNB1L is associated with schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:555-66. 2008
    ..However, other explanations are possible, and further analyses will be required to clarify the correct functional mechanism...
  35. ncbi Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease
    Elaine Green
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK
    Am J Psychiatry 162:35-42. 2005
    ..Further molecular genetic analysis of this region is required to identify the gene(s)...
  36. ncbi A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder
    Darko Turic
    Department of Psychological Medicine, Cardiff University, School of Medicine, Heath Park, Cardiff, United Kingdom
    Biol Psychiatry 57:1461-6. 2005
    ..SLC1A3 is thus both a functional and positional candidate gene for ADHD...
  37. ncbi Copy number variation in schizophrenia in the Japanese population
    Masashi Ikeda
    Medical Research Council MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Biol Psychiatry 67:283-6. 2010
    ..Copy number variants (CNVs) have been shown to increase the risk to develop schizophrenia. The best supported findings are at 1q21.1, 15q11.2, 15q13.3, and 22q11.2 and deletions at the gene neurexin 1 (NRXN1)...
  38. ncbi Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    J Psychiatr Res 40:622-6. 2006
    ....
  39. ncbi Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression
    Nicholas J Bray
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, UK
    Hum Mol Genet 14:1947-54. 2005
    ..Our data indicate that variation in the DTNBP1 gene confers susceptibility to schizophrenia through reduced expression, and that this, therefore, represents a primary aetiological mechanism in the disorder...
  40. ncbi A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease
    Denise Harold
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Pharmacogenet Genomics 16:75-7. 2006
    ..Treatment with acetylcholinesterase (AChE) inhibitors aims to reverse this deficit and does ameliorate the decline in cognition in some AD patients, although response is variable...
  41. ncbi Pooled DNA genotyping on Affymetrix SNP genotyping arrays
    George Kirov
    Department of Psychological Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    BMC Genomics 7:27. 2006
    ..However, thus far, this conclusion is based upon published data concerning only a small number of SNPs...
  42. ncbi Support for the involvement of large copy number variants in the pathogenesis of schizophrenia
    George Kirov
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK
    Hum Mol Genet 18:1497-503. 2009
    ..2 and schizophrenia (P = 0.026). This study confirms the involvement of rare CNVs in the pathogenesis of schizophrenia and contributes to the growing list of specific CNVs that are implicated...
  43. ncbi Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 128:19-20. 2004
    ..These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior...
  44. ncbi Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
    Lesley Jones
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom
    PLoS ONE 5:e13950. 2010
    ..We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes...
  45. ncbi Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease
    Denise Harold
    Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK
    Hum Genet 113:258-67. 2003
    ..Levels of linkage disequilibrium were generally low across the CHAT locus but two of the coding variants, D7N and A120T, proved to be in complete linkage disequilibrium...
  46. ncbi Is COMT a susceptibility gene for schizophrenia?
    Hywel J Williams
    Department of Psychological Medicine, School of Medicine, Cardiff Uniiversity, Henry Wellcome Building, Health Park, Cardiff CF14 4XN, UK
    Schizophr Bull 33:635-41. 2007
    ....
  47. ncbi A comparison of four clustering methods for brain expression microarray data
    Alexander L Richards
    Department of Psychological Medicine, School of Medicine, University Hospital Wales, Heath Park, Cardiff, Wales, UK
    BMC Bioinformatics 9:490. 2008
    ..The results are compared on speed, gene coverage and GO enrichment. The effects of combining the clusters produced by each method are also assessed...
  48. ncbi Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1
    Nicholas J Bray
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:1169-74. 2008
    ..Our data provide complementary evidence for chromosome 8p as a susceptibility locus for schizophrenia, and suggest that genetic variation within this region may influence risk, at least in part, through effects on DTNBP1 expression...
  49. ncbi Effects of differential genotyping error rate on the type I error probability of case-control studies
    Valentina Moskvina
    Bioinformatics and Biostatistics Unit, School of Medicine, Wales College of Medicine, Cardiff University, Cardiff, UK
    Hum Hered 61:55-64. 2006
    ....
  50. ncbi Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
    ..5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86)...
  51. ncbi Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes
    Nicholas J Bray
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 13:2885-92. 2004
    ..02). Our data indicate that, in human brain, most of the cis-acting variance in APOE expression is accounted for by the epsilon4 haplotype, but there are additional, small, cis-acting influences associated with promoter genotype...
