John H Lazarus

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi Thyroid disease in pregnancy and childhood
    J H Lazarus
    Cardiff University School of Medicine, Centre for Endocrine and Diabetes Sciences, Academic Centre, Llandough Hospital, Llandough, Cardiff, UK
    Minerva Endocrinol 30:71-87. 2005
  2. ncbi Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia
    R J Clifton-Bligh
    Department of Medicine, Level 5 Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 19:399-401. 1998
  3. ncbi Postpartum thyroiditis
    J H Lazarus
    Autoimmunity 35:169-73. 2002
  4. pmc Screening for thyroid disease in pregnancy
    J H Lazarus
    Centre for Endocrine and Diabetes Sciences, Cardiff University, Cardiff CF14 4XN, Wales, UK
    J Clin Pathol 58:449-52. 2005
  5. ncbi Significance of low thyroid-stimulating hormone in pregnancy
    John H Lazarus
    Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff University, Heath Park, Cardiff, UK
    Curr Opin Endocrinol Diabetes Obes 14:389-92. 2007
  6. pmc Screening for thyroid dysfunction in pregnancy: is it worthwhile?
    John H Lazarus
    Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, University Hospital of Wales, Heath Park, Wales, Cardiff CF14 4XN, UK
    J Thyroid Res 2011:397012. 2011
  7. doi Epidemiology of Graves' orbitopathy (GO) and relationship with thyroid disease
    John H Lazarus
    Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Best Pract Res Clin Endocrinol Metab 26:273-9. 2012
  8. pmc Antenatal thyroid screening and childhood cognitive function
    John H Lazarus
    Centre for Endocrine and Diabetes Sciences, Cardiff School of Medicine, Cardiff, Wales, United Kingdom
    N Engl J Med 366:493-501. 2012
  9. ncbi Epidemiology and prevention of thyroid disease in pregnancy
    John H Lazarus
    University of Wales College of Medicine, Cardiff, Wales, United Kingdom
    Thyroid 12:861-5. 2002
  10. pmc Unusual complications of thyroid carcinoma
    P J D Owen
    Department of Medicine, University Hospital of Wales, Cardiff, UK
    Postgrad Med J 79:55-6. 2003

Collaborators

Detail Information

Publications58

  1. ncbi Thyroid disease in pregnancy and childhood
    J H Lazarus
    Cardiff University School of Medicine, Centre for Endocrine and Diabetes Sciences, Academic Centre, Llandough Hospital, Llandough, Cardiff, UK
    Minerva Endocrinol 30:71-87. 2005
    ..Screening for both thyroid dysfunction and thyroid antibodies ideally at a preconception clinic but certainly in early gestation is recommended...
  2. ncbi Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia
    R J Clifton-Bligh
    Department of Medicine, Level 5 Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 19:399-401. 1998
    ..The mutant protein exhibits impaired DNA binding and loss of transcriptional function. Our observations represent the first description of a genetic cause for thyroid agenesis...
  3. ncbi Postpartum thyroiditis
    J H Lazarus
    Autoimmunity 35:169-73. 2002
    ..Recent studies have shown an increase in both Th2 and Th1 cytokine release from lymphocytes in ante partum women destined to develop PPTD. More data are required on the cellular immune changes both ante partum and post partum in PPT...
  4. pmc Screening for thyroid disease in pregnancy
    J H Lazarus
    Centre for Endocrine and Diabetes Sciences, Cardiff University, Cardiff CF14 4XN, Wales, UK
    J Clin Pathol 58:449-52. 2005
    ..PPTD can be predicted by measurement of antiTPOAb in early gestation...
  5. ncbi Significance of low thyroid-stimulating hormone in pregnancy
    John H Lazarus
    Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff University, Heath Park, Cardiff, UK
    Curr Opin Endocrinol Diabetes Obes 14:389-92. 2007
    ..To describe the significance of low thyroid-stimulating hormone in pregnancy...
  6. pmc Screening for thyroid dysfunction in pregnancy: is it worthwhile?
    John H Lazarus
    Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, University Hospital of Wales, Heath Park, Wales, Cardiff CF14 4XN, UK
    J Thyroid Res 2011:397012. 2011
    ..The clinical epidemiological evidence base does not justify universal screening at the present time. However, it is probable that more evidence will be produced which may alter this view in the future...
  7. doi Epidemiology of Graves' orbitopathy (GO) and relationship with thyroid disease
    John H Lazarus
    Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Best Pract Res Clin Endocrinol Metab 26:273-9. 2012
    ..The probability is that a reduction of the incidence of GO will be achieved by influencing the environmental factors...
  8. pmc Antenatal thyroid screening and childhood cognitive function
    John H Lazarus
    Centre for Endocrine and Diabetes Sciences, Cardiff School of Medicine, Cardiff, Wales, United Kingdom
    N Engl J Med 366:493-501. 2012
    ..Children born to women with low thyroid hormone levels have been reported to have decreased cognitive function...
  9. ncbi Epidemiology and prevention of thyroid disease in pregnancy
    John H Lazarus
    University of Wales College of Medicine, Cardiff, Wales, United Kingdom
    Thyroid 12:861-5. 2002
    ..Another approach is to at least improve the prediction of postpartum thyroid disease (PPT) because the TPO antibody has a sensitivity of only 50%...
  10. pmc Unusual complications of thyroid carcinoma
    P J D Owen
    Department of Medicine, University Hospital of Wales, Cardiff, UK
    Postgrad Med J 79:55-6. 2003
    ....
  11. ncbi Aspects of treatment of subclinical hypothyroidism
    John H Lazarus
    Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Wales, United Kingdom
    Thyroid 17:313-6. 2007
  12. pmc Congenital hypothyroidism
    J H Lazarus
    University of Wales College of Medicine, Cardiff CF14 4XN, UK
    Arch Dis Child 90:112-3. 2005
  13. doi Lithium and thyroid
    John H Lazarus
    Centre for Endocrine and Diabetes Sciences, Cardiff University School of Medicine, University Hospital of Wales, Cardiff CF14 4 XN, Wales, UK
    Best Pract Res Clin Endocrinol Metab 23:723-33. 2009
    ..There is no clinical benefit of lithium therapy in thyroid cancer. More research is required on the cellular proliferative effects of lithium as well as its impact on the immune system...
  14. doi Glucocorticoid administration for Graves' hyperthyroidism treated by radioiodine. A questionnaire survey among members of the European Thyroid Association
    J H Lazarus
    Centre for Endocrine and Diabetes Sciences, Cardiff University School of Medicine, Cardiff, UK
    J Endocrinol Invest 33:409-13. 2010
    ..However, no randomized clinical trial has been performed to ascertain the optimum glucocorticoid therapy...
  15. doi Thyroid function in pregnancy
    John H Lazarus
    Centre for Endocrine and Diabetes Sciences, Cardiff University School of Medicine, University Hospital of Wales, Heath Park, UK
    Br Med Bull 97:137-48. 2011
    ..Evaluation of strategies to screen thyroid function in early pregnancy. Areas timely for developing research are the following: placental thyroid hormone physiology, thyroid hormone therapy and screening thyroid function...
  16. ncbi Hyperthyroidism during pregnancy: etiology, diagnosis and management
    John H Lazarus
    Cardiff University, Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, Wales, UK
    Womens Health (Lond Engl) 1:97-104. 2005
    ..Radioiodine therapy is contraindicated in pregnancy but thyroid surgery may be performed safely in the second trimester. Autoimmune thyroiditis and Graves' hyperthyroidism occur quite commonly in postpartum women...
  17. ncbi Clinical manifestations of postpartum thyroid disease
    J H Lazarus
    Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Thyroid 9:685-9. 1999
    ..The risk of recurrent PPT is 70% if previous PPT was experienced and 25% if the patient was euthyroid after the first pregnancy...
  18. ncbi Thyroid hormone and intellectual development: a clinician's view
    J H Lazarus
    Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Thyroid 9:659-60. 1999
    ..There are important implications for possible screening for thyroid dysfunction during pregnancy arising from these studies...
  19. ncbi Thyroid disorders associated with pregnancy: etiology, diagnosis, and management
    John H Lazarus
    Department of Medicine, University of Wales College of Medicine, Cardiff, Wales, UK
    Treat Endocrinol 4:31-41. 2005
    ..Women having transient PPTD with hypothyroidism should be monitored frequently, as there is a 50% chance of these patients developing hypothyroidism during the next 7 years...
