David Lloyd

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint Encystation in Acanthamoeba castellanii: development of biocide resistance
    D Lloyd
    Department of Microbiology, School of Biosciences, Cardiff University, Wales, United Kingdom
    J Eukaryot Microbiol 48:11-6. 2001
  2. ncbi request reprint The plasma membrane of microaerophilic protists: oxidative and nitrosative stress
    D Lloyd
    Microbiology BIOSI 1 Main Building, Cardiff University, PO Box 915, Cardiff CF10 3TL, UK
    Microbiology 150:1183-90. 2004
  3. ncbi request reprint 'Anaerobic protists': some misconceptions and confusions
    David Lloyd
    Cardiff School of Biosciences, Cardiff University, Main Building, PO Box 915, Cardiff CF1 3TL, UK
    Microbiology 150:1115-6. 2004
  4. ncbi request reprint Redox rhythmicity: clocks at the core of temporal coherence
    David Lloyd
    Microbiology, School of Biosciences, Cardiff University, Wales, UK
    Bioessays 29:465-73. 2007
  5. ncbi request reprint Cycles of mitochondrial energization driven by the ultradian clock in a continuous culture of Saccharomyces cerevisiae
    David Lloyd
    Microbiology BIOSI 1, Main Building, Cardiff University, PO Box 915, Cardiff CF10 3TL, Wales, UK
    Microbiology 148:3715-24. 2002
  6. ncbi request reprint The temporal architecture of eukaryotic growth
    David Lloyd
    Microbiology, Cardiff School of Biosciences, BIOSI 1, Main Building, Cardiff University, P O Box 915, Cardiff CF10 3TL, Wales, UK
    FEBS Lett 580:2830-5. 2006
  7. ncbi request reprint Respiratory oscillations in yeasts
    David Lloyd
    School of Biosciences, Cardiff University, P O Box 915, Cardiff CF10 3TL, Wales, UK
    Adv Exp Med Biol 641:118-40. 2008
  8. ncbi request reprint Respiratory oscillations in yeast: clock-driven mitochondrial cycles of energization
    David Lloyd
    Microbiology BIOSI 1, Main Building, Cardiff University, P O Box 915, Cardiff, UK
    FEBS Lett 519:41-4. 2002
  9. ncbi request reprint Alfred Russel Wallace deserves better
    David Lloyd
    School of Biosciences Microbiology, Cardiff University, Main Building, Museum Avenue, Cathays Park, Cardiff CF10 3AT, Wales, UK
    J Biosci 35:339-49. 2010
  10. ncbi request reprint The microaerophilic flagellate Giardia intestinalis: oxygen and its reaction products collapse membrane potential and cause cytotoxicity
    D Lloyd
    School of Biochemistry and Molecular Genetics and Cellular Analysis Facility, School of Microbiology and Immunology, University of New South Wales, Kensington, Sydney 2052, Australia
    Microbiology 146:3109-18. 2000

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Encystation in Acanthamoeba castellanii: development of biocide resistance
    D Lloyd
    Department of Microbiology, School of Biosciences, Cardiff University, Wales, United Kingdom
    J Eukaryot Microbiol 48:11-6. 2001
    ..Chlorhexidine diacetate resistance was observed at between 24 and 36 h. The molecular biology and biochemistry of the modifications that underlie these changes are now being investigated...
  2. ncbi request reprint The plasma membrane of microaerophilic protists: oxidative and nitrosative stress
    D Lloyd
    Microbiology BIOSI 1 Main Building, Cardiff University, PO Box 915, Cardiff CF10 3TL, UK
    Microbiology 150:1183-90. 2004
    ..Oxonol uptake thereby provides a sensitive and early indication of plasma-membrane perturbation by agents that may lead to cytotoxicity and eventually to cell death by necrotic or apoptotic pathways...
  3. ncbi request reprint 'Anaerobic protists': some misconceptions and confusions
    David Lloyd
    Cardiff School of Biosciences, Cardiff University, Main Building, PO Box 915, Cardiff CF1 3TL, UK
    Microbiology 150:1115-6. 2004
  4. ncbi request reprint Redox rhythmicity: clocks at the core of temporal coherence
    David Lloyd
    Microbiology, School of Biosciences, Cardiff University, Wales, UK
    Bioessays 29:465-73. 2007
    ..g. the daily cycles driven by circadian clocks) and underpins these rhythms, which cannot be understood in isolation. Ultradian rhythms are the foundation upon which the coherent functioning of the organism depends...
