K M Meek

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint Organization of collagen fibrils in the corneal stroma in relation to mechanical properties and surgical practice
    K M Meek
    The Open University, Oxford Research Unit, United Kingdom
    J Refract Surg 15:695-9. 1999
  2. doi request reprint Corneal cross-linking--a review
    Keith M Meek
    Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Ophthalmic Physiol Opt 33:78-93. 2013
  3. ncbi request reprint An X-ray scattering investigation of corneal structure in keratocan-deficient mice
    Keith M Meek
    Structural Biophysics Group, Cardiff School of Optometry and Vision Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, Wales, UK
    Matrix Biol 22:467-75. 2003
  4. ncbi request reprint Transparency, swelling and scarring in the corneal stroma
    K M Meek
    Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Cardiff, UK
    Eye (Lond) 17:927-36. 2003
  5. pmc Changes in the refractive index of the stroma and its extrafibrillar matrix when the cornea swells
    Keith M Meek
    Structural Biophysics Group, Department of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Biophys J 85:2205-12. 2003
  6. ncbi request reprint The organization of collagen in the corneal stroma
    Keith M Meek
    Structural Biophysics Group, Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK
    Exp Eye Res 78:503-12. 2004
  7. doi request reprint The use of X-ray scattering techniques to quantify the orientation and distribution of collagen in the corneal stroma
    Keith M Meek
    Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Prog Retin Eye Res 28:369-92. 2009
  8. ncbi request reprint Corneal and scleral collagens--a microscopist's perspective
    K M Meek
    Department of Optometry and Vision Sciences, Cardiff University, P O Box 905, CF10 3NB, Cardiff, UK
    Micron 32:261-72. 2001
  9. pmc Ultrastructural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy
    S Akhtar
    Department of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Br J Ophthalmol 85:720-31. 2001
  10. pmc The integration of the corneal and limbal fibrils in the human eye
    R H Newton
    The Oxford Research Unit, The Open University, Oxford OX1 5HR, United Kingdom
    Biophys J 75:2508-12. 1998

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Organization of collagen fibrils in the corneal stroma in relation to mechanical properties and surgical practice
    K M Meek
    The Open University, Oxford Research Unit, United Kingdom
    J Refract Surg 15:695-9. 1999
    ..X-ray diffraction helps our understanding of the underlying structural and hence mechanical reasons for refractive problems following surgery...
  2. doi request reprint Corneal cross-linking--a review
    Keith M Meek
    Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Ophthalmic Physiol Opt 33:78-93. 2013
    ..To review cross-linking the cornea using riboflavin and ultraviolet A light, which has been widely adopted, refined and applied in a range of corneal surgeries and pathologies where the strength of the cornea might be compromised...
  3. ncbi request reprint An X-ray scattering investigation of corneal structure in keratocan-deficient mice
    Keith M Meek
    Structural Biophysics Group, Cardiff School of Optometry and Vision Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, Wales, UK
    Matrix Biol 22:467-75. 2003
    ..Alternatively, it might change the osmotic balance between the inside and outside of fibrils, causing them to swell and move further apart...
  4. ncbi request reprint Transparency, swelling and scarring in the corneal stroma
    K M Meek
    Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Cardiff, UK
    Eye (Lond) 17:927-36. 2003
    ..This paper briefly reviews current explanations for corneal transparency and uses a well-developed model to try to explain the increased light scattering either accompanying corneal swelling or following phototherapeutic keratectomy (PTK)...
  5. pmc Changes in the refractive index of the stroma and its extrafibrillar matrix when the cornea swells
    Keith M Meek
    Structural Biophysics Group, Department of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Biophys J 85:2205-12. 2003
    ..041 to 1.052. This change would be expected to make only a small contribution to the large increase in light scattering observed when the cornea swells to H = 8...
  6. ncbi request reprint The organization of collagen in the corneal stroma
    Keith M Meek
    Structural Biophysics Group, Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK
    Exp Eye Res 78:503-12. 2004
    ....
  7. doi request reprint The use of X-ray scattering techniques to quantify the orientation and distribution of collagen in the corneal stroma
    Keith M Meek
    Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Prog Retin Eye Res 28:369-92. 2009
    ..The implications of the knowledge gained so far are discussed in relation to the optical and biomechanical properties of the cornea, and their alteration due to disease and surgical intervention...