  52. ncbi Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 16:2703-12. 2007
    ..Where samples overlapped, the genotyping consistency was high, estimated to average at 97.3%. Our large-scale linkage analysis consolidates clear evidence for a susceptibility locus for LOAD on 10q21.2...
  53. ncbi Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder
    Elaine K Green
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 153:1347-9. 2010
    ..Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052)...
  54. ncbi Analysis of neurogranin (NRGN) in schizophrenia
    Rhodri Ll Smith
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine, School of Medicine, Cardiff University, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 156:532-5. 2011
    ..Finally, analysis of a brain expression dataset of at least 130 individuals did not identify any eQTLs that were correlated with associated SNP rs12807809 following correction for multiple testing...
  55. ncbi Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    Paul Hollingworth
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 43:429-35. 2011
    ..0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10))...
  56. ncbi No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 58:78-80. 2005
    ..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()...
  57. ncbi Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
    Hywel J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 20:387-91. 2011
    ..7 × 10(-5)). Including earlier reported data for trans-disorder effects for ZNF804A and CACNA1C, six out of eight of the most robustly associated loci for either disorder show trans-disorder effects...
  58. ncbi Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder
    Tom Fowler
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Br J Psychiatry 194:62-7. 2009
    ..Children with attention-deficit hyperactivity disorder (ADHD) are thought to be at higher risk of psychopathy. Early biological and social adversity may contribute to this risk...
  59. ncbi No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study
    Sophie Mills
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    BMC Psychiatry 4:15. 2004
    ..Two studies showed that subjects with the low activity Met allele performed better on the Wisconsin Card Sorting Test (WCST) and another study found an effect on processing speed and attention...
  60. ncbi Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)
    Rachel Raybould
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, Wales, UK
    Biol Psychiatry 57:696-701. 2005
    ..We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample...
  61. ncbi Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia
    Natalie Cope
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Am J Hum Genet 76:581-91. 2005
    ..006 in trios; 1-degree-of-freedom tests). Our data strongly implicate KIAA0319 as a susceptibility gene for dyslexia. The gene product is expressed in brain, but its specific function is currently unknown...
  62. ncbi Cannabis, COMT and psychotic experiences
    Stanley Zammit
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Psychiatry 199:380-5. 2011
    ..A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transferase (COMT) gene on psychosis has been reported, but not adequately replicated...
  63. ncbi Association analysis of the HOPA12bp polymorphism in schizophrenia and manic depressive illness
    George Kirov
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff CF144 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 118:16-9. 2003
    ..6%, P = 0.6. We conclude that the HOPA polymorphism is unlikely to be a major risk factor in the pathogenesis of these major psychiatric disorders although there could be a small effect in schizophrenia...
  64. ncbi Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia
    Detelina Grozeva
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, UK
    Arch Gen Psychiatry 67:318-27. 2010
    ..The possible involvement of copy number variants (CNVs) in bipolar disorder has received little attention to date...
  65. ncbi A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain
    Nicholas J Bray
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, CF14 4XN, Wales, UK
    Am J Hum Genet 73:152-61. 2003
    ....
  66. ncbi Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Eur Child Adolesc Psychiatry 18:26-32. 2009
    ....
  67. ncbi Mood-incongruent psychosis in bipolar disorder: conditional linkage analysis shows genome-wide suggestive linkage at 1q32.3, 7p13 and 20q13.31
    Marian L Hamshere
    Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research in Wales, Cardiff, CF14 4XN, UK
    Bipolar Disord 11:610-20. 2009
    ..Findings in recent association studies at two specific genes suggest that the occurrence of mood-incongruent psychotic features may indicate a relatively homogeneous subset of the bipolar phenotype. We examined this hypothesis...
  68. ncbi An update on the genetics of schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Curr Opin Psychiatry 19:158-64. 2006
    ..This paper reviews recent molecular genetic studies of schizophrenia and evaluates claims implicating specific genes as susceptibility loci...
  69. ncbi The genetic deconstruction of psychosis
    Michael J Owen
    Department of Psychological Medicine, The School of Medicine, Cardiff University, Cardiff, UK
    Schizophr Bull 33:905-11. 2007
    ....
