Robert Mansel

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. doi request reprint Results of a national training programme in sentinel lymph node biopsy for breast cancer
    R E Mansel
    Department of Surgery, Cardiff University, Cardiff, UK
    Br J Surg 100:654-61. 2013
  2. pmc Expression of Placenta growth factor (PlGF) in non-small cell lung cancer (NSCLC) and the clinical and prognostic significance
    Lijian Zhang
    Department of Surgery, Peking University School of Oncology, Haidian District, Beijing, China
    World J Surg Oncol 3:68. 2005
  3. pmc Real time PCR analyses of expression of E-cadherin, alpha-, beta- and gamma-catenin in human breast cancer for predicting clinical outcome
    Amit Goyal
    Department of Surgery, School of Medicine, Cardiff University, Cardiff, UK
    World J Surg Oncol 6:56. 2008
  4. pmc Lymphangiogenesis and lymph node metastasis in breast cancer
    Giles H Cunnick
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, CF14 4XN, Wales, UK
    Mol Cancer 7:23. 2008
  5. pmc Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Mol Cancer 7:71. 2008
  6. pmc Tumour suppressor function of MDA-7/IL-24 in human breast cancer
    Neill Patani
    Department of Breast Surgery, The London Breast Institute, The Princess Grace Hospital, 42 52 Nottingham Place, W1U 5NY, London, UK
    Cancer Cell Int 10:29. 2010
  7. pmc The mRNA expression of SATB1 and SATB2 in human breast cancer
    Neill Patani
    Department of Breast Surgery, St, George s University of London, London, UK
    Cancer Cell Int 9:18. 2009
  8. pmc Angiomotin and angiomotin like proteins, their expression and correlation with angiogenesis and clinical outcome in human breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, UK
    BMC Cancer 6:16. 2006
  9. doi request reprint Detection of breast cancer metastasis in sentinel lymph nodes using intra-operative real time GeneSearch BLN Assay in the operating room: results of the Cardiff study
    Robert E Mansel
    Department of Surgery, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
    Breast Cancer Res Treat 115:595-600. 2009
  10. ncbi request reprint European randomized, multicenter study of goserelin (Zoladex) in the management of mastalgia
    Robert E Mansel
    Department of Surgery, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    Am J Obstet Gynecol 191:1942-9. 2004

Detail Information

Publications78

  1. doi request reprint Results of a national training programme in sentinel lymph node biopsy for breast cancer
    R E Mansel
    Department of Surgery, Cardiff University, Cardiff, UK
    Br J Surg 100:654-61. 2013
    ....
  2. pmc Expression of Placenta growth factor (PlGF) in non-small cell lung cancer (NSCLC) and the clinical and prognostic significance
    Lijian Zhang
    Department of Surgery, Peking University School of Oncology, Haidian District, Beijing, China
    World J Surg Oncol 3:68. 2005
    ..This study examined PlGF expression at protein and message levels in non-small cell lung cancer (NSCLC), in which no reports on the significance of PlGF expression is available to date...
  3. pmc Real time PCR analyses of expression of E-cadherin, alpha-, beta- and gamma-catenin in human breast cancer for predicting clinical outcome
    Amit Goyal
    Department of Surgery, School of Medicine, Cardiff University, Cardiff, UK
    World J Surg Oncol 6:56. 2008
    ..The E-cadherin catenin system acts as an invasion suppressor of epithelial malignancies. However, it is debatable whether expression of E-cadherin or catenins is a useful prognostic marker in invasive breast cancer...
  4. pmc Lymphangiogenesis and lymph node metastasis in breast cancer
    Giles H Cunnick
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, CF14 4XN, Wales, UK
    Mol Cancer 7:23. 2008
    ..The cDNA from 153 frozen archived breast samples were analysed with Q-PCR for all seven lymphangiogenic markers. This was correlated with various prognostic factors as well as patient survival...
  5. pmc Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Mol Cancer 7:71. 2008
    ..To investigate the expression of EPLIN-alpha, epithelial protein lost in neoplasm, in human breast cancer tissues/cells and investigate the cellular impact of EPLIN-alpha on breast cancer cells...