  5. ncbi request reprint Cycles of mitochondrial energization driven by the ultradian clock in a continuous culture of Saccharomyces cerevisiae
    David Lloyd
    Microbiology BIOSI 1, Main Building, Cardiff University, PO Box 915, Cardiff CF10 3TL, Wales, UK
    Microbiology 148:3715-24. 2002
    ..cerevisiae. It is proposed that mitochondria undergo cycles of energization in response to energetic demands driven by this ultradian clock output...
  6. ncbi request reprint The temporal architecture of eukaryotic growth
    David Lloyd
    Microbiology, Cardiff School of Biosciences, BIOSI 1, Main Building, Cardiff University, P O Box 915, Cardiff CF10 3TL, Wales, UK
    FEBS Lett 580:2830-5. 2006
    ....
  7. ncbi request reprint Respiratory oscillations in yeasts
    David Lloyd
    School of Biosciences, Cardiff University, P O Box 915, Cardiff CF10 3TL, Wales, UK
    Adv Exp Med Biol 641:118-40. 2008
    ....
  8. ncbi request reprint Respiratory oscillations in yeast: clock-driven mitochondrial cycles of energization
    David Lloyd
    Microbiology BIOSI 1, Main Building, Cardiff University, P O Box 915, Cardiff, UK
    FEBS Lett 519:41-4. 2002
    ....
  9. ncbi request reprint Alfred Russel Wallace deserves better
    David Lloyd
    School of Biosciences Microbiology, Cardiff University, Main Building, Museum Avenue, Cathays Park, Cardiff CF10 3AT, Wales, UK
    J Biosci 35:339-49. 2010
    ..It is time that Wallace's relationship with Darwin is reconsidered in preparation for 2013, the centenary of Wallace's death, and he should be recognized as at least an equal in the Wallace-Darwin theory of evolution...
  10. ncbi request reprint The microaerophilic flagellate Giardia intestinalis: oxygen and its reaction products collapse membrane potential and cause cytotoxicity
    D Lloyd
    School of Biochemistry and Molecular Genetics and Cellular Analysis Facility, School of Microbiology and Immunology, University of New South Wales, Kensington, Sydney 2052, Australia
    Microbiology 146:3109-18. 2000
    ..Inactivation of the O(2)-consuming system and loss of viability were also observed on exposure to singlet oxygen photochemically generated from rose bengal or toluidine blue...
  11. doi request reprint Mitochondria-derived organelles in the diplomonad fish parasite Spironucleus vortens
    Coralie O M Millet
    School of Biosciences, Cardiff University, Cardiff, Wales CF10 3AT, UK
    Exp Parasitol 135:262-73. 2013
    ..vortens may necessitate more complex intracellular compartmentation of redox reactions than previously recognized. Control of infection requires biochemical characterization of redox-related organelles...
  12. doi request reprint Effect of garlic and allium-derived products on the growth and metabolism of Spironucleus vortens
    Coralie O M Millet
    School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK
    Exp Parasitol 127:490-9. 2011
    ..vortens. However, chemically synthesized derivatives of garlic constituents might prove a useful avenue for future research...
  13. doi request reprint A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging
    Flora L Thorp-Greenwood
    Department of Chemistry, Cardiff University, Cardiff, Cymru Wales, UK CF10 3AT
    Chem Commun (Camb) 47:3096-8. 2011
    ..The luminescence of the vessel and its copper binding ability suggest potential as a bimodal fluorescence/PET imaging agent...
  14. pmc Diallyl disulphide depletes glutathione in Candida albicans: oxidative stress-mediated cell death studied by two-photon microscopy
    Katey M Lemar
    Microbiology BIOSI 1, Main Building, Cardiff University, PO Box 915, Cardiff CF10 3TL, UK
    Yeast 24:695-706. 2007
    ..The results indicate that DADS is an effective antifungal agent able to trigger cell death in Candida, most probably by eliciting oxidative stress as a consequence of thiol depletion and impaired mitochondrial function...