  8. ncbi request reprint Corneal and scleral collagens--a microscopist's perspective
    K M Meek
    Department of Optometry and Vision Sciences, Cardiff University, P O Box 905, CF10 3NB, Cardiff, UK
    Micron 32:261-72. 2001
    ..The full potential of this technique has yet to be realised...
  9. pmc Ultrastructural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy
    S Akhtar
    Department of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Br J Ophthalmol 85:720-31. 2001
    ..To investigate the ultrastructural localisation of proteoglycans (PG), betaig-h3 (keratoepithelin), tenascin-C (TN-C)), fibrillin, and fibronectin in bullous keratopathy (BK) corneas...
  10. pmc The integration of the corneal and limbal fibrils in the human eye
    R H Newton
    The Oxford Research Unit, The Open University, Oxford OX1 5HR, United Kingdom
    Biophys J 75:2508-12. 1998
    ..On the basis of these results we propose a model as to how the human cornea and sclera fuse together...
  11. ncbi request reprint The use of X-ray scattering techniques to determine corneal ultrastructure
    K M Meek
    Biophysics Group, Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cathays Park, CF10 3NB, Cardiff, UK
    Prog Retin Eye Res 20:95-137. 2001
    ....
  12. ncbi request reprint Congenital hereditary endothelial dystrophy and band keratopathy in an infant with corpus callosum agenesis
    S Akhtar
    Department of Optometry and Vision Science, University of Wales Cardiff, Cardiff, United Kingdom
    Cornea 20:547-52. 2001
    ..The band keratopathy was regarded as a secondary change. The association with corpus callosum agenesis does not appear to have been described previously...
  13. ncbi request reprint Hyaluronidase treatment, collagen fibril packing, and normal transparency in rabbit corneas
    C J Connon
    The Open University, Oxford Research Unit, United Kingdom
    J Refract Surg 16:448-55. 2000
    ..The purpose of this investigation was to examine changes in the arrangement of stromal collagen fibrils after hyaluronidase treatment...
  14. ncbi request reprint An x-ray diffraction investigation of corneal structure in lumican-deficient mice
    A J Quantock
    Biophysics Group, Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cathays Park, Cardiff CF10 3NB, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 42:1750-6. 2001
    ..In the present study, mutant corneas were examined by synchrotron x-ray diffraction to see what structural changes might lie behind the loss of transparency...
  15. doi request reprint A structural investigation of corneal graft failure in suspected recurrent keratoconus
    S Hayes
    Structural Biophysics Research Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Eye (Lond) 24:728-34. 2010
    ..To learn more about the structural basis for graft failure, we examined the removed tissue for the presence of abnormalities in the stroma and limiting membranes...
  16. pmc Clinical and ultrastructural findings in mare's tail lines of the corneal epithelium
    S Akhtar
    Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, Kings Edward VII Avenue, PO Box 905, Cardiff CF10 3NB, UK
    Br J Ophthalmol 88:864-7. 2004
    ..Mare's tail lines are uncommon, grey, parallel, tapering epithelial lines, which may give rise to discomfort or to visual symptoms. The authors report the clinical and ultrastructural findings in two patients..
  17. ncbi request reprint Gelatinous drop-like corneal dystrophy in a child with developmental delay: clinicopathological features and exclusion of the M1S1 gene
    S Akhtar
    School of Optometry and Vision Sciences, Cardiff University, UK
    Eye (Lond) 19:198-204. 2005
    ..We report the histopathological and molecular genetic findings in a Caucasian child with GDLD who also exhibited global developmental delay...
  18. doi request reprint Investigation of gammaE-crystallin target protein binding to bovine lens alpha-crystallin by small-angle neutron scattering
    M J Clarke
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cathays, Cardiff, CF24 4LU, UK
    Biochim Biophys Acta 1800:392-7. 2010
    ..The relative sizes observed for the complexes weighted by the respective scattering powers of the various components imply that gammaE-crystallin binds in a central cavity of the alpha-crystallin oligomer, during chaperone action...
  19. ncbi request reprint Glycation changes the charge distribution of type I collagen fibrils
    J C Hadley
    Oxford Research Unit, The Open University, Oxford, UK
    Glycoconj J 15:835-40. 1998
    ..Not all lysine and arginine residues are involved; there appear to be specific residues that suffer a loss of positive charge...
  20. ncbi request reprint Anaylsis of birefringence during wound healing and remodeling following alkali burns in rabbit cornea
    Y Huang
    Department of Optometry and Vision Sciences, University of Cardiff, Cardiff, CF10 3NB, UK
    Exp Eye Res 73:521-32. 2001
    ..The technique presented here for birefringence evaluation can provide an alternative way to monitor wound healing and tissue remodeling, both visually and quantitatively...