  6. pmc Tumour suppressor function of MDA-7/IL-24 in human breast cancer
    Neill Patani
    Department of Breast Surgery, The London Breast Institute, The Princess Grace Hospital, 42 52 Nottingham Place, W1U 5NY, London, UK
    Cancer Cell Int 10:29. 2010
    ..Furthermore, mRNA expression of MDA-7 is assessed in a cohort of women with BC and correlated with established pathological parameters and clinical outcome...
  7. pmc The mRNA expression of SATB1 and SATB2 in human breast cancer
    Neill Patani
    Department of Breast Surgery, St, George s University of London, London, UK
    Cancer Cell Int 9:18. 2009
    ..SATB2 mRNA expression is significantly associated with increasing tumour grade and poorer OS. These results are consistent with the notion that SATB1 acts as a 'master genome organizer' in human breast carcinogenesis...
  8. pmc Angiomotin and angiomotin like proteins, their expression and correlation with angiogenesis and clinical outcome in human breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, UK
    BMC Cancer 6:16. 2006
    ..This study examined the expression of angiomotin and its analogues, angiomotin-like 1 (L1) and -like 2 (L2) in breast tumour tissues, and analysed their correlation with angiogenesis and clinical outcomes...
  9. doi request reprint Detection of breast cancer metastasis in sentinel lymph nodes using intra-operative real time GeneSearch BLN Assay in the operating room: results of the Cardiff study
    Robert E Mansel
    Department of Surgery, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
    Breast Cancer Res Treat 115:595-600. 2009
    ..We conducted a prospective clinical feasibility study of the GeneSearch Breast Lymph Node (BLN) Assay (Veridex, LLC, Warren, NJ) to confirm its potential usefulness within the UK healthcare system...
  10. ncbi request reprint European randomized, multicenter study of goserelin (Zoladex) in the management of mastalgia
    Robert E Mansel
    Department of Surgery, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    Am J Obstet Gynecol 191:1942-9. 2004
    ..Breast pain is a common symptom in patients attending breast clinics. The purpose of this study was to evaluate the efficacy of goserelin (Zoladex) as compared with sham injection in patients with mastalgia...
  11. ncbi request reprint Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial
    Robert E Mansel
    Department of Surgery, Cardiff University, Cardiff, UK
    J Natl Cancer Inst 98:599-609. 2006
    ....
  12. ncbi request reprint Internal mammary node drainage and its role in sentinel lymph node biopsy: the initial ALMANAC experience
    Robert E Mansel
    Department of Surgery, Wales College of Medicine, University of Cardiff, UK
    Clin Breast Cancer 5:279-84; discussion 285-6. 2004
    ..Internal mammary SLN biopsy may be associated with some additional morbidity. Current evidence suggests that internal mammary SLN biopsy is still a research tool...
  13. ncbi request reprint A phase II trial of Afimoxifene (4-hydroxytamoxifen gel) for cyclical mastalgia in premenopausal women
    Robert Mansel
    Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
    Breast Cancer Res Treat 106:389-97. 2007
    ..The current study compared the safety and efficacy of two doses of a topical gel containing 4-hydroxytamoxifen (Afimoxifene, formerly known as 4-OHT) with placebo gel for the treatment of moderate to severe cyclical mastalgia...
  14. ncbi request reprint The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells
    Mahir A A Al-Rawi
    Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 XN, UK
    Int J Oncol 27:721-30. 2005
    ..This might have a significant impact on the lymphatic spread of solid tumours. Furthermore, interruption of IL-7 signalling might provide an attractive therapeutic option in cancer lymphatic metastasis...
  15. ncbi request reprint Genetic manipulation of stromal cell-derived factor-1 attests the pivotal role of the autocrine SDF-1-CXCR4 pathway in the aggressiveness of breast cancer cells
    Hua Kang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, UK
    Int J Oncol 26:1429-34. 2005
    ..SDF-1, together with its receptor CXCR4 may provide important information for predicting the aggressive nature and constitute important therapeutic targets in human breast cancer...
  16. ncbi request reprint Factors affecting failed localisation and false-negative rates of sentinel node biopsy in breast cancer--results of the ALMANAC validation phase
    Amit Goyal
    Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Breast Cancer Res Treat 99:203-8. 2006
    ..A major aim of this prospective multicentre validation study was to quantify detection and false-negative rates of SLNB and evaluate factors influencing them...
