Tracey Amanda Martin


Affiliation: Cardiff University
Country: UK


  1. request reprint
    Martin T, Harrison G, Mansel R, Jiang W. The role of the CD44/ezrin complex in cancer metastasis. Crit Rev Oncol Hematol. 2003;46:165-86 pubmed
    ..This article reviews the role of CD44, ezrin family and the CD44/ezrin complex in cancer cells and their clinical impact in patients with cancer. ..
  2. Martin T. The role of tight junctions in cancer metastasis. Semin Cell Dev Biol. 2014;36:224-31 pubmed publisher
    ..This review will discuss recent insights into how TJ are involved in the process of tumour metastasis. ..
  3. Jiang W, Ye L, Ruge F, Owen S, Martin T, Sun P, et al. YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells. J Transl Med. 2015;13:280 pubmed publisher
    ..This effect is likely attributed to the inhibition of the HGF receptor activation. These results indicate that YZXJ has a therapeutic role in lung cancer and that combined strategy with methods to block HGF and EGF should be considered. ..
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    Martin T, Watkins G, Jiang W. KiSS-1 expression in human breast cancer. Clin Exp Metastasis. 2005;22:503-11 pubmed
    ..Over-expression of KiSS-1 in breast cancer cells result in more aggressive phenotype. Together, it suggests that KiSS-1 plays a role beyond the initial metastasis repressor in this cancer type. ..
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    Martin T, Jordan N, Davies E, Jiang W. Metastasis to Bone in Human Cancer Is Associated with Loss of Occludin Expression. Anticancer Res. 2016;36:1287-93 pubmed
    ..The discrepancy between this and the in vitro data indicating a reduction in migration/growth rate of occludin knockdown indicates that loss of occludin leads to complex changes in human cancer cell phenotype. ..
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    Martin T, Mansel R, Jiang W. Loss of occludin leads to the progression of human breast cancer. Int J Mol Med. 2010;26:723-34 pubmed
    ..This loss of or aberrant expression has clear repercussions as to the importance of occludin in maintaining TJ integrity in breast tissues. Such inappropriate expression could play a part in breast cancer development. ..
  7. Frugtniet B, Martin T, Zhang L, Jiang W. Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion. BMC Cancer. 2017;17:224 pubmed publisher
    ..These findings highlight nWASP as an important potential therapeutic target in lung cancer invasion and demonstrate that inhibiting nWASP activity using the inhibitor wiskostatin can significantly alter cell behaviour in vitro. ..
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    Martin T, Pereira G, Watkins G, Mansel R, Jiang W. N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer. Clin Exp Metastasis. 2008;25:97-108 pubmed
    ..It is concluded that N-WASP, a member of the N-WASP family may act as a tumour progression suppressor in human breast cancer and may therefore have significant clinical value in this condition. ..
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    Martin T, Harrison G, Mason M, Jiang W. HAVcR-1 reduces the integrity of human endothelial tight junctions. Anticancer Res. 2011;31:467-73 pubmed
    ..HAVcR-1 was co-precipitated with the TJ regulatory factor Ras homolog gene family, member C (Rho C). HAVcR-1 may have a novel function as part of the regulatory apparatus for TJ in human endothelial cells. ..

More Information


  1. Martin T, Jiang W. Claudin-16/paracellin-1, cloning, expression, and its role in tight junction functions in cancer and endothelial cells. Methods Mol Biol. 2011;762:383-407 pubmed publisher
    ..J Cell Biochem 105:41-52,2008). This suggests that claudin-16 plays a role beyond that of an initial metastasis repressor in this cancer type. ..
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    Martin T, Das T, Mansel R, Jiang W. Synergistic regulation of endothelial tight junctions by antioxidant (Se) and polyunsaturated lipid (GLA) via Claudin-5 modulation. J Cell Biochem. 2006;98:1308-19 pubmed
    ..Interestingly, this combination was also able to completely reverse the effect of 17beta-estradiol in these cells. ..
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    Zhao H, Martin T, Davies E, Ruge F, Yu H, Zhang Y, et al. The Clinical Implications of RSK1-3 in Human Breast Cancer. Anticancer Res. 2016;36:1267-74 pubmed
    ..RSK1 and 3 but not RSK2 are down-regulated in breast tumour and are associated with disease progression. RSK may be a key component in the progression and metastasis of breast cancer. ..
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    Martin T, Watkins G, Jiang W. The Coxsackie-adenovirus receptor has elevated expression in human breast cancer. Clin Exp Med. 2005;5:122-8 pubmed
    ..We conclude that CAR expression is elevated in primary breast cancers. This may have a bearing on its use as means of delivery for gene therapy and suggests that further work is necessary to understand this complex molecule. ..
  5. Martin T, Jiang W. Loss of tight junction barrier function and its role in cancer metastasis. Biochim Biophys Acta. 2009;1788:872-91 pubmed publisher
    ..This article will present data showing how modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the successful metastasis of a number of different cancer types...
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    Martin T, Das T, Mansel R, Jiang W. Enhanced tight junction function in human breast cancer cells by antioxidant, selenium and polyunsaturated lipid. J Cell Biochem. 2007;101:155-66 pubmed
    ..This combination also completely reversed the effect of 17-beta-estradiol in these cells. ..
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    Martin T, Gomez K, Watkins G, Douglas Jones A, Mansel R, Jiang W. Expression of breast cancer specific gene-1 (BCSG-1/gamma-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. Oncol Rep. 2006;16:207-12 pubmed
    ..307, P < 0.05), and weakly with transglutaminase-7 (r = 0.183). BCSG-1 is increased in breast tumour cells, is negatively associated with tumour grade and significantly correlates with levels of transglutaminase-3. ..
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    Martin T, Mansel R, Jiang W. Antagonistic effect of NK4 on HGF/SF induced changes in the transendothelial resistance (TER) and paracellular permeability of human vascular endothelial cells. J Cell Physiol. 2002;192:268-75 pubmed
    ..NK4 was able to prevent the decrease in levels of ZO-1 protein by HGF/SF. ..