  15. pmc Allyl alcohol and garlic (Allium sativum) extract produce oxidative stress in Candida albicans
    Katey M Lemar
    Microbiology, Cardiff School of Biosciences, Main Building, Cardiff CF10 3TL, Wales, UK
    Microbiology 151:3257-65. 2005
    ..Known targets for AA are alcohol dehydrogenases Adh1 and 2 (in the cytosol) and Adh3 (mitochondrial), although the significant decrease in NAD(P)H after addition of AA is indicative of another mechanism of action...
  16. ncbi request reprint The "primitive" microaerophile Giardia intestinalis (syn. lamblia, duodenalis) has specialized membranes with electron transport and membrane-potential-generating functions
    David Lloyd
    School of Biosciences Microbiology, Cardiff University, PO Box 915, Cardiff CF10 3TL, Wales, UK
    Microbiology 148:1349-54. 2002
    ..That these functions occur in distinctive specialized membrane systems supports the growing evidence that G. intestinalis may not be primitive, but is derived from an aerobic, mitochondria-containing flagellate...
  17. pmc What yeast and cardiomyocytes share: ultradian oscillatory redox mechanisms of cellular coherence and survival
    David Lloyd
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AT Wales, UK
    Integr Biol (Camb) 4:65-74. 2012
    ..Experiments with yeast and in cardiac cells reveal astonishing parallels and similarities in their dynamic biochemical organization...
  18. doi request reprint Carbohydrate and amino acid metabolism of Spironucleus vortens
    Coralie O M Millet
    School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK
    Exp Parasitol 129:17-26. 2011
    ..vortens under in vitro conditions...
  19. ncbi request reprint Respiratory oscillations in yeast: mitochondrial reactive oxygen species, apoptosis and time; a hypothesis
    David Lloyd
    Microbiology BIOSI 1, Cardiff University, P O Box 915, CF10 3TL, Cardiff, UK
    FEMS Yeast Res 3:333-9. 2003
    ..Our hypothesis is that unrepaired cellular constituents and components (especially mitochondria) eventually lead to cellular senescence and apoptosis when a finite number of respiratory cycles has occurred...
  20. ncbi request reprint Ultradian metronome: timekeeper for orchestration of cellular coherence
    David Lloyd
    Microbiology BIOSI 1, Cardiff University, P O Box 915, Cardiff, CF10 3TL, UK
    Trends Biochem Sci 30:373-7. 2005
    ..g. Acanthamoeba castellanii and Paramecium tetraurelia), as well as cultured mammalian cells. We suggest that ultradian timekeeping is a basic universal necessity for coordinated intracellular coherence...
  21. ncbi request reprint Observation of a chaotic multioscillatory metabolic attractor by real-time monitoring of a yeast continuous culture
    Marc R Roussel
    Microbiology Group, Cardiff School of Biosciences, Cardiff University, UK
    FEBS J 274:1011-8. 2007
    ..e. the set of dissolved gas concentrations which are consistent with the multioscillatory state. Computation of the leading Lyapunov exponent reveals the dynamics on this attractor to be chaotic...
  22. doi request reprint Uptake and localisation of rhenium fac-tricarbonyl polypyridyls in fluorescent cell imaging experiments
    Vanesa Fernández-Moreira
    School of Chemistry, Cardiff University, Cardiff, Wales, UK CF10 3AT
    Org Biomol Chem 8:3888-901. 2010
    ..The patterns of uptake and localisation are correlated with structural and electronic features of the complexes in an attempt to establish ground-rules for the design and application of rhenium complexes in imaging of eukaryotes...
  23. doi request reprint Probing intracellular oxygen by quenched phosphorescence lifetimes of nanoparticles containing polyacrylamide-embedded [Ru(dpp(SO3Na)2)3]Cl2
    Michael P Coogan
    School of Chemistry, Cardiff University, Cardiff, Wales, UK CF10 3AT
    Photochem Photobiol Sci 9:103-9. 2010
    ..Spatial resolution of intracellular structures defined by nanoparticle phosphorescence intensity imaging indicates potential usefulness of the application of lifetime imaging techniques for mapping of intracellular O(2) distributions...