  17. ncbi request reprint Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer
    Simon R Davies
    Metastasis and Angiogenesis Research Group, Department of Surgery, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, United Kingdom
    Ann Surg Oncol 14:1909-18. 2007
    ..The CCN family has three Wnt-inducted secreted proteins named WISP-1, WISP-2 and WISP-3. These molecules are known to play a diverse role in cells, but their role in cancer cells remains controversial...
  18. ncbi request reprint Transcript analyses of stromal cell derived factors (SDFs): SDF-2, SDF-4 and SDF-5 reveal a different pattern of expression and prognostic association in human breast cancer
    Hua Kang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Oncol 35:205-11. 2009
    ..These SDFs thus have prognostic value and warrant further investigation in their biological functions and clinical value...
  19. ncbi request reprint The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells
    Mohammad K Zia
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Mol Med 20:605-11. 2007
    ..Low levels of VHL occur in most aggressive breast tumours. Taken together, VHL is a powerful putative tumour suppressor gene in human breast cancer...
  20. pmc Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer
    Hua Kang
    Wales College of Medicine, Cardiff University, Cardiff, UK
    Breast Cancer Res 7:R402-10. 2005
    ....
  21. ncbi request reprint Elevated levels of tumour endothelial marker-8 in human breast cancer and its clinical significance
    Gaynor Davies
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Int J Oncol 29:1311-7. 2006
    ..We conclude that TEM-8 is a useful marker for identifying tumour associated micro-vessels and that elevated levels are associated with disease progression, which may have some bearing on the prognostic outcome in breast cancer...
  22. doi request reprint Recent advances in sentinel lymph node biopsy for breast cancer
    Amit Goyal
    Department of Surgery, School of Medicine, Cardiff University, Cardiff, UK
    Curr Opin Oncol 20:621-6. 2008
    ..This article reviews the recent advancements and refinements of the sentinel lymph node (SLN) biopsy technique in breast cancer...
  23. ncbi request reprint Transforming acidic coiled-coil-containing protein 2 (TACC2) in human breast cancer, expression pattern and clinical/prognostic relevance
    Shan Cheng
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, U K
    Cancer Genomics Proteomics 7:67-73. 2010
    ..This suggests that TACC2 may mediate an oncogenic effect on breast cancer cells and indicates that TACC2 may be a potential therapeutic target...
  24. ncbi request reprint A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia
    Amit Goyal
    Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Breast J 11:41-7. 2005
    ..This study showed that GLA (Efamast) efficacy did not differ from that of placebo fatty acids, regardless of whether or not antioxidant vitamins were present...
  25. ncbi request reprint Expression of MLN64 influences cellular matrix adhesion of breast cancer cells, the role for focal adhesion kinase
    Wei Cai
    Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Int J Mol Med 25:573-80. 2010
    ..MLN64 contributes to the development and progression of breast cancer through the regulation of cell proliferation and adhesive capacity...
  26. ncbi request reprint Transcriptional and translational modulation of KAI1 expression in ductal carcinoma of the breast and the prognostic significance
    Fraz A Malik
    Department of Surgery, Cardiff University School of Medicine, Cardiff, Wales, UK
    Int J Mol Med 23:273-8. 2009
    ..0136). KAI1 inverse correlation with tumour progression may be used as a strong prognostic marker...
  27. ncbi request reprint The elevated level of CXCR4 is correlated with nodal metastasis of human breast cancer
    Hua Kang
    University Department of Surgery, Wales College of Medicine, Metastasis and Angiogenesis Research Group, Cardiff University, Heath Park, Cardiff CF4 4XN, UK
    Breast 14:360-7. 2005
    ..The elevated levels of CXCR4 suggest that the patient has high possibility of lymph node metastasis. CXCR4 may be a useful prognostic indicator and a potential therapeutic target in cancer therapies in patients with breast cancer...
  28. ncbi request reprint Expression of transcription factor CREB1 in human breast cancer and its correlation with prognosis
    Alok Chhabra
    Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
    Oncol Rep 18:953-8. 2007
    ..We conclude that the level of CREB1 expression is aberrant in human breast cancer and is associated with disease progression in breast cancer patients...
  29. ncbi request reprint Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer
    Jane Lane
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Int J Mol Med 12:253-7. 2003
    ..It is concluded that aggressive breast tumours have a reduced level of delta-6-desaturase. This aberrant expression has clinical bearings to the outcome in patients with breast cancer...
