Emyr Lloyd-Evans

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. doi Endolysosomal calcium regulation and disease
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem Soc Trans 38:1458-64. 2010
  2. doi Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases
    Emyr Lloyd-Evans
    School of Biosciences, Biomedical Sciences Building, Cardiff University, Museum Avenue, Cardiff CF10 3AX, United Kingdom
    Cell Calcium 50:200-5. 2011
  3. ncbi Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport
    Danielle te Vruchte
    Glycobiology Institute, Department of Biochemistry, South Parks Road, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 279:26167-75. 2004
  4. doi Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Traffic 11:419-28. 2010
  5. pmc Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking
    Margarida Ruas
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Curr Biol 20:703-9. 2010
  6. doi Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
    Anthony J Morgan
    Department of Pharmacology, University of Oxford, U K
    Biochem J 439:349-74. 2011
  7. doi Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis
    Elena Elliot-Smith
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Mol Genet Metab 94:204-11. 2008
  8. doi Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
    Nat Med 14:1247-55. 2008
  9. doi Disorders of cholesterol metabolism and their unanticipated convergent mechanisms of disease
    Frances M Platt
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom email
    Annu Rev Genomics Hum Genet 15:173-94. 2014

Collaborators

Detail Information

Publications9

  1. doi Endolysosomal calcium regulation and disease
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem Soc Trans 38:1458-64. 2010
    ..In the present review, we provide a summary of the current knowledge on mechanisms of calcium homoeostasis within the endolysosomal system and how these mechanisms may be affected in human metabolic disorders...
  2. doi Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases
    Emyr Lloyd-Evans
    School of Biosciences, Biomedical Sciences Building, Cardiff University, Museum Avenue, Cardiff CF10 3AX, United Kingdom
    Cell Calcium 50:200-5. 2011
    ..In this review we provide a summary of the current knowledge on the role of lysosomal Ca(2+) signaling in the pathogenesis of this group of diseases...
  3. ncbi Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport
    Danielle te Vruchte
    Glycobiology Institute, Department of Biochemistry, South Parks Road, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 279:26167-75. 2004
    ..It is suggested that accumulating GSL is part of a mislocalized membrane microdomain and is responsible for the deficit in endocytic trafficking found in NPC disease...
  4. doi Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Traffic 11:419-28. 2010
    ..We review the potential role of each of the individual storage lipids in initiating the pathogenic cascade and propose a model of NPC1 and NPC2 function based on the current knowledge...
  5. pmc Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking
    Margarida Ruas
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Curr Biol 20:703-9. 2010
    ..We propose that NAADP regulates endolysosomal Ca(2+) storage and release via TPCs and coordinates endoplasmic reticulum Ca(2+) release in a role that impacts on Ca(2+) signaling in health and disease [6]...
  6. doi Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
    Anthony J Morgan
    Department of Pharmacology, University of Oxford, U K
    Biochem J 439:349-74. 2011
    ..These developments underscore a new central role for the endolysosomal system in cellular Ca2+ regulation and signalling...
  7. doi Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis
    Elena Elliot-Smith
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Mol Genet Metab 94:204-11. 2008
    ..However, functional improvement was greatest with NB-DNJ treatment which may potentially be caused by novel anti-inflammatory properties of NB-DNJ...
  8. doi Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
    Nat Med 14:1247-55. 2008
    ..This unique calcium phenotype represents a new target for therapeutic intervention, as elevation of cytosolic calcium with curcumin normalized NPC1 disease cellular phenotypes and prolonged survival of the NPC1 mouse...
  9. doi Disorders of cholesterol metabolism and their unanticipated convergent mechanisms of disease
    Frances M Platt
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom email
    Annu Rev Genomics Hum Genet 15:173-94. 2014
    ..This surprising finding is not only shedding light on details of cellular cholesterol homeostasis but also suggesting novel approaches to therapy. ..