  21. ncbi request reprint Neonatal development of the corneal stroma in wild-type and lumican-null mice
    Nicola Beecher
    Structural Biophysics Group, Cardiff School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Invest Ophthalmol Vis Sci 47:146-50. 2006
    ..The authors investigate the stromal matrix structure in wild-type and lumican-deficient corneas in this developmental phase...
  22. ncbi request reprint An x-ray diffraction study of corneal structure in mimecan-deficient mice
    Nicola Beecher
    Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Wales, UK
    Invest Ophthalmol Vis Sci 46:4046-9. 2005
    ..This study was performed to investigate the fibrillar architecture of the corneal stroma in mice homozygous for a null mutation in the corneal KSPG, mimecan...
  23. ncbi request reprint Mapping collagen organization in the human cornea: left and right eyes are structurally distinct
    Craig Boote
    Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 47:901-8. 2006
    ..The present study was designed to examine and compare the organization of collagen fibrils in the corneal stroma of left and right eyes...
  24. ncbi request reprint A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and X-ray scattering techniques
    Sally Hayes
    Structural Biophysics Research Group, School of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, United Kingdom
    Exp Eye Res 84:423-34. 2007
    ..The observed abnormalities in collagen distribution and orientation are consistent with a mechanism of keratoconus progression that involves inter-fibrillar or inter-lamellar slippage causing a redistribution of tissue within the cornea...
  25. ncbi request reprint Collagen organization in the chicken cornea and structural alterations in the retinopathy, globe enlarged (rge) phenotype--an X-ray diffraction study
    Craig Boote
    Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff CF24 4LU, UK
    J Struct Biol 161:1-8. 2008
    ..We postulate that corneal flattening in rge chickens may be related to biomechanical changes brought about by an alteration in collagen arrangement at the corneal periphery...
  26. ncbi request reprint Comparative study of fibrillar collagen arrangement in the corneas of primates and other mammals
    Sally Hayes
    Structural Biophysics Research Group, School of Optometry and Vision Institute, Cardiff University, Cardiff, United Kingdom
    Anat Rec (Hoboken) 290:1542-50. 2007
    ..This finding may be related to differences in the frequency of action and the forces generated by the various extraocular muscles during eye movement and image fixation...
  27. pmc Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase
    Yasutaka Hayashida
    Department of Ophthalmology, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 103:13333-8. 2006
    ..The enzymatic sulfation of KS GAG chains is thus identified as a key requirement for PG biosynthesis and collagen matrix organization...
  28. doi request reprint Immunochemical localization of keratan sulfate proteoglycans in cornea, sclera, and limbus using a keratanase-generated neoepitope monoclonal antibody
    Saeed Akhtar
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Invest Ophthalmol Vis Sci 49:2424-31. 2008
    ..To evaluate the use of neoepitope monoclonal antibody BKS-1, which recognizes keratanase-generated keratan sulfate (KS) stubs on keratan sulfate proteoglycans in human cornea, limbus, and sclera...
  29. ncbi request reprint Atypical composition and ultrastructure of proteoglycans in the mouse corneal stroma
    Robert D Young
    School of Optometry and Vision Sciences, Cardiff University UK
    Invest Ophthalmol Vis Sci 46:1973-8. 2005
    ..In the present study, the corneal stroma of the mouse was examined to provide some baseline PG morphologies in this species...
  30. ncbi request reprint Changes in collagen orientation and distribution in keratoconus corneas
    Keith M Meek
    School of Optometry and Vision Sciences, Cardiff University, UK
    Invest Ophthalmol Vis Sci 46:1948-56. 2005
    ..To map the collagen orientation and relative distribution of collagen fibrillar mass in keratoconus corneal buttons...
  31. pmc Clinical and morphological features including expression of betaig-h3 and keratan sulphate proteoglycans in Maroteaux-Lamy syndrome type B and in normal cornea
    Saeed Akhtar
    Department of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Br J Ophthalmol 86:147-51. 2002
    ..To carry out a detailed morphological study of the cornea of a 16 year old female with a Maroteaux-Lamy syndrome (MLS)...
  32. pmc Transparency of the bovine corneal stroma at physiological hydration and its dependence on concentration of the ambient anion
    Oksana Kostyuk
    Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, PO Box 905, Cardiff CF10 3NB, UK
    J Physiol 543:633-42. 2002
    ..It is suggested that the ordering force between corneal collagen fibrils, generated in part by anion binding, may be crucial to the physiological functioning of the visual system...
  33. ncbi request reprint Collagen organization in the secondary chick cornea during development
    Andrew J Quantock
    Biophysics Group, Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cathays Park, Cardiff CF10 3NB, Wales, UK
    Invest Ophthalmol Vis Sci 44:130-6. 2003
    ..This study was designed to provide better appreciation of collagen reorganization in the avian corneal stroma during the latter stages of embryogenesis...
  34. ncbi request reprint Organization of corneal collagen fibrils during the healing of trephined wounds in rabbits
    Che J Connon
    Biophysics Group, Department of Optometry and Vision Sciences, Cardiff University, United Kingdom
    Wound Repair Regen 11:71-8. 2003
    ..We speculate that collagen is artefactually displaced during trephination, resulting in an abnormal alignment of the fibrils surrounding the wound edge, and that this influences the wound healing process...
  35. ncbi request reprint Annulus of collagen fibrils in mouse cornea and structural matrix alterations in a murine-specific keratopathy
    Andrew J Quantock
    Structural Biophysics Group, Department of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 44:1906-11. 2003
    ..Mice with corneas predisposed to topographical changes (the SKC strain) were also examined, to establish the size and spacing of stromal collagen fibrils and the integrity of the annulus...
  36. ncbi request reprint Persistent haze and disorganization of anterior stromal collagen appear unrelated following phototherapeutic keratectomy
    Che J Connon
    Dept of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    J Refract Surg 19:323-32. 2003
    ..The theoretical effects on corneal transparency induced by changes in collagen fibril packing following phototherapeutic keratectomy were compared to changes in objective measurements of haze...
  37. ncbi request reprint Proteoglycan alterations and collagen reorganisation in the secondary avian cornea during development
    Che J Connon
    Structural Biophysics Group, Department of Optometry and Vision Sciences, School of Biosciences, Cardiff University, Cardiff, UK
    Ophthalmic Res 35:177-84. 2003
    ..The current histochemical study was designed to establish the character and distribution of corneal PG filaments in relation to collagen organisation during tissue morphogenesis...
  38. ncbi request reprint Collagen fibrils appear more closely packed in the prepupillary cornea: optical and biomechanical implications
    Craig Boote
    Department of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 44:2941-8. 2003
    ..The present study was designed to quantify the collagen fibril spacing and diameter across the normal human cornea and to relate this to the properties of the tissue...
  39. ncbi request reprint X-ray scattering used to map the preferred collagen orientation in the human cornea and limbus
    Hossein Aghamohammadzadeh
    Structural Biophysics Group, Cardiff School of Optometry and Vision Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK
    Structure 12:249-56. 2004
    ..The detailed structural information provided is an important step toward understanding the shape and the mechanical properties of the tissue...
  40. ncbi request reprint Spatial and temporal alterations in the collagen fibrillar array during the onset of transparency in the avian cornea
    Che J Connon
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Exp Eye Res 78:909-15. 2004
    ....
  41. ncbi request reprint The structure and swelling of corneal scar tissue in penetrating full-thickness wounds
    Che J Connon
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi kamigyo ku, Kyoto 602 0841, Japan
    Cornea 23:165-71. 2004
    ..The purpose of this study was to determine corneal thickness and to examine the collagen and proteoglycans in full-thickness corneal scars up to 16 months following wounding...
  42. ncbi request reprint Lamellar orientation in human cornea in relation to mechanical properties
    Craig Boote
    Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Wales, UK
    J Struct Biol 149:1-6. 2005
    ..It is possible that, through a direct impact on the elastic modulus of the tissue, an imbalance of superior-inferior and nasal-temporal fibrils in some eyes might affect corneal shape...
  43. pmc The biomechanics of amnion rupture: an X-ray diffraction study
    Che J Connon
    School of Pharmacy, University of Reading, Reading, United Kingdom
    PLoS ONE 2:e1147. 2007
    ..These data provide an accurate insight into the biomechanical process of amnion rupture and highlight X-ray diffraction as a new and powerful tool in our understanding of this process...
  44. doi request reprint Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy
    Sally Hayes
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cathays, Cardiff, Wales, United Kingdom
    J Cataract Refract Surg 34:657-61. 2008
    ..To evaluate the importance of complete epithelial removal before riboflavin-ultraviolet-A (UVA) corneal collagen crosslinking therapy...