S MacGregor

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc Quantitative trait locus analysis of longitudinal quantitative trait data in complex pedigrees
    Stuart Macgregor
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 171:1365-76. 2005
  2. ncbi request reprint A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42
    S MacGregor
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Kings Buildings, Edinburgh, UK
    Mol Psychiatry 9:1083-90. 2004
  3. ncbi request reprint Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes
    D J Porteous
    Medical Genetics Section, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, EH4 2XU
    Cold Spring Harb Symp Quant Biol 68:383-94. 2003
  4. doi request reprint P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?
    Elaine K Green
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Heath Park, UK
    Am J Med Genet B Neuropsychiatr Genet 150:1063-9. 2009
  5. ncbi request reprint False disease region identification from identity-by-descent haplotype sharing in the presence of phenocopies
    Stuart Macgregor
    Institute of Evolutionary Biology, University of Edinburgh, West Mains Road, Edinburgh, United Kingdom
    Twin Res Hum Genet 9:9-16. 2006
  6. ncbi request reprint Is schizophrenia linked to chromosome 1q?
    Stuart Macgregor
    Institute of Cell, Animal and Population Biology, Ashworth Laboratory, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Science 298:2277; author reply 2277. 2002
  7. ncbi request reprint Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder
    Nigel M Williams
    Department of Psychological Medicine and Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University
    Arch Gen Psychiatry 63:366-73. 2006
  8. ncbi request reprint Longitudinal data analysis in pedigree studies
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles, 90089, USA
    Genet Epidemiol 25:S18-28. 2003
  9. ncbi request reprint Use of phenotypic covariates in association analysis by sequential addition of cases
    Stuart Macgregor
    Biostatistics and Bioinformatics Unit, Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Eur J Hum Genet 14:529-34. 2006
  10. doi request reprint Linkage analysis in a large family from Pakistan with depression and a high incidence of consanguineous marriages
    Muhammad Ayub
    St Luke s Hospital, Middlesborough, UK
    Hum Hered 66:190-8. 2008

Detail Information

Publications24

  1. pmc Quantitative trait locus analysis of longitudinal quantitative trait data in complex pedigrees
    Stuart Macgregor
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 171:1365-76. 2005
    ..The CF-based techniques should allow efficient multivariate analyses of many data sets in human and natural population genetics...
  2. ncbi request reprint A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42
    S MacGregor
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Kings Buildings, Edinburgh, UK
    Mol Psychiatry 9:1083-90. 2004
    ..These results, together with results from a number of other recent studies, stress the importance of the 1q42 region in susceptibility to both BPAD and SCZ...
  3. ncbi request reprint Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes
    D J Porteous
    Medical Genetics Section, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, EH4 2XU
    Cold Spring Harb Symp Quant Biol 68:383-94. 2003
  4. doi request reprint P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?
    Elaine K Green
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Heath Park, UK
    Am J Med Genet B Neuropsychiatr Genet 150:1063-9. 2009
    ..Our data do not provide support for rs2230912 or the other polymorphisms studied within the P2RX7 locus, being involved in susceptibility to mood disorders...
  5. ncbi request reprint False disease region identification from identity-by-descent haplotype sharing in the presence of phenocopies
    Stuart Macgregor
    Institute of Evolutionary Biology, University of Edinburgh, West Mains Road, Edinburgh, United Kingdom
    Twin Res Hum Genet 9:9-16. 2006
    ....
  6. ncbi request reprint Is schizophrenia linked to chromosome 1q?
    Stuart Macgregor
    Institute of Cell, Animal and Population Biology, Ashworth Laboratory, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Science 298:2277; author reply 2277. 2002
  7. ncbi request reprint Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder
    Nigel M Williams
    Department of Psychological Medicine and Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University
    Arch Gen Psychiatry 63:366-73. 2006
    ..Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association...
  8. ncbi request reprint Longitudinal data analysis in pedigree studies
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles, 90089, USA
    Genet Epidemiol 25:S18-28. 2003
    ..Several areas for future research are discussed...
  9. ncbi request reprint Use of phenotypic covariates in association analysis by sequential addition of cases
    Stuart Macgregor
    Biostatistics and Bioinformatics Unit, Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Eur J Hum Genet 14:529-34. 2006
    ..We also illustrate the use of the method for taking account of a dimensional measure of psychosis in a study of the schizophrenia susceptibility gene, dysbindin, in bipolar disorder...
  10. doi request reprint Linkage analysis in a large family from Pakistan with depression and a high incidence of consanguineous marriages
    Muhammad Ayub
    St Luke s Hospital, Middlesborough, UK
    Hum Hered 66:190-8. 2008
    ..The effect of inbreeding on linkage analysis in an extended pedigree is discussed...
  11. ncbi request reprint Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder
    Elaine K Green
    Department of Psychological Medicine and Biostatics and Bioinformatics Unit, University of Wales College of Medicine, Cardiff
    Arch Gen Psychiatry 62:642-8. 2005
    ..The most consistent finding has been that one particular haplotype (the "core" haplotype) is overrepresented in cases compared with control subjects...
  12. pmc Common sequence variants on 20q11.22 confer melanoma susceptibility
    Kevin M Brown
    Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85028, USA
    Nat Genet 40:838-40. 2008
    ..The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases...
  13. doi request reprint Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study
    Penelope A Lind
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 11:174-82. 2008
    ..Because of the large number of phenotypes tested, these possibly significant findings will need to be confirmed in further studies...
  14. pmc Optimal two-stage testing for family-based genome-wide association studies
    Stuart Macgregor
    Am J Hum Genet 82:797-9; author reply 799-800. 2008
  15. pmc Genome partitioning of genetic variation for height from 11,214 sibling pairs
    Peter M Visscher
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 81:1104-10. 2007
    ....
  16. ncbi request reprint Most pooling variation in array-based DNA pooling is attributable to array error rather than pool construction error
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Hum Genet 15:501-4. 2007
    ..This has important implications for optimal study design for array-based pooling. Given carefully constructed pools, resources should be allocated to increasing the number of arrays per sample rather than to constructing multiple pools...
  17. pmc Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 103:12469-74. 2006
    ..Our data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function...
  18. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
  19. pmc GAIA: an easy-to-use web-based application for interaction analysis of case-control data
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Med Genet 7:34. 2006
    ..The importance of testing for interactions between loci in association analysis has been highlighted in a number of recent high profile publications...
  20. ncbi request reprint Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK
    Elaine K Green
    Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK
    Br J Psychiatry 188:21-5. 2006
    ..Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder...
  21. ncbi request reprint No association between schizophrenia and polymorphisms in COMT in two large samples
    Hywel J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 162:1736-8. 2005
    ..The authors examined these hypotheses...
  22. pmc Longitudinal variance-components analysis of the Framingham Heart Study data
    Stuart Macgregor
    Biostatistics and Bioinformatics Unit, University of Wales College of Medicine, Heath Hospital, Cardiff, United Kingdom
    BMC Genet 4:S22. 2003
    ..The traits of interest were BMI, HDLC, total cholesterol, and height. The longitudinal method allowed the characterization of the change in QTL effects with aging. A QTL affecting BMI was shown to act mainly at early ages...
  23. ncbi request reprint Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)
    Rachel Raybould
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, Wales, UK
    Biol Psychiatry 57:696-701. 2005
    ..We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample...