Daryn R Michael
Affiliation: Cardiff University
- Liver X receptors, atherosclerosis and inflammationDaryn R Michael
Cardiff School of Biosciences, Cardiff University, UK
Curr Atheroscler Rep 14:284-93. 2012..In addition, we discuss the major limitations of LXRs as therapeutic targets for the treatment of atherosclerosis and how these are being addressed...
- TGF-β inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: a dominant role for Smad-2Daryn R Michael
Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Biochim Biophys Acta 1822:1608-16. 2012....
- Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapyJames E McLaren
Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
Prog Lipid Res 50:331-47. 2011..A clear understanding of macrophage foam cell biology will hopefully enable novel foam cell targeting therapies to be developed for use in the clinical intervention of atherosclerosis...
- The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-β and requires Smads, p38 mitogen-activated protein kinase and c-JunRebecca C Salter
Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, United Kingdom
Int J Biochem Cell Biol 43:805-11. 2011..The inhibition of macrophage ADAMTS-4 expression is likely to contribute to the anti-atherogenic, plaque stabilisation action of TGF-β...
- Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophagesJames E McLaren
Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK
Lipids 46:1053-61. 2011....
- IL-33 reduces macrophage foam cell formationJames E McLaren
Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
J Immunol 185:1222-9. 2010..In conclusion, IL-33 has a protective role in atherosclerosis by reducing macrophage foam cell formation suggesting that IL-33 maybe a potential therapeutic agent against atherosclerosis...