Huw R Morris

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. doi request reprint Recent advances in the genetics of the ALS-FTLD complex
    Huw R Morris
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Curr Neurol Neurosci Rep 12:243-50. 2012
  2. ncbi request reprint Genetics of Parkinson's disease
    Huw R Morris
    Department of Neurology, Ophthalmology and Audiological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Ann Med 37:86-96. 2005
  3. ncbi request reprint Autosomal dominant Parkinson's disease and the route to new therapies
    Huw R Morris
    School of Medicine, Cardiff University, CF14 4XN, Wales
    Expert Rev Neurother 7:649-56. 2007
  4. doi request reprint Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease
    Laura L Kilarski
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Neurology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Mov Disord 27:1522-9. 2012
  5. doi request reprint SGCE mutations cause psychiatric disorders: clinical and genetic characterization
    Kathryn J Peall
    MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Henry Wellcome Building, Heath Park, Cardiff, UK
    Brain 136:294-303. 2013
  6. doi request reprint The genetic aetiology of late-onset chronic progressive cerebellar ataxia. A population-based study
    Mark Wardle
    Dept of Neurology, Ophthalmology and Audiological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    J Neurol 256:343-8. 2009
  7. doi request reprint Quality of life in young- compared with late-onset Parkinson's disease
    M Duleeka W Knipe
    Department of Neurology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Mov Disord 26:2011-8. 2011
  8. doi request reprint The motor phenotype of Parkinson's disease in relation to age at onset
    Mirdhu M Wickremaratchi
    Department of Neurology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Mov Disord 26:457-63. 2011
  9. pmc Variation in tau isoform expression in different brain regions and disease states
    Elisa Majounie
    MRC Centre for Neuropsychatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Neurobiol Aging 34:1922.e7-1922.e12. 2013
  10. doi request reprint Familial frontotemporal dementia with amyotrophic lateral sclerosis and a shared haplotype on chromosome 9p
    Justin P Pearson
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, CF14 4XN, UK
    J Neurol 258:647-55. 2011

Collaborators

Detail Information

Publications17

  1. doi request reprint Recent advances in the genetics of the ALS-FTLD complex
    Huw R Morris
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Curr Neurol Neurosci Rep 12:243-50. 2012
    ..The identification of mutations in these genes represents an important step forward in our understanding of the clinical, pathological, and genetic spectrum of ALS/FTLD diseases...
  2. ncbi request reprint Genetics of Parkinson's disease
    Huw R Morris
    Department of Neurology, Ophthalmology and Audiological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Ann Med 37:86-96. 2005
    ....
  3. ncbi request reprint Autosomal dominant Parkinson's disease and the route to new therapies
    Huw R Morris
    School of Medicine, Cardiff University, CF14 4XN, Wales
    Expert Rev Neurother 7:649-56. 2007
    ..The further study and understanding of the route by which alpha-synuclein and LRRK2 lead to PD, and how these processes can be therapeutically manipulated, is likely to lead to new disease-modifying treatments...
  4. doi request reprint Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease
    Laura L Kilarski
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Neurology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Mov Disord 27:1522-9. 2012
    ..The overall frequency of mutations in known EOPD genes was lower than previously estimated. Our study shows an increased likelihood of mutations in patients with lower AAO, family history, or parental consanguinity...
  5. doi request reprint SGCE mutations cause psychiatric disorders: clinical and genetic characterization
    Kathryn J Peall
    MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Henry Wellcome Building, Heath Park, Cardiff, UK
    Brain 136:294-303. 2013
    ..SGCE mutations are likely to have a pleiotropic effect in causing both motor and specific psychiatric symptoms...
  6. doi request reprint The genetic aetiology of late-onset chronic progressive cerebellar ataxia. A population-based study
    Mark Wardle
    Dept of Neurology, Ophthalmology and Audiological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    J Neurol 256:343-8. 2009
    ..Furthermore, there is marked geographic and ethnic variation in the relative importance of these individual disorders and the cause of such observed variation remains unexplained...
  7. doi request reprint Quality of life in young- compared with late-onset Parkinson's disease
    M Duleeka W Knipe
    Department of Neurology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Mov Disord 26:2011-8. 2011
    ..001, respectively), with similar findings seen in both early- and late-onset groups. Our study highlights the need for accurate diagnosis and treatment of depression in younger-onset patients in order to improve quality of life...
  8. doi request reprint The motor phenotype of Parkinson's disease in relation to age at onset
    Mirdhu M Wickremaratchi
    Department of Neurology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Mov Disord 26:457-63. 2011
    ..Parkinson's disease (PD) is heterogeneous and age at onset may define variation in clinical phenotype. Most previous studies have used various age cut-offs and have been based on clinical case series...
  9. pmc Variation in tau isoform expression in different brain regions and disease states
    Elisa Majounie
    MRC Centre for Neuropsychatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Neurobiol Aging 34:1922.e7-1922.e12. 2013
    ..4R-tau expression levels were related to the MAPT H1 and H1c haplotypes. Similar regional variation was seen in PSP case and in control samples...
  10. doi request reprint Familial frontotemporal dementia with amyotrophic lateral sclerosis and a shared haplotype on chromosome 9p
    Justin P Pearson
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, CF14 4XN, UK
    J Neurol 258:647-55. 2011
    ..Sequencing of this region did not identify any evidence of a pathogenic exonic mutation. This suggests that the pathogenic change affects non-coding DNA and that the disease is caused by variation in gene or protein expression...
  11. doi request reprint The effect of age and the H1c MAPT haplotype on MAPT expression in human brain
    Jesse B G Hayesmoore
    Neuropsychiatric Genetics Group, Cardiff University School of Medicine, Cardiff, UK
    Neurobiol Aging 30:1652-6. 2009
    ..We did, however, detect an effect of age on expression of MAPT H1 with a relative decrease in MAPT H1 expression with increased age. Our data suggest that there is an interaction between age and the expression of MAPT...
  12. doi request reprint Psychiatric disorders, myoclonus dystonia, and the epsilon-sarcoglycan gene: a systematic review
    Kathryn J Peall
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff, United Kingdom
    Mov Disord 26:1939-42. 2011
    ..Mutations in the maternally imprinted epsilon-sarcoglycan gene occur in 30%-50% of myoclonus-dystonia cases. Psychiatric symptoms, particularly obsessive-compulsive disorder, have been described in some patients...
  13. pmc A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease
    Peter Holmans
    Department of Psychological Medicine and Neurology, Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Hum Mol Genet 22:1039-49. 2013
    ....
  14. doi request reprint Perry syndrome due to the DCTN1 G71R mutation: a distinctive levodopa responsive disorder with behavioral syndrome, vertical gaze palsy, and respiratory failure
    Victoria Newsway
    MRC Centre for Neuropsychatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom
    Mov Disord 25:767-70. 2010
    ..The family was initially thought to have autosomal dominant behavioral variant frontotemporal dementia with Parkinsonism. This report expands the clinical definition of this distinctive syndrome...
  15. doi request reprint Clinical and genetic characteristics of non-Asian dentatorubral-pallidoluysian atrophy: A systematic review
    Mark Wardle
    Department of Neurology, Ophthalmology and Audiological Medicine, Cardiff University, United Kingdom
    Mov Disord 24:1636-40. 2009
    ..Non-Asian DRPLA clinico-genetic phenomenology are similar to Asian series and our study confirms marked genetic anticipation together with a clear association between repeat length and clinical phenotype and disease severity...
  16. pmc Analysis of copy number variation using quantitative interspecies competitive PCR
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Nucleic Acids Res 36:e112. 2008
    ....
  17. ncbi request reprint Aripiprazole associated with severe exacerbation of Parkinson's disease
    Mirdhu Wickremaratchi
    Mov Disord 21:1538-9. 2006