  30. ncbi request reprint Bone morphogenetic proteins 1 to 7 in human breast cancer, expression pattern and clinical/prognostic relevance
    Simon R Davies
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, UK
    J Exp Ther Oncol 7:327-38. 2008
    ..Recently, BMP molecules have further been shown to have an impact on the biological behaviour of breast cancer cells. In this study, we looked, for the first time, at the expression of a panel of BMPs in breast carcinomas...
  31. ncbi request reprint PGF isoforms, PLGF-1 and PGF-2 and the PGF receptor, neuropilin, in human breast cancer: prognostic significance
    Astrid Escudero-Esparza
    Department of Surgery, Cardiff School of Medicine, Cardiff University, Cardiff, UK
    Oncol Rep 23:537-44. 2010
    ..Our study shows that PLGF isoforms PLGF-1 and PGF-2 and indeed their receptor neuopilin, have an aberrant pattern of expression and that high levels of the PLGF-1 and neuropilin are linked to a poor prognosis...
  32. ncbi request reprint Biphasic effects of 17-beta-estradiol on expression of occludin and transendothelial resistance and paracellular permeability in human vascular endothelial cells
    Lin Ye
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    J Cell Physiol 196:362-9. 2003
    ....
  33. ncbi request reprint Morbidity in breast cancer patients with sentinel node metastases undergoing delayed axillary lymph node dissection (ALND) compared with immediate ALND
    Amit Goyal
    Department of Surgery, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Ann Surg Oncol 15:262-7. 2008
    ..This study was designed to compare morbidity in patients undergoing complete ALND in the first (and only) operation versus those undergoing the two-step procedure (SLN biopsy followed by delayed completion ALND)...
  34. ncbi request reprint Is there a role of sentinel lymph node biopsy in ductal carcinoma in situ?: analysis of 587 cases
    Amit Goyal
    Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, UK
    Breast Cancer Res Treat 98:311-4. 2006
    ..The study was designed to determine when the risk of finding invasive disease on final pathology in patients with an initial diagnosis of DCIS was sufficiently high to justify the use of SLNB...
  35. ncbi request reprint Reduced expression of BMPR-IB correlates with poor prognosis and increased proliferation of breast cancer cells
    Sivan M Bokobza
    Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Cancer Genomics Proteomics 6:101-8. 2009
    ..The aim of the current study is to identify the role of BMPR-IB, one of these receptors, in breast cancer...
  36. ncbi request reprint Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Prostaglandins Leukot Essent Fatty Acids 74:235-45. 2006
    ..The study has also reported a link between 15-LOX-2 and oestrogen receptor status in breast tumours. Both isoforms of 15-lipoxygenase have a tumour suppressing role in breast cancer...
  37. ncbi request reprint Loss of occludin leads to the progression of human breast cancer
    Tracey A Martin
    Metastasis and Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Int J Mol Med 26:723-34. 2010
    ..This loss of or aberrant expression has clear repercussions as to the importance of occludin in maintaining TJ integrity in breast tissues. Such inappropriate expression could play a part in breast cancer development...
  38. ncbi request reprint Enhanced tight junction function in human breast cancer cells by antioxidant, selenium and polyunsaturated lipid
    Tracey A Martin
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    J Cell Biochem 101:155-66. 2007
    ..This combination also completely reversed the effect of 17-beta-estradiol in these cells...
  39. doi request reprint Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer
    Lin Ye
    Department of Surgery, Cardiff University School of Medicine, Cardiff, UK
    Cancer Sci 101:2137-44. 2010
    ..Bone morphogenetic protein-10 (BMP-10) may function as a tumor suppressor in breast cancer...
  40. pmc The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer
    Jane Lane
    Metastasis Research Group, University Department of Surgery, Cardiff University School of Medicine, Heath Park, Cardiff, CF4 4XN, UK
    Int Semin Surg Oncol 5:23. 2008
    ..The purpose of this study was to investigate the expression of these GEFs, in human breast cancer and assess the affect on clinical outcome...
  41. ncbi request reprint The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer
    Jane Lane
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Int J Oncol 33:585-93. 2008
    ..This, together with significant correlation between ROCKI and poor outcome in clinical breast cancer, indicates that it is a potential target in human breast cancer...
