Emyr Lloyd-Evans

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. doi Endolysosomal calcium regulation and disease
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem Soc Trans 38:1458-64. 2010
  2. ncbi Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases
    Emyr Lloyd-Evans
    School of Biosciences, Biomedical Sciences Building, Cardiff University, Museum Avenue, Cardiff CF10 3AX, United Kingdom
    Cell Calcium 50:200-5. 2011
  3. ncbi Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport
    Danielle te Vruchte
    Glycobiology Institute, Department of Biochemistry, South Parks Road, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 279:26167-75. 2004
  4. doi Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Traffic 11:419-28. 2010
  5. pmc Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking
    Margarida Ruas
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Curr Biol 20:703-9. 2010
  6. doi Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
    Anthony J Morgan
    Department of Pharmacology, University of Oxford, U K
    Biochem J 439:349-74. 2011
  7. doi Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis
    Elena Elliot-Smith
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Mol Genet Metab 94:204-11. 2008
  8. doi Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
    Nat Med 14:1247-55. 2008

Collaborators

Detail Information

Publications8

  1. doi Endolysosomal calcium regulation and disease
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem Soc Trans 38:1458-64. 2010
    ..In the present review, we provide a summary of the current knowledge on mechanisms of calcium homoeostasis within the endolysosomal system and how these mechanisms may be affected in human metabolic disorders...
  2. ncbi Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases
    Emyr Lloyd-Evans
    School of Biosciences, Biomedical Sciences Building, Cardiff University, Museum Avenue, Cardiff CF10 3AX, United Kingdom
    Cell Calcium 50:200-5. 2011
    ..In this review we provide a summary of the current knowledge on the role of lysosomal Ca(2+) signaling in the pathogenesis of this group of diseases...
  3. ncbi Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport
    Danielle te Vruchte
    Glycobiology Institute, Department of Biochemistry, South Parks Road, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 279:26167-75. 2004
    ..It is suggested that accumulating GSL is part of a mislocalized membrane microdomain and is responsible for the deficit in endocytic trafficking found in NPC disease...
  4. doi Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Traffic 11:419-28. 2010
    ..We review the potential role of each of the individual storage lipids in initiating the pathogenic cascade and propose a model of NPC1 and NPC2 function based on the current knowledge...
  5. pmc Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking
    Margarida Ruas
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Curr Biol 20:703-9. 2010
    ..We propose that NAADP regulates endolysosomal Ca(2+) storage and release via TPCs and coordinates endoplasmic reticulum Ca(2+) release in a role that impacts on Ca(2+) signaling in health and disease [6]...
  6. doi Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
    Anthony J Morgan
    Department of Pharmacology, University of Oxford, U K
    Biochem J 439:349-74. 2011
    ..These developments underscore a new central role for the endolysosomal system in cellular Ca2+ regulation and signalling...
  7. doi Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis
    Elena Elliot-Smith
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Mol Genet Metab 94:204-11. 2008
    ..However, functional improvement was greatest with NB-DNJ treatment which may potentially be caused by novel anti-inflammatory properties of NB-DNJ...
  8. doi Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
    Nat Med 14:1247-55. 2008
    ..This unique calcium phenotype represents a new target for therapeutic intervention, as elevation of cytosolic calcium with curcumin normalized NPC1 disease cellular phenotypes and prolonged survival of the NPC1 mouse...