  20. doi Therapy of endocrine disease: Impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis
    Peter N Taylor
    Thyroid Research Group, Institute of Molecular and Experimental Medicine IMEM, Cardiff University School of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Eur J Endocrinol 170:R1-R15. 2014
    ..Although the detrimental effects of severe iodine deficiency are well recognised, the benefits of correcting mild-to-moderate iodine deficiency are uncertain...
  21. ncbi Complement activation in postpartum thyroiditis
    O E Okosieme
    Department of Medicine, University of Wales College of Medicine, Cardiff, UK
    QJM 95:173-9. 2002
    ..Although these antibodies are able to activate the complement cascade in vitro, it is not known whether complement activation plays any role in the pathogenesis of this disease...
  22. ncbi Thyroxine excess and pregnancy
    J H Lazarus
    Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Acta Med Austriaca 21:53-6. 1994
    ..Differentiation by measurement of TsAb and thyroidal iodine uptake is important because of therapeutic considerations...
  23. doi Resistance to thyroid hormone in pregnancy
    Simi Dhingra
    Department of Obstetrics and Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff, UK
    Obstet Gynecol 112:501-3. 2008
    ..We report a case series of three patients with this condition, the changes in thyroid function tests during their pregnancies, and their obstetric outcome...
  24. ncbi Increased prevalence of thyroglobulin antibodies in Sri Lankan schoolgirls--is iodine the cause?
    L D Premawardhana
    Department of Medicine, University of Wales College of Medicine, Cardiff, UK
    Eur J Endocrinol 143:185-8. 2000
    ..Salt iodination was made compulsory in 1993 but there has been no recent study, using modern techniques, of its benefits or harmful effects...
  25. ncbi Thyroid disease and vascular function
    Penelope J D Owen
    Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, Wales, United Kingdom
    Thyroid 17:519-24. 2007
    ..The various methods used to assess arterial function are reviewed and the changes demonstrated in human and animal models of thyroid dysfunction...
  26. ncbi Evolution of thyroid autoimmunity during iodine prophylaxis--the Sri Lankan experience
    G Mazziotti
    Department of Medicine, University of Wales College of Medicine, Cardiff, UK
    Eur J Endocrinol 149:103-10. 2003
    ..To study the evolution of thyroid autoimmunity, in relation to the change in goitre prevalence, during 3 Years of iodine prophylaxis in Sri Lanka...
  27. ncbi Thyroglobulin: current aspects of its role in autoimmune thyroid disease and thyroid cancer
    O E Okosieme
    Department of Medicine, University Hospital Wales College of Medicine, Cardiff, UK
    Minerva Med 94:319-30. 2003
    ..The use of rh-TSH in stimulating Tg prior to testing has improved the sensitivity of Tg values in the suppressed state...
  28. ncbi Thyroid peroxidase antibodies in early pregnancy: utility for prediction of postpartum thyroid dysfunction and implications for screening
    L D K E Premawardhana
    Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Thyroid 14:610-5. 2004
    ..We recommend TPOAb in early pregnancy as a useful predictor of PPTD, particularly in populations where PPTD does not occur in TPOAb-negative women...
  29. pmc Hyperthyroidism and pregnancy
    Helen Marx
    Department of Obstetrics, University Hospital of Wales, Cardiff CF14 4XN
    BMJ 336:663-7. 2008
  30. ncbi Thyroid dysfunction: reproduction and postpartum thyroiditis
    John H Lazarus
    Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Semin Reprod Med 20:381-8. 2002
    ..There is a significant rate of hypothyroidism in long-term follow-up of women who have transient postpartum thyroid dysfunction...
  31. ncbi Determinants of long-term outcome after radioiodine therapy for solitary autonomous thyroid nodules
    Hemanth Bolusani
    Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, Cardiff, South Wales, UK
    Endocr Pract 14:543-9. 2008
    ..To determine the incidence and clinical predictors of hypothyroidism in one institution after radioiodine treatment of solitary toxic nodules...
  32. ncbi Peripheral cytokine expression in autoimmune thyroiditis: effects of in vitro modulation by rosiglitazone and dexamethasone
    O E Okosieme
    Centre for Endocrine and Diabetes Science, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Thyroid 16:953-60. 2006
    ....
  33. ncbi Thyroglobulin epitope recognition in a post iodine-supplemented Sri Lankan population
    O E Okosieme
    Department of Medicine, University of Wales College of Medicine, Cardiff, UK
    Clin Endocrinol (Oxf) 59:190-7. 2003
    ....
  34. ncbi High leptin levels in women developing postpartum thyroiditis
    G Mazziotti
    Department of Medicine, University of Wales College of Medicine Cardiff, UK
    Clin Endocrinol (Oxf) 60:208-13. 2004
    ..There is experimental evidence that leptin is required for the development of T helper 1 (Th1)-mediated autoimmune diseases. However, to our knowledge, there are no studies demonstrating such a role in human autoimmune thyroid disease...
  35. ncbi Prevalence of thyroid antibodies in Nigerian patients
    O E Okosieme
    Centre for Endocrine and Diabetes Science, School of Medicine, Cardiff University, Cardiff CF14 4XN
    QJM 100:107-12. 2007
    ..Thyroid antibody testing is not routinely available in developing countries, and few studies have measured thyroid antibodies in Africans. The significance of thyroid autoimmunity in an African setting is thus unclear...
  36. ncbi A cross-sectional and a prospective study of thyroid disorders in lithium-treated patients
    George Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, Wales, UK
    J Affect Disord 87:313-7. 2005
    ..The effects of lithium treatment on the thyroid gland have been demonstrated in a number of studies. Most of this research is based on cross-sectional studies and prospective studies are required to confirm these observations...
  37. ncbi Subclinical hypothyroidism: the case for treatment
    Penelope J D Owen
    Dept Medicine, University of Wales College of Medicine, Llandough Hospital, Penarth CF64 2XX, Wales, UK
    Trends Endocrinol Metab 14:257-61. 2003
  38. ncbi Early changes in thyroid-stimulating antibody activity following radioiodine therapy
    Akheel A Syed
    Department of Medical Biochemistry, University Hospital of Wales and University of Wales College of Medicine, Cardiff, UK
    Med Princ Pract 12:266-8. 2003
    ....
  39. ncbi Thyroglobulin antibodies in serum of patients with differentiated thyroid cancer: relationship between epitope specificities and thyroglobulin recovery
    Onyebuchi E Okosieme
    Centre for Endocrine and Diabetes Science, School of Medicine, Cardiff University, Cardiff, UK
    Clin Chem 51:729-34. 2005
    ..We identified the epitopes on Tg recognized by TgAb-positive sera from patients with DTC and examined the association between epitope specificity patterns and Tg recovery...
  40. ncbi Islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes from Sri Lanka
    L D K E Premawardhana
    Department of Medicine, Caerphilly Miners Hospital, Caerphilly, UK
    J Endocrinol Invest 29:968-74. 2006
    ..The prevalence of islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes mellitus (Type 1 DM) from Sri Lanka is described...
  41. pmc Management of thyroid disorders
    L D K E Premawardhana
    Department of Medicine, Caerphilly Miners Hospital, Caerphilly, UK
    Postgrad Med J 82:552-8. 2006
    ..The effects of drugs and pregnancy on thyroid function have also been investigated widely. This short review attempts to give an overview and clarify the current management of common thyroid disorders...
  42. doi Augmentation index in resistance to thyroid hormone (RTH)
    P J D Owen
    Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff, UK
    Clin Endocrinol (Oxf) 70:650-4. 2009
    ..The cardiac effects of RTH have been described but vascular function has yet to be fully evaluated in this condition. We have measured the arterial function of those with RTH to assess any vascular changes...
  43. pmc An unusual cause of jaundice
    P J D Owen
    Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff
    BMJ 335:773-4. 2007
  44. ncbi Subacute thyroiditis in an immunosuppressed patient
    K Obuobie
    Department of Medicine, University Hospital of Wales, Cardiff, UK
    J Endocrinol Invest 25:169-71. 2002
    ..We speculate that this case suggests a minimal role of autoimmunity in the development of subacute thyroiditis...
  45. ncbi Thyroglobulin autoantibodies in iodized subjects: relationship between epitope specificities and longitudinal antibody activity
    O E Okosieme
    Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Thyroid 15:1067-72. 2005
    ..The objectives were: (1) to observe the longitudinal profile of TgAb epitope specificities and (2) to examine the relationship between these specificities and the course of thyroid autoimmunity in this population...