  42. ncbi request reprint N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer
    Tracey A Martin
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Clin Exp Metastasis 25:97-108. 2008
    ..It is concluded that N-WASP, a member of the N-WASP family may act as a tumour progression suppressor in human breast cancer and may therefore have significant clinical value in this condition...
  43. ncbi request reprint Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients
    Christian Parr
    Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Clin Cancer Res 13:3568-76. 2007
    ..The role of matriptase-2 and its cellular function in cancer is unknown. This study aimed to provide new insights into the significance of matriptase-2 in cancer...
  44. ncbi request reprint Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
    Int J Mol Med 17:583-90. 2006
    ..It is highly expressed in aggressive breast tumours and is associated with clinical outcome. The enzyme is a potential therapeutic target in breast cancer...
  45. ncbi request reprint Differential expression of the CCN family members Cyr61, CTGF and Nov in human breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University of Wales College of Medicine, Cardiff University, Cardiff, UK
    Endocr Relat Cancer 11:781-91. 2004
    ..While Cyr61 appears to act as a factor stimulating aggressiveness, CTGF and Nov may act as tumour suppressors...
  46. ncbi request reprint Molecular detection of micro-metastasis in breast cancer
    Wen G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Crit Rev Oncol Hematol 43:13-31. 2002
    ..The current article discusses recent developments, in the detection of micro-metastasis using molecular biology techniques...
  47. ncbi request reprint The localisation and reduction of nuclear staining of PPARgamma and PGC-1 in human breast cancer
    Gareth Watkins
    Metastasis and Angiogenesis Research Group, University Deptartment of Surgery, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    Oncol Rep 12:483-8. 2004
    ..It is concluded that both PPARgamma and its coactivator PGC-1 play important roles in the development and progression of breast cancer, and may have a significant bearing on patient prognosis...
  48. ncbi request reprint Psoriasin is aberrantly expressed in human breast cancer and is related to clinical outcomes
    Wen G Jiang
    Metastasis Research Group, University of Wales College of Medicine, Cardiff, UK
    Int J Oncol 25:81-5. 2004
    ..02 and p<0.001, vs disease-free, respectively). It is concluded that aberrant expression of psoriasin is commonly seen in human breast cancer and that excessively high levels are correlated with the clinical outcomes...
  49. ncbi request reprint Hepatocyte growth factor disrupts tight junctions in human breast cancer cells
    Tracey A Martin
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Cell Biol Int 28:361-71. 2004
    ..We conclude that regulation of tight junctions could be of fundamental importance in the prevention of metastasis of breast cancer cells...
  50. ncbi request reprint Levels of expression of endothelial markers specific to tumour-associated endothelial cells and their correlation with prognosis in patients with breast cancer
    Gaynor Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Clin Exp Metastasis 21:31-7. 2004
    ..We conclude that elevated levels of TEM-1, TEM-7R and TEM-8 (but not TEM-2, 4, 5, 6 and 7) are associated with either nodal involvement, and/or disease progression, and may therefore, have a prognostic value in breast cancer...
  51. ncbi request reprint The hepatocyte growth factor regulatory factors in human breast cancer
    Christian Parr
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Clin Cancer Res 10:202-11. 2004
    ..This study determined the expression of this HGF regulatory system in breast cancer. We examined HGF, the HGF receptor (c-Met), HGFA, matriptase, and the activation inhibitors (HAI-1 and HAI-2), tissues from patients with breast cancer...
  52. ncbi request reprint Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers
    Wen G Jiang
    University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Clin Cancer Res 9:6432-40. 2003
    ..This study determined the levels of expression and the distribution of Rho-A, -B, -C, and -G, and Rho-6, -7, and -8, as well as Rho-GDI-beta, and Rho-GDI-gamma, in breast cancer and assessed their prognostic value...
  53. ncbi request reprint Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET
    Wen G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Clin Cancer Res 9:4274-81. 2003
    ..This study examined if inhibition of HGF/SF receptor expression by cancer cells and HGF/SF expression by stromal fibroblasts affects the growth of mammary cancer...
  54. ncbi request reprint Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer
    Wen G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Prostaglandins Leukot Essent Fatty Acids 69:275-81. 2003
    ....