  24. ncbi request reprint Nitrosative stress induced cytotoxicity in Giardia intestinalis
    D Lloyd
    Department of Microbiology, Cardiff University, Cardiff, Wales, UK
    J Appl Microbiol 95:576-83. 2003
    ..To investigate the antigiardial properties of the nitrosating agents: sodium nitrite, sodium nitroprusside and Roussin's black salt...
  25. ncbi request reprint Encystation of Acanthamoeba castellanii: dye uptake for assessment by flow cytometry and confocal laser scanning microscopy
    C Connell
    Microbiology (BIOSI 1, Cardiff University, Wales, UK
    J Appl Microbiol 90:706-12. 2001
    ..SIGNIFICANCE AND IMPACT OF THE STUDY: Rapid and precise determination of the growth cycle of a dangerous ocular pathogen...
  26. ncbi request reprint Bioluminescence of Vibrio fischeri in continuous culture: optimal conditions for stability and intensity of photoemission
    Stefanie Scheerer
    Cardiff University, Cardiff School of Biosciences, PO Box 915, Cardiff CF10 3TL, UK
    J Microbiol Methods 67:321-9. 2006
    ..This system provided a reliable long-term (more than 1 month) continuous culture facility for the reproducible measurement of perturbation of V. fischeri by monitoring changes in luminescence...
  27. doi request reprint The microaerophilic flagellate, Trichomonas vaginalis, contains unusual acyl lipids but no detectable cardiolipin
    Irina A Guschina
    School of Biosciences, Cardiff University, Cardiff CF10 3TL, United Kingdom
    J Eukaryot Microbiol 56:52-7. 2009
    ..These data are discussed in relation to the organism's phylogenetic origin as a parasite showing secondary adaptation to microaerobic conditions...
  28. ncbi request reprint Giardia intestinalis, a eukaryote without hydrogenosomes, produces hydrogen
    David Lloyd
    Microbiology BIOSI 1, Main Building, Cardiff University, PO Box 915, Cardiff CF10 3TL, Wales, UK
    Microbiology 148:727-33. 2002
    ..intestinalis; the physiological characterization of its hydrogenase, and its recently elucidated gene sequence, will aid further phylogenetic investigations...
  29. pmc Kinetics, stereospecificity, and expression of the malolactic enzyme
    C E Arthurs
    Microbiology Group Cardiff School of Biosciences, Cardiff University, Cardiff CF1 3TL, Wales, United Kingdom
    Appl Environ Microbiol 65:3360-3. 1999
    ....
  30. ncbi request reprint Antimicrobial properties of Allium sativum (garlic)
    J C Harris
    Microbiology Group, School of Biosciences, University of Wales, Cardiff, UK
    Appl Microbiol Biotechnol 57:282-6. 2001
    ..This review aims to address the historical use of garlic and its sulfur chemistry, and to provide a basis for further research into its antimicrobial properties...
  31. ncbi request reprint The microaerophilic flagellate Giardia intestinalis: Allium sativum (garlic) is an effective antigiardial
    J C Harris
    Microbiology Group, School of Biosciences BIOSI Main Building, Cardiff University, Cardiff CF10 3TL, UK
    Microbiology 146:3119-27. 2000
    ..Allyl mercaptan, however, only gave an increase in distended vesicles, suggesting that this biocide has a different mode of action...
  32. ncbi request reprint Membrane inlet mass spectrometric measurement of O2 and CO2 gradients in cultures of Lactobacillus paracasei and a developing Cheddar cheese ecosystem
    J D Tammam
    School of Biosciences, Microbiology Group, Cardiff University, UK
    Int J Food Microbiol 65:11-22. 2001
    ..Measurement of gases in a cheese ecosystem provides the first description of mass spectrometry being used to monitor the processes of microbial gaseous exchange with respect to O2 and CO2 in a cheese ecosystem...
  33. ncbi request reprint Garlic (Allium sativum) as an anti-Candida agent: a comparison of the efficacy of fresh garlic and freeze-dried extracts
    K M Lemar
    Microbiology BIOSI 1, Cardiff University, Cardiff, Wales, UK
    J Appl Microbiol 93:398-405. 2002
    ..To determine the effects of fresh and freeze-dried extracts of Allium sativum on the physiology and morphology of Candida albicans...
