James E McLaren

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. doi request reprint Interferon gamma: a master regulator of atherosclerosis
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Cytokine Growth Factor Rev 20:125-35. 2009
  2. doi request reprint STAT1 contributes to the maintenance of the latency III viral programme observed in Epstein-Barr virus-transformed B cells and their recognition by CD8+ T cells
    James E McLaren
    Department of Medical Biochemistry, Henry Wellcome Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    J Gen Virol 90:2239-50. 2009
  3. doi request reprint Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK
    Lipids 46:1053-61. 2011
  4. doi request reprint IL-33 reduces macrophage foam cell formation
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    J Immunol 185:1222-9. 2010
  5. doi request reprint Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Prog Lipid Res 50:331-47. 2011
  6. doi request reprint ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages
    Na Li
    School of Biosciences, Cardiff University, Cardiff, United Kingdom
    J Immunol 185:3041-8. 2010
  7. ncbi request reprint The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate
    Anna Lissina
    aINSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie PARIS6, Hopital Pitie Salpetriere, Paris, France bInstitute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, Wales, UK cInstitut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France Anna Lissina and Solène Fastenackels contributed equally to this writing of this work Current address Centro de Investigacion en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
    AIDS 28:477-86. 2014
  8. ncbi request reprint A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells
    Kristin Ladell
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Immunity 38:425-36. 2013
  9. pmc Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity
    Ian R Humphreys
    Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK
    Eur J Immunol 42:3235-42. 2012
  10. pmc The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    J Immunol 184:5827-34. 2010

Collaborators

Detail Information

Publications10

  1. doi request reprint Interferon gamma: a master regulator of atherosclerosis
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Cytokine Growth Factor Rev 20:125-35. 2009
    ..This review will focus on evaluating the contribution of IFN-gamma to atherosclerosis and, in particular, how it regulates immune responses to the disease...
  2. doi request reprint STAT1 contributes to the maintenance of the latency III viral programme observed in Epstein-Barr virus-transformed B cells and their recognition by CD8+ T cells
    James E McLaren
    Department of Medical Biochemistry, Henry Wellcome Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    J Gen Virol 90:2239-50. 2009
    ..These results suggest that STAT1 is involved in maintaining the latency III viral program observed in transformed B cells and regulating immunorecognition by EBV-specific T cells...
  3. doi request reprint Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK
    Lipids 46:1053-61. 2011
    ....
  4. doi request reprint IL-33 reduces macrophage foam cell formation
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    J Immunol 185:1222-9. 2010
    ..In conclusion, IL-33 has a protective role in atherosclerosis by reducing macrophage foam cell formation suggesting that IL-33 maybe a potential therapeutic agent against atherosclerosis...
  5. doi request reprint Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Prog Lipid Res 50:331-47. 2011
    ..A clear understanding of macrophage foam cell biology will hopefully enable novel foam cell targeting therapies to be developed for use in the clinical intervention of atherosclerosis...
  6. doi request reprint ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages
    Na Li
    School of Biosciences, Cardiff University, Cardiff, United Kingdom
    J Immunol 185:3041-8. 2010
    ..These studies suggest a critical role for ERK signaling in the IFN-gamma-mediated changes in macrophage cholesterol homeostasis and gene expression during atherosclerosis...
  7. ncbi request reprint The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate
    Anna Lissina
    aINSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie PARIS6, Hopital Pitie Salpetriere, Paris, France bInstitute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, Wales, UK cInstitut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France Anna Lissina and Solène Fastenackels contributed equally to this writing of this work Current address Centro de Investigacion en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
    AIDS 28:477-86. 2014
    ....
  8. ncbi request reprint A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells
    Kristin Ladell
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Immunity 38:425-36. 2013
    ..A protective CD8+ T cell repertoire therefore encompasses the capacity to control TCR-accessible mutations, ultimately driving the development of more complex viral escape variants that disrupt antigen presentation...
  9. pmc Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity
    Ian R Humphreys
    Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK
    Eur J Immunol 42:3235-42. 2012
    ..These data imply that high-avidity central memory T cells wane with declining antigen levels, leaving lower avidity T cells with reduced functional capabilities...
  10. pmc The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    J Immunol 184:5827-34. 2010
    ..We show, for the first time, a novel proatherogenic role for both TL1A and DR3 that implicates this pathway as a target for the therapeutic intervention of atherosclerosis...