  55. ncbi request reprint Expression of peroxisome-proliferator activated receptor-gamma (PPARgamma) and the PPARgamma co-activator, PGC-1, in human breast cancer correlates with clinical outcomes
    Wen G Jiang
    Metastasis Research Group, University of Wales College of Medicine, Cardiff, United Kingdom
    Int J Cancer 106:752-7. 2003
    ..We conclude that there is aberrant expression of PPARgamma and its co-activator, PGC-1, in human breast cancer and low levels of these molecules in cancer tissues are associated with poor clinical outcomes...
  56. ncbi request reprint Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist
    Tracey A Martin
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Carcinogenesis 24:1317-23. 2003
    ..This may occur by decreasing angiogenesis. This gives a clear indication of the therapeutic worth of NK4...
  57. ncbi request reprint The role of the CD44/ezrin complex in cancer metastasis
    Tracey A Martin
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, S Wales CF14 4XN, UK
    Crit Rev Oncol Hematol 46:165-86. 2003
    ..This article reviews the role of CD44, ezrin family and the CD44/ezrin complex in cancer cells and their clinical impact in patients with cancer...
  58. ncbi request reprint Effect of lymphatic tumor burden on sentinel lymph node biopsy in breast cancer
    Amit Goyal
    Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, UK
    Breast J 11:188-94. 2005
    ..Extranodal invasion in the SLN is a marker of lymphatic obstruction and is significantly associated with reduced radioisotope uptake. The lymphatic tumor burden does not seem to affect blue dye uptake or internal mammary drainage...
  59. ncbi request reprint Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: the role of promoter methylation of TSC genes
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, UK
    Eur J Cancer 41:1628-36. 2005
    ..However, the TSC genes have not been studied in breast cancer. The current study investigated the expression of the TSC gene products and the potential mechanisms of their aberrancy in human breast cancer cells and tissues...
  60. ncbi request reprint Expression of Com-1/P8 in human breast cancer and its relevance to clinical outcome and ER status
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Int J Cancer 117:730-7. 2005
    ..The expression levels of Com-1 in breast tumours are correlated with the prognosis of the patients and with the long term overall survival in association with ER status...
  61. ncbi request reprint Synergistic regulation of endothelial tight junctions by antioxidant (Se) and polyunsaturated lipid (GLA) via Claudin-5 modulation
    Tracey A Martin
    Department of Surgery, Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Heath Park, Cardiff, UK
    J Cell Biochem 98:1308-19. 2006
    ..Interestingly, this combination was also able to completely reverse the effect of 17beta-estradiol in these cells...
  62. ncbi request reprint Expression of transglutaminases in human breast cancer and their possible clinical significance
    Wen G Jiang
    University Department of Surgery, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    Oncol Rep 10:2039-44. 2003
    ..Higher levels of TGases-4 and 5 were noted in patients with local recurrence. Breast cancer displays an aberrant expression of TGases, wherein the levels of TGases-2, 3 and 7 have a relationship with node involvement and patient outcome...
  63. ncbi request reprint Aberrant expression of 5-lipoxygenase-activating protein (5-LOXAP) has prognostic and survival significance in patients with breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, School of Medicine Cardiff University, Heath Park, Cardiff, CF1A 4XN, UK
    Prostaglandins Leukot Essent Fatty Acids 74:125-34. 2006
    ..Furthermore, 5-LOXAP had a significant prognostic value in patients with breast cancer. This identifies 5-LOXAP as a potential therapeutic target in breast cancer...
  64. ncbi request reprint Antagonistic effect of NK4 on HGF/SF induced changes in the transendothelial resistance (TER) and paracellular permeability of human vascular endothelial cells
    Tracey A Martin
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    J Cell Physiol 192:268-75. 2002
    ..NK4 was able to prevent the decrease in levels of ZO-1 protein by HGF/SF...
  65. ncbi request reprint Metastatic cutaneous Crohn's disease of the nipple: report of a case
    Amit Goyal
    Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom
    Dis Colon Rectum 49:132-4. 2006
    ..Histopathologic examination following excision of the fistulas and total duct excision, however, showed well-defined granulomas containing multinucleated giant cells characteristic of extraintestinal Crohn's disease...
  66. ncbi request reprint Expression of autocrine motility factor (AMF) and its receptor, AMFR, in human breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    J Histochem Cytochem 54:231-41. 2006
    ..This strongly indicates that the AMF-AMFR complex plays an important role in the progression of breast cancer, as well as having a prognostic role...