  34. ncbi request reprint Amino acid fermentation in non-starter Lactobacillus spp. isolated from cheddar cheese
    J D Tammam
    School of Biosciences, Microbiology Group, Cardiff University, Wales and Hannah Research Institute, Ayr, Scotland
    Lett Appl Microbiol 30:370-4. 2000
    ..Amino acid catabolites were detected by gas chromatography mass spectrometry (GCMS) in culture supernatant fluids of a representative non-starter lactic acid bacteria isolate Lactobacillus paracasei CI6...
  35. ncbi request reprint Hydrogen sulfide: clandestine microbial messenger?
    David Lloyd
    Microbiology, Cardiff School of Biosciences, Cardiff University, Main Building, P O Box 915, Cardiff CF10 3TL, UK
    Trends Microbiol 14:456-62. 2006
    ..It is expected that future research will uncover a host of novel functions, not only in eukaryotes but also in prokaryotic species...
  36. ncbi request reprint Biological time is fractal: early events reverberate over a life time
    David Lloyd
    Microbiology, BIOSI 1, Main Building, Cardiff University, PO Box 915, Cardiff CF10 3TL Wales, UK
    J Biosci 33:9-19. 2008
  37. doi request reprint The diplomonad fish parasite Spironucleus vortens produces hydrogen
    Coralie O M Millet
    School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom
    J Eukaryot Microbiol 57:400-4. 2010
    ..Metronidazole (1 mM) inhibited H(2) production by 50%, while CO(2) production was not affected. This suggests that metronidazole may be reduced by an enzyme of the H(2) pathway, thus competing for electrons with H(+)...
  38. ncbi request reprint Current trends in research into the waterborne parasite Giardia
    Samantha Lane
    School of Biosciences, Microbiology, Cardiff University, Wales, UK
    Crit Rev Microbiol 28:123-47. 2002
    ..The phylogeny of the organism remains uncertain, but there is a growing opinion that Giardia is not an ancient primitive eukaryote, but that it is derived from a more complex mitochondria-containing protozoon...
  39. ncbi request reprint The antioxidant potential of pyruvate in the amitochondriate diplomonads Giardia intestinalis and Hexamita inflata
    G A Biagini
    School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney 2052, Australia
    Microbiology 147:3359-65. 2001
    ..intestinalis and H. inflata, pyruvate exerts antioxidant activity at physiological levels, and (ii) it is the absence of a respiratory chain in the diplomonads which facilitates the observed antioxidant activity...
  40. ncbi request reprint The antibacterial activity of vancomycin towards Staphylococcus aureus under aerobic and anaerobic conditions
    M T E Suller
    School of Pure and Applied Biology, University of Wales, Cardiff, UK
    J Appl Microbiol 92:866-72. 2002
    ....
  41. ncbi request reprint Fluorescent rhenium-naphthalimide conjugates as cellular imaging agents
    Emily E Langdon-Jones
    School of Chemistry, Main Building, Cardiff University, Cardiff CF10 3AT, Cymru Wales, U K
    Inorg Chem 53:3788-97. 2014
    ..Significant differences were noted between the free ligands and complexes, with the Re(I) complex of L(2) showing hydrogenosomal localization in S. vortens. ..
  42. pmc Oxygen induction of a novel fatty acid n-6 desaturase in the soil protozoon, Acanthamoeba castellanii
    Andrew J Rutter
    School of Biosciences, Cardiff University, Cardiff CF10 3US, Wales, U K
    Biochem J 368:57-67. 2002
    ....
  43. ncbi request reprint Continuous culture of photobacterium
    David T Pooley
    Department of Medical Physics and Bioengineering, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Biosens Bioelectron 19:1457-63. 2004
    ..The non-standard control methodologies reported may have important research and industrial applications, for example in providing immediate process control or as an inferential method to optimize biomass: product yield ratios...
  44. ncbi request reprint Recent advances in the treatment of Acanthamoeba keratitis
    Raman Kumar
    Department of Microbiology, Cardiff University, Wales, United Kingdom
    Clin Infect Dis 35:434-41. 2002
    ..Immunization thus may eventually become the best approach for reduction of the incidence of amebic infection in humans...
