Stuart J Moat
Affiliation: Cardiff University
- Folate augmentation of treatment - evaluation for depression (FolATED): protocol of a randomised controlled trialSeren Haf Roberts
North Wales Section of Psychological Medicine, Institute of Medical and Social Care Research IMSCaR, Bangor University, Academic Unit, Wrexham Technology Park, Wrexham, LL13 7YP, UK
BMC Psychiatry 7:65. 2007....
- Folate, homocysteine, endothelial function and cardiovascular diseaseStuart J Moat
Cardiovascular Sciences Research Group, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, UK
J Nutr Biochem 15:64-79. 2004..The potential beneficial role of folic acid supplements on vascular disease are currently being tested in randomized placebo controlled studies...
- Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotypeStuart J Moat
Cardiovascular Sciences Research Group, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, Wales CF14 4XN, United Kingdom
Clin Chem 49:295-302. 2003..It has been proposed that riboflavin may act together with folate to lower plasma tHcy, particularly in individuals with the thermolabile MTHFR T variant...
- Methylenetetrahydrofolate reductase 677C-->T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trialPauline A L Ashfield-Watt
Cardiovascular Sciences Research Group, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, Wales, United Kingdom
Am J Clin Nutr 76:180-6. 2002..Low folate status and elevated plasma homocysteine are associated with increased risk of neural tube defects and cardiovascular disease. Homocysteine responses to folate may be influenced by genetic variants in folate metabolism...
- Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemiaZoe L Clarke
Wales Heart Research Institute, Wales College of Medicine, Cardiff University, Heath Park Campus, Cardiff, CF14 4XN, United Kingdom
Eur J Pharmacol 551:92-7. 2006..While low dose folic acid may restore this response in a homocysteine-dependent manner, the higher dose has an additional effect on nitric oxide-mediated relaxation that would appear to be independent of homocysteine lowering...
- Short-term high-dose folic acid does not alter markers of endothelial cell damage in patients with coronary heart diseaseSagar N Doshi
Cardiovascular Sciences Research Group, Department of Pharmacology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
Int J Cardiol 94:203-7. 2004....
- Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesisStuart J Moat
Department of Medical Biochemistry, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, United Kingdom
Eur J Pharmacol 530:250-8. 2006..This study demonstrates that folic acid reverses the endothelial dysfunction induced by BH4 depletion independently of either the regeneration or stabilization of BH4 or an antioxidant effect...
- Homocysteine and endothelial function in human studiesStuart J Moat
Department of Medical Biochemistry and Immunology, Wales College of Medicine, Cardiff University and the University Hospital of Wales, Cardiff, United Kingdom
Semin Vasc Med 5:172-82. 2005..However, changes in FMD may not translate into vascular endpoints, and the outcomes of clinical intervention trials with different doses of folic acid are awaited with interest...
- Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine loweringSagar N Doshi
Cardiovascular Sciences Research Group, Wales Heart Research Institute, Department of Pharmacology, University of Wales College of Medicine, Heath Park, Cardiff, UK
Circulation 105:22-6. 2002..02). FMD improvement did not correlate with reductions in either fHcy or tHcy at any time. CONCLUSIONS: These data suggest that folic acid improves endothelial function in CAD acutely by a mechanism largely independent of homocysteine...
- Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery diseaseCheerag Shirodaria
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
Circulation 115:2262-70. 2007..We compared the effects of folic acid on human vessels using pharmacological high-dose versus low-dose treatment, equivalent to dietary folate fortification...
- Plasma total homocysteine: instigator or indicator of cardiovascular disease?Stuart J Moat
Department of Medical Biochemistry and Immunology, University Hospital of Wales and Wales College of Medicine, Heath Park, Cardiff CF14 4XW, UK
Ann Clin Biochem 45:345-8. 2008..This lack of effect of tHcy lowering strongly suggests that homocysteine is not an instigator but merely an indicator of CVD...
- Treatment of coronary heart disease with folic acid: is there a future?Stuart J Moat
Am J Physiol Heart Circ Physiol 287:H1-7. 2004
- Lowering plasma homocysteine with folic acid in cardiovascular disease: what will the trials tell us?Sagar N Doshi
Cardiovascular Institute, Mount Sinai School of Medicine, New York, USA
Atherosclerosis 165:1-3. 2002
- Letter by Powers et al regarding article, "Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C-->T polymorphism"Hilary J Powers
Circulation 114:e65; author reply e66. 2006
- An indirect response model of homocysteine suppression by betaine: optimising the dosage regimen of betaine in homocystinuriaAngela Matthews
Department of Chemical Pathology and Neonatal Screening, Sheffield Children's Hospital, Manchester, UK
Br J Clin Pharmacol 54:140-6. 2002..CONCLUSIONS: PK-PD modelling allows recommendations for optimal dosage of betaine in the treatment of homocystinuria, that have the potential for improved patient compliance and both therapeutic and pharmacoeconomic benefit...
- Statins and micronutrients: unanswered questionsMartin McKee
J R Soc Med 97:459-60. 2004