  46. ncbi Association of postpartum thyroid dysfunction with antepartum hormonal and immunological changes
    A A Kokandi
    Department of Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    J Clin Endocrinol Metab 88:1126-32. 2003
    ..Thus, the immunological determinants of PPTD may in part occur antenatally, although the mechanism(s) for this is still unclear...
  47. pmc Clinical features of dysthyroid optic neuropathy: a European Group on Graves' Orbitopathy (EUGOGO) survey
    David McKeag
    Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff CF 4 4XN, UK
    Br J Ophthalmol 91:455-8. 2007
    ..This study was performed to determine clinical features of dysthyroid optic neuropathy (DON) across Europe...
  48. ncbi Effect of nadolol on plasma lipids in hyperthyroidism
    M D Littley
    University of Wales College of Medicine, Llandough Hospital, Penarth, S. Glam, Wales, United Kingdom
    Horm Metab Res 21:331-3. 1989
    ..7%, P less than 0.05) was significantly greater (P less than 0.05) than the rise in the placebo group (8.8%). Nadolol increases triglyceride more than placebo during the early management of hyperthyroidism...
  49. ncbi The effects of thyrotoxicosis and its treatment on central arterial stiffness
    K Obuobie
    Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF64 4XN, UK
    Eur J Endocrinol 147:35-40. 2002
    ..To assess central arterial stiffness in thyrotoxicosis using the technique of pulse wave analysis...
  50. ncbi Increased central arterial stiffness in hypothyroidism
    K Obuobie
    Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom CF14 4XN
    J Clin Endocrinol Metab 87:4662-6. 2002
    ..Furthermore, these abnormalities are reversed after adequate T(4) replacement...
  51. ncbi Subclinical hypothyroidism, arterial stiffness, and myocardial reserve
    P J D Owen
    Centre for Endocrine and Diabetes Sciences, Cardiff University, University Hospital of Wales, Cardiff CF14 4XN, Wales, United Kingdom
    J Clin Endocrinol Metab 91:2126-32. 2006
    ..Subclinical hypothyroidism (SCH) is associated with increased risk of cardiac disease; its impact on arterial function is less clear...
  52. ncbi McCune-Albright syndrome: growth hormone dynamics in pregnancy
    K Obuobie
    Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    J Clin Endocrinol Metab 86:2456-8. 2001
    ....
  53. ncbi W546X mutation of the thyrotropin receptor causes subclinical hypothyroidism in various clinical settings
    Pietro Locantore
    Clin Endocrinol (Oxf) 67:317-9. 2007
  54. ncbi The prevalence of elevated serum C-reactive protein levels in inflammatory and noninflammatory thyroid disease
    Elizabeth N Pearce
    Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Thyroid 13:643-8. 2003
    ..00001). These results indicate that there is only a limited role for measurement of CRP levels in the diagnosis of thyroid diseases other than subacute thyroiditis...
  55. ncbi Medical management of thyroid dysfunction in pregnancy and the postpartum
    Onyebuchi E Okosieme
    Prince Charles Hospital, Department of Endocrinology and Diabetes, Cwm Taff NHS Trust Merthyr Tydfil, Mid Glamorgan CF479DT, UK
    Expert Opin Pharmacother 9:2281-93. 2008
    ..Uncontrolled thyroid dysfunction in pregnancy is associated with adverse fetal and maternal outcomes...
  56. ncbi Is there an association between life events, postnatal depression and thyroid dysfunction in thyroid antibody positive women?
    Rossana G Oretti
    Bro Morgannwg NHS Trust, Bridgend, Mid Glamorgan, UK
    Int J Soc Psychiatry 49:70-6. 2003
    ..Postnatal depression is more common in women positive for thyroid autoantibodies, independent of thyroid hormone dysfunction, but the basis of this association is unclear...
  57. doi Iodine deficiency in the UK and Ireland
    John H Lazarus
    Lancet 372:888. 2008
  58. ncbi Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience
    Mark F Prummel
    Department of Endocrinology and Metabolism, F5 171 Academic Medical Center, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 148:491-5. 2003
    ..The European Group on Graves' Orbitopathy aims to overcome this and has designed a preliminary case record form (CRF) to assess Graves' orbitopathy patients. This form was used in this first multi-center study...