John J Miles

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. doi request reprint Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination
    John J Miles
    T Cell Modulation Laboratory, Department of Infection, Immunity and Biochemistry, Cardiff University School of Medicine, Cardiff, UK
    Immunol Cell Biol 89:375-87. 2011
  2. pmc Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection
    John J Miles
    Department of Infection, Cardiff University School of Medicine, Heath Park, Cardiff, UK
    PLoS Pathog 6:e1001198. 2010
  3. pmc T-cell receptor specificity maintained by altered thermodynamics
    Florian Madura
    Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 288:18766-75. 2013
  4. pmc Peptide length determines the outcome of TCR/peptide-MHCI engagement
    Julia Ekeruche-Makinde
    Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
    Blood 121:1112-23. 2013
  5. pmc T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
    Julia Ekeruche-Makinde
    Institute of Infection and Immunity, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, Wales, United Kingdom
    J Biol Chem 287:37269-81. 2012
  6. pmc Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition
    David K Cole
    Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    J Immunol 185:2600-10. 2010
  7. pmc Structural and biophysical determinants of αβ T-cell antigen recognition
    John S Bridgeman
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, UK
    Immunology 135:9-18. 2012
  8. pmc A single autoimmune T cell receptor recognizes more than a million different peptides
    Linda Wooldridge
    Institute of Infection and Immunity, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 287:1168-77. 2012
  9. pmc Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes
    Anna M Bulek
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK
    Nat Immunol 13:283-9. 2012
  10. pmc Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability
    Kim M Miles
    Cardiff University, School of Medicine, Heath Park, Cardiff, UK
    Mol Immunol 48:728-32. 2011

Collaborators

Detail Information

Publications13

  1. doi request reprint Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination
    John J Miles
    T Cell Modulation Laboratory, Department of Infection, Immunity and Biochemistry, Cardiff University School of Medicine, Cardiff, UK
    Immunol Cell Biol 89:375-87. 2011
    ..This review provides a catalog of αβ TCR bias by disease and by species, and discusses the mechanisms that govern this inherent and widespread phenomenon...
  2. pmc Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection
    John J Miles
    Department of Infection, Cardiff University School of Medicine, Heath Park, Cardiff, UK
    PLoS Pathog 6:e1001198. 2010
    ..Such pattern recognition receptor-like traits within the αβ TCR system further blur the boundaries between the adaptive and innate immune systems...
  3. pmc T-cell receptor specificity maintained by altered thermodynamics
    Florian Madura
    Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 288:18766-75. 2013
    ..These findings advance our understanding of the molecular mechanisms that can govern the exquisite peptide specificity characteristic of TCR recognition...
  4. pmc Peptide length determines the outcome of TCR/peptide-MHCI engagement
    Julia Ekeruche-Makinde
    Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
    Blood 121:1112-23. 2013
    ..Accordingly, the effective recognition of pMHCI Ag, which is a prerequisite for successful CD8(+) T-cell immunity and protective vaccination, can only be achieved by length-matched Ag-specific CD8(+) T-cell clonotypes...
  5. pmc T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
    Julia Ekeruche-Makinde
    Institute of Infection and Immunity, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, Wales, United Kingdom
    J Biol Chem 287:37269-81. 2012
    ..This proof-of-concept study demonstrates that it is possible to design altered peptide antigens for the selection of superior T-cell clonotypes with enhanced antigen recognition properties...
  6. pmc Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition
    David K Cole
    Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    J Immunol 185:2600-10. 2010
    ..Heteroclitic peptide-based immune interventions therefore require careful evaluation to ensure efficacy in the clinic...
  7. pmc Structural and biophysical determinants of αβ T-cell antigen recognition
    John S Bridgeman
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, UK
    Immunology 135:9-18. 2012
    ..Understanding the principles that govern pMHC recognition by T-cells will unlock pathways to the rational development of immunotherapeutic approaches for the treatment of infectious disease, cancer and autoimmunity...
  8. pmc A single autoimmune T cell receptor recognizes more than a million different peptides
    Linda Wooldridge
    Institute of Infection and Immunity, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 287:1168-77. 2012
    ....
  9. pmc Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes
    Anna M Bulek
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK
    Nat Immunol 13:283-9. 2012
    ..Thus, highly focused peptide-centric interactions associated with suboptimal TCR-pMHCI binding affinities might lead to thymic escape and potential CD8(+) T cell-mediated autoreactivity...
  10. pmc Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability
    Kim M Miles
    Cardiff University, School of Medicine, Heath Park, Cardiff, UK
    Mol Immunol 48:728-32. 2011
    ..Our results further highlight the fact that heteroclitic peptide-based immune interventions require careful evaluation to ensure that wildtype antigen specificity is maintained in vivo...
  11. pmc Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor
    David K Cole
    Department of Infection, Immunity, and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 284:27281-9. 2009
    ..This "innate" pattern of antigen recognition probably explains the unique characteristics and extraordinary frequencies of CD8(+) T-cell responses to this epitope...
  12. pmc CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope
    Chihiro Motozono
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    PLoS ONE 8:e66152. 2013
    ..These findings explain the preferential selection of Phe at the C-terminus of VY8 in HLA-B(*)35∶01(+) individuals and demonstrate that HIV-1 can exploit the limitations of T cell recognition in vivo. ..
  13. pmc MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs
    Linda Wooldridge
    Department of Infection, Cardiff University, Cardiff, United Kingdom
    J Immunol 184:3357-66. 2010
    ..Thus, the low solution binding affinity of the pMHCI/CD8 interaction is essential for the maintenance of CTL Ag specificity...