  70. ncbi Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder
    Deborah C Lawson
    Department of Psychologycal Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 116:84-9. 2003
    ..0, 95% CI = 1.09, 3.5), and TDT analysis indicated a statistical trend toward association. Our findings highlight the importance of phenotype definition and the need for the MAOA VNTR to be further examined...
  71. ncbi Advances in genetic findings on attention deficit hyperactivity disorder
    Anita Thapar
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Psychol Med 37:1681-92. 2007
    ....
  72. ncbi Mutational analysis of phospholipase A2A: a positional candidate susceptibility gene for bipolar disorder
    N J Jacobsen
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 4:274-9. 1999
    ..Evidence for linkage was more significant when analysing the 22 families comprising the Cardiff centre sample, which were expected to be most genetically similar to pedigree 324...
  73. ncbi Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasis
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
    Am J Med Genet 114:491-6. 2002
    ..Our data, therefore, do not support the hypothesis that genetic variation in MAOA and COMT is involved individually or in combination in the etiology of schizophrenia...
  74. ncbi Analysis of copy number variation using quantitative interspecies competitive PCR
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Nucleic Acids Res 36:e112. 2008
    ....
  75. ncbi Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia
    H J Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 120:42-6. 2003
    ..05 level. These results do not suggest that PRODH or PsPRODH contribute to the aetiology of schizophrenia, and that the putative schizophrenia susceptibility gene in 22q11 remains unknown...
  76. ncbi Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Mol Psychiatry 7:508-14. 2002
    ..2). These SNPs will therefore be suitable for studying neuropsychiatric phenotypes that are putatively related to NMDA dysfunction. Pooled analysis provided no support for association between any of the GRIN genes and schizophrenia...
  77. ncbi Screening the human protocadherin 8 (PCDH8) gene in schizophrenia
    N J Bray
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Genes Brain Behav 1:187-91. 2002
    ..These results suggest that any contribution of PCDH8 polymorphisms to schizophrenia susceptibility is likely to be weak, although the existence of rare variations of stronger effect cannot be excluded...
  78. ncbi Association analysis of the glial cell line-derived neurotrophic factor (GDNF) gene in schizophrenia
    H J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Schizophr Res 97:271-6. 2007
    ..We conclude that our sample does not provide independent statistically significant evidence for association between GDNF and schizophrenia, nor does it replicate previous specific reports of association...
  79. ncbi A genome-wide association study in 574 schizophrenia trios using DNA pooling
    G Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Cardiff, UK
    Mol Psychiatry 14:796-803. 2009
    ..05, with the best result at P=1.2 x 10(-6) for rs11064768. This SNP is within the gene CCDC60, a coiled-coil domain gene. The third best SNP (P=0.00016) is rs893703, within RBP1, a candidate gene for schizophrenia...
  80. ncbi Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability
    D W Morris
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 129:97-103. 2004
    ..As these are the only clear cut functional candidate genes in the region, identification of the putative susceptibility locus for RD on 15q will require more methodical non-hypothesis driven positional cloning approaches...
  81. ncbi Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia
    George Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:458-65. 2008
    ..Both genes have been affected by CNVs in patients with autism and mental retardation, but neither has been previously implicated in SZ...
  82. ncbi Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine
    M J Arranz
    Department of Psychological Medicine, Institute of Psychiatry, Denmark Hill, London, UK
    Mol Psychiatry 3:61-6. 1998
    ..These results provide further evidence suggesting that genetic variation at 5-HT2A receptors may influence clozapine response and strengthen the candidacy of these receptors as important therapeutic targets...
  83. ncbi Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease
    A R Morgan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 147:727-31. 2008
    ..024, OR = 1.18), and rs5030882 in CXXC6 (P = 0.046, OR = 1.29) in 1,160 cases and 1,389 controls. These results would not survive correction for multiple testing but warrant attempts at confirmation in independent samples...
  84. ncbi Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder
    T Bowen
    Division of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 3:67-71. 1998
    ....
  85. ncbi Mutation screening of the Homer gene family and association analysis in schizophrenia
    N Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 120:18-21. 2003
    ..05). Our results suggest it is unlikely that sequence variants in the Homer genes contribute to the aetiology of schizophrenia, but the variants we identified are plausible candidates for other neuropsychiatric phenotypes...
  86. ncbi Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?
    Nigel M Williams
    Department of Psychological Medicine, Cardiff University, UK
    Schizophr Bull 31:800-5. 2005
    ....
  87. ncbi The future of psychiatric genetics
    Marianne B M van den Bree
    Department of Psychological Medicine, University of Wales, College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Ann Med 35:122-34. 2003
    ..In this article, we consider the difficulties that complex diseases pose to genetic research, discuss progress and make suggestions regarding future directions...
  88. ncbi Recent advances in the genetics of schizophrenia
    Michael C O'Donovan
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
    Hum Mol Genet 12:R125-33. 2003
    ....
  89. ncbi Genetics of psychosis; insights from views across the genome
    Michael C O'Donovan
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Heath Park, Cardiff CF23 6BQ, UK
    Hum Genet 126:3-12. 2009
    ..They also provide grounds for optimism that larger studies will reveal more about the origins of these disorders, although currently, very little of the genetic risk of either disorder is explained...
  90. ncbi Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Hum Genet 110:471-8. 2002
    ..Our assay conditions are generalisable, universal, robust and, therefore, for the first time, permit high-throughput association analysis at a realistic cost...
  91. ncbi Genome scans and microarrays: converging on genes for schizophrenia?
    Nigel M Williams
    Department of Psychological Medicine, Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    Genome Biol 3:REVIEWS1011. 2002
    ..Microarray expression analysis may identify new candidate genes and pathways, and a number of intriguing preliminary findings have already been reported...
  92. ncbi Schizophrenia genetics: advancing on two fronts
    Michael J Owen
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Curr Opin Genet Dev 19:266-70. 2009
    ..There is evidence both for an increased burden of CNVs in schizophrenia and that risk is conferred by specific large deletions at 1q21.1 and at 15q13.2 and by deletions of NRXN1 which encodes the synaptic scaffolding protein neurexin 1...
  93. ncbi Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis
    Nigel M Williams
    MRC Centre in Neuropsychiatric Genetics and Genomics and Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, UK
    Lancet 376:1401-8. 2010
    ..We aimed to establish whether burden of CNVs was increased in ADHD, and to investigate whether identified CNVs were enriched for loci previously identified in autism and schizophrenia...
  94. ncbi HTR2A: association and expression studies in neuropsychiatric genetics
    Nadine Norton
    Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Ann Med 37:121-9. 2005
    ..In this review we examine and summarize these findings in various neuropsychiatric phenotypes...
  95. ncbi Genetic abnormalities of chromosome 22 and the development of psychosis
    Nigel M Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Curr Psychiatry Rep 6:176-82. 2004
    ..However, although a number of genes have been implicated as possible schizophrenia susceptibility loci, further confirmatory studies are required...
  96. ncbi Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder
    C Guy
    Division of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales
    Am J Psychiatry 154:1146-7. 1997
    ..The purpose of this study was to identify the specific expanded CAG/CTG trinucleotide repeat associated with bipolar disorder...
  97. ncbi Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD
    D Turic
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 127:68-72. 2004
    ..All were tested for possible association with ADHD using a combination of pooled and individual genotyping. The results of our study do not suggest that polymorphisms in these genes contribute to susceptibility to ADHD...
  98. ncbi Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
    M C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 14:30-6. 2009
    ..17 (95% CI 1.06-1.29), P=0.0009). The SNP maps 85 kb from the nearest gene encoding fibroblast growth factor receptor 2 (FGFR2) making this a potential susceptibility gene for schizophrenia...
  99. ncbi Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis. Molecular genetic study
    D Ivanov
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Br J Psychiatry 183:409-13. 2003
    ..None of the controls showed a pattern of genotypes consistent with hemizygosity. CONCLUSIONS: VCFS may be less frequent among patients with psychosis than previously suggested; this rate is not increased among early-onset patients...
  100. ncbi Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease
    A R Morgan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 144:762-70. 2007
    ..Two SNPs in SGPL1 demonstrated marginal evidence of association, with uncorrected P values of 0.042 and 0.056, suggesting that variation in SGPL1 may confer susceptibility to LOAD...
  101. ncbi Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 7:1092-100. 2002
    ..35, P = 0.006, P = 0.078 corrected for 13 alleles)...