  45. ncbi request reprint Trichomonas vaginalis and Giardia intestinalis produce nitric oxide and display NO-synthase activity
    Kristina M Harris
    Microbiology Biosi1, Cardiff University, Wales, United Kingdom
    J Eukaryot Microbiol 53:S182-3. 2006
  46. ncbi request reprint Noninvasive methods for the investigation of organisms at low oxygen levels
    David Lloyd
    School of Biosciences Microbiology, Main Building, Cardiff University, P O Box 915, Cardiff CF10 3TL, Wales, United Kingdom
    Adv Appl Microbiol 51:155-83. 2002
  47. ncbi request reprint Low tyrosine content of growth media yields aflagellate Salmonella enterica serovar Typhimurium
    Victoria L Gray
    Microbiology, Cardiff School of Biosciences 1, Cardiff University, Main Building, PO Box 915, Cardiff CF10 3TL, UK
    Microbiology 152:23-8. 2006
    ..Therefore, culture media containing less than 1.20 g tyrosine l(-1), and of limited carbohydrate source, when used for serological testing of clinical isolates, may result in an incomplete serological identification...
  48. pmc The O2-dependence of respiration and H2O2 production in the parasitic nematode Ascaridia galli
    T A Paget
    Department of Microbiology, University College, Cardiff, Wales, U K
    Biochem J 256:633-9. 1988
    ..7. These results are discussed in relation to potential O2 toxicity in A. galli...
  49. ncbi request reprint Nitrite inhibits hydrogen production and kills the cattle parasite Tritrichomonas foetus
    D Lloyd
    Microbiology BIOSI 1, Cardiff University, Cardiff, Wales, UK
    J Appl Microbiol 93:492-6. 2002
    ....
  50. ncbi request reprint Cell death mechanisms in the human opportunistic pathogen Candida albicans
    Katey M Lemar
    Cardiff School of Biosciences, BIOSI 1, Microbiology, PO Box 915, Cardiff CF10 3TL, Wales, UK
    J Eukaryot Microbiol 50:685-6. 2003
    ..We suggest that mechanisms that these anti-candidal agents have in common is the triggering some of the characteristics of apoptotic cell death...
  51. ncbi request reprint Giardia: highly evolved parasite or early branching eukaryote?
    David Lloyd
    Microbiology BIOSI, Cardiff University, PO Box 915, Wales, CF10 3TL, Cardiff, UK
    Trends Microbiol 10:122-7. 2002
    ..In this case, these organisms might have arisen much more recently from aerobic free-living flagellates...
  52. doi request reprint Peptones from diverse sources: pivotal determinants of bacterial growth dynamics
    V L Gray
    Microbiology, Cardiff School of Biosciences 1, Cardiff University, Cardiff, Wales, UK
    J Appl Microbiol 104:554-65. 2008
    ....
  53. ncbi request reprint Membrane inlet ion trap mass spectrometry for the direct measurement of dissolved gases in ecological samples
    G Cowie
    Microbiology Group PABIO, University of Wales, Cardiff, UK
    J Microbiol Methods 35:1-12. 1999
    ..The initial increase in O2 concentration stimulated respiration and inhibited the final pathway in dentrification producing higher concentrations of N2O and reducing the concentration of N2...
  54. pmc Haemoprotein terminal oxidases in the nematodes Nippostrongylus brasiliensis and Ascaridia galli
    T A Paget
    Department of Microbiology, University College, Wales, U K
    Biochem J 256:295-8. 1988
    ..These results suggest that cytochrome aa3 is the major functional oxidase in N. brasiliensis, whereas the CO-reacting b-type cytochrome dominates in A. galli...
  55. pmc Flow cytometric assessment of the postantibiotic effect of methicillin on Staphylococcus aureus
    M T Suller
    School of Pure and Applied Biology, University of Wales, Cardiff, United Kingdom
    Antimicrob Agents Chemother 42:1195-9. 1998
    ..Flow cytometry thus provides a rapid and sensitive alternative to traditional techniques that have been used to study PAE, with the added advantage that physiological changes can be detected as they arise...
  56. ncbi request reprint Rapid and sensitive quantitation of antibiotics in fermentations by electrospray mass spectrometry
    J Morgan
    Microbiology Group, School of Biosciences, University of Wales Cardiff, PO Box 915, Cardiff CF1 3TL, Wales, UK
    Rapid Commun Mass Spectrom 15:1229-38. 2001
    ..Specificity is not matched by other methods and antibiotic analogues (e.g. the five forms of erythromycin) can be determined within minutes...
  57. ncbi request reprint Flow cytometry of yeasts
    D Lloyd
    University of Wales, Cardiff, United Kingdom
    Curr Protoc Cytom . 2001
    ..Despite the increasing usefulness of digital imaging techniques, flow cytometry remains the method of choice for the resolution of population heterogeneities...
  58. ncbi request reprint The impact of sludge amendment on gas dynamics in an upland soil: monitored by membrane inlet mass spectrometry
    S K Sheppard
    Microbiology Group, Cardiff School of Biosciences, University of Wales Cardiff, P O Box 915, Cardiff CF1 3TL, UK
    Bioresour Technol 96:1103-15. 2005
    ..Soil microbial fermentative activity was enhanced over periods of a few months as shown by elevated CO2 concentrations...
  59. ncbi request reprint Hydrogen production in Giardia intestinalis, a eukaryote with no hydrogenosomes
    David Lloyd
    Trends Parasitol 18:155-6. 2002
  60. ncbi request reprint Menadione kills trophozoites and cysts of Giardia intestinalis
    Timothy Paget
    Department of Applied Biology, University of Hull, UK
    Microbiology 150:1231-6. 2004
    ..3. Menadione (LD(50) in mice, 0.5 g kg(-1)) is therefore a potentially more useful and general anti-giardial agent than metronidazole, as it is active against cysts as well as trophozoites...
  61. ncbi request reprint A tuneable attractor underlies yeast respiratory dynamics
    Douglas B Murray
    The Systems Biology Institute, 953 Shinanomachi Research Park, Keio University School of Medicine, 35 Shinanomachi, Shimjuku ku, Tokyo 160 852, Japan
    Biosystems 90:287-94. 2007
    ..These complex dynamics can be represented by a tuneable attractor that orchestrates cellular complexity and coherence to the environment...
  62. ncbi request reprint Single and cell population respiratory oscillations in yeast: a 2-photon scanning laser microscopy study
    Miguel A Aon
    The Institute of Molecular Cardiobiology, Johns Hopkins Medicine, 1059 Ross Building, Baltimore, MD 21205 2195, USA
    FEBS Lett 581:8-14. 2007
    ....
  63. ncbi request reprint Generation and maintenance of synchrony in Saccharomyces cerevisiae continuous culture
    Douglas B Murray
    Faculty of Engineering, Science and Technology, South Bank University, 103 Borough Road, SE1 OAA, London, UK
    Exp Cell Res 287:10-5. 2003
    ..It is concluded that endogenously produced acetaldehyde and sulfite tune the oscillation of mitochondrial energization state whereas sulfide mediates population synchrony...
  64. ncbi request reprint The Gts1 protein stabilizes the autonomous oscillator in yeast
    Claire A Adams
    Biochemical Engineering Laboratory, National Institute of Bioscience and Human Technology, Tsukuba, Japan
    Yeast 20:463-70. 2003
    ..It is postulated that Gts1p is involved in the mechanism that communicates external conditions, such as temperature, to the central oscillating loop...
  65. ncbi request reprint Bacterial-like energy metabolism in the amitochondriate protozoon Hexamita inflata
    Giancarlo A Biagini
    School of Biochemistry and Molecular Genetics, The University of New South Wales, Sydney, NSW 2052, Australia
    Mol Biochem Parasitol 128:11-9. 2003
    ..This study also indicates that, as with other amitochondriate protozoa and some bacteria, the ADH pathway significantly contributes to the energy yield of the cell, particularly under O(2)-limited conditions...
  66. ncbi request reprint Why go bipedal? Locomotion and morphology in Australian agamid lizards
    Christofer J Clemente
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, UK
    J Exp Biol 211:2058-65. 2008
    ..However, both behavioural and threshold data suggest that some lizards actively attempt to run bipedally, implying some unknown advantage to bipedal locomotion...