  67. ncbi request reprint The potential lymphangiogenic effects of hepatocyte growth factor/scatter factor in vitro and in vivo
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, UK
    Int J Mol Med 16:723-8. 2005
    ..Hepatocyte growth factor has potential lymphangiogenic activities, and this may have important implications in the nodal spread of cancer cells...
  68. ncbi request reprint Down-regulation of PEDF expression by ribozyme transgene in endothelial and lung cancer cells and its impact on angiogenesis in vitro
    Lijian Zhang
    Department of Surgery, Peking University School of Oncology, Peking University, 38 Xueyuan Road, Haidian District, Beijing, PR China
    Oncol Rep 14:1615-9. 2005
    ..Expression of PEDF in both cancer cells and endothelial cells are correlated with the angiogenic process' paracrine and autocrine pattern...
  69. ncbi request reprint How mammillary fistulas should be managed
    Satheesha Hanavadi
    Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Breast J 11:254-6. 2005
    ..Mammillary fistulas should be treated more appropriately in a specialized breast unit with particular interest in benign breast disease...
  70. ncbi request reprint Loss of tight junction plaque molecules in breast cancer tissues is associated with a poor prognosis in patients with breast cancer
    Tracey A Martin
    Metastasis and Angiogenesis Research Group, Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, Wales CF14 4XN, UK
    Eur J Cancer 40:2717-25. 2004
    ..We conclude that low levels of tight junction plaque molecules, such as ZO-1 and MUPP-1, in breast cancer are associated with poor patients prognosis...
  71. ncbi request reprint Expression of pigment epithelial derived factor is reduced in non-small cell lung cancer and is linked to clinical outcome
    Lijian Zhang
    Department of Surgery, Peking University School of Oncology, Haidian District, Beijing, PR China
    Int J Mol Med 17:937-44. 2006
    ..PEDF is an important factor in NSCLC development and may be a of prognostic value for NSCLC patients...
  72. ncbi request reprint Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer
    Satheesha Hanavadi
    University Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff, CF4 4XN, United Kingdom
    Ann Surg Oncol 13:802-8. 2006
    ..However, there is little clinical information to support this hypothesis. We examined the expression of IL-11 and its receptor in primary breast cancer tissue samples and correlated their level of expression with the clinical outcome...
  73. ncbi request reprint Targeting matrilysin and its impact on tumor growth in vivo: the potential implications in breast cancer therapy
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Clin Cancer Res 11:6012-9. 2005
    ..The current study examined if targeting matrilysin using retroviral ribozyme transgenes may have an impact on breast cancer cells and may have clinical implications...
  74. ncbi request reprint Ductal carcinoma in situ: surgery and radiotherapy
    Robert E Mansel
    University of Wales, College of Medicine, Cardiff, UK
    Breast 12:447-50. 2003
    ..There are widely disparate philosophies concerning diagnosis, classification and treatment. This review discusses the management of DCIS in light of the new data from randomised trials...
  75. ncbi request reprint Expression of breast cancer specific gene-1 (BCSG-1/gamma-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer
    Tracey A Martin
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Heath Park, Cardiff, CF4 4XN, UK
    Oncol Rep 16:207-12. 2006
    ..307, P < 0.05), and weakly with transglutaminase-7 (r = 0.183). BCSG-1 is increased in breast tumour cells, is negatively associated with tumour grade and significantly correlates with levels of transglutaminase-3...
  76. ncbi request reprint Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells
    Martin Albrecht
    Institute of Anatomy and Cell Biology, Philipps University, Marburg, Germany
    J Med Food 7:274-83. 2004
    ..Overall, this study demonstrates significant antitumor activity of pomegranate-derived materials against human prostate cancer...
  77. ncbi request reprint Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer
    Anne Fleissig
    Cancer Research UK Psychosocial Oncology Group, Brighton and Sussex Medical School, Falmer, UK
    Breast Cancer Res Treat 95:279-93. 2006
    ..001) and greater levels of anxiety (p < 0.01). In view of the benefits regarding arm functioning and quality of life, the data from this randomised study support the use of SNB in patients with clinically node negative breast cancer...
  78. ncbi request reprint [Expression of placental growth factor and pigment epithelium-derived factor in non-small cell lung cancer and the prognostic significance thereof]
    Li Jian Zhang
    Department of Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China Email
    Zhonghua Yi Xue Za Zhi 85:3328-